SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2023
·
IF 4.4
Hua-jin Zeng,Li Sun,Si-meng Liu,Ling-bo Qu,Ran Yang
In recent years, seeking and screening of compounds that can inhibit and/or depolymerize protein aggregation has been a hot issue in the field of pharmaceutical research. As a new material, quantum dots have been widely concerned by medical researchers. In present study, a novel 4-mercaptophenylboronic acid functionalized MoS 2 quantum dots (4-MPBA-MoS 2 QDs) was successfully synthesized through a one-pot hydrothermal approach by using molybdate dehydrate and 4-mercaptophenylboronic acid as Mo and S source, respectively. Transmission electron microscopy observation showed that the morphology and microstructure of the 4-MPBA-MoS 2 QDs displayed uniform spherical shape with a diameter of approximately 1.5 ∼ 3.0 nm. The UV and fluorescence spectra experiments indicated that the prepared QDs had good water solubility and two weak absorption peaks were appeared at 280 nm and 310 nm. When the excitation wavelength was set to 310 nm, the 4-MPBA-MoS 2 QDs had the strongest fluorescence intensity, and the maximum emission wavelength appeared at 405 nm. In vitro experiments showed that the 4-MPBA-MoS 2 QDs could significantly reduce the aggregation of bovine serum albumin (BSA). Especially when the mass ratio of BSA to 4-MPBA-MoS 2 QDs was 1:5, the inhibition rate could reach 76.4%. Cell experiment showed that the presence of 4-MPBA-MoS 2 QDs could obviously decrease the cytotoxicity induced by BSA amyloid fibrils. Moreover, the depolymerization of BSA amyloid fibrils by 4-MPBA-MoS 2 QDs and its excellent cell permeability were also observed. Molecular docking studies have shown that 4-MPBA-MoS 2 QDs may stabilize the BSA structure through van der Waals forces, hydrophobic force, electrostatic interactions and hydrogen bonds formed between the outer layer of 4-MPBA and BSA to prevent fibrosis aggregation. The results of this study suggested that 4-MPBA-MoS 2 QDs showed low cytotoxicity, good biocompatibility and solubility, and had a great potential in the design of new drugs for the treatment of amyloid-related diseases.
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高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2023
·Vol. 170
·期 7
·077512
·
IF 3.9
Jinjin Zhang,Wenjing Liu,Qi Wang,Jianying Qu
In this paper, composites of Ti3C2/ZIF-8/ZIF-67 were obtained through in situ growing ZIF-8/ZIF-67 on Ti3C2 with two-dimensional structure prepared by etching MXene using HF. Furtherly, novel materials of Ti3C2 modified with hollow polyhedrons composed of Co nanoparticles and N-doped carbon nanotube (Ti3C2/CoNP-NCNTHP) was got through derivation with high temperature calcination. The materials were combinations of two-dimensional nanosheets and three-dimensional hollow polyhedras, which were characterized by SEM, TEM, XRD, XPS and EIS. Based on this, a new electrochemical sensor of Ti3C2/CoNP-NCNTHP/GCE was constructed to detect paracetamol (PA) and 4-aminophenol (4-AP) simultaneously. Under optimal conditions, the linear ranges for detection of PA and 4-AP were 0.50–350.00 μM and 0.50–200.00 μM with the limits of detection of 0.05 μM and 0.07 μM, respectively. This proposed sensor has lower detection limits and good linear ranges, which was successfully applied for river water and acetaminophen tablets with good accuracy and has potential prospects for practical applications.
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RSC Advances
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2023
·Vol. 13
·期 20
·13556-13563
·
IF 3.9
Xia Xu,Mingqiang Li,Liming Yang,Bing Hu
Reasonable design of bimetallic nanomaterials with support is beneficial to improve catalytic performance. This work reports a new kind of sodium sesquicarbonate-supporting Fe2O3@Pt via etching Fe3O4@Pt@SiO2, which exhibits highly efficient and stable catalytic reduction performance towards 4-NP. Sodium sesquicarbonate-supporting Fe2O3@Pt has an interconnected one-dimensional network structure that provides sufficient channels for mass transfer. At the same time, a large amount of Fe2O3@Pt is exposed on its surface, which hinders the aggregation of pt clusters and Fe2O3 nanoparticles, and facilitates the direct contact of Fe2O3@Pt reaction sites with reactant molecules, thus improving the catalytic rate of 4-NP reduction reaction. Moreover, the introduction of non-metallic Fe can not only reduce the consumption of precious metal Pt, but also improve the catalytic efficiency due to the synergistic effect. This study opens up a new avenue to develop robust catalysts for heterogeneous catalytic reactions.
