JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Hua Yu,Zhexuan Gao,Huanping Wang,Shilong Zhao,Degang Deng,Shiqing Xu
Developing phosphor-converted light-emitting diodes (pc-LEDs) for portable near-infrared (NIR) spectroscopy applications has generated significant demand for NIR-II phosphors. However, developing a NIR-II phosphor with both broadband emission and good thermal stability remains a significant challenge. Herein, we report a novel Ni 2+ -doped Mg 4 Nb 2 O 9 (MNO) phosphor that exhibits a full-width at half maximum (FWHM) of 213 nm, covering a wavelength range of 1100–1700 nm, with a peak at 1319 nm when excited by 405 nm ultraviolet (UV) light. The optimized phosphor exhibited an internal quantum efficiency (IQE) of 38.31 %. By combining first-principles calculations with experimental analysis, we established that Ni 2+ ions occupy the three octahedral cation sites in the MNO host. Notably, the MNO: 0.004Ni 2+ phosphor maintains 102 % of its initial emission intensity at 423 K compared to room temperature (RT), exhibiting a zero-thermal-quenching property, which can be attributed to the thermal energy transfer from oxygen vacancy defects to activator ions, large thermal energy barrier, as well as the high rigidity of the MNO host. An NIR-II pc-LED device was constructed by encapsulating the optimized phosphor within a UV LED chip. The application of nondestructive NIR spectroscopy in detection, night vision, and bioimaging further demonstrates the potential of this device.
研究领域:
材料科学
·
光学
·
光电子学
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
·
2025
·
IF 12.9
Jingchuan He,Tingting Li,Xiaoqin Pan,Zhihua Deng,Jifu Huang,Xiaocheng Mo,Xiaoju Shen,Xiumei Qin,Xingye Yang,Ming Gao,Jie Yang
Combination therapy is a promising strategy for lung adenocarcinoma (LUAD), due to the advantages of overcoming drug resistance, side effects, and tumor heterogeneity. Herein, we report a novel dual-targeting bimetallic nanozyme (MH-iRGD) consisting of nanosized manganese ferrite (MF) after encapsulating with dopamine and methacrylic anhydride to modify hyaluronic acid, followed by integrin receptor targeting peptide (HS-PEG3400-iRGD) modification for LUAD targeted therapy. Our study confirmed that MH-iRGD combined with near-infrared irradiation (NIR) possessed dramatic photothermal effects and reactive oxygen species (ROS) production and GSH depletion abilities. Importantly, MH-iRGD possessed dual-targeting capacities for LUAD cells overexpressed CD44 and αV-integrin receptors owing to hyaluronic acid coating and iRGD modification. Inhibitors of CD44 and integrins could impair the uptake of MH-iRGD in LUAD cells. Moreover, MH-iRGD+NIR displayed excellent anti-LUAD effects as a result of the production of intracellular ROS, consumption of glutathione (GSH) and mitochondrial dysfunction. Mechanistically, NIR robustly strengthened MH-iRGD-induced ferroptosis and apoptosis by down-regulating SLC7A11, GPX4, Bcl-2 levels while up-regulating Bax level. Specifically, ferroptosis and apoptosis were increased while the LUAD progression was inhibited after intravenous injection of MH-iRGD+NIR in xenograft mouse models. Taken together, our results indicate that MH-iRGD+NIR serves as a promising targeted therapy for LUAD, which broadens the applications of highly active dual-targeting bimetallic nanozymes.
研究领域:
肿瘤学
·
生物材料学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Cell Reports Physical Science
·
2025
·
IF 7.3
Mengxuan Du,Binge Huang,Songlin Xin,Liqin Wu,Xiaojun He
Multidrug-resistant bacterial pneumonia (MDR-BP), particularly involving biofilm eradication, presents therapeutic challenges. While reactive oxygen species (ROS)-mediated chemodynamic therapy offers antibacterial potential, limitations in biocatalytic performance and nanotherapeutic efficacy hinder traditional approaches. We developed nitrogen-doped ruthenium single-atom catalysts (Ru-N-SACs) as a dual-functional nanotherapeutic platform. This nanozyme exhibits peroxidase-mimicking catalytic activity, generating ROS selectively. Near-infrared laser stimulation further enhances its activity and provides photothermal disruption of biofilms. The resulting synergistic action achieves complete biofilm eradication and improves survival in pneumonia models. Comprehensive multi-omics analyses elucidated the therapeutic effectiveness and regulatory mechanisms of Ru-N-SACs against MDR-BP pathogenesis. This work demonstrates a paradigm combining catalytic ROS generation and photothermal therapy for managing deep-tissue infections. It advances the design of precision-engineered nanozymes within antimicrobial nanomedicine, addressing the critical need for innovative strategies against MDR pathogens.
