Materials Science & Engineering C-Materials for Biological Applications
·
2016
·
IF 3.42
Na An,Huiming Lin,Chunyu Yang,Ting Zhang,Ruihan Tong,Yuhua Chen,Fengyu Qu
The targeting drug release is significant to the anticancer treatment. In this context, the redox-responsive drug delivery has attracted most attention owing to the intracellular reductive environment, such as the high concentration of glutathione reductase in many cancer cells. Herein, a glutathione sensitive drug delivery nanoplatform was constructed by using core-shell mesoporous silica nanocomposite (Fe 3 O 4 @mSiO 2 ) as carrier. By a simple silane coupling reaction, the glutathione cleavable diselenide linker has been prepared and grafted on to Fe 3 O 4 @mSiO 2 to insure the encapsulation of anticancer drug doxorubicin. The detail release kinetics studies reveal the glutathione triggered drug release, which could be further adjusted by varying the amount of diselenide linker. To improve the tumor-targeting, folic acid was grafted. The cellular uptake and drug release investigation was carried out using HeLa (cervical cancer cell line) as the model cancer cell and L02 and HUVEC (human hepatic cell line and human umbilical vein endothelial cells, non-cancerous cell lines) as control, indicating the enhanced cytotoxicity toward HeLa cells that benefits from the fast endocytosis and enhanced cellular drug release owing to their overexpressing folic acid receptors and high concentration of glutathione. Associating with the magnetic targeting, these novel nanomaterials are expected to be promising in the potential application of tumor-targeting therapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2017
·Vol. 9
·期 8
·2824-2835
·
IF 7.367
Zhi-Qiang Zhou,Li-Yun Yang,Ren Yan,Jie Zhao,Yu-Qi Liu,Lu Lai,Feng-Lei Jiang,Thomas Maskow,Yi Liu
Although cation exchange (CE) has been studied for many years and some mechanisms were proposed, there is still a knowledge gap in CE and problems such as the need for high temperature and it being time-consuming are still unaddressed. We developed a new mild strategy for CE by introducing a new ideal template and first applied this doping strategy to detect Cd2+ and Hg2+. This strategy adopted Mn-doped ZnSe quantum dots (QDs) as the template and the introduction occurs via a two-step CE reaction: first Zn2+ was partially substituted by X (X = Cd2+, Hg2+, Cu2+, Ag+ or Pb2+), later Mn2+ (in the deep structure of QDs) was substituted by X. Remarkably, Mn2+ in the lattice can be easily substituted by a dopant and its replacement by a dopant helps to bury the metal ions. The ultra-fast introduction of Cd2+ and Hg2+ (70 minutes for Cd2+ and 19 minutes for Hg2+) was realized at room temperature; other metal ions such as Ag+, Cu2+ and Pb2+ can be buried at 50 °C. This mild reaction temperature offers a solution for introducing impurities without sacrificing the interfacial structure of nanocrystals. HRTEM, XPS and ICP measurements were applied to analyze the introduction process. Furthermore, the spectroscopic method was employed to analyze the introduction, migration and distribution of metal ions. Then, we proposed a mechanism for the chemical conversion of nanocrystals by CE. Through this strategy, full-color light-emitting doped QDs were fabricated. Strikingly, a new turn-on probe for the detection of Cd2+ and Hg2+ with improved selectivity was developed by adopting this doping strategy. The detection limit is 36 nM for Cd2+ and 20 nM for Hg2+, which is competitive with the limit of detection reported by other groups using QDs as sensors.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2017
·Vol. 5
·期 4
·669-677
·
IF 4.21
Chao Wei,Yan Zhang,Zhongchen Song,Yiru Xia,Heng Xu,Meidong Lang
Stimuli-responsive nanocarriers have been limited for bench-to-bedside translation mainly because the stimuli sensitivity and responsive rate are not high enough to ensure sufficient drug concentration at the target sites for superior therapeutic benefits. Herein, we reported an enhanced bioreduction-responsive and biodegradable nanocarrier based on the amphiphilic poly(ester urethane) copolymers (PAUR-SeSe) bearing multiple diselenide groups on the backbone. The copolymer could spontaneously self-assemble into stable micelles in aqueous medium with an average diameter of 68 nm, which could be rapidly disassembled in a reductive environment as a result of the reduction-triggered cleavage of diselenide groups. Furthermore, the PAUR-SeSe micelles showed an enhanced drug release profile and cellular uptake compared with the disulfide-containing analogue (PAUR-SS). CCK8 assays revealed that the antitumor activity of DOX-loaded PAUR-SeSe micelles was much higher than that of DOX-loaded PAUR-SS micelles. Besides, the blank micelles and degradation products were nontoxic up to a tested concentration of 50 μg mL−1. Therefore, the enhanced therapeutic efficacy and good biocompatibility demonstrated that this drug nanocarrier had great potential for smart antitumor drug delivery applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2016
