PROCEEDINGS OF THE COMBUSTION INSTITUTE
·
2024
·
IF 5.3
Qingbo Zhu,Bingzhi Liu,Zhihong Hu,Shuyao Chen,Qiang Xu,Zhandong Wang
Tetramethylethylenediamine (TMEDA) is a promising green propellant that has been studied as a substitute for hydrazine. An in-depth study of the TMEDA thermal decomposition mechanism is important for future applications in engines. In this work, pyrolysis experiments of TMEDA were carried out in an atmospheric jet-stirred reactor (JSR) from 610 to 1000 K. Abundant intermediate species were analyzed and quantified by synchrotron vacuum ultraviolet photoionization mass spectrometry (SVUV-PIMS) and gas chromatography (GC). The results show that the pyrolysis of TMEDA mainly produces hydrocarbons, amines, imines , and nitriles , among which HCN and C 2 H 5 N are the main nitrogen-containing intermediates. Based on the experimental results, a detailed chemical kinetic model for describing the thermal decomposition of TMEDA was updated to improve predictions. The updated model can satisfactorily predict the consumption of TMEDA and the generation of most intermediates. Furthermore, detailed experimental measurements combined with kinetic analysis are used to clarify the decomposition reaction pathways of TMEDA. The rate of production (ROP) analysis indicates that unimolecular C-C bond dissociation is one of the leading consumption pathways of TMEDA, forming the (CH 3 ) 2 NCH 2 radical. In addition, the H-atom abstraction reactions involving CH 3 radicals formed by the C-N bond dissociation of (CH 3 ) 2 NCH 2 radicals further promote the consumption of TMEDA. Sensitivity analysis highlights that the unimolecular C-C bond dissociation reaction of TMEDA and the reactions involving CH 3 radicals mainly control the pyrolysis behavior of TMEDA. The detailed experimental results and kinetic analysis in this work are expected to contribute valuable references to further research on the combustion mechanism of TMEDA.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry A
·
2024
·
IF 10.7
Yiyuan Yao,Shifu Wang,Chaohai Wang,Zetong Wu,Chengming Xiao,Xin Guo,Xin Yan,Junwen Qi,Yujun Zhou,Zhigao Zhu,Yue Yang,Xuning Li,Jiansheng Li
The selective distribution of reactive oxygen species originating from the optimized activation of peroxymonosulfate (PMS) offers opportunities to achieve the effective elimination of contaminants in water, but the synergistic mechanism of this process is still unclear, especially the reaction intermediates on the multi-metal catalysts. Herein, we proposed a coordinate metal regulation strategy to modulate active sites by designing an FeCoMnNiCu Prussian blue analogue-derived high-entropy alloy system that possesses a 0D-1D hybrid nanoarchitectonic structure. The electronegativity differences between the metals induce significant variation in the coordination environment during pyrolysis, creating highly active Fe, Co, and Mn sites and secondary active Ni and Cu sites, thus enhancing interfacial electron transfer and reducing the adsorption energy of PMS activation. In situ Raman analysis and DFT calculations revealed that FeIVO and ˙OH species were involved in the excitation process followed by the efficient elimination of various pollutants, which represents a breakthrough in the design of multi-metal Fenton-like catalysts for sustainable water decontamination.
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Liuyue Li,Jixiang Zhang,Yifang Li,Bianhua Liu,Jiali Yu,Nian Li,Zhenyang Wang,Jun Zhao
Two-dimensional (2D) nanomaterials have attracted many researchers to explore the effect of ice control and rapid deicing due to their functional groups, large specific surface area, and excellent photothermal properties. However, the impact of size effects on ice crystal formation, growth, and photothermal performance has been rarely explored. Here, graphene oxide nanosheets (GO NSs) with controllable sizes were used as a representative of 2D nanomaterials to probe the effect of size on ice crystal regulation and rapid rewarming in cell cryopreservation. All sizes of GO NSs exhibited notable inhibitory effects on ice crystal size during the recrystallization process. Significantly, when the size of GO NSs was smaller than a certain size (<150 nm), they showed a more significant ice recrystallization suppression effects, which could reduce the ice crystal size to about 17% of that of pure water. Meanwhile, the photothermal experiments also indicated that smaller-sized GO NSs exhibited better photothermal behavior, with 90 nm GO NSs (GO-90) heating to 70 °C in just 1 min induced by an 808 nm laser (2 W/cm2). Furthermore, applying GO-90 (200 μg/mL) to cell cryopreservation, cell viability could reach 95.2% and 93% with a low amount of traditional cryoprotectant (2% v/v DMSO) for A549 cells and HeLa cells after recovery, respectively. With the assistance of a 808 nm laser, the rewarming time was also shortened to 20 s, greatly improving the rewarming rate. Our work associated specific sizes of 2D nanomaterials with their ice growth inhibition behaviors during recrystallization and photothermal properties to synergistically improve cell cryopreservation efficiency, providing guidance for effectively designing novel 2D nanomaterials for collaborative control of ice crystals in cell cryopreservation.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2024
