FOOD CHEMISTRY
·
2026
·
IF 10.4
Chenyang Wang,Cuiyu Huang,Licheng Yu,Xiwen He,Langxing Chen,Yukui Zhang
In this work, a fluorescent sensor based on dual-emissive RhB/COF@ZIF-90 composite was fabricated for ratiometric detection of tetracycline (TC) residues in foods. To mitigate the aggregation-caused quenching (ACQ) effect of TAPB-DMTA COF, ZIF-90 on TAPB-DMTA COF composite was fabricated by an in situ growth strategy. Rhodamine B (RhB) was subsequently encapsulated within the ZIF-90 framework to construct a dual-emission fluorescent probe. When TC was present, the fluorescence signal at 460, 525 and 570 nm increased linearly with the amount of TC. The I 570 /I 460 and I 525 /I 570 ratio signals were demonstrated in the two linear ranges of 5–100 nM and 0.1–20 μM concentrations of TC, respectively. This multi-signal sensor exhibited a low detection limit of 0.29 nM, enabling highly sensitive detection of TC. Furthermore, this work paves the way for developing other MOF/COF hybrids as multi-emission fluorescent sensors for application in antibiotic sensing in foods.
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Jia Gao,Yifeng Lin,Lan Zhang
Microwave-assisted in situ covalent bonding enables rapid ZIF-90 SPME coating. • Covalent bonding enhanced coating adhesion stability and thermal resistance. • ZIF-90 based SPME-GC–MS achieves rapid, sensitive multi-pesticide residue detection. In this study, a novel microwave-assisted in situ covalent bonding strategy was developed for the rapid fabrication of zeolitic imidazolate framework-90 (ZIF-90) coated solid-phase microextraction (SPME) fibers. Coupled with gas chromatography–mass spectrometry (GC–MS), the prepared fibers were applied for the determination of multi-pesticide residues in vegetables. Under optimized extraction and desorption conditions, the ZIF-90 coated fiber showed satisfactory linearity for 14 pesticide residues in the range of 0.01–10 μg/L, with correlation coefficients ( R 2 ) of 0.9925–0.9999 and limits of detection (LODs) of 0.0026–0.0779 μg/L. The intra-day and inter-day relative standard deviations (RSDs) for a single fiber were ≤ 7.8% and ≤ 8.9%, respectively, and fiber-to-fiber RSDs ranged from 1.5% to 9.4% ( n = 6). The method was successfully applied to cucumber and water spinach matrices, with recoveries of 81.1%–118.6%. These results demonstrate that the ZIF-90 composite exhibited outstanding adhesion stability, thermal tolerance (up to 500 °C), and excellent reusability (>70 cycles), which is a promising candidate for the trace analysis of multi-pesticide residues in complex food matrices. Download: Download high-res image (200KB) Download: Download full-size image
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Xiru Zhang,Manyan Qiu,Yiyi Zhang,Qianyu Zhao,Bo Qu,Wei Zhang,Xianlong Zhang,Yujun Jiang
Foodborne pathogens have posed a great threat on food safety and public health, and thus the development of accurate and sensitive methods for the detection of foodborne pathogens is of great significance. In this study, a novel Pyrococcus furiosus Argonaute ( Pf Ago) biosensing platform based on metal-organic framework (MOF) nanozyme (namely AgoZyme) was developed for the detection of Salmonella typhimurium . Inspired by the catalytic characteristics of horseradish peroxidase, we synthesized a Hemin@ZIF-90 nanozyme with peroxidase-like activity by encapsulating hemin into a zeolitic imidazolate framework-90 through a self-assembly strategy. By integrating the specific recognition and cleavage capabilities of Pf Ago with the highly catalytic performance of Hemin@ZIF-90, the AgoZyme biosensor exhibited excellent detection sensitivity and specificity. This biosensor had a limit of detection of 1 CFU/mL in a linear range from 10 1 to 10 8 CFU/mL. This work provided a new insight for designing and developing novel biosensors for food safety detection.