·
IF 3.782
Tingting Zhao,Xin Liu,Yuebin Li,Mingguang Zhang,Jian He,Xuewen Zhang,Hui Liu,Xingguo Wang,Haoshuang Gu
Hydrophobic ZnSe:Mn/ZnS core-shell fluorescence quantum dots (QDs) and anticancer drug paclitaxel (PTX) have been co-loaded into folate conjugated hybrid silica nanocapsules via F127 micelles based soft-template method in a mild aqueous environment at room temperature . The encapsulation of QDs shows a F127: QDs mass ratio dependent behavior, which impact much on the morphology and optical properties of composite nanocapsules . These as prepared composite nanocapsules also exhibit good photoluminescence stability under the temperature ranges from 19 °C to 49 °C. In addition, the aqueous solubility of PTX (0.1 μg/mL) can be efficiently enhanced about 630 times to 62.99 μg/mL, and the loaded PTX could be released during 12 h sustainably. These tunable fluorescence, enhanced drug loading efficiency and sustained release behavior manifest that the hybrid nanocapsule is a promising theranostic nanoplatform for future combined fluorescence imaging and chemotherapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2016
·Vol. 4
·期 35
·13476-13481
·
IF 8.262
Dandan Zhao,Qingmiao Fan,Qingwen Tian,Zhengji Zhou,Yuena Meng,Dongxing Kou,Wenhui Zhou,Sixin Wu
A non-hydrazine solution process has been considered as a promising way for the deposition of Cu(In,Ga)(S,Se)2(CIGSSe) thin films. However, from our previous work, the presence of a fine-grained layer in the absorber layer was shown to be an obstacle to further improve the solar cell efficiency. Here, an improved fabrication route is proposed to solve this problem. A mixture of Cu2S, In2Se3, Ga and Se was simultaneously dissolved in 1,2-ethanedithiol and 1,2-ethylenediamine, forming a homogeneous precursor solution to deposit CIGSSe nanocrystal films. By optimizing the selenization method by using rapid thermal processing (RTP) combined with an improved graphite box, large grains throughout the whole absorber layer were successfully obtained. Based on such a high-quality CIGSSe absorber layer, an encouraging power conversion efficiency of 11.8% has been achieved with a Jsc of 28.25 mA cm−2, a Voc of 596 mV and a FF of 69.79% and without an antireflection coating.
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 79
·75023-75031
·
IF 3.289
Qian Zhou,Ailian Wang,Huayi Li,Zhi Luo,Tao Zheng,Liaoyun Zhang,Youliang Hu
Five salicylates with different sizes of hydrocarbon substituents were firstly synthesized and employed as ecofriendly internal donors of the Ziegler–Natta catalyst for propylene polymerization. The influences of these salicylates and traditional, industrial, internal donor diisobutyl phthalates on the microstructure of polypropylene and active center in a Ziegler–Natta catalyst were studied. It was found that the catalyst activities of the catalysts containing salicylate internal donors with a proper volume were higher than the catalysts containing diisobutyl phthalate internal donors. GPC results showed that the molecular weights of polypropylene prepared by salicylate internal donors were lower than those prepared by diisobutyl phthalate, which indicated that the polypropylene chains produced by salicylate internal donors were easier to transfer than those prepared by diisobutyl phthalate internal donors. Deconvolution of the GPC curves exhibited that as the volume of the salicylate internal donor increased some of the active centers for low molecular weight transferred into the active centers for high molecular weight. The results of 13C-NMR and SSA both suggested that a salicylate internal donor with an appropriate catalyst size volume was beneficial for increasing the isotactic sequence length, isotacticity index and regular triads “mm” of polypropylene. However, further increasing the volume of the salicylate internal donor in