IONICS
·
2024
·
IF 2.4
Qiu Shengzhou,Wu Chenxi,Akter Sima,Hong Shaoli,Liu Huihong,Mahmud Sakil
This study presents the development of copper oxide–modified screen-printed carbon electrodes (CuO/SPCE) for the sensitive electrochemical detection of isoniazid (INZ). The electrodeposition of CuO on the surface of SPCE in a dilute CuSO 4 solution forms CuO amorphisms or clusters, which catalyze the oxidation of INZ. The sensor exhibited a linear response to INZ concentrations ranging from 4 to 200 μM with a correlation coefficient of 0.991 and a limit of detection (LoD) of 8.39 μM. Stability and reproducibility were confirmed through repetitive measurements with relative standard deviations of 0.27% and 1.20%, respectively. Interference studies demonstrated the sensor’s selectivity toward INZ, and a real sample analysis of pharmaceutical tablets yielded recovery rates ranging from 99.50 to 105.03%. Hence, regular monitoring of INZ dosage levels in human body fluids is critical, necessitating the development of sensitive, effective, and consistent methods to quantify INZ in clinical and pharmaceutical samples. Graphical Abstract
研究领域:
医学诊断
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分析化学
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生物传感技术
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Xiufeng Wang,Wenhui Ai,Ge Chen,Yao Jin,Jiayao Chen,Fang Wang,Ting Zhou,Guodong Zhang,Zhiqing Zhang
A novel Mo-MnO 2 nanoflowers (NFs) with oxidase-like (OXD-like) activity was performed by microwave-assisted hydrothermal synthesis, and the doping of Mo resulted in enhanced enzyme-like activity and stronger affinity for the chromogenic substrate 3,3′,5,5′-Tetramethylbenzidine (TMB) than single MnO 2 by the same synthesis method. In the presence of oxygen, Mo-MnO 2 NFs oxidized the colorless TMB to blue oxTMB, and the addition of isoniazid and ascorbic acid inhibited the color development reaction. Besides, it was further investigated that the inhibitory mechanism of INH and AA on the color development reaction of Mo-MnO 2 -TMB system, mainly due to the electrostatic interaction. The absorbance change of oxTMB at 652 nm could be used to quantitative detect isoniazid (INH) and ascorbic acid (AA). The linear ranges of colorimetric detection were 1–40 μM for INH and 1–30 μM for AA, and the limits of detection (LOD) were 0.436 μM for INH and 0.579 μM for AA, respectively. The successful application of this sensing platform in real samples further validated its practicality, demonstrating the broad potential in the field of colorimetric sensing.
研究领域:
生物化学
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纳米医学
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分析化学
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产品关联
DOI
高影响因子
Heliyon
·
2024
·
IF 3.4
Yan Dai,Hao Zhang
In this article, copper carbonate analog with good peroxidase-like activity was successfully synthesized for the first time via a simple co-precipitation of CuSO 4 ▪5H 2 O and Na 2 CO 3 . The obtained copper carbonate analog exhibited excellent intrinsic peroxidase-like activity towards a classical peroxidase substrate of 3, 3′, 5, 5′ -tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (H 2 O 2 ) under an acidic environment. The study of the catalytic mechanism confirmed that the hydroxyl radical produced from the decomposition of H 2 O 2 is the main reactive oxygen species responsible for the catalytic oxidation of TMB to oxTMB. Moreover, results from kinetic parameter analysis indicated that H 2 O 2 was more easily and/or likely to attach to the copper carbonate analog than TMB. Subsequently, the effects of experimental conditions (buffer pH, temperature, and incubation time) on the catalytic activity of the copper carbonate analog were also optimized. Finally, a copper carbonate analog-based colorimetric sensor was developed to determine isoniazid. Under the optimal conditions, the linear range for isoniazid was as broad as 0–178.6 μM, and the detection limit was as low as 8.47 μM. The spiked recoveries of isoniazid in normal human serum has been observed in the range of 94.8%–105.5 %. This strategy focuses on the development of a green, cost-efficient peroxidase mimic with high activity, good biocompatibility, and a simple synthesis process.