研究领域:
生物传感器
·
食品安全
·
纳米技术
·
分子诊断学
·
微生物学
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Materials Chemistry Frontiers
·
2023
·Vol. 7
·期 14
·2896-2905
·
IF 7
Ke-Xin Li,Guo-Wei Guan,Ling-Min Pei,Qing-Yuan Yang
Since peroxidases have potential applications as biocatalysts, it is important to improve their usefulness. Traditional “semiconductor photocatalyst + peroxidase” catalytic cascade systems are inspired by nature's photosynthesis and provide the basis for maintaining the optimal stability and reactivity of the peroxidase enzyme. However, inherent fragility, non-recyclability, and low catalytic efficiency still limit their industrial application. In this work, we present a new generation of photoperoxidase catalytic platform, g-C3N4/PDI-HRP@ZIF-90 (graphite carbon nitride; PDI: perylene diimide; and HRP: horseradish peroxidase), for efficient photo-peroxidase catalysis. This new composite catalyst was created by introducing a rationally designed metal–organic framework (ZIF-90) in situ as a dual “modulator” for the “semiconductor photocatalyst + peroxidase” catalytic cascade system, which is highly applicable to industrial applications. In situ introduced modulators of ZIF-90 not only significantly increase the electron transfer rate but also significantly improve enzyme stability, cyclability, and molecular transfer rates between photoenzyme catalytic systems through spatial confinement. The new catalytic system (semiconductor + MOF + peroxidase) is capable of responding to a cascade catalytic reaction with wavelengths > 420 nm and is resistant to a catalytic environment at pH = 3. This work outlines a versatile and effective strategy to use the properties of MOFs to improve two major drawbacks of the efficient industrial use of peroxidases (inefficiency and poor stability), paving the way for efficient green biomanufacturing industrialization using peroxidases.
研究领域:
生物化学
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材料科学
·
环境科学
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ACS Applied Nano Materials
·
2024
·
IF 5.3
Senyi Gong,Mengdi Shang,Runnan Shao,Sen Li,Li He,Yanfei Cai,Teng Wang,Jian Jin,Zhaoqi Yang
Chemotherapy as a primary treatment for breast cancer is limited due to drug resistance in clinical treatment. The rapid proliferation and invasive biological properties of breast cancer, resulting in intratumoral hypoxia and adaptive antioxidation, are common manifestations of drug-resistant breast cancer. Photodynamic therapy is a potential strategy to overcome drug resistance, but its effectiveness is often limited by tumor hypoxia. In order to overcome the problem of tumor hypoxia and improve the effectiveness of photodynamic therapy, a strategy that employs ZIF-90 nanoparticles simultaneously delivering a hypoxia-induced drug (TPZ) and photosensitizer Ce6 labeled antisense nucleic acid (Ce6-G3139) into breast cancer cells was developed. Owing to the pH responsiveness of ZIF-90, TPZ and Ce6-G3139 are able to be efficiently released inside the tumor microenvironment. First, Ce6-G3139 can perform gene therapy, downregulating the expression of antiapoptotic protein BCL-2 and accelerating cell apoptosis. On the other hand, photosensitizer Ce6 can undergo photodynamic therapy (PDT), producing reactive oxygen species that interfere with the apoptosis mechanism of cells. More importantly, although the continuous consumption of oxygen in PDT aggravates the hypoxic environment of the tumor, the hypoxic-induced chemotherapy drug was further activated. Our research results indicate that the designed strategy targeting the hypoxic microenvironment of drug-resistant breast cancer exhibits significant anticancer effects both in vitro and in vivo, favoring the development of a PDT treatment paradigm that is effective against drug resistance under hypoxic conditions.
研究领域:
肿瘤学
·
纳米技术
·
药学
·
生物医学工程
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2026
·Vol. 65
·期 34
·18449-18463
·
IF 3.9
Kasuri Amna,Khan Palwasha,Khan Asim Laeeq,Gilani Mazhar Amjad,AlMohamadi Hamad,Batool Mehwish,Usman Muhammad,Zaman Muhammad,Yasin Muhammad
Mixed matrix membranes (MMMs) are promising for overcoming
the
permeability–selectivity limitations of polymeric membranes,
yet their performance is often restricted by filler aggregation and
interfacial defects at high loadings. Here, we introduce ZIF-90 in
a porous liquid-like dispersion form as a filler for high-performance
MMMs. Carbene functionalization provides liquid-like interfacial compatibility
while preserving the microporosity of ZIF-90, enabling homogeneous
nanoscale dispersion within a polydimethylsiloxane (PDMS) matrix at
high loading. This architecture creates continuous selective transport
pathways and suppresses nonselective interfacial defects. Consequently,
the ZIF-90-PL/PDMS membrane exhibits enhanced permeability and selectivity,
achieving a total flux of 3.86 kg m –2 h –1 and a separation factor of 29.3 for ethanol recovery at 60 ° C
with 45 wt % loading, outperforming conventional MMMs. Mechanistic
analysis reveals that functionalization enhances ethanol-selective
sorption and reduces diffusion resistance, mitigating the permeability–selectivity
trade-off. These findings establish the porous liquid-like MOF dispersion