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2024
·
IF 8
Jian Li,Xinhui Su,Nian Liu
Organic molecules with strong absorption in the near-infrared (NIR)-II region are highly desired for cancer photothermal theranostics. However, it remains challenges to construct NIR-II photothermal agents with desired optical properties. This study reports a donor engineering approach to simultaneously manipulate the absorption and nonradiative transitions of croconaine dyes. By introducing different donor units with increasing electron donating ability to the backbone, the absorption of the synthesized croconaines were gradually red-shifted to NIR-II region, especially the benzo[ c , d ]indolium conjugated croconaine (CR1045). The extensive conjugation of CR1045 had a narrower HOMO-LUMO energy gap and strong NIR-II light responsiveness. Importantly, the steric repulsion between this large planar donor and croconate acceptor of CR1045 promotes the formation of a twisted intramolecular charge transfer (TICT) state, making it more prone to direct the absorbed energy towards heat-producing non-radiative decay rather than other dissipative pathways. And the nanoformulated CR1045 exhibits excellent optoacoustic generation capability and ultrahigh photothermal conversion efficiency (∼84%). In vitro and in vivo investigations confirm good optoacoustic imaging and effective photothermal treatment of tumors. Therefore, this work offers insights into donor regulation for the future development of efficient NIR-II photothermal agents.
研究领域:
生物医学工程
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肿瘤学
·
材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Zhongyu Tong,Jiamin Li,Yuqing Yan,Feifeng Huang,Guanyu Zhu,Huanping Wang,Hua Yu,Degang Deng
The development of tunable broadband near-infrared (NIR) fluorescent materials with excellent luminescent properties is still a challenge for the next generation of intelligent NIR light sources. Here, a series of Cr 3+ doped magnetoplum type NIR phosphors were prepared by the high-temperature solid-state method. Their luminescent properties and the methods to broaden the luminescence bandwidth were discussed in detail. In BaAl 12 O 19 : Cr 3+ phosphor, Cr 3+ -Cr 3+ ion pair was constructed based on heavily doped Cr 3+ ions, so as to broaden its spectral emission range. With the increase of Cr 3+ doping concentration, the full width at half maximum (FWHM) of BaAl 12 O 19 : Cr 3+ sample increased from 18.5 nm to 93.7 nm. Furthermore, the crystal field environment of Cr 3+ ions in BaAl 12 O 19 : Cr 3+ phosphors was changed by cationic substitution (Sr 2+ substituted Ba 2+ ion site). The FWHM of NIR emission increases from 49.37 nm to 123.78 nm, and the internal quantum efficiency (IQE) increases from 65.6 % to 76.2 %, with good thermal stability ( I 373 K / I 298 K = 77.3 %). An intense NIR emission of 31.3 mW at 100 mA is produced by the phosphor-converted light-emitting diode (pc-LED), exhibiting a photoelectric efficiency of 15.3 %.
研究领域:
材料科学
·
光学材料
·
固态化学
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光子学
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发光光谱学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Lihong Zhang,Chunlin Yang,Chaowen Chen,Chunhui Zhou,Meiqing Li,Ziyi Cui,Pengqi Yang,Haiqun Cao,Zhengyan Wu
Foliar off-target loss and premature exposure are the two major challenges in traditional pesticide applications. The development of intelligent systems for precise pesticide delivery represents a significant advancement in enhancing pesticide efficiency while minimizing environmental pollution. Here, a sandwich-structured MXene-based nano-platform with near-infrared (NIR) responsiveness (EMPP/CD@PEG) was successfully constructed. The fabrication process involved anchoring polydopamine-functionalized Prussian blue (PB@PDA) onto MXene nanosheets, loading emamectin benzoate (EB), and subsequently modifying the nanosheets with a temperature-sensitive cyclodextrin@polyethylene glycol (CD@PEG) hydrogel. Upon NIR irradiation, PB@PDA-modified MXene functioned as a photothermal agent, achieving a photothermal conversion efficiency of 47.5 %. This effect triggered the breakdown of the CD@PEG gel network, resulting in and the release of EB. The enhanced photothermal performance of PB@PDA-modified MXene was primarily attributed to the excellent light absorption properties of MXene. Additionally, the deposition of PB@PDA nanoparticles on the MXene surface increased its roughness, leading to multiple scattering and refraction of incident light, further improving photothermal efficiency. More importantly, the LC 50 values of EMPP/CD@PEG against Spodoptera frugiperda , Corn borer , and Mythimna separata were 0.0806 mg/L, 0.1250 mg/L, and 0.1044 mg/L, respectively, demonstrating higher insecticidal activity compared to commercial suspension concentrates. Moreover, EMPP/CD@PEG exhibited superior foliar affinity, photostability, and safety for maize plants and HK-2 cells, attributed to the encapsulation and stabilization effects of the nanocarriers. As a result, this work offers valuable insights into the development of sustainable and eco-friendly pesticide nano-formulations in agriculture production.