研究领域:
生物化学
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医学诊断
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产品关联
DOI
PubMed
高影响因子
CHEMISTRY-A EUROPEAN JOURNAL
·
2015
·Vol. 21
·期 43
·15439-15445
·
IF 5.731
Yuan-Yuan Jiang,Hong-Bin Dai,Yu-Jie Zhong,De-Min Chen,Ping Wang
Graphical Highly active and robust : Ni–Pt alloy nanocatalysts supported on mesoporous ceria, prepared by a one-pot evaporation-induced self-assembly method, selectively promote decomposition of hydrazine monohydrate at a high rate to generate hydrogen with high selectivity (see figure). Moreover, the catalysts exhibit high cycle stability. The development of active, selective, and robust catalysts is a key issue in promoting the practical application of hydrazine monohydrate (N 2 H 4 ⋅ H 2 O) as a viable hydrogen carrier. Herein, the synthesis of a supported Ni–Pt bimetallic nanocatalyst on mesoporous ceria by a one-pot evaporation-induced self-assembly method is reported. The catalyst exhibits exceptionally high catalytic activity, 100 % selectivity, and satisfactory stability in promoting H 2 generation from an alkaline solution of N 2 H 4 ⋅ H 2 O at moderate temperatures. For example, the Ni 60 Pt 40 /CeO 2 catalyst enabled complete decomposition of N 2 H 4 ⋅ H 2 O to generate H 2 at a rate of 293 h −1 at 30 °C in the presence of 2 M NaOH, which compares favorably with the reported N 2 H 4 ⋅ H 2 O decomposition catalysts. Phase/structural analysis by XRD, TEM, and Auger electron spectroscopy was conducted to gain insight into the excellent catalytic performance of the Ni–Pt/CeO 2 catalyst.
研究领域:
材料科学
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化学工程
·
能源存储与转换
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产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2019
·
IF 5.155
Jianmin Chen,Hongtao Zou,Qilu Yao,Minghong Luo,Xiugang Li,Zhang-Hui Lu
The development of highly active, stable, and inexpensive catalysts for efficient and complete dehydrogenation of hydrazine is highly attractive but still very challenging. Herein, Cr 2 O 3 -modified NiFe (NiFe-Cr 2 O 3 ) nanopartciles (NPs) have been designed as the heterogeneous catalyst. Both the catalytic activity and hydrogen selectivity of Ni 0.9 Fe 0.1 -Cr 2 O 3 NPs were improved remarkably as compared with those of their mono-metallic counterparts. The prepared Ni 0.9 Fe 0.1 -Cr 2 O 3 catalyst exhibited an outstanding catalytic activity to release 3.0 equiv. (H 2 + N 2 ) from hydrazine in only 8.5 min at 70 °C, providing a turnover frequency (TOF) value of 893.5 h −1 based on surface metal atoms. Systematic studies indicated that the small size and high surface area of Ni 0.9 Fe 0.1 -Cr 2 O 3 as well as the strong synergistic electronic effect between Cr 2 O 3 and NiFe NPs resulted in the excellent activity of Ni 0.9 Fe 0.1 -Cr 2 O 3 catalyst. Such a highly rapid, long term durability, and low cost catalyst may encourage greatly the practical application of hydrous hydrazine as a chemical hydrogen storage material.
研究领域:
材料科学
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催化化学
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DOI
高影响因子
JOURNAL OF FLUORESCENCE
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2023
·Vol. 34
·期 4
·1603-1615
·
IF 2.7
Yang Yun-Shang,Yuan Yi-Zhen,Zhang Ying-Peng,Guo Hui-Chen,Xue Ji-Jun
Widely utilized in the chemical industry and agriculture, hydrazine is easily absorbed by living things and can cause physical harm when in touch for an extended period of time. As a result, a novel cinnamaldehyde chalcone C5 was produced by Friedel Crafts process and aldol condensation reaction. Triphenylamine was used as the raw material for hydrazine determination in both reactions. Chalcone C5 exhibits significant AIE behavior in a mixed mixture of ethanol and water in addition to having great selectivity and a low detection limit (0.119 nm) for hydrazine. The solvent effect test revealed a linear relationship between the Stokes shift of C5 in the solvent and the rise in solvent orientation polarization. It is important to note that C5 is not harmful to MCF-7 cells, mouse kidney cells, or pig kidney cells. Furthermore, research on cell imaging has demonstrated that probe C5 may be utilized to image the fluorescence of hydrazine in active MCF-7 cells.
