FOOD CHEMISTRY
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2024
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IF 8.5
Ruge Lin,Yi Wang,Huan Cheng,Xingqian Ye,Shiguo Chen,Haibo Pan
In this study, we addressed the limited water solubility of curcumin by utilizing epigallocatechin-3-gallate to form nanoparticles through self-assembly. The resulting particles, ranging from 100 to 150 nm, exhibited a redshift in the UV–visible spectrum, from 425 nm to 435 nm, indicative of potential π-π stacking. Molecular docking experiments supported this finding. Curcumin loaded with epigallocatechin-3-gallate showed exceptional dispersibility in aqueous solutions, with 90.92 % remaining after 60 days. The electrostatic screening effect arises from the charge carried by epigallocatechin-3-gallate on the nanoparticles, leading to enhanced retention of curcumin under different pH, temperature, and ionic strength conditions. Furthermore, epigallocatechin-3-gallate can interact with other hydrophobic polyphenols, improving their dispersibility and stability in aqueous systems. Applying this principle, a palatable beverage was formulated by combining turmeric extract and green tea. The nanoparticles encapsulated with epigallocatechin-3-gallate show potential for improving the applicability of curcumin in aqueous food systems.
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Food Chemistry-X
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2024
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IF 6.5
Jia Cheng Qian,Heng Peng Zhang,Yi Wang,Dan Liu
Cruciferous vegetables (CVs) are globally consumed with some health benefits believed to arise from indole-3-carbinol (I3C), a labile phytochemical liberated from indole glucosinolates, but few reports describe the effect of cooking on I3C reactions. Here, we present heat-promoted direct conversions of I3C in broccoli florets into indole derivatives, which are unique in the N -indolylmethylation and -hydroxymethylation of indole nuclei by 3-methyleneindole and formaldehyde formed in situ from the I3C dehydration and the dimerization of I3C to 3,3′-diindolylmethane (DIM), respectively. Such N -substituted indoles were found in a range of 0.4–4.6 μg per gram of steamed broccoli florets, with a novel compound N -(indol-3-ylmethyl)-3,3′-diindolylmethane (DIM-1) bio-evaluated to inhibit A375 cells with an IC 50 value of 1.87 μM. In aggregation, the investigation discloses the promoting effect of heating on the I3C transformation in CVs and identifies DIM-1 as an anti-cancer drug candidate, and thus updates the knowledge of I3C and bioactive derivatives thereof.
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POSTHARVEST BIOLOGY AND TECHNOLOGY
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2024
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IF 6.4
Ruiling Zhuo,Xiaokang Zhang,Yong Chen,Mengyang Xing,Shiping Tian,Boqiang Li
Penicillium expansum , a causal agent of blue mold rot, leads to substantial postharvest losses in the fruit industry. Due to environmental pollution and the emergence of fungicide-resistant strains, the use of synthetic chemical fungicides faces severe challenges. Natural antifungal compounds derived from plants are considered promising alternatives. In this study, the antifungal activities of coumarin and five hydroxylated derivatives against P. expansum and involved mechanisms were investigated. Among the six coumarins, 3-hydroxycoumarin (3-HC) demonstrated strong inhibitory effects on mycelial growth, germ tube elongation, conidiation, patulin production, and the best control effect on blue mold in apple and jujube fruit. Moreover, 3-HC increased the sensitivity of P. expansum to the cell wall, oxidative, and osmotic stresses . In silico analyses, including target fishing, molecular docking, and molecular dynamics simulations, revealed that the mitogen-activated protein kinase (MAPK) family in P. expansum (Pempks), were the potential targets of 3-HC. Bio-layer interferometry and ATP competition assays found that 3-HC could directly bind to PempkB and PempkC , and inhibit the MAPK activity. Our results suggested that 3-HC may act as an ATP-competitive MAPK inhibitor to affect the MAPK signaling pathway and inhibit the development and pathogenicity of P. expansum .