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高影响因子
Inorganics
·
2023
·Vol. 11
·期 6
·236
·
IF 2.9
Jia-Lin Cui,Zhong-Liang Liu,Hui-Hui Li,Chun-Zhong Li
The synthesis of highly efficient heterogeneous catalysts with uniformly dispersed noble metal particles and a suitable size is crucial for various industrial applications. However, the high cost and rarity of noble metals limit their economic efficiency, making it essential to improve the catalytic performance with lower noble metal loading. Herein, a two-step method was developed for the synthesis of uniformly dispersed ~3 nm Pt nanoparticles (NPs), strongly anchored on Ni(OH)2nanosheets (NSs), which was proven by adequate structural characterizations. XPS analysis demonstrated that Ni(OH)2NSs with abundant oxygen vacancies provided sufficient anchor sites for Pt NPs and prevented their agglomeration. The catalytic performance of Ptn/Ni(OH)2(n (represents the addition amount of Pt precursors during the synthesis, μmol) = 5, 10, 15, and 20) NSs with controllable Pt loading were evaluated via the reduction of 4-nitrophenol to 4-aminophenol as a model reaction. The Pt10/Ni(OH)2NSs exhibited the best activity and stability, with a reaction rate constant of 0.02358 s−1and negligible deterioration in ten reaction cycles. This novel synthetic method shows potentials for the synthesis of highly efficient noble-metal-supported catalysts for heterogeneous catalysis.Keywords:Pt/Ni(OH)2nanosheets;oxygen vacancy;heterogeneous catalysis;reduction of 4-nitrophenol
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MACROMOLECULAR BIOSCIENCE
·
2023
·
IF 4.6
Xiuxia Sun,Qi Chen,Angelique A. Guan,Shuaishuai Yuan,Zhibo Li
Abdominal wall defect caused by surgical trauma, congenital rupture, or tumor resection may result in hernia formation or even death. Tension-free abdominal wall defect repair by using patches is the gold standard to solve such problems. However, adhesions following patch implantation remain one of the most challenging issues in surgical practice. The development of new kinds of barriers is key to addressing peritoneal adhesions and repairing abdominal wall defects. It is already well recognized that ideal barrier materials need to have good resistance to nonspecific protein adsorption, cell adhesion, and bacterial colonization for preventing the initial development of adhesion. Herein, electrospun poly(4-hydroxybutyrate) (P4HB) membranes infused with perfluorocarbon oil are used as physical barriers. The oil-infused P4HB membranes can greatly prevent protein attachment and reduce blood cell adhesion in vitro. It is further shown that the perfluorocarbon oil-infused P4HB membranes can reduce bacterial colonization. The in vivo study reveals that perfluoro(decahydronaphthalene)-infused P4HB membranes can significantly prevent peritoneal adhesions in the classic abdominal wall defects’ model and accelerate defect repair, as evidenced by gross examination and histological evaluation. This work provides a safe fluorinated lubricant-impregnated P4HB physical barrier to inhibit the formation of postoperative peritoneal adhesions and efficiently repair soft-tissue defects.
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International Journal of Electrochemical Science
·
2023
·
IF 1.5
Fang Wang,Shu Xian Zhao,Han Zeng,Wen Shan Huo
Petaloid-shapedZnO grafted with 4,5-imidazoledicarboxylic acid was proposed as a composite to entrap Hemoglobin molecules through the synergistic effect of covalent bonding and adjacent complexation between the hetero-atoms of the imidazolyl ring andtheheme sites in Hemoglobin. The morphology, structuralfeatures, and physiochemical properties ofthecomposite with Hemoglobin anchoring were investigated by photography, spectroscopy, and electrochemicalmethods, as well as the mechanism of charge shuttle of the heme protein into the composite and the dynamics of enzymaticcatalysis. Experimental results revealed that intricate interactions between components of the complex and the integrated Hemoglobin molecules alter the mechanism of charge shuttle between cofactors in the enzyme and the conductive matrix with partial heme sites in coordination with the imidazolyl ring as an intra-molecular electron relay. Such interactions arealso responsible for theprocess of substrate binding for the cofactors in the redox protein. The rapid kinetics of heterogeneous charge convection is found to be 89.0 s -1 with a unique pattern of two electrons per proton. This interactions would also lead to a lower affinity to hydrogen peroxide (893.0 μM), a high detection limit (0.9 mM), inferior sensitivity (4.5×10 -5 A•L•mol-1) and moderate kinetics of substrate attachment and transformation (1.9×10 6 and 29.8 s -1 ).