as an emerging class of membrane fillers for future separation membranes.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Jianqi Mao,Wanli Qiao,Xinping He,Xiwei Qu,Chunhai Yi
ZIF-90 is in-situ grown in benzimidazole-containing polyimide (DB55) via Zn 2+ anchoring for CO₂ separation. • In-situ growth gives uniform filler dispersion and strong interfacial adhesion via Zn 2+ -benzimidazole coordination. • The in-situ grown membrane shows 2.5-fold higher CO₂ permeability than blended MMMs. The intrinsic permeability-selectivity trade-off and CO₂-induced plasticization, exacerbated under high-feed pressure and elevated operating temperatures, severely restrict the application of polyimide membranes in CO₂ capture processes. In this work, a benzimidazole-containing polyimide (DB55) was employed as an anchoring platform for Zn 2+ ions to carry out the confined in-situ growth of ZIF-90 crystals directly within the polymer chains. The coordination bonds between Zn 2+ and the benzimidazole groups of DB55, as evidenced by FTIR and XRD, effectively suppress polymer chain mobility and filler agglomeration, facilitating rapid gas transport. The optimized ZIF-90/dB55–2 membrane exhibits a CO₂ permeability of 269.57 Barrer with CO₂/N₂ and CO₂/CH₄ selectivities of 42.04 and 40.08, respectively, surpassing the 2008 Robeson upper bound for CO₂/CH₄ separation. Compared with physically blended membranes, the optimized in-situ grown membranes show a clear advantage in permeability (approximately 4.4-fold over pristine DB55) along with improved solvent resistance, while the physically blended membranes exhibit slightly higher selectivity due to the partial conversion of Zn 2+ into ZIF-90 during in-situ growth. Temperature-dependent tests reveal that the incorporation of ZIF-90 reduces the activation energies for CO₂, N₂, and CH₄ permeation, and that the ZIF-90/dB55–2 membrane exhibits a smaller decline in CO₂/CH₄ selectivity with increasing temperature than the pristine DB55 membrane. Pressure-dependent tests up to 3.0 MPa further reveal that the MMMs retain stable performance with a smaller loss in CO₂/CH₄ selectivity (6.9%) than the neat polymer (10.0%), indicating enhanced plasticization resistance. This work offers a promising approach to simultaneously improve permeability, selectivity, and operational stability in polyimide-based membranes via in-situ MOF growth within a suitably designed polymer matrix.
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CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Peijing Shao,Zheng He,Yutao Hu,Yao Shen,Shihan Zhang,Yanan Yu
Carbonic anhydrase (CA) enzyme-based absorption processes represent a promising approach to flue gas CO 2 capture owing to their rapid absorption rates and low energy penalties. However, CA enzymes exhibit poor stability and activity under typical flue gas conditions, thus constraining their industrial utilization. Enzyme immobilization has been proposed as a potential means of improving associated stability and activity levels, thus overcoming these limitations. Herein, a variety of zeolitic imidazolate frameworks including ZIF-8, ZIF-11, and ZIF-90 with a range of organic ligands were synthesized as adsorption-based carriers for CA enzyme immobilization. In a series of experiments, CA immobilized on ZIF-8 (CA/ZIF-8) was found to retain higher activity levels that were approximately 86% of those of the free enzyme, as compared to 44% and 16% for CA/ZIF-11 and CA/ZIF-90, respectively. Immobilized CA and associated carrier frameworks were characterized via XRD, SEM, and BET. Variations in CA enzyme secondary structural characteristics in the context of immobilization were monitored via FTIR and CD to explore the molecular basis for variable activity levels associated with different carriers, revealing more hydrophilic materials to be conducive to the preservation of enzymatic activity. In addition, carrier precursor selection should take both hydrophilicity and the potential inhibitory effects of functional groups on the CA enzyme into account.
研究领域:
化学工程
·
环境科学
·
材料科学
·
生物化学
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2022
·
IF 5.999
Yifeng Wang,Xi Luo,Xiaolong Sun,Jiahuan Hu,Qing Guo,Baoxing Shen,Yongqian Fu
In this study, we synthesized a novel biocatalyst by encapsulating lactate dehydrogenase (LDH) in the metal-organic framework ZIF-90 by one-pot embedding. It showed strong biological activity for efficient synthesis of D -phenyllactic acid ( D -PLA). The morphology and structure of LDH@ZIF-90 was systematically characterized by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectroscopy, confocal laser scanning microscopy (CLSM) and gas sorption . According to thermogravimetric analysis (TGA), the enzyme loading of the biocatalyst was 3 %. The Michaelis–Menten constant (K m ) and maximal reaction rate (V max ) of LDH@ZIF-90 were similar to those of free LDH, which proved that ZIF-90 had good biocompatibility to encapsulate LDH. At the same time, LDH@ZIF-90 exhibited enhanced tolerance to temperature, pH and organic solvents , and its reusability was greatly improved with 68 % of initial enzyme activity remaining after 7 rounds of recylcing. Overall, LDH encapsulated in ZIF-90 may be an economically competitive and environmentally friendly novel biocatalyst for the synthesis of D -PLA.