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Haonan Zhao,Cuilian Wen,Lijin Luo,Jiamin Qian,Xi Lin,Yang Xu,Zhongzhi Tang,Xinyi Wang,Rongtao Zheng,Baisheng Sa
The integration of osteogenic and antibacterial properties into biomaterials is crucial for addressing infected bone defects. Mesoporous bioactive glass (MBG) is widely recognized for its bioactivity and tunable porous structure, making it a promising candidate for bone repair. However, conventional MBG lacks inherent antibacterial properties, limiting its application in postoperative infection management. In this study, we have successfully developed Ti 3 C 2 T x MXene modified MBG (Ti 3 C 2 T x /MBG) nanocomposites with osteogenic and antibacterial properties. The results reveal that the incorporation of Ti 3 C 2 T x MXene significantly enhances the mineralization capability, as evidenced by accelerated hydroxyapatite formation in simulated body fluid within 7 days compared to pure MBG. Notably, the nanocomposite exhibits no cytotoxicity toward MC3T3-E1 cells and markedly upregulates key osteogenic genes, including Alp, Runx2, Col1a1, Opn, and Ocn . Moreover, Ti 3 C 2 T x /MBG nanocomposite displays remarkable photothermal antibacterial efficacy, achieving 99.6% inhibition of Staphylococcus aureus under near-infrared irradiation. This study proposes a versatile strategy to synthesize multifunctional MXene/MBG nanocomposites with enhanced apatite mineralization, osteogenic gene expression, and antibacterial activity, demonstrating great potential for bone tissue engineering and other biomedical applications.
研究领域:
生物医学材料
·
组织工程
·
纳米技术
·
骨再生
·
抗菌治疗
✓ 已验证
产品关联
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2017
·
IF 5.951
Qingyong Tian,Weijing Yao,Wei Wu,Jun Liu,Zhaohui Wu,Li Liu,Zhigao Dai,Changzhong Jiang
Efficiently reclaiming the utilization of solar light in a photocatalysis system remains very challenging. By integrating full advantage of upconversion material, plasmonic metals, and narrow bandgap semiconductors, β-NaYF4:18%Yb3+ and 2%Tm3+@SnO2@Ag nanoparticles (denoted as NaYF4@SnO2@Ag NPs) are designed and successfully synthesized as a wide-spectral (UV–vis-NIR) responsive upconversion and plasmonic-enhanced photocatalyst. The as-obtained NaYF4@SnO2@Ag NPs present broadband optical absorption dimension, excellent photocatalytic efficiency, and good stability for the degradation of organic dyes. The enhanced photocatalytic performance of NaYF4@SnO2@Ag NPs can be attributed to the synergistic effects of the components composed in this core/shell architecture that result in higher photocarriers yield and favor the efficient transfer of photocarriers and energy. This work gives insight to guidance of fabricating efficient, multicomponent upconversion catalysts and proposes a potential in the field of high-efficiency environmental and energy-related applications.
研究领域:
材料科学
·
环境科学
·
纳米技术
✓ 已验证
DOI
高影响因子
BIOMACROMOLECULES
·
2026
·
IF 5.9
Yu Chen,Zhentan Lu,Dong Wang
The combinations of phototherapeutic modalities with chemotherapy represent an innovative antitumor strategy. Herein, we constructed a NIR laser regulated nanoplatform (PTE@TPP-NM(DOX/IR780)) via the self-assembly process of PEG-b-PCL modified with mitochondrial targeting triphenylphosphine (TPP), reactive oxygen species (ROS)-sensitive polymer (PTE), DOX, and IR780. Under 808 nm laser irradiation, IR780 in PTE@TPP-NM(DOX/IR780) generated abundant reactive oxygen species (ROS) and heat for photothermal therapy (PTT) and photodynamic therapy (PDT), while ROS oxidized PTE to release DOX for chemotherapy. The signal 808 nm laser could effectively regulate PTT, PDT, and chemotherapy in real-time, enhancing the synergistic efficacy. PTE@TPP-NM(DOX/IR780) could result in depolarization of the mitochondrial membrane and inhibition of the expression of heat shock proteins to amplify antitumor effect. Enhanced therapeutic effect was demonstrated via in vivo and in vitro experiment. This study provided a promising strategy for the design of multifunctional nanocarriers to address the limitation of combined therapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2026
·
IF 4.6
Yang Li-Kai,Hou Qian-Qian,Ying Shu-Di,Zhai Cong-Cong,Yang Xu,Yin Yu-Lin,Liu Qian,Wei Bing,Shao Ming-Wei,Zhao Pan-Pan,Zhao Xiu-Xian,Li Wen-Ting,Ma Jia-Chen,Zong Chuan-Yong,Nie Yong,Jiang Xu-Chuan
The efficient regulation of sunlight to minimize unnecessary energy exchange through windows plays a vital role in advancing building energy efficiency. However, the inferior stability of cerium-doped tungsten trioxide (CWO) as a near-infrared (NIR) shielding material, combined with the poor mechanical properties of its coatings, poses significant challenges for long-term thermal insulation performance. Here, a hierarchical thermal insulation coating with multifunctional integration has been developed. The inner layer’s excellent NIR shielding performance (94.4%) results in a temperature reduction of 13.6 °C, demonstrating outstanding thermal insulation. Meanwhile, the external layer composed of polysilsesquioxane grafted by carboxylated hexafluoropropylene trimer offers exceptional weather resistance due to the low surface energy. The fluorosilicone coating effectively mitigates oxidation of CWO, as evidenced by the retention of NIR shielding performance even after 30 days of exposure to 60 °C and 90% relative humidity. Furthermore, the coating demonstrates superior anti-graffiti properties and achieves an ultra-high mechanical strength of 0.49 GPa through precise fluorine content modulation. This hierarchical design integrates high hardness, excellent abrasion resistance, anti-graffiti functionality, transparency, and long-term operational durability into a single smart window system, offering a promising solution for reducing building energy consumption.
