查找使用阿拉丁产品的科研文献

Development of amphiphile 4-armed PEO-based Ti4+ complex for highly selective enrichment of phosphopeptides

Yu-Lin Huang,Jian Wang,Ying-Hua Jiang,Peng-Yuan Yang,Guo-Wei Wang,Feng Liu

Protein phosphorylation is a reversible and important post-translational modification. Identification of phosphopeptides without enrichment is difficult for the low-abundance of phosphopeptides in real complex biological samples. Therefore, the effective and selective concentration of phosphopeptides prior to proteomic identification by mass spectrometer is necessary. In this study, we synthesized a novel titanium-based immobilized metal ion affinity chromatography material for highly selective enrichment of phosphopeptides. To improve material hydrophilia to the maximum extent, titanium ions were immobilized on the 4-armed Poly(ethylene oxide)(4μ-PEO-Ti 4+ ), a totally soluble polymer with large molecular weight (20000 g/mol). The 4μ-PEO-Ti 4+ was used to enrich phosphopeptides from tryptic digests of standard proteins and real complex biological samples, followed by MALDI-TOF MS analysis. In enrichment of phosphopeptides from 4 pmol β-casein, the 4μ-PEO-Ti 4+ performed the best property with starting material of 99–132 μg, loading buffer of 50% ACN/5% TFA (v/v), elution buffer of 10% NH 3 ·H 2 O (v/v) and elution time of 30 min. The 4μ-PEO-Ti 4+ has a superior detection sensitivity as low as 2 fmol for phosphopeptides. The high selectivity of 4μ-PEO-Ti 4+ allows a deep enrichment of phosphopeptides of β-casein from a mixture with BSA of 1000-fold abundant. The 4μ-PEO-Ti 4+ shows great stability and endurability and can be recycled up to at least 5 times. In addition, 4μ-PEO-Ti 4+ could detect 10 and 15 phosphopeptides from non-fat milk and nonenzymatic human saliva, respectively. In total, 4μ-PEO-Ti 4+ is a novel excellent material which shows great sensitive and selective enrichment of low-abundance phosphopeptides in real complex biological samples.

Oxygen Vacancy-Induced Dipole Moment Enhancement in BiVO 4 for Efficient Pyro-Catalytic Hydrogen Evolution

Jie Zhang,Qifeng Jia,Meng Li

Pyroelectric catalysis utilizes temperature fluctuations to drive hydrogen production reactions, but its application is limited due to the relatively weak spontaneous polarization intensity of most materials. Electron localization function (ELF) and density functional theory (DFT) calculations demonstrates that the presence of oxygen vacancies induces an asymmetric charge distribution in the BiVO4 lattice and disrupts its local symmetry. This distortion leads to an enhanced local dipole moment, thereby effectively improving the macroscopic spontaneous polarization capability. The COMSOL simulation indicates that the fluctuation of temperature difference and the pyroelectric potential exhibit a nonlinear response relationship. The polarization field induced by the pyroelectric effect effectively promotes the separation of electrons and holes, resulting in a remarkably high hydrogen evolution rate of 5.38 mmol h-1 g-1 for BiVO4-VO. This work not only provides profound atomic-level insight into the defect-mediated polarization enhancement mechanism but also establishes a practical foundation for designing high-performance pyroelectric catalysts that can efficiently harvest low-grade waste heat for sustainable hydrogen production.

Preparation of Menthyl 3-amino-4-(2,4,5-trifluorophenyl) Butyrate and Investigation of its Hypoglycemic Activity

Kuang Xinmou,Su Minru,Li Hao,Sheng Xiaolan,Cai Huan,Xie Shuilin,Liu Zhonghua

Background: 3-Amino-4-(2,4,5-trifluorophenyl) butyric acid has potential pharmacological effects in promoting insulin secretion. Menthol promotes drug transdermal absorption and hypoglycemic effects. Objective: The objective of the study was to combine the 3-amino-4-(2,4,5- trifluorophenyl) butyric acid and menthol to develop a new candidate drug molecule that can be used as a hypoglycemic drug in type II diabetes. Methods: In this study, the molecular structure of 3-amino-4-(2,4,5-trifluorophenyl) butyric acid in sitagliptin was modified by replacing pyrazine imidazole with menthol. The structure of the target compound was characterized by nuclear magnetic resonance (NMR). The anti-diabetic activity of BHF in N000180 BKS.Cg-Dock7m+/ +Leprdb/Nju mice with spontaneous diabetes was preliminarily studied. Results: A potential multi-target drug molecule, 3-amino-4-(2,4,5-trifluorophenyl) butyrate (BHF), was synthesized by combining 3-amino-4-(2,4,5-trifluorophenyl) butyric acid and menthol. BHF is suitable for hyperglycemic mice and has a significant hypoglycemic effect; the low dose of 10 mg/kg-1 started to be effective, and the high dose of 40 mg/kg-1 was more effective than the positive drug metformin. Conclusion: In this study, BHF has been synthesized and presented significant antidiabetic activities.