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ChemistrySelect
·
2023
·Vol. 8
·期 13
·e202300298
·
IF 2.1
Hong Du,Jing Zheng,Yi Mao,Wen-tao Pan,Yan Zhang,Lin-yu Zhu,Xue-Bo Yin,Min Zhang
Graphical Herein, magnetic Nitrogen-doped carbon microtubes with Co nanoparticles (Fe 3 O 4 @C−Co) were prepared. The obtained Fe 3 O 4 @C−Co exhibited an excellent catalytic performance due to the synergistic effect between the hollow porous nitrogen-doped carbon support and the dispersed Co nanoparticles. Furthermore, owing to the magnetism of the magnetic Fe 3 O 4 NPs and newly-generated Co NPs, the catalysts could be easily collected and recycled, exhibiting potential application in catalytic and other fields. Heterogeneous catalysts with controllable interface structures are of great importance to demonstrate the relationship between structure and property. Herein, magnetic Nitrogen-doped carbon microtubes with Co nanoparticles (Fe 3 O 4 @C−Co) were prepared, which could be used for the reduction of 4-nitrophenol(4-NP). In the process, MoO 3 @FeOOH core-shell structure was fabricated, then ZIF-67 was decorated on the MoO 3 @FeOOH. After adding 2-methylimidazole, MoO 3 microrods were removed. Then the prepared FeOOH@ZIF-67 microtubes are converted to Fe 3 O 4 @C−Co hybrid microtubes through pyrolysis. Due to the unique structures, the obtained Fe 3 O 4 @C−Co composites improved the dispersion of Co nanoparticles (NPs), diminished Co leaching, and promoted catalytic activity. The plentiful nitrogen improved electronic conductivity and brought additional active sites. The resulting Fe 3 O 4 @C−Co implies outstanding catalytic ability towards the reduction of 4-NP. The synergistic effect between the hollow microtube and the fine dispersed Co NPs within Fe 3 O 4 @C−Co offered an excellent catalytic efficiency. More particularly, this achievement opens a new avenue to the targeted design of well-defined nanocatalysts for practical applications in environmental remediation.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2023
·Vol. 24
·期 6
·5393
·
IF 5.6
Yuying Hou,Yufei Wang,Xiaoyu Liu,Naveed Ahmad,Nan Wang,Libo Jin,Na Yao,Xiuming Liu
C4H (cinnamate 4-hydroxylase) is a pivotal gene in the phenylpropanoid pathway, which is involved in the regulation of flavonoids and lignin biosynthesis of plants. However, the molecular mechanism of C4H-induced antioxidant activity in safflower still remains to be elucidated. In this study, a CtC4H1 gene was identified from safflower with combined analysis of transcriptome and functional characterization, regulating flavonoid biosynthesis and antioxidant defense system under drought stress in Arabidopsis. The expression level of CtC4H1 was shown to be differentially regulated in response to abiotic stresses; however, a significant increase was observed under drought exposure. The interaction between CtC4H1 and CtPAL1 was detected using a yeast two-hybrid assay and then verified using a bimolecular fluorescence complementation (BiFC) analysis. Phenotypic and statistical analysis of CtC4H1 overexpressed Arabidopsis demonstrated slightly wider leaves, long and early stem development as well as an increased level of total metabolite and anthocyanin contents. These findings imply that CtC4H1 may regulate plant development and defense systems in transgenic plants via specialized metabolism. Furthermore, transgenic Arabidopsis lines overexpressing CtC4H1 exhibited increased antioxidant activity as confirmed using a visible phenotype and different physiological indicators. In addition, the low accumulation of reactive oxygen species (ROS) in transgenic Arabidopsis exposed to drought conditions has confirmed the reduction of oxidative damage by stimulating the antioxidant defensive system, resulting in osmotic balance. Together, these findings have provided crucial insights into the functional role of CtC4H1 in regulating flavonoid biosynthesis and antioxidant defense system in safflower.Keywords:cinnamate 4-hydroxylase;safflower;flavonoid biosynthesis;antioxidant;Arabidopsis
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高影响因子
CERAMICS INTERNATIONAL
·
2023
·
IF 5.2
Shuang-Yin Zhu,Dan Zhao,Rui-Juan Zhang,Qing-Xia Yao,Wen Liu
Researches on fluorescence intensity ratio (FIR) based temperature sensors have become more and more popular in recent years. Herein, we co-doped Pb 2+ and Sm 3+ into the host material Ba 2 MgY 2 (BO 3 ) 4 (BMYB) to prepare a new series of phosphors. The Pb 2+ activated phosphor BMYB:0.03 Pb 2+ presents a wide blue emission band centered at 416 nm under 278 nm laser excitation with internal quantum efficiency of 46%. In the presence of both Pb 2+ and Sm 3+ , energy transfer will occur between them, resulting in tunable color emission. Besides, the phosphor has an absolute sensitivity of 0.96% K −1 at 575 K, which makes it an excellent candidate for temperature sensing. These findings suggest that prepared phosphor is a potential candidate for color tunable phosphor and temperature sensing material.