✓ 已验证
产品关联
DOI
高影响因子
Nanoscale
·
2019
·Vol. 11
·期 40
·18874-18880
·
IF 6.97
Guanying Chen,Mingjuan Sun,Juan Li,Mingshan Zhu,Zaizhu Lou,Baojun Li
Anisotropic plasmonic metals have attracted significant attention in enhancing the catalytic performance of catalysts due to their broad light-harnessing capabilities and active hot electrons; however, limited investigations have been dedicated towards improving their electrochemical reaction performance in the visible and near infrared (NIR) regions. Herein, anisotropic Pt-edged Au nanodisks (NDs) were synthesized by controlling the preferential loading of Pt and used as catalysts for plasmon-enhanced electrochemical methanol oxidation reactions (MORs) under visible-NIR light irradiation by, and the light-enhanced electric current over the Pt-edged Au NDs was found to be 3-fold higher than that under dark conditions. Wavelength-dependent electric current over the Pt-edged Au NDs for the MOR in the visible-NIR light region demonstrates that the light-induced enhancement of the electric current is due to surface plasmon resonance (SPR) of the Au NDs. Furthermore, plasmonic hot electron transfer was studied by the single-particle photoluminescence images and spectra of Au NDs and Pt–Au NDs, and the dipole surface plasmon resonance (DSPR) mode was proved to be the main channel for hot electron transfer. During the electrochemical reaction under visible-NIR light irradiation, a plasmonic hot electron is transferred to the electrode, and a “hot hole” is left on the surface, boosting the MOR.
研究领域:
材料科学
·
催化化学
·
纳米技术
·
物理化学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2023
·Vol. 21
·期 1
·1-15
·
IF 10.2
Luo Tingting,Jiang Mingyang,Cheng Ziqiang,Lin Yuntao,Chen Yuling,Zhang Zhenyu,Zhou Jian,Zhou Wenhua,Yu Xue-Feng,Li Shuchun,Geng Shengyong,Yang Hongyu
As a common tumor with high incidence, osteosarcoma possesses extremely poor prognosis and high mortality. Improving the survival of osteosarcoma patients is still a great challenge due to the precipice of advancement in treatment. In this study, a combination strategy of gene therapy and photothermal therapy (PTT) is developed for efficient treatment of osteosarcoma. Two-dimensional (2D) FePS 3 nanosheets are synthesized and functionalized by poly-L-lysine-PEG-folic acid (PPF) to fabricate a multifunctional nanoplatform (FePS@PPF) for further loading microRNAs inhibitor, miR-19a inhibitor (anti-miR-19a). The photothermal conversion efficiency of FePS@PPF is up to 47.1% under irradiation by 1064 nm laser. In vitro study shows that anti-miR-19a can be efficiently internalized into osteosarcoma cells through the protection and delivery of FePS@PPF nanaocarrier, which induces up-regulation of PTEN protein and down-regulation p-AKT protein. After intravenous injection, the FePS@PPF nanoplatform specifically accumulates to tumor site of osteosarcoma-bearing mice. The in vitro and in vivo investigations reveal that the combined PTT-gene therapy displays most significant tumor ablation compared with monotherapy. More importantly, the good biodegradability promotes FePS@PPF to be cleared from body avoiding potential toxicity of long-term retention. Our work not only develops a combined strategy of NIR-II PTT and gene therapy mediated by anti-miR-19a/FePS@PPF but also provides insights into the design and applications of other nanotherapeutic platforms.
研究领域:
肿瘤学
·
纳米医学
·
生物材料学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）