FOOD HYDROCOLLOIDS
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2022
·
IF 11.504
Peng Wang,Yucheng Zou,Yang Li,Zeyu Qin,Xingquan Liu,Hui Zhang
In this study, chitosan-dialdehyde-β-cyclodextrin-curcumin (CS-DCD-CUR) and alginate dialdehyde (ADA) were alternately deposited on the surface of electrospun cellulose acetate (CA) nanofibers driven by Schiff base bonding and electrostatic attraction. With the increasing number of bilayers, the self-assembled nanofibers showed an increased average fiber diameter from 441 to 576 nm and had relatively rough surfaces. The improved thermal stability and tensile strength of self-assembled nanofibers were attributed to the interactions between CS-DCD-CUR and ADA. The self-assembled nanofibers exhibited pH-sensitive release characteristics under acidic conditions due to the weakening of the electrostatic interaction and the hydrolysis of Schiff-base. Moreover, the self-assembled nanofibers could be used for sustained and controlled release of the curcumin within 620 min and maintained the antioxidant activities . The highest radical scavenging activities against ABTS and DPPH radicals of the nanofibers were 24.75% and 83.56%, respectively. These results suggested that the layer-by-layer self-assembled nanofibers provided a pH-responsive sustained delivery system for bioactive substances with potential applications in functional foods.
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FOOD CHEMISTRY
·
2021
·
IF 7.514
Yongsheng Ni,Hongqing Nie,Jingyao Wang,Junwei Lin,Qiaoling Wang,Jing Sun,Wentao Zhang,Jianlong Wang
The exploration of novel functional packaging films is of great scientific and technological interest. Herein, a novel chitosan/hollow g-C 3 N 4 /curcumin (CS-HCNS-Cur) biocomposite films was successful fabricated with integrated functions of slow release, antimicrobial activity and food freshness preservation. CS-HCNS-Cur films take the advantages of the excellent thermal stability and slow-release ability of HCNS to curcumin. Among the characterizations including scanning electron microscopy, transmission electron microscope, atomic force microscopy, fourier transform infrared spectroscopy, mechanical properties and the rheological properties measurements confirmed the successful fabrication of CS-HCNS-Cur films. The averaged water contact angle and water vapor permeability of this film were 105.83° and 105.03 × 10 −5 g·mm (m 2 ·h·kPa) −1 , respectively. This film showed pH-responsive and slow-release ability. Moreover, this film can effectively store bananas for 10 days. Therefore, CS-HCNS-Cur films have promising potential for applications in functional food packaging.
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International Journal of Nanomedicine
·
2022
·
IF 7.033
Yumeng Wei,Mingtang Zeng,Chao Pi,Hongping Shen,Jiyuan Yuan,Ying Zuo,Jie Wen,Pu Guo,Wenmei Zhao,Ke Li,Zhilian Su,Xinjie Song,Shaozhi Fu,Robert J Lee,Ling Zhao
Purpose Paclitaxel (PTX) has been widely utilized for the treatment of breast cancer. However, drawbacks, such as poor aqueous solubility, rapid blood clearance and severe toxicity, greatly reduce its efficacy and safety. Herein, a novel self-developed curcumin derivative (CUD) was chosen as the carrier to develop a long-acting PTX nano-delivery system (PTX-Sln@CUD) in order to improve its pharmacokinetic behavior, anti-breast cancer efficacy and safety. Methods PTX-Sln@CUD was prepared using solid dispersion and ultrasonic technology. Relevant physical and chemical properties, including stability and release behavior, were characterized. The clearance of PTX-Sln@CUD in vivo was studied by pharmacokinetic experiments. The anti-tumor activity of PTX-Sln@CUD was investigated in vitro and in vivo. Hemolysis experiments, acute toxicity and cumulative toxicity studies were performed in mice to determine the safety of PTX-Sln@CUD. Results The average particle size, PDI, Zeta potential, encapsulation efficiency and loading efficiency of the PTX-Sln@CUD were 238.5 ± 4.79 nm, 0.225 ± 0.011, −33.8 ± 1.26 mV, 94.20 ± 0.49% and 10.98 ± 0.31%, respectively. PTX-Sln@CUD was