·Vol. 25
·期 19
·10563
·
IF 4.9
Fei Ran,Kailang Mu,Gang Liu,Yuchen Liu,Yuxin Pang,Guo Feng,Lingli Zhou,Leqiang Peng
Plant-derived medicinal materials have significant potential and promising applications in wound healing and skin regeneration. This study aims to develop a plant-based extract hydrogel from Bletilla striata (Thunb.Reichb.f.), specifically a glucosyloxybenzyl 2-isobutylmalates extract (B), and characterize its potential effects on wound healing. We synthesized the hydrogel using carbomer (C), glycerol (G), and triethanolamine (T) as the matrix, incorporating B into the hydrogel base, and evaluated its physical and chemical properties. In vitro tests assessed the biocompatibility of the glucosyloxybenzyl 2-isobutylmalates-carbomer-glycerol-triethanolamine (B-CGT) hydrogel and its effects on cell proliferation, migration, and adhesion. Animal model experiments evaluated its potential to promote wound healing. The results showed that the prepared B-CGT hydrogel possessed a good three-dimensional network structure and stability, demonstrating significant free radical scavenging capacity in antioxidant tests. In cell experiments, the B-CGT hydrogel exhibited no potential cytotoxicity and showed good hemocompatibility and promotion of cell proliferation. Animal experiments indicated that wounds treated with the B-CGT hydrogel healed significantly faster, with improved formation of new epithelial tissue and collagen. This study suggests that the developed B-CGT hydrogel is a promising candidate for wound dressings, with excellent physicochemical properties and controlled drug release capabilities, effectively promoting the wound healing process.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2024
·Vol. 29
·期 16
·3940
·
IF 4.2
Qianqian Tang,Rong Yang,Jinnuo Li,Mingsong Zhou,Dongjie Yang
In this paper, N-vinylpyrrolidone was copolymerized with acrylic acid and itaconic acid by free radical polymerization, and a series of polyacrylic acid-co-itaconic acid-co-N-vinylpyrrolidone (PAIN) dispersants with different pyrrolidone ligand contents were synthesized and characterized. Then, the cobalt blue nano-pigment slurry (20 wt%) was prepared through a water-based grinding method, and the optimum grinding technology was explored and determined as follows: PAIN2 as a dispersant, a dispersant dosage of 10 wt%, and a grinding time of 480 min. According to this optimum grinding technology, the prepared pigment slurry had a significantly decreased agglomeration, theD90of which was 82 nm, and separately increased to 130 nm and 150 nm after heat storage for 3 and 7 days, exhibiting excellent heat storage stability. Additionally, its TSI value was also the lowest (1.9%), indicating good dispersion stability. The QCM and adorption capacity measuring results showed PAIN2 had a larger adsorption capacity, and the formed adsorption layer had a higher rigidity and was not easy to fall off. This was caused by both the interaction of carboxyl groups and the pyrrolidone ligand (strong coordination interaction) in PAIN2 with cobalt blue. The XPS and FT–IR measurements further proved the above-mentioned adsorption mechanism.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS & DESIGN
·
2024
·
IF 7.6
Sheng Zhou,Dengxian Wu,Guanjie Zhou,Qing Jiang,Zhihong Xu
Sporopollenin exine capsules (SECs), extracted from plant pollen grains, are becoming increasingly popular as natural microcapsules for a broad spectrum of bio-composite applications due to their plentiful supply, resilience to chemicals and physical stress, unique species-specific designs, exceptional consistency in structure, and significant internal volume. However, SECs have a relatively bioinert interface hindering their application in biomaterials. Thus, surface modification is an efficient strategy to convert SECs into biocompatible materials better for biological applications. Previous approaches predominantly depend on labor-intensive, multi-stage procedures that are time-consuming. Herein, we report an ultrafast, one-step, and effective modification strategy to render SECs biocompatibility by coating them with ferric ions and tannic acids, which endow them with a better cell adhesion property. In summary, our results show that this ultrafast and one-step biocompatibility strategy enhances the functional characteristics of SECs and holds wide-ranging implications for bio-composite applications. .
