Science Advances
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2025
·Vol. 11
·期 6
·
IF 12.5
Feng Wu,Sisi Lin,Huilong Luo,Chuhan Wang,Jinyao Liu,Xinyuan Zhu,Yan Pang
Transplantation of beneficial bacteria to specific microbiota has been widely exploited to treat diseases by reshaping a healthy microbial structure. However, direct exposure of exogenous bacteria in vivo suffers from low bioavailability and infection risk. Here, we describe a noncontact microbiota transplantation system (NMTS) by core-shell microgel-enabled nonleakage envelopment. Bacteria are encapsulated into the core of core-shell microgels via two-step light-initiated emulsion polymerization of gelatin methacrylate. NMTS is versatile for biocontainment of diverse strains, showing near complete encapsulation and negligible influence on bacterial activity. As a proof-of-concept study on probiotic transplantation to the gut microbiota, NMTS demonstrates the shielding effect to protect sealed bacteria from intraluminal insults of low pH and bile acid, the toughness to prevent bacterial leakage during entire gastrointestinal passage and reduce infection risk, and the permeability to release beneficial metabolites and reconstruct a balanced intestinal microbial structure, proposing a contactless fashion for advanced microbiota transplantation.
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International Journal of Nanomedicine
·
2025
·
IF 6.5
Xinwen Li,Lin Cao,Jianmin Li,Zhengyang Li,Hongyu Ma,Shifeng Cheng,Hongyi Xu,Yang Zhao
Background Inflammatory bowel disease (IBD) is a chronic inflammatory bowel disease with no clinical cure. Excessive production of reactive oxygen species (ROS) at the inflammatory sites leads to the onset and progression of IBD. And the current non-invasive imaging methods are not ideal for the diagnosis and monitoring of IBD.Methods Herein, we developed inulin (IN)-coated cerium oxide nanoparticles (CeO2@IN NPs) for treatment and monitoring of IBD guided by computed tomography (CT). The physicochemical properties, ROS scavenging ability and CT imaging capabilities of CeO2@IN were investigated in vitro. Moreover, the therapeutic and targeted inflammation imaging effects of CeO2@IN were validated in dextran sulfate sodium (DSS)-induced colitis model.Results CeO2@IN with catalase (CAT) and superoxide dismutase (SOD) capabilities effectively scavenged ROS, thus protecting the cells against oxidative stress. In colitis model mice, orally administered CeO2@IN successfully traversed the gastrointestinal tract to reach the colon under the protection of IN, and effectively reduced intestinal inflammation, thereby maintaining the intestinal epithelial integrity. Notably, CeO2@IN performed better than conventional CT contrast agents for gastrointestinal tract imaging, particularly in detecting the inflamed areas in the colon. In addition, CeO2@IN exhibited excellent biocompatibility in vitro and in vivo.Conclusion The study provided a novel integrated diagnostic and therapeutic tool for the treatment and monitoring of IBD, presenting great potential as a clinical application for IBD.
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Research
·
2024
·
IF 8.5
Lei Li,Shouhua He,Boyi Liao,Manchun Wang,Huimin Lin,Ben Hu,Xinyue Lan,Zhilin Shu,Chao Zhang,Meng Yu,Zhaowei Zou
The intestinal and intratumoral microbiota are closely associated with tumor progression and response to antitumor treatments. The antibacterial or tumor microenvironment (TME)-modulating approaches have been shown to markedly improve antitumor efficacy, strategies focused on normalizing the microbial environment are rarely reported. Here, we reported the development of an orally administered inulin-based hydrogel with colon-targeting and retention effects, containing hollow MnO2 nanocarrier loaded with the chemotherapeutic drug Oxa (Oxa@HMI). On the one hand, beneficial bacteria in the colon specifically metabolized Oxa@HMI, resulting in the degradation of inulin and the generation of short-chain fatty acids (SCFAs). These SCFAs play a crucial role in modulating microbiota and stimulating immune responses. On the other hand, the hydrogel matrix underwent colon microbiota-specific degradation, enabling the targeted release of Oxa and production of reactive oxygen species in the acidic TME. In this study, we have established, for the first time, a microbiota-targeted drug delivery system Oxa@HMI that exhibited high efficiency in colorectal cancer