found to be stable at room temperature for half a year. The cumulative release rates of PTX-Sln@CUD at 24, 96 and 168 h were 17.98 ± 2.60, 57.09 ± 2.32 and 72.66 ± 4.16%, respectively, which were adherent to zero-order kinetics. T 1/2 , MRT (0-t) and AUC (0-t) of the PTX-Sln@CUD group were 4.03-fold (44.293 h), 7.78-fold (38.444 h) and 6.18-fold (14.716 mg/L*h) of the PTX group, respectively. PTX-Sln@CUD group demonstrated stronger anti-breast cancer activity than the PTX group. Importantly, the PTX-Sln@CUD group was safer compared to the PTX group both in vitro and in vivo. Conclusion PTX-Sln@CUD was verified as promising therapeutic nanoparticles for breast cancer and provided a novel strategy to solve the problem of low efficacy and poor safety of clinical chemotherapy drugs.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Mingli Yue,Bixian Wang,Jianbo Zhao,Liangzhong Lv,Ying Fu,Fei Ye
Cancer, the world’s second leading killer, has increasing crude incidence rates and faces multiple prevention/control challenges. Curcumin (Cur) has anticancer activity but low bioavailability, restricting its use in cancer therapy. A nanomaterial (Fe₃O₄/PDA@Cur) for targeted curcumin delivery is developed in this work, which has a magnetic Fe 3 O 4 core made by solvothermal synthesis and a polydopamine (PDA) shell made by one-pot synthesis. Results show that drug loading rate reached 40.3 % when the mass ratio of Fe₃O₄/PDA: Cur was 1:3. The hemolysis rate was measured to be 1.24 % in the hemocompatibility test. The complex exhibited good antibacterial efficacy against both Staphylococcus aureus ( S. aureus , MIC 250.0 μg/mL and MBC 500.0 μg/mL), Escherichia coli ( E. coli , MIC 625.0 μg/mL and MBC 1250.0 μg/mL), which was attributed to the properties of the incorporated PDA. The material has good blood compatibility and antibacterial effects, and it effectively prevents secondary infection at the tumor site and red-blood-cell lysis. Notably, at pH 5.0, drug release reached 75.5 % via pH-responsive mechanisms which tumor microenvironment (pH 5.0–6.5), drug release is accelerated in these regions, enabling targeted therapy that minimizes toxicity to normal cells and systemic side effects, thereby enhancing treatment safety. This complex, which possesses both drug delivery and antibacterial properties, holds significant clinical importance for preventing opportunistic infections during tumor treatment.
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JOURNAL OF FOOD COMPOSITION AND ANALYSIS
·
2025
·
IF 4.6
Qingqing Zou,Xinyu Luo,Xiaofang Tian,Meijie Xie,Baiyan Zheng,Shuting Yang,Mei Wang,Shan Mou,Qianchun Zhang
The sensitive and specific detection of curcumin and vanillin are important for food safety, quality control, and consumer health protection. Here, a nitrogen-doped carbon quantum dots (N-CQDs)-based nanosensor was developed for the highly sensitive detection of curcumin and vanillin. N-CQDs were synthesized via solvothermal method using L-theanine and 2,4,6-trimethyl-1,3-phenylenediamine (2,4,6-TMPDA) as carbon precursors. The excitation wavelength of the N-CQDs was 360 nm and the emission wavelength was 455 nm. The structural features of N-CQDs were characterized by FT-IR, X-ray photoelectron spectroscopy (XPS), X-ray powder diffraction (XRD) and Raman spectroscopy. Subsequently, the effects of pH and NaCl concentrations on N-CQDs fluorescence were studied. More importantly, leveraging the quenched fluorescence for multi-molecule sensing, the selective and sensitive detection of curcumin and vanillin were achieved, with linear ranges of 0.010-50 μM and 0.10-50 μM, respectively, and LODs of 3 nM and 30 nM, respectively. Using the developed fluorescence method, curcumin in chicken essence samples and vanillin in montmorillonite powder, chocolate beans, high-mountain sugar, and plum sugar were quantified. The recovery rate for curcumin was 93.4-106%, and for vanillin was 93.0-110%. The measured contents were further validated by HPLC-UV. Overall, the high N-CQDs selectivity for curcumin/vanillin enables rapid, sensitive fluorescence food analysis.