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Journal of Water Process Engineering
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2024
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IF 6.3
Yingying Liu,Wanjing Cui,Xiuge Chen,Ming Wang,Haifeng Zhang,Zhi Wang
Reverse osmosis (RO) membrane technology is applied widely on the water desalinization for relieving the challenge of freshwater scarcity. Polyamide (PA) membranes with superior water flux and rejection in the RO process are currently in high demand. In this study, a novel reactive additive N-(3-Aminopropyl)-imidazole (N-IM) was utilized to optimize the interfacial polymerization (IP) process and enhance PA-RO membrane performance. N-IM made the nascent film more porous and created an RO membrane with a thicker PA separation layer. The modified membrane exhibited a more hydrophilic surface, ascribing to more carboxylic acid groups. This membrane exhibited an improved water flux, increasing from 59.67 L/(m 2 ∙h) of original membrane to 82.76 L/(m 2 ∙h) of the modified membrane with the addition of 0.5 % w/v N-IM concentration, which was attributed to the enhanced hydrophilicity and increased water trapping capacity provided by the imidazole ring in N-IM. Additionally, the NaCl rejection increased from 98.75 % to 98.97 %, which can be attributed to the thicker separation layer and more carboxylic acid groups. In addition, the membrane showed excellent stability of performance and good pH stability. The study presents a novel approach to producing RO membranes with exceptional performance.
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Small
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2024
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IF 13
Lei Zhang,Jianzha Zheng,Cong Liu,Yifei Xie,Hanyu Lu,Qinrong Luo,Yulong Liu,Huidong Yang,Kai Shen,Yaohua Mai
Antimony selenosulfide (Sb 2 (S,Se) 3 ) is an emerging quasi-1D photovoltaic semiconductor with exceptional photoelectric properties. The low-symmetry chain structure contains complex defects and makes it difficult to improve electrical properties via doping method. This article reports a doping strategy to enhance the efficiency of Sb 2 (S,Se) 3 solar cells by using alkali halide (CsI) as the hydrothermal reaction precursor. It is found that the Cs and I ions are effectively doped and atomically coordinate with Sb ions and S/Se ions. The CsI-doping Sb 2 (S,Se) 3 absorbers exhibit enhanced grain morphologies and reduced trap densities. The consequential CsI-doping Sb 2 (S,Se) 3 based solar cells demonstrate favorable band alignment, suppressed carrier recombination, and improved device performance. An efficiency as high as 10.05% under standard AM1.5 illumination irradiance is achieved. This precursor-based alkali halide doping strategy provides a useful guidance for high-efficiency antimony selenosulfide solar cells.
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CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Xiaomeng Ni,Jingjing Liu,Fangxian Xu,Jing Zhang,Sai Jiang,Bijun Fang,Huafei Guo,Ningyi Yuan,Jianning Ding,Shuai Zhang
Doping the light absorber layer of antimony chalcogenides with extrinsic ions is an effective approach for improving their photovoltaic quality. These dopant ions generally reside at positions other than the crystal lattice or form an alloy (e.g., AgSb(S,Se) 3 ) with a poor device performance. Therefore, incorporating such ions into an antimony chalcogenide lattice such that there is a positive influence on device quality would be highly useful. Herein, doping of Nd 3+ for Sb 2 (S,Se) 3 is carried out via a modified hydrothermal deposition process. Notably, these ions are incorporated into the crystal lattice and migrate to the CdS/Sb 2 (S,Se) 3 interface after doping, which are characterized using X-ray diffraction, X-ray photoelectron spectroscopy, and time-of-flight secondary ion mass spectrometry. Nd 3+ doping produces benign effects on the crystal orientation, film morphology, optoelectronic properties, and defect passivation of the Sb 2 (S,Se) 3 films. Consequently, all the photoelectrical parameters of Sb 2 (S,Se) 3 solar cells doped with Nd 3+ are enhanced, delivering a remarkable efficiency of 8.24 %. Furthermore, the best device stored in air only shows a slight decrease in efficiency in the 2400-h aging test. Overall, this study provides an effective doping strategy to improve the photovoltaic quality of Sb 2 (S,Se) 3 films.