✓ 已验证
产品关联
DOI
高影响因子
ACS Biomaterials Science & Engineering
·
2024
·
IF 5.4
Hao Jin,Xuanqi Zhu,Heng Liu,Lu Wang,Shuwei Liu,Hao Zhang
The clinical treatment of bone defects includes allogeneic bone transplantation and autologous bone transplantation. However, they all have their own limitations, and the scope of application is limited. In recent years, bone tissue engineering scaffolds based on a variety of materials have been well developed and achieved good bone regeneration ability. However, most scaffold materials always face problems such as high biotoxicity, leading to inflammation and poor bioactivity, which limits the bone regeneration effect and prolongs the bone regeneration time. In our work, we prepared hydroxyapatite, erythropoietin (EPO), and osteogenic growth peptide (OGP) codoped type-I collagen (Col I) polypeptide nanofiber membranes (NFMs) by electrostatic spinning. In cell experiments, the composite NFMs had low cytotoxicity and promoted osteogenic differentiation of rat bone marrow mesenchymal stem cells. Quantitative real-time polymerase chain reaction and alkaline phosphatase staining confirmed the high expression of osteogenic genes, and alizarin red S staining directly confirmed the appearance of calcium nodules. In animal experiments, the loaded hydroxyapatite formed multiple independent mineralization centers in the defect center. Under the promotion of Col I, EPO, and OGP, the bone continued to grow along the mineralization centers as well as inward the defect edge, and the bone defect completely regenerated in about two months. The hematological and histological analyses proved the safety of the experiments. This kind of design to promote bone regeneration by simulating bone composition, introducing mineralization center and signal molecules, can shorten repair time, improve repair effect, and has good practical prospects in the future.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Yanning Zheng,Dankui Liao,Bimei Xie,Jinlei Sun,Jianhua Sun,Zhangfa Tong,Guangzhi Zhou
Effective removal of antibiotic residues from water is crucial for maintaining balance and cleanliness in the ecological environment. To achieve this, we conducted a study on the development of a highly efficient catalyst from the in-situ growth of Fe 3 O 4 nanoparticles on nitrogen-doped hollow porous carbon spheres (Fe 3 O 4 @N-HollCS). We controlled the in-situ growth time to optimize its performance. Material characterization and theoretical calculations revealed that the improved catalytic performance of Fe 3 O 4 @N-HollCS is due to electron transfer from the graphitic-N in N-HollCS to the catalytic interface of Fe 3 O 4 nanoparticles. Fe 3 O 4 @N-HollCS, with an ordered mesoporous structure and high specific surface area, had remarkable adsorption capacity for NOR antibiotics, with an enrichment efficiency exceeding 60% within 10 min. Moreover, the Fe 3 O 4 @N-HollCS degraded more than 90% of fluoroquinolone antibiotics, especially norfloxacin (NOR), which was eliminated within 60 min. The Fe 3 O 4 @N-HollCS also exhibited stable catalytic recycling ability within 10 magnetic separations. Fukui function predicted the sensitive sites of NOR, and we proposed potential degradation pathways. Ecological structure activity relationship model evaluation showed that the intermediate produced by Fe 3 O 4 @N-HollCS degradation of NOR has low levels of ecotoxicity. Overall, Fe 3 O 4 @N-HollCS catalysts have great potential for antibiotic wastewater treatment.
✓ 已验证
产品关联
DOI
高影响因子
Food Science & Nutrition
·
2024
·
IF 3.5
Xi Chen,Yong Zhu,Muhammad Mazhar,Likang Qin
Camellia seed oil (CSO), a potential prebiotic agent, can significantly increase the relative abundance of Akkermansia muciniphila ( A. muciniphila ) in mice gut microbiota following oral administration, this study aims to investigate the enhancing effect in vitro. The results showed that after 24-h co-cultivation with 0.5% (v/v) CSO, the growth of A. muciniphila increased from 11.61 ± 0.04 Log 10 CFU/mL to 12.17 ± 0.10 Log 10 CFU/mL ( p < 0.05), accompanied by a reduction in the oxidation–reduction potential (ORP) value of the media from −126.67 ± 1.78 mV to −117.33 ± 0.72 mV ( p < 0.05). Additionally, squalene and (+)-α-tocopherol, bioactive compounds present in CSO, were found to promote A. muciniphila proliferation (squalene OD 600 : 1.086 ± 0.002, tocopherol OD 600 : 1.100 ± 0.003, DMSO control OD 600 : 0.991 ± 0.003, p < 0.0001). Transcriptomic and metabolomic profiling revealed 464, 121, and 194 differentially expressed genes (DEGs) and 212, 160, and 156 differentially expressed metabolites (DEMs) in A. muciniphila co-cultivated with CSO after 4, 16, and 24 h, respectively ( p < 0.05). The upregulated DEGs and DEMs were primarily enriched in pathways associated with energy generation (e.g., gap , icd , sucC , GOZ73_RS04175 , succinate, phosphoenolpyruvate), nucleotide metabolism (e.g., mazG, deoxyguanosine), amino acid metabolism (e.g., argF , metK, L-tyrosine), translation (e.g., rplO , rpmC ), and environmental adaptation (e.g., murA , katE , reduced nicotinamide adenine dinucleotide). These findings suggest that various bioactive compounds present in CSO exhibit prebiotic effects on the in vitro proliferation of A. muciniphila by facilitating nutrient utilization and environmental adaptation. This study provides insights into the extended utilization of CSO.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2024