研究领域:
生物化学
·
催化
·
材料科学
·
生物技术
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ADVANCED FUNCTIONAL MATERIALS
·
2026
·
IF 19
Wenjia Liu,Nina Zhang,Xu Guo,Xiaofan Zhang,Ying Wang,Jinchao Zhang,Kun Ge,Guoqiang Zhou
Immunotherapy is rapidly emerging as a potent, targeted therapy for breast cancer. However, the low immunogenicity and immunosuppressive tumor microenvironment (TME) in breast cancer limit its efficacy. In this study, a novel nanoreactor, CeO 2 :Mn (CM) embedded with the zeolitic imidazolate framework-90 (ZIF-90) and loaded with 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), is developed and designated CeO 2 :Mn/ZIF-90/ABTS (CMZA). Zn 2+ release from ZIF-90 degradation in the TME triggers pyroptosis and elevates intracellular •O 2 − levels by inhibiting the electron-transport chain. Furthermore, the CM nanozyme exhibits multienzyme activities, including superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT), which convert •O 2 − to H 2 O 2 , generate •OH, produce O 2 , and oxidize ABTS to oxidized ABTS (oxABTS). The oxABTS exhibits strong near-infrared absorption and converts 808 nm light into heat, enhancing CM catalysis and depleting intracellular glutathione (GSH), thereby further amplifying the accumulation of reactive oxygen species (ROS). Collectively, CMZA induces NLRP3/c-Caspase-1/GSDMD-N pyroptosis through Zn 2+ release and photothermal-enhanced multienzyme activity, reshaping the TME and boosting immunogenicity to limit tumor progression and metastasis.
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ChemNanoMat
·
2021
·Vol. 7
·期 12
·1361-1368
·
IF 3.154
Zhaoyu Han,Yue Qian,Yiyang Wu,Yanfei Cai,Jian Jin,Zhaoqi Yang
Graphical A hybrid drug delivery system based on ZIF-90 encapsulated with Doxorubicin and Ce6-G3139 has been established to induce apoptosis for enhanced chemotherapy. Metal-organic frameworks are highly porous and biodegradable and have found numerous applications in biomedicine. However, the traditional chemotherapy of MOF-drug delivery system remains a great challenge because of adverse side effects and cell tolerance. In this work, we have fabricated a hybrid drug delivery system based on ZIF-90 encapsulated with Doxorubicin (DOX) and Ce6-G3139 for enhanced chemotherapy. The released DOX can enter cell nucleus and trigger cell death. In addition, the G3139 binds to the anti-apoptotic gene Bcl-2 in tumor cells and related proteins are downregulated to inhibit cell proliferation. Meanwhile, the photosensitizer Ce6 carried by the nucleic acid will generate abundant reactive oxygen species under a near-infrared (NIR) laser irradiation thus induces more cell apoptosis. It was worth mentioning that in vitro MTT test in the MCF-7 cells assays revealed that DOX@ ZIF-90/Ce6-G3139 nanoparticles possessed stronger anticancer capability than free DOX or DOX@ ZIF-90 nanoparticles indicating that the investigation offers an exciting new therapeutic strategy for the treatment of chemotherapy.
研究领域:
生物医学工程
·
癌症治疗
·
纳米技术
·
药学
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BIOMEDICINE & PHARMACOTHERAPY
·
2021
·
IF 6.53
Mengdi Shang,Yiyang Wu,Yeyang Wang,Yanfei Cai,Jian Jin,Zhaoqi Yang
Triple negative breast cancer (TNBC) is a greatly aggressive subtype of breast cancer with high recurrence and mortality rates. Chemotherapy as a primary treatment for cancer is limited due to toxic side effects and drug resistance. Therefore, low toxicity and more effective breast cancer therapeutic approaches are greatly desired. In this study, a strategy which using ZIF-90 nanoparticles co-deliver Ce6-anti-miR-21 and Ce6-anti-miR-155 into the tumor cells was developed. Due to the pH responsive drug release of ZIF-90, antisense oligonucleotides (anti-miRNAs) and photosensitizers are able to be efficiently released inside tumor microenvironment. The nano delivery system captures overexpressed oncogenic miRNAs while the photosensitizer Ce6 generates ROS under light irradiation to effectively induce the apoptosis of tumor cell. This combinatorial effect was verified by results showing that the purposed therapic method could effectively inhibit tumor cell proliferation and metastasis. The concept of antisense oligonucleotide combined with photodynamic therapy has great potential in cancer treatment or adjuvant therapy.
研究领域:
肿瘤学
·
分子生物学
·
纳米技术
·
癌症治疗
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