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Food Bioscience
·
2025
·
IF 5.9
Kangkang Zhi,Yi Shi,Weibing Lin,Huilan Yang,Yawen Zhu,Jiajia Cui,Wen Zhang,Junlong Wang,Ji Zhang
The present study developed a natural nano-assembled delivery system with curcumin (Cur)-synergistic bioactivity using natural oleanolic acid (OA). The OA self-assembled nanoparticles (OA NPs) were systematically prepared via region-limited self-assembly, with their size (20–600 nm) regulated by varying key preparation parameters. The XPS, FTIR, CAT, and MD revealed that the 3-hydroxy oxygen and 17-carboxyl oxygen of OA act as hydrogen bond donor and acceptor, respectively, to form hydrogen bonds. Together with van der Waals forces, these interactions drive the formation of hydrophilic surface-exposed nanoparticles. The OA NPs exhibited good biocompatibility, demonstrated by favorable blood safety (hemolysis rate <5 %) and low cytotoxicity (cell viability >90 %). The Cur was efficiently encapsulated into OA NPs, achieving a LC of 22.81 % and EE of 68.43 %. The encapsulated Cur showed significantly improved physicochemical properties, with a 29.02-fold increase in water solubility, a 3.64-fold enhancement in photostability, and a 2.77-fold improvement in thermal stability compared to free Cur. In vivo , OA NPs exhibited intestinal retention time three times longer than gastric retention, and release studies confirmed their intestinal-selective and sustained-release behavior, which followed the Korsmeyer–Peppas model. The Cur-OA NPs demonstrated optimal antioxidant activity, showing 2.45-fold higher potency (based on EC 50 values) than free Cur, attributable to the synergistic effect between Cur and OA NPs. This study highlights the potential of Cur-OA NPs as an oral antioxidant formulation and offers a promising strategy for developing natural nanocarriers with curcumin-synergistic bioactivity.
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FOOD CHEMISTRY
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2024
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IF 8.5
Shumin Wang,Shengnan Wang,Lanxin Zhang,Peng Wang,He Liu
This study aims to create composite carriers by combining cyclodextrin metal organic frameworks (CD-MOFs) with soybean hull polysaccharide (SHP) polymers for enhanced performance. A cubic structured composite carrier was successfully synthesized, exhibiting potential for delivering functional factors. Interaction between cyclodextrin (CD) and SHP was predominantly driven by hydrogen bonding forces, as evidenced by Fourier transform infrared spectroscope (FTIR), Raman spectroscopy. Characterization methods such as Powder X-ray diffraction (XRD), Differential scanning calorimetry (DSC), and FTIR confirmed successful encapsulation of Curcumin (Cur) within γ-CD-MOF@SHP. At 35 °C, with a Cur to carrier mass ratio of 1:3, loading efficiency improved after 24 h of immersion. SHP demonstrated a protective effect on Cur, reducing release in the stomach while maximizing release in the intestine, thus enhancing Cur utilization. Additionally, γ-CD-MOF composites were shown to stabilize functional factors and regulate their release. Overall, the combination of MOFs and polymers holds promise for functional factor delivery.
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高影响因子
Frontiers in Pharmacology
·
2024
·
IF 4.4
Jie Wen,Lingmao Zhao,Zhuohan Li,Chao Pi,Xianhu Feng,Peng Shi,Hongru Yang,Ligang Chen,Xiaodong Wang,Furong Liu,Yumeng Wei,Ling Zhao
Chemotherapy remains the first choice of treatment for colon cancer despite the inevitable adverse effects. Curcumin (CU) possesses antitumor activity but has poor aqueous solubility, low bioavailability, and weak activity. To address this, nine novel monocarbonyl CU analogues were designed, synthesized, and evaluated in the present study. Among them, CA8 exhibited the highest water solubility, which was approximately 2.37 × 106 times that of CU. In addition, compared with CU, its cytotoxicity on Caco-2 cells (19.2 times/48 h) was stronger. Of note, CA8 arrestedthe cell cycle of Caco-2 cells at the G2/M phase and induced apoptosis. Meanwhile, acute toxicity experiments indicated that KM mice tolerated CA8 for up to 300 mg/kg CA8 (oral administration) and 50 mg/kg CA8 (intraperitoneal injection). The oral administration of CA8 to Sprague Dawley rats exhibited higher AUC (0-t) (6.23-fold) and longer MRT (0-t) (3.35-fold) than that of CU. CA8 also inhibited the proliferation and angiogenesis of tumor cells more than CU and tegafur. Finally, CA8 may exert anti-tumor effects through the activation of JNK pathway and inhibition of AKT pathway. These results suggest that CA8 is a safe and highly effective new drug for colon cancer treatment.