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高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2023
·Vol. 332
·期 6
·1953-1960
·
IF 1.6
Luo Qingyun,Wang Chongshi,Zhu Wei,Yu Hongchao,Wang Chunyan,Chen Chuanhong
Due to its high adsorption capacity and adsorption efficiency, polymer gel shows excellent performances in the treatment of wastewater containing thorium. In this work, glutaraldehyde cross-linked N -(4-Aminobenzoyl)-ʟ-glutamic acid modified chitosan (CCS-AGA) was used to adsorb Th(IV) ions from aqueous solutions for the first time. FT-IR and SEM results revealed the chemical structure and surface morphology of this material. The influence of solution pH, contact time and initial concentration of Th ions on the adsorption of Th(IV) by CCS-AGA was investigated. The experimental data suggest that the adsorption behavior of CCS-AGA could be accurately predicted by the Langmuir model. The maximum theoretical adsorption capacity of CCS-AGA for Th(IV) was 162 mg/g. Moreover, this material exhibited excellent reusability and adsorption selectivity for Th(IV).
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Reaction Chemistry & Engineering
·
2023
·Vol. 8
·期 7
·1673-1683
·
IF 3.9
Zhen Wu,Hongli Bai,Yifan Ji,Tao Wang,Zihe Zhao,Yetao Jiang,Xiaoyu Wang,Jiaxing Xu,Aiyong He,Sheng Chen,Lei Hu
Lignin valorisation is hindered by intrinsic difficulties. The breaking of the anti-degradation barrier of lignin for the transformation of lignin has become a hot topic in current research. In the present work, the carbon-nitride-supported molybdenum catalyst (Mo/CN) was synthesised by a two-step method from ammonium molybdate and dicyandiamide and used for the enhancement of lignin depolymerisation to produce high-value phenols. The SEM, TEM, XPS, XRD and FT-IR results of Mo/CN confirmed that the two-step method is advantageous for the high dispersion of MO nanoparticles on the CN carrier. The CN and various CN-supported metal catalysts were examined carefully to evaluate their catalytic activities for kraft lignin conversion, and this indicated that the loading of molybdenum on CN was a favourable method for the catalytic depolymerisation of kraft lignin. A depolymerisation residue yield of 4.33%, tetrahydrofuran-soluble products (TSPs) yield of 61.6%, and a monomer yield of 23.4% could be obtained when kraft lignin depolymerisation was performed on 2% Mo/CN in 50% ethanol at 220 °C for 2 h. High-value phenols such as butylated hydroxytoluene (BHT) and 4-propylguaiacol dominated the depolymerisation products. Moreover, the synthetic catalyst presents good applicability for different industrial lignins. To understand the role Mo/CN played in the degradation of lignin, a β-O-4 type lignin dimer 2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)ethenone was used as a model, and the degradation pathways of the model based on Mo/CN are proposed.
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JOURNAL OF CHEMICAL THERMODYNAMICS
·
2022
·
IF 3.269
Jinbei Yang,Shucui Han,Hongcun Chen,Meiqiong Yu,Zhongliang Yao
Density and viscosity data of pure liquid 4‑fluoronitrobenzene and 2‑fluoronitrobenzene were determined in the temperature range from 303.15 to 353.15 K at the local atmospheric pressure of 100.8 kPa. Saturated vapor pressures of the two isomers and isobaric vapor–liquid equilibrium (VLE) data for the binary system of the two isomers at 10.0 kPa were measured experimentally by a modified Rose still. The relationship of density to temperature is accurately correlated by the DIPPR equation. The viscosity data were well described by the Litovitz, Ghatee, VFT, and Andrade equations. Among them, Andrade equation shows the best accuracy. Both Antoine and Riedel equations can successfully correlate the relationship between saturated vapor pressure and temperature, while Riedel equation is more accurate due to the small average relative deviation. The binary VLE data were correlated with NRTL and Wilson models, and the binary interaction parameters were obtained. The VLE data predicted by the obtained parameters are in good agreement with the experimental data, and the binary system did not exhibit azeotropic behavior. The thermodynamic properties of the pure components described above and the vapor–liquid equilibrium data provided are critical for the design and operation of the distillation of the isomeric mixture of 4‑fluoronitrobenzene + 2-fluoronitrobenzene.
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