a catalyst would lead to the polypropylene chain containing more stereo-defects. Moreover, the active centers with different stereospecificity parameters, piso, in the catalyst could explain the trend of stereo-defects in polypropylene chains when different internal donors were used. In addition, it was found that the isotactic sequence length and isotacticity index of polypropylene prepared by isobutyl 2-benzyloxy-3,5-isopropyl benzoate were close to that produced by a diisobutyl phthalate internal donor. Moreover, the lamella thickness distribution of the polypropylene produced by a salicylate internal donor was broad, which might have potential application for expanded polypropylene materials.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2016
·Vol. 18
·期 7
·1-8
·
IF 2.101
Zhao Chenhao,Fang Shuzhen,Hu Zhibiao,Qiu Sheng’en,Liu Kaiyu
The carbon substrate with unique 3D macroporous structure has been prepared through the immediate carbonization of ethylenediaminetetraacetic acid (EDTA) and KOH mixture. The porous carbon composed of micro- and small mesoporous (2–5 nm) structure has a BET specific surface area of 1824.8 m 2 g −1 . The amorphous and nanosized Se is uniformly encapsulated into the porous structure of porous carbon using melting diffusion route, and the weight content of Se in target Se/C composite can be as high as ~50 %. As an Li–Se battery cathode, the Se/C composite delivers a reversible (2nd) discharge capacity of 597.4 mAh g −1 at 0.24C and retains a discharge capacity of 538.4 mAh g −1 at 0.24C after 100 cycles. Furthermore, the composite also has a stable capacity of 291.0 mAh g −1 at a high current of 4.8C. The high specific area and good porous size of EDTA-derived carbon substrate may a be responsibility for the excellent electrochemical performances of Se/C composite.
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 74
·70452-70459
·
IF 3.289
Makkawi Osman,Yanmin Huang,Wei Feng,Guangbo Liu,Yunfeng Qiu,PingAn Hu
Phase engineering of two-dimensional (2D) materials offers unique opportunities for acquiring novel opto-electronic properties and allows for the searching of outstanding candidates for applications in opto-electronic detectors, sensors, catalysis, or phase-change memory devices. Here, we report the phase-transformation from β-InSe to γ-In2Se3, exploiting the thermal annealing route to trigger the process starting at 200 °C that expands the family of phase-change materials. The presence of γ-In2Se3 is solidly confirmed by the characteristic peaks in X-ray diffraction (XRD) and energy dispersive X-ray (EDX), and is quite stable at ambient condition, thus facilitating substantial application in phase-change memory devices. A Raman shift in the A′1 mode from 225 cm−1 to 230 cm−1 further illustrates the phase transformation. Besides the photoluminescence (PL) peak of β-InSe, the ∼2 eV PL peak, ascribed to γ-In2Se3, is observed in the annealed nanosheet. The increased PL band gap of β-InSe as a function of annealing temperature during phase transformation was possibly affected by the suppressed interlayer coupling, as well as the planar quantum confinement of photo-excited carriers by the external surfaces of the sheets. The photodetector performance with respect to photocurrent, mobility, detectivity, responsivity, and external quantum efficiency was subsequently evaluated after thermal annealing, showing deteriorated optical performance. The present work proved that thermal annealing could induce the successful phase transformation, and adjusted the opto-electronic properties in some extent, providing useful information for processing 2D materials based nano-devices.
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2017
·Vol. 184
·期 5
·1353-1360
·
IF 4.58
Liu Qiao,Liu Xing-Pei,Wei Yu-Pin,Mao Chang-Jie,Niu He-Lin,Song Ji-Ming,Jin Bao-Kang,Zhang Sheng-Yi
CdSe:Eu nanocrystals were successfully synthesized and characterized by transmission electron microscopy, X-ray powder diffraction, and X-ray photoelectric spectroscopy. The CdSe:Eu nanocrystals showed enhanced green electrochemiluminescence (ECL) intensity when compared to pure CdSe nanocrystals. Further, the nanocrystals were used to design an ECL immunosensor for the detection of carcinoembryonic antigen (CEA) that has a linear response over the 1.0 fg·mL −1 to 100 ng·mL −1 CEA concentration range with a 0.4 fg·mL −1 detection limit. The assay was applied to the determination of CEA in human serum samples.