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INORGANIC CHEMISTRY COMMUNICATIONS
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2024
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IF 4.4
Yujuan Sun,Jun Wu,Xiashi Zhu
A novel poly[1-vinyl-3-benzyltriethylammonium proline ionic liquid] membrane(PIL/PVDF membrane) were prepared through the blending poly[1-vinyl-3-benzyltriethylammonium proline ionic liquid](P[Pro][TEA])-poly(vinylidene fluoride)(PVDF) phase inversion method. A series of PIL/PVDF membrane characterization (NMR, FT-IR, SEM, EDS, and XPS) was performed. The properties of PIL/PVDF membrane (contact angle, water flux, mechanical properties, thermal stability,electric charge property, specific surface area and pore diameter) were evaluated. A solid phase extraction − high performance liquid chromatography (SPE-HPLC) method for separation/analysis of quercetin was developed. The factors affecting the adsorption and elution (time, dosage, pH etc.) were investigated. Under optimal conditions, the method has been successfully applied to the separation/analysis of quercetin in tea, and the recovery rates are satisfactory (86.4–106.0 %). The concentration factor of quercetin was 10. The adsorption capacity of PIL/PVDF membrane towards quercetin was 22.1 mg g −1 . The extraction mechanism was preliminarily discussed. The established SPE-HPLC method was simple and reliable, which provided application prospects for extraction and detection of quercetin.
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CHEMICO-BIOLOGICAL INTERACTIONS
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2024
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IF 4.7
Long Zhang,Weibin Li,Xiaohui Chen,Dongmin Cao,Siyuan You,Fan Shi,Zhengqiong Luo,Hongyu Li,Xiangchen Zeng,Yabin Song,Na Li,Yoshie Akimoto,Gang Rui,Yu Chen,Zuoxing Wu,Ren Xu
Bone metastases caused by breast cancer pose a major challenge to the successful treatment of breast cancer patients. Many researchers have suggested that herbal medicines are extremely effective at preventing and treating cancer-associated osteolysis. Previous studies have revealed that Morusin (MOR) is cytotoxic to many cancer cells ex vivo . Nevertheless, how MOR contributes to osteolysis induced by breast cancer is still unknown, and the potential mechanism of action against osteolysis is worthy of further study. The protective effect and molecular mechanism of MOR in inhibiting breast cancer cell-induced osteolysis were verified by experiments and network pharmacology. Cell function was assessed by cell proliferation, osteoclast (OC) formation, bone resorption, and phalloidin staining. Tumour growth was examined by micro-CT scanning in vivo . To identify potential MOR treatments, the active ingredient–target pathway of breast cancer was screened using network pharmacology and molecular docking approaches. This study is the first to report that MOR can prevent osteolysis induced by breast cancer cells. Specifically, our results revealed that MOR inhibits RANKL-induced osteoclastogenesis and restrains the proliferation, invasion and migration of MDA-MB-231 breast cells through restraining the PI3K/AKT/MTOR signalling pathway. Notably, MOR prevented bone loss caused by breast cancer cell-induced osteolysis in vivo , indicating that MOR inhibited the development of OCs and the resorption of bone, which are essential for cancer cell-associated bone distraction. This study showed that MOR treatment inhibited osteolysis induced by breast cancer in vivo . MOR inhibited OC differentiation and bone resorption ex vivo and in vivo and might be a potential drug candidate for treating breast cancer-induced osteolysis.
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CERAMICS INTERNATIONAL
·
2024
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IF 5.1
Xiuna Tian,Youfeng Wen,Hongjian Dou,Lingyuan Wu,Changjun Wang,Youzi Zhang
In the clinical diagnosis and treatment of diseases, there is an urgent need to find suitable materials for real-time temperature monitoring of biological tissues. The paper provides a detailed study of the effects of Nd 3+ doping concentration on the negative thermal expansion performance and NIR fluorescence properties of Sc 2 (MoO 4 ) 3 . The results obtained from Rietveld refinement of in-situ XRD data indicates that high concentration of Nd 3+ doping significantly influences the negative thermal expansion performance of the material, as well as alters the temperature-dependent changes in NIR fluorescence intensity and lifetime. In addition, a NIR fluorescence lifetime temperature probe doped with Nd 3+ /Yb 3+ /Er 3+ has been constructed. When the temperature increased from 303 K to 403 K, the fluorescence intensity of the probe at 1538 nm increased by a factor of 127.5. Furthermore, as the temperature rose from 323 K to 403 K, the fluorescence lifetime of the probe at 1538 nm extended from 41.93 μs to 204 μs. By utilizing the lifetime of Er 3+ for temperature sensing, a relative sensitivity of 6.03%K −1 was achieved at 323 K, indicating significant potential application value of this probe in the field of biological temperature measurement.