Polyethyleneimine-oleic acid micelle-stabilized gold nanoparticles for reduction of 4-nitrophenol with enhanced performance

Wang Longgang,Zhang Xuan,Cui Yanshuai,Guo Xiaolei,Chen Shengfu,Sun Haotian,Gao Dawei,Yang Qinghua,Kang Jianxin

Abstract Noble metal nanoparticles have been drawing great attention for the treatment of water pollutants. The catalytic activity of noble metal nanoparticles is usually reduced due to their aggregation. Amphiphilic molecule micelles have potential to stabilize the noble nanoparticles against aggregation. In this study, a novel facile method was reported for preparing polyethyleneimine-oleic acid (PEI-oleic acid) micelle-stabilized gold nanoparticles (PO-AuNPs n ), where the gold nanoparticles (AuNPs) were embedded in the shell area of micelles. When the molar ratio of [N] to [Au] was 50, 100, and 200, the mean diameter of AuNPs was 3.52 ± 0.42, 3.11 ± 0.28, and 2.85 ± 0.48 nm, respectively. The corresponding zeta potential of the PO-AuNPs n was determined to be 26.2, 28.9 and 35.7 mV, respectively. Furthermore, PO-AuNPs n remained stable in aqueous solution at room temperature for more than 1 month. More importantly, PO-AuNPs n had higher catalytic activity for 4-nitrophenol (4-NP) reduction in aqueous solution compared with previous reports, where PO-AuNPs 200 showed a K nor value of 9367 s −1  g −1 . It is believed that PO-AuNPs n showed high catalytic activity because of their small size, high stability, and the location of AuNPs in the shell area, which made it easier for AuNPs to contact with 4-NP. The method described in this report represents a new method to prepare small and stable noble metal nanoparticles for catalytic applications in the future.

MoO2 Sacrificial Layer for Optimizing Back Contact Interface of Cu2ZnSn(S,Se)4 Solar Cells

Bin Xu,Xiaoshuang Lu,Chuanhe Ma,Yulin Liu,Ruijuan Qi,Rong Huang,Ye Chen,Pingxiong Yang,Junhao Chu,Lin Sun

Synthesis and biological evaluation of novel 2-(substituted isoxazol-4-yl)-5-arylamino-1,3,4-oxadiazoles

Liu Feng,Wang Meiyan,Teng Xinhuan,Zhang Peizhi,Jiang Lin

A series of 2-(5-methyl-3-(4-chloro/trifluoromethylphenyl)isoxazol-4-yl)-5-arylamino-1,3,4-oxadiazoles were synthesized from 4-chloro/trifluoromethyl benzaldehyde, ethyl acetoacetate, hydroxylamine hydrochloride, hydrazine hydrate, and aryl isocyanate by multi-step reactions. The structures of the target compounds were elucidated by IR, 1 H NMR, MS, and elemental analysis. All these compounds were tested for in vitro antifungal activities against Botrytis cinerea and Rhizoctonia cerealis by the mycelium growth rate method, and the results indicated that some compounds displayed high antifungal activity against Botrytis cinerea.

Catalytic Performance and Mechanism of Iron meso-Tetra(4-carboxyphenyl)porphine for Oxygen Reduction Reaction

Liu X.,Yue Q.-x.,Wang Y.-h.,Lei M.-d.,Zhang Y.-l.,Zhang Y.-w.,Ji A.-l.,Zhang Y.-c.,Zhang X.-q.,Ding R.,Liu J.