Schematic of the assay: GCE-glassy-carbon electrode, Ab- Antibody, BSA- Bovine serum albumin, Ag- Antigen. CdSe:Eu nanocrystals were used to design an ECL immunosensor for the detection of carcinoembryonic antigen.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2016
·Vol. 27
·期 7
·6656-6664
·
IF 1.798
Lin Yibing,Lin Yu,Wu Jihuai,Zhang Xiaolong,Fang Biaopeng
In this study, after CdS quantum dots sensitized ZnO hierarchical spheres (ZnO HS), we used a simple process to deposit CdSe QDs on ZnO by spin-coating-based SILAR, and applied to photoanodes of quantum dots-sensitized solar cells. Before CdS and CdSe QDs deposition, the ZnO HS photoanodes were modified by Zn(CH 3 COO) 2 ·2H 2 O methanol solution to further enhance the open-circuit voltage and power conversion efficiency (PCE). The program of modifying photoanodes and the number of CdSe spin-SILAR cycles are evaluated on the optical and electrochemical properties of the cells. As a result, a high energy conversion efficiency of 2.49 % was obtained by using modified ZnO HS/CdS photoanode under AM 1.5 illumination of 100 mW cm −2 . And further decorated by the CdSe QDs, the ZnO HS/CdS/CdSe cell achieved a PCE of 5.36 % due to the modification of ZnO HS nanostructure, the enhanced absorption in the visible region, the lower recombination reaction and higher electron lifetime.
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 31
·25656-25661
·
IF 3.289
Zhixiang Jiang,Katarzyna Matras-Postolek,Ping Yang
Several kinds of hydrophobic quantum dots (QDs) including CdSe, CdTe, CdSe/CdxZn1−xS, and CdTe/CdSe/ZnSe were fabricated via organic synthesis to observe morphology variation during shell coating. CdSe QDs prepared at a relatively high temperature revealed a hexagonal structure and rod morphology. On being coated with a CdxZn1−xS shell, tetrahedron and rod morphologies were observed. It was found that the reaction temperature and injection rate play important roles. The photoluminescence properties of the core/shell QDs depended strongly on their preparation conditions such as temperature and ligands. For CdSe cores created at a relatively low temperature, CdxZn1−xS shell coating resulted in the formation of cubic CdSe/CdxZn1−xS core/shell QDs. This is ascribed to the role of a CdS interlayer. In contrast, multishell CdTe/CdSe/ZnSe QDs revealed a spherical morphology. Furthermore, the self-assembly of QDs with hexagonal structures occurs while regular assembled structures were not observed for QDs with a cubic morphology according to their transmission electron microscopy images. This is ascribed to a dipole force between QDs. This phenomenon is just related to the morphology and crystal structures rather than their composition.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry A
·
2016
·Vol. 4
·期 11
·4125-4133
·
IF 8.262
Li Chen,Weilin Chen,Huaqiao Tan,Jiansheng Li,Xiaojing Sang,Enbo Wang
Quantum dot sensitized solar cells with high theoretical conversion efficiency, low production cost and a simple production process have received great attention in recent years. For CdSe-sensitized cells, the most significant defect of CdSe is that it has the weak absorption between 550 and 600 nm and no absorption after 650 nm, so it is crucial to find a wide spectrum photosensitizer to make up for the defect. Here, wide spectrum and pure inorganic Donor–Acceptor (D–A) Type Polyoxometalate (POM) K6H4[α-SiW9O37Co3(H2O)3]·17H2O (denoted as T) is firstly introduced into QDSCs as a collaborative cosensitizer with CdSe. The T has a visible characteristic peak centering between 550 and 600 nm, and also has stronger absorption after 650 nm, which could make up for the defect of CdSe to constitute a wide spectrum of absorption. The fluorescence spectrum, surface photovoltage spectrum, ultraviolet photoelectron spectroscopy spectrum and solid diffuse spectrum were used to explore the photosensitivity of T. In addition, the D–A type POM can act as a good intermediate for the injection of electrons and improve the visible photocurrent response; meanwhile, it can obviously reduce the dark current and increase the electron lifetime, which can solve the problem about the high recombination at the QD/TiO2/electrolyte interface. In general, the best photovoltaic performance of T and CdSe cosensitized solar cells is increased to 6.59% (Jsc = 18.37 mA cm−2, Voc = 0.57 V, FF = 0.63), which is improved by 32.33% compared to those of the pure CdSe-sensitized cells (Jsc = 16.20 mA cm−2, Voc = 0.50 V, FF = 0.61, η = 4.98%).
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）