研究领域:
化学
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生物医学
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材料科学
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DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2024
·
IF 2
Pengjun Yao,Farao Zhang,Yang Yu
In this paper, the mole fraction solubility of 2-hydrazino-4-methylbenzothiazole (MHB) in acetone, toluene, methanol, ethanol, water, ethyl acetate, n-propanol, isopropanol, 1-butanol, and methanol/ethanol/n-propanol/acetone + water was determined by the isothermal saturation method at 273.15 to 318.15 K under 101.2 kPa. Meanwhile, high-performance liquid chromatography was used to detect the solubility of MHB. The mole fraction of MHB increased with the increase of temperature in monosolvents, and the composition of solvent mixtures also played a decisive role in the solubility of MHB in mixed systems. Then, four models for five monosolvents (Apelblat, van’t Hoff, λh, NRTL, and the Jouyban model) and three models for mixed solvents [Jouyban–Acree (J–A), van’t Hoff–Jouyban–Acree (V–J–A), and modified Apelblat–Jouyban–Acree (A–J–A) model] were utilized to correlate the mole fraction of MHB. The maximum deviations [relative average deviation (RAD) and root-mean-square deviation (RMSD)] between the experimental data and the solubility data calculated by the models for monosolvents were 7.13% and 6.11 × 10–4 (from the Jouyban model in pure ethyl acetate), respectively. The maximum RAD and RMSD for mixed systems were 1.58% (from the A–J–A model in methanol + water) and 1.35 × 10–4 (from the J–A and A–J–A models in acetone + water), respectively.
研究领域:
化学工程
·
药物化学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Ningning He,Hao Li,Chong Cheng,Hao Dong,Xirui Lu,Jun Wen,Xiaolin Wang
Uranium extraction from seawater has attracted attention owing to the growing demand for nuclear energy. However, it remains challenging because of the complexities of the marine environment, such as competing metal ions , high salinity , alkaline pH (8.3), and continuous biofouling. In this study, a new hyperbranched poly(amido amine)-modified adsorbent (PAO- h -PAMAM) was prepared by a simple hydrothermal method. The synergistic effect of hyperbranched poly(amido amine) and amidoxime groups not only endows the adsorbent with good adsorption performance and selectivity towards uranium ions but also adjusts the optimal adsorption pH of amino-functionalized adsorbents to suit the marine environment. Moreover, PAO- h -PAMAM exhibits an excellent antibacterial activity (96.5%) against marine bacteria and retains its adsorption performance well in multiple adsorption-desorption cycles. In view of its good adsorption performance, excellent antibacterial activity, and marine applicability, the PAO- h -PAMAM adsorbent is a promising candidate for uranium extraction from seawater.
研究领域:
材料科学
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环境科学
·
核能工程
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DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Yao Xu,Xin Tang,Yun Xing,Ziyu Pu,Chengshuang Ling,Qing Yang,Xiaoli Xiong
Hydrazine (N 2 H 4 ) is considered to be a highly toxic substance harmful to human body and environment, and has received much attention in the field of electrochemical detection in recent years. In this study, 3D hierarchical flowerball-like CoSe 2 /MnSe nanosheet arrays (CoSe 2 /MnSe FNSAs) were obtained using CoMn-LDH as precursor and cobalt glycerate spheres as the sacrificial template by simple hydrothermal reaction and selenization method. Bimetal selenides have more active electrochemical activity and more abundant electrochemical redox reactions. The unique hierarchical flowerball-like nanosheet array heterostructure can accelerate ionic diffusion kinetics and improve electron transfer. As a hydrazine electrochemical sensor, CoSe 2 /MnSe FNSAs exhibits excellent electrocatalytic performance with a wide detection range of 0.001–7.45 mM and a low detection limit of 0.4 μM. This strategy provides a new choice for the detection of environmental organic pollutants.