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Food Biophysics
·
2024
·Vol. 19
·期 2
·321-333
·
IF 2.8
Shi Liangliang,Cheng Yingxue,Jia Chenyue,Lin Hong,Zhang Weinong,He Junbo
To improve the emulsifying property of sodium caseinate (NaCas) as stabilizer of oil-in-water emulsions and encapsulation of bioactive compounds, three hexaglycerol mono-fatty acid esters were chosen as small molecular weight surfactants to complex with NaCas. Hexaglycerol monooleate (HGMO) was found to be the optimal surfactant and the optimal mass ratio was 1:1, through characterization of particle size, Zeta-potential, and turbidity. Fluorescence and FTIR spectra indicated that the hydrophobic interaction and hydrogen bond provided driving forces to the formation of stable complex. The complexation of HGMO to NaCas increased the surface hydrophobicity and decreased surface tension compared with NaCas, and strengthened the EAI and ESI. The NaCas-HGMO complex had good stabilization on rice bran oil-in-water emulsions, in a wide pH and ionic strength, and the forwarding Cur encapsulation in O/W emulsions dramatically reduced the degradation during storage at 4℃. Therefore, the present NaCas-HGMO complex might be employed as an effective emulsifier to stable O/W emulsions that load lipophilic bioactives in functional foods or beverages.
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JOURNAL OF FOOD ENGINEERING
·
2025
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IF 5.8
Shumin Wang,Shengnan Wang,Ziyang Zhang,Jun Li,He Liu,Chunlei Liu
A thermoresponsive composite carrier, γ-cyclodextrin metal–organic frameworks (γ-CD-MOFs) functionalized with N-isopropylacrylamide (PNIPAm) and soy hull polysaccharides (SHP), was developed to enhance curcumin (Cur) encapsulation and controlled release. X-Ray diffraction (XRD) confirmed that surface functionalization preserved the crystalline structure of γ-CD-MOF, while FTIR indicated hydrogen bonding as the primary interaction between γ-CD-MOF and Cur. Successful PNIPAm and SHP integration was verified by their characteristic functional group signals and the detection of nitrogen and sulfur elements via X-ray photoelectron spectroscopy (XPS). Thermal analyses revealed improved stability of the Cur-loaded composite. The encapsulation efficiency of Cur reached 56.60 ± 0.14 %. In vitro release studies demonstrated suppressed release below the lower critical solution temperature (LCST), with a cumulative release of only 16.51 ± 0.51 % at 25 °C. At elevated temperatures (37 °C and 45 °C), PNIPAm collapse triggered rapid release of 79.68 ± 0.78 % and 81.58 ± 0.31 %, respectively. Kinetic modeling showed Fickian diffusion at 25 °C and non-Fickian diffusion at higher temperatures, reflecting the combined effects of diffusion and matrix erosion. Overall, γ-CD-MOF-PNIPAm@SHP provides a stable, thermoresponsive platform for efficient encapsulation and temperature-triggered release of hydrophobic bioactives, highlighting the potential of MOF-polymer composites for targeted and stimuli-responsive delivery in functional food and pharmaceutical applications.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2025
·Vol. 105
·期 7
·3593-3605
·
IF 3.5
Zhi-feng Tan,Guan-hua Zhao,Da-yong Zhou,Zhen-wen Shao,Liang Song
Background Traditional methods for fabricating protein-polyphenol conjugates have not preserved the structural and functional integrity essential for the food industry effectively. This research introduces an advanced encapsulation methodology designed to overcome these limitations, with the potential to enhance the stability of edible oil matrices significantly, leading to improved preservation techniques and extended shelf life. Results Glycated pea protein isolate-curcumin conjugates ( g PPI-CUR) were developed, demonstrating a marked improvement in the oxidative stability of walnut oil (WO), a proxy for edible oil matrices. Characterized by a Z-average diameter