The catalytic performance and mechanism of the prepared iron meso-tetra (4-carboxyphenyl) porphyrin (FeTCPP) on oxygen reduction reaction in alkaline environments were studied. At high concentrations of FeTCPP, the oxygen reduction reaction followed an efficient direct 4-electron transfer mechanism instead of 2+2 electron transfer mechanism. The central iron ion in FeTCPP underwent redox reactions from Fe III to Fe II . O 2 molecules formed a superoxide anion coordination complex with Fe II TCCP, transferring an electron from the central iron ion. Protonation of the complex formed a superoxide hydrogen radical complex, which then acquired another electron, generating a hydroperoxide radical and completing the first 2-electron reduction. The peroxide formed a coordination complex with Fe II TCCP to produce a peroxide complex Fe III TCCP:O 2 – with intramolecular charge transfer. And then it acquired two electrons, completing the second 2-electron reduction and being reduced to OH – . When the concentration of Fe III TCCP was high, the complex Fe III TCCP:O 2 – could protonate without stepwise reactions, directly acquiring three electrons from the electrode surface and being reduced to OH – . The oxygen reduction reaction exhibited a 4-electron mechanism. Both the 2+2 and 4-electron pathways occurred simultaneously, with the 4-electron pathway becoming more prominent as the concentration of FeTCPP increased.

Novel pyrazole-4-carboxamides and aromatic carboxamides derivatives containing a hydrazine moiety as potential SDHIs

Bo Luo,Wei Zhou,Xingai Zhang,Pei Zhao,Xiaoxiao Zhang,Longge Zhang,Hongyan Ding,Lailiang Qu

To promote the discovery and development of novel SDHIs fungicides, a series of novel pyrazole-4-carboxamides 4a-t and aromatic carboxamides 8a-i with a hydrazine scaffold were designed, synthesized, and evaluated for their antifungal activities. The results showed that compound 4i exhibited outstanding antifungal activity against R. solani with EC 50 value of 0.24 μg/mL, which was about three times more potent than that of Boscalid (EC 50  = 0.74 μg/mL). Moreover, compound 4i also displayed promising antifungal activities against Sclerotinia sclerotiorum, B. cinerea, Alternaria alternate , and F. graminearum (IC 50  = 1.21–4.50 μg/mL), indicating a broad spectrum of antifungal activities. Additionally, in vivo antifungal activities results showed that 4i could significantly inhibit the growth of R. solani in rice leaves with good protective efficacy (55.21%) and excellent curative efficacy (73.06%) at 100 μg/mL. The results of the SDH enzymatic inhibition assay showed that compound 4i generated significant SDH inhibition with IC 50 value of 6.47 μM, which was superior to Boscalid (IC 50  = 7.92 μM). Furthermore, SEM analysis showed that compound 4i could remarkably disrupt the typical structure and morphology of R. solani hyphae. The molecular docking study revealed that compound 4i could form H-bonds interactions and π-π interactions with TRP173 and TRY58 at the activity site of SDH, which was similar to that of Boscalid. The DFT calculation provided crucial information regarding electron transfer, which was essential in understanding the mechanism of molecules and target enzymes. These results indicated that compound 4i showed potential as a SDHIs fungicide and warranted further investigation.

Poly(cyclotriphosphazene-co-tris(4-hydroxyphenyl)ethane) Microspheres with Intrinsic Excitation Wavelength Tunable Multicolor Photoluminescence

Majid Basharat,Wei Liu,Shuangkun Zhang,Yasir Abbas,Zhanpeng Wu,Dezhen Wu

Functional photoluminescent materials with a tunable multicolor emission without incorporation of metals is the current focus on luminescent materials due to their multifaceted applications. Herein, novel poly(cyclotriphosphazene-co-tris(4-hydroxyphenyl)ethane) microspheres are synthesized with size distribution of ≈0.8–1.6 µm by reacting hexachlorocyclotriphosphazene and tris(4-hydroxyphenyl)ethane at different molar ratios under facile conditions. The thermogravimetric analysis shows that the microspheres are highly thermally stable with 10% weight loss at around 500 °C. Fluorescence microscopy results show that the microspheres emit three blue, green, and red colors with an emission maximum at 487, 530, and 623 nm under different excitation wavelengths of 365, 420, and 546 nm, respectively. Furthermore, under UV and visible (365 and 420 nm) excitations, microspheres demonstrate extraordinary photobleaching stability and highly intense luminescence for expending time and repeating excitations. The microspheres also demonstrate semiconductor-like optical absorption at 235–285 nm with a tail extended to 700 nm. This exploration provides an insight for the preparation of intrinsic superior wavelength tunable multicolor emission materials from phosphazene. These microspheres are potential candidates for anti-counterfeits, solar cells, full spectrum fluorescence emitters, organic light emitting diodes, biological, catalysis applications and unlock new areas of research on multicolor photoluminescence.

Mechanistic insight into the photocatalytic hydrogenation of 4-nitroaniline over band-gap-tunable CdS photocatalysts

Weiming Wu,Rui Lin,Lijuan Shen,Ruowen Liang,Rusheng Yuan,Ling Wu

CdS photocatalysts with tunable band gaps (2.17–2.32 eV) were successfully prepared by a solvothermal method. Photocatalytic hydrogenation of 4-nitroaniline over the obtained samples was evaluated in the presence of HCO2NH4 as a hole scavenger upon purging with N2 under visible light irradiation (λ ≥ 420 nm). The CdS sample prepared by CdCl2 and sulfur powder in ethylenediamine showed excellent catalytic activity, giving 100% of 4-nitroaniline conversion and 95% of p-phenylenediamine selectivity after 35 min of visible light irradiation. The results of electron spin resonance revealed that its photoexcited holes could efficiently react with HCO2− ions within HCO2NH4 molecules to produce ˙CO2− radicals with strong reductive abilities. Furthermore, photoexcited electrons of the obtained sample exhibited relatively strong reductive abilities as compared to other CdS samples. Therefore, this sample showed the highest catalytic activity among the CdS samples for the photocatalytic hydrogenation of 4-nitroaniline.

Silver nanoparticles supported on short magnetic PVA/PEI nanofibers for the reduction of 4-nitrophenol

Yujiao Zou,Chenyu Li,Ni Li,Yili Zhao

Silver nanoparticles (Ag NPs)-based nanomaterials are effective catalysts for a wide range of reactions. The recyclability and efficient catalytic properties of Ag-based nanocatalysts have been the focus of significant research interest. Herein, to address these challenges, we incorporated Fe 3 O 4 nanoparticles (NPs) into a polyvinyl alcohol/polyethyleneimine (PVA/PEI) solution to fabricate PVA/PEI@Fe 3 O 4 nanofibrous mats via electrospinning. Subsequently, the magnetic nanofibrous mats were homogenized to produce short magnetic nanofibers, which can be easily separated from the solution using a magnet. These short PVA/PEI@Fe 3 O 4 nanofibers were then immersed in an aqueous solution of AgNO 3 to adsorb and reduce Ag ions, resulting in the formation of Ag NPs with an average diameter of approximately 15 nm, uniformly dispersed on the nanofiber surface. The resulting short PVA/PEI@Fe 3 O 4 /Ag nanofibers exhibit excellent catalytic activity for the reduction of 4-NP, achieving a high conversion rate of 97.0 %. Furthermore, they demonstrated remarkable recyclability, maintaining high catalytic activity throughout six consecutive cycles. The short magnetic nanofibers proposed in this study are anticipated to facilitate the practical application of electrospun nanofibers in the catalytic removal of pollutants.

Dual emission and efficient energy transfer in (4-BTP)2ZnBr4:Mn2+ for enhanced optical properties

Chenbo Xu,Jianing Zhang,Yuexiao Pan,Yangyang Liu,Xiaoyun Yang,Hongping Xiao,Jun Zou

The quest for advanced luminescent materials with high quantum yields and excellent stability is essential for the development of light-emitting diodes (LEDs). In this context, we present a novel zero-dimensional (0D) organic-inorganic hybrid metal halides (OIHMHs), (4-BTP) 2 ZnBr 4 :Mn 2+ , which exhibits dual emission characteristics. The material achieves a photoluminescence quantum yield (PLQY) of 87.6 % under 365 nm excitation, indicating its high radiative efficiency. Furthermore, it demonstrates remarkable water resistance, maintaining its photoluminescence (PL) performance after two months of immersion in water, and excellent thermal stability up to 325 °C. Importantly, the successful incorporation of Mn 2+ ions into the (4-BTP) 2 ZnBr 4 matrix allows for tunable emission from blue-violet to green, depending on the excitation wavelength and Mn 2+ concentration. A stable white light emission in LED with a color rendering index (CRI) of 88 and correlated color temperature (CCT) of 6757 K has been obtained with the phosphor (4-BTP) 2 ZnBr 4 :Mn 2+ . This work contributes to the fundamental understanding of energy transfer mechanisms in hybrid materials.