研究领域:
材料科学
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环境科学
·
分析化学
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产品关联
DOI
高影响因子
Analytical Methods
·
2014
·Vol. 7
·期 2
·793-798
·
IF 1.938
Xiaojing Si,Lin Jiang,Xinyue Wang,Yaping Ding,Liqiang Luo
The electrodeposited graphene (EGR) and cysteic acid (CA) composite (CA/EGR) was fabricated through an electrochemical method for the modification of glassy carbon electrode (GCE). Fourier transform infrared spectroscopy (FT-IR) was carried out to characterize the proposed CA film. The electrochemical performance of the CA/EGR modified GCE (CA/EGR/GCE) was demonstrated with cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The modified GCE was designed to act as an electrochemical sensor for isoniazid. The obtained detection linearity at the CA/EGR/GCE ranged from 0.1 to 200 μM with the detection limit of 0.03 μM (S/N = 3). Moreover, the sensor was employed for practical sample analysis with satisfactory recoveries, further validating the reliable practicability for electroanalysis. In addition, CA/EGR/GCE also displayed good reproducibility, high stability and excellent anti-interference ability for the determination of isoniazid.
研究领域:
药物分析
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry A
·
2024
·
IF 10.7
Ying Luo,Da Lei,Maohua Li,Yuansheng Ge,Jiguang Li,Baiyi Zu,Jun Yao,Xincun Dou
Metal organic frameworks (MOFs) have made great progress in the field of fluorescent sensing; however, whether the electronic structure and recognized sites can be adjusted by external functionalization still remains challenging. Here, by postmodifying 5-carboxyfluorescein (Flu), externally coupled orbitals were introduced into the electronic structure of UiO-66-OH, and thus an effective photo-induced energy transfer (PET) process was established in functionalized MOFs (UiO-66-Flu), resulting in the reduction of the intrinsic blue fluorescence. Due to the formation of the ester bond by effective incorporation of the surface –OH with Flu, the hydrazinolysis reaction triggered by hydrazine could happen and the Zr6O6 clusters could further reduce the reaction energy barrier through strong hydrogen bonding with hydrazine, resulting in a remarkably low limit of detection (LOD, 27.17 nM) and a fast response (4 s). Furthermore, with polyvinylidene fluoride (PVDF) as the dispersion medium, UiO-66-Flu was fabricated into a UiO-66-Flu/PVDF film sensor, enabling the rapid detection of gaseous hydrazine within 2 s in simulated practical scenarios. We expect that the present fluorescent ligand modifying concept will not only deepen the understanding of electronic structure engineering in functionalized MOF design, but also shine light on the exploration of high-performance MOF-based sensing strategies.
研究领域:
材料科学
·
化学工程
·
分析化学
·
传感器与执行器
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Huimin Shangguan,Peixin Niu,Zixuan Teng,Xingjiang Liu,Ailing Sun,Liuhe Wei
Hydrazine (N 2 H 4 ) is widely used in agrochemicals and pharmaceuticals, but unintentional releases of hydrazine can be transmitted through food, organisms and the environment, ultimately posing a serious hazard to human health. Consequently, the development of a rapid and sensitive analytical tool for the detection of N 2 H 4 is necessary. In this study, we present the synthesis and application of a novel molecular probe ( Probe PM ). The probe is characterised by its simple synthesis, high yield and a range of analytical properties including very high sensitivity (limit of detection as low as 17.1 nM) and a pronounced fluorescence spectral blue shift of 146 nm. These attributes have enabled the successful implementation of Probe PM in the qualitative and quantitative detection and visualization of hydrazine in diverse environmental and biological matrices, including water samples, soil samples, food products, and biological systems. The probe has great potential for detecting environmental and food safety.
研究领域:
分析化学
·
环境科学
·
食品安全
·
生物医学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）