·
IF 3.7
Jingyun Ye,Ming Jin,Decheng Wan
We here show that the typical poison of thiols, if below a certain level, promotes rather than suppresses the catalytic activity of gold nanoclusters (AuNCs). A few thiol groups functionalized hyperbranched polyethylenimine (PEI, Mn = 2000 Da) patched on a mesoporous polymeric bead aid the direct synthesis of AuNCs. The nucleation efficiency of AuNC is 93-fold favored at a level of 2 thiols per PEI (0.04 equiv of the amino units) than that by neat PEI, and AuNCs (1.3 nm) are obtained up to a gold load of 6.3% on the support. Unexpectedly, the catalytic activity of AuNCs is favored by the thiol up to 2 thiols per PEI, as evaluated from the surface-normalized rate constant of the model reaction of 4-nitrophenol-reduction. The catalytic promotion by thiols probably stems from optimized electron density on AuNC. If the residual NH groups of PEI were further fully treated with glycidyltrimethylammonium chloride, the catalytic activity is again enhanced, where the accelerated mass transfer is responsible for the promotion. Overall, the catalytic activity reaches an unprecedented value (metal-normalized rate constant kc = 29.4 L mmol–1 s–1 and turnover frequency = 1623 h–1, as evaluated with the model reaction of 4-nitrophenol reduction) ever reported for supported AuNCs. Our results suggest that orthogonal ligand optimization is an effective manner of triggering the release of the catalytic potential of AuNCs, among which thiol is unique.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Simeng Wang,Siqi Zhang,Yifan Cui,Xugang Lu,Mei Zhang,Jun Chen,Yipu Cao,Changchun Zhou,Bangcheng Yang
3D printing was widely used for the modification of bioceramic structures. Here, Bioactive titanium dioxide (TiO 2 ) ceramics with macropore structures were prepared by controlling the pore size through 3D printing, and further obtained secondary micropores by altering the sintering temperature. The structures and in vitro bioactivity of materials were characterized, and the properties of the ceramics for osteogenic differentiation of rabbits bone marrow mesenchymal stem cells (rBMSCs) were investigated. The results showed that titanium dioxide ceramics could induce apatite formation in SBF, which indicated it is bioactive. All materials exhibited porous structures, which could promote the proliferation and osteogenic differentiation of rBMSCs. Importantly, the structure with 200 μm pore size significantly promoted the proliferation and adhesion of cells. Furthermore, more secondary micropores formed on the surface of materials with the decreased sintering temperature, which promoted cell proliferation. The pore size of 400 μm significantly upregulated the expression of osteogenesis-related genes, including Col I, ALP, Runx2, and OPN. It had the strongest osteogenic ability when sintered at 1100 °C compared to other groups. This implies that the 3D-printed TiO 2 ceramics have good osteogenic properties, and the hierarchical structure consisting of macroscopic pores and secondary micropores can control it well.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2024
·Vol. 47
·期 21
·e70021
·
IF 2.8
Qiang Chang,Kehang He,Yikao Hu,Yiming Liu,Xun Liao
Thrombin was immobilized on magnetic core-shell mesoporous silica nanoparticles (Fe 3 O 4 @nSiO 2 @mSiO 2 ) for the first time and used to screen enzyme inhibitors from extracts of Notopterygium incisum . The immobilized thrombin was characterized by Fourier-transform infrared spectroscopy, transmission electronic microscopy, thermal gravimetric analysis, and vibrating sample magnetometry. The results demonstrated that the immobilized thrombin possessed good thermal stability and high-temperature resistance for feasible storage and reuse. Two ligands, notopterol ( 1 ) and isoimperatorin ( 2 ) were fished out from the extract of N. incisum using the immobilized thrombin. They inhibited thrombin with IC 50 values of 59.35 ± 1.420 and 107.8 ± 1.660 µM, respectively. This is the first report of thrombin-inhibitory activity associated with notopterol and isoimperatorin. Meanwhile, the inhibition mechanism of both compounds was investigated by enzyme kinetic analysis and molecular docking. The method used enables rapid screening for thrombin inhibitors from medicinal plants, providing an efficient tool for the discovery of anti-thrombotic active compounds.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）