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iScience
·
2024
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IF 4.6
Ruobing Wang,Dan Su,Yueze Liu,Hua Huang,Jiangdong Qiu,Zhe Cao,Gang Yang,Hao Chen,Wenhao Luo,Jinxin Tao,Guihu Weng,Taiping Zhang
Summary Nuclear factor kappa B (NF-κB) plays a pivotal role in the development of pancreatic cancer, and its phosphorylation has previously been linked to the regulation of NUAK2. However, the regulatory connection between NF-κB and NUAK2, as well as NUAK2’s role in pancreatic cancer, remains unclear. In this study, we observed that inhibiting NUAK2 impeded the proliferation, migration, and invasion of pancreatic cancer cells while triggering apoptosis. NUAK2 overexpression partially resisted apoptosis and reversed the inhibitory effects of the NF-κB inhibitor. NF-κB transcriptionally regulated NUAK2 transcription by binding to the promoter region of NUAK2. Mechanistically, NUAK2 knockdown remarkably reduced the expression levels of p -SMAD2/3 and SMAD2/3, resulting in decreased nuclear translocation of SMAD4. In SMAD4-negative cells, NUAK2 knockdown impacted FAK signaling by downregulating SMAD2/3. Moreover, NUAK2 knockdown heightened the sensitivity of pancreatic cancer cells to gemcitabine, suggesting that NUAK2 inhibitors could be a promising strategy for pancreatic cancer treatment.
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CERAMICS INTERNATIONAL
·
2025
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IF 5.6
Yuan Liu,Junxia Wang,Jin Wang,Die Liu,Kunqi Liu,Long Kang,Tongmin Zhang
Composite ceramics, which integrate the advantages of multiple crystal structures, are considered promising candidates for nuclear waste forms capable of simultaneously immobilizing various radionuclides. In this study, a series of 0.4Sr 0.5 Zr 2 (PO 4 ) 3 –0.6Ce 1- x Nd x PO 4 composite ceramics were designed to co-immobilize the simulated fission product Sr and actinide surrogates Ce and Nd. These composite ceramics exhibited homogeneous phase distribution and high densification. Among them, the irradiation-induced damage in the representative sample, 0.4Sr 0.5 Zr 2 (PO 4 ) 3 –0.6Ce 0.6 Nd 0.4 PO 4 composite ceramic, was systematically evaluated under both He 2+ and Xe 20+ irradiation. After He 2+ irradiation, the crystallinity of the irradiated layer was retained despite the disruption of Raman-active bonding groups by point defects. Notably, the Ce 0.6 Nd 0.4 PO 4 phase exhibited significantly higher resistance to He 2+ irradiation than the Sr 0.5 Zr 2 (PO 4 ) 3 phase, as confirmed by GIXRD patterns and geometric phase analysis (GPA). Furthermore, fragmentation of Ce 0.6 Nd 0.4 PO 4 grains was observed, which was attributed to defect accumulation, the thermal spike effect, and the thermal expansion mismatch. Following Xe 20+ irradiation, the irradiated layer of the composite ceramic exhibited reduced crystallinity without complete amorphization, while the Raman-active bonding groups remained largely intact. Additionally, pore formation at grain boundaries was likely caused by the segregation and accumulation of irradiation-induced defects.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2024
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IF 5.7
Lichun Guo,Mengqing Zhang,Ying Fei,Wei Zhao
This study examines the inhibitory effects of a range of sweeteners on α-glucosidase. Our findings revealed that only one natural sweetener, namely, glycyrrhetinic acid 3-O-mono-beta-d-glucuronide (GAMG), derived from licorice, exhibited a mixed-type inhibition against α-glucosidase with a IC50 value of 0.73 ± 0.05 mg/mL. The fluorescence intensity of α-glucosidase was quenched by GAMG in the formation of an α-glucosidase–GAMG complex. GAMG has been shown to induce conformational changes in α-glucosidase, likely through hydrogen bonding, van der Waals force, and alkyl–alkyl interactions with amino acid residues, including Arg 281, Leu 283, Trp 376, Asp 404, Asp 443, Trp 481, Asp 518, Phe 525, Ala 555, and Asp 616. Additional animal validation experiments demonstrated that GAMG slowed starch digestion, thereby attenuating the postprandial glycemic response. Taken together, these findings provide evidence that GAMG is a natural sweetener with potent inhibitory activity that selectively targets α-glucosidase. This study supports the use of GAMG as a natural sweetener, which holds a high biological value and may be beneficial for managing postprandial hyperglycemia.
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