of 158.37 nm and an encapsulation efficiency of 80.94%, these conjugates demonstrated exceptional performance in reducing lipid oxidation and aldehyde formation. Molecular docking analysis confirmed the formation of robust bonds with curcumin, thereby amplifying antioxidant activity. The uniform distribution of g PPI-CUR throughout the walnut oil matrix, as validated by confocal microscopy, ensured sustained bioactivity and mitigated the risk of localized oxidation. Electron spin resonance spectroscopy corroborated the superior antioxidant properties of the conjugates, which translated into a substantial 19-day increase in the shelf-life of the oil. Conclusion The g PPI-CUR conjugates enhanced the oxidative stability of walnut oil significantly, as demonstrated by the increased shelf life and reduced lipid oxidation. This study introduced an effective encapsulation method that improved the stability and extended the shelf life of edible oils, aligning with consumer demands for high-nutrition food products. The results indicate that the g PPI-CUR conjugates could serve as a promising antioxidant strategy for food preservation, offering a practical approach to enhance food quality and safety. © 2025 Society of Chemical Industry.
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Biomolecules
·
2025
·Vol. 15
·期 8
·1070
·
IF 4.8
Man Wang,Hongying Liu,Wei Zhao,Huafen Wang,Yuwei Zhuang,Jie Yang,Zhaohui Liu,Jing Zhu,Sichong Chen,Jinghui Cheng
In the context of critical challenges in curcumin-modified polyurethane synthesis—including limited curcumin bioavailability and suboptimal biodegradability/biocompatibility—a novel polyurethane material (Cur-PU) with good mechanical, shape memory, pH-responsive, and biocompatibility was synthesized via a one-pot, two-step synthetic protocol in which HO-PCL-OH served as the soft segment and curcumin was employed as the chain extender. The experimental results demonstrate that with the increase in Cur units, the crystallinity of the Cur-PU material decreases from 32.6% to 5.3% and that the intensities of the diffraction peaks at 2θ = 21.36°, 21.97°, and 23.72° in the XRD pattern gradually diminish. Concomitantly, tensile strength decreased from 35.5 MPa to 19.3 MPa, and Shore A hardness declined from 88 HA to 65 HA. These observations indicate that the sterically hindered benzene ring structure of Cur imposes restrictions on HO-PCL-OH crystallization, leading to lower crystallinity and retarded crystallization kinetics in Cur-PU. As a consequence, the material’s tensile strength and hardness are diminished. Except for the Cur-PU-3 sample, all other variants exhibited exceptional shape-memory functionality, with Rfand Rrexceeding 95%, as determined by three-point bending method. Analogous to pure curcumin solutions, Cur-PU solutions demonstrated pH-responsive chromatic transitions: upon addition of hydroxide ion (OH−) solutions at increasing concentrations, the solutions shifted from yellow-green to dark green and finally to orange-yellow, enabling sensitive pH detection across alkaline gradients. Hydrolytic degradation studies conducted over 15 weeks in air, UPW, and pH 6.0/8.0 phosphate buffer solutions revealed mass loss <2% for Cur-PU films. Surface morphological analysis showed progressive etching with the formation of micro-to-nano-scale pores, indicative of a surface-erosion degradation mechanism consistent with pure PCL. Biocompatibility assessments via L929 mouse fibroblast co-culture experiments demonstrated ≥90% cell viability after 72 h, while relative red blood cell hemolysis rates remained below 5%. Collectively, these findings establish Cur-PU as a biocompatible material with tunable mechanical properties, and pH responsiveness, underscoring its translational potential for biomedical applications such as drug delivery systems and tissue engineering scaffolds.
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危险品化学品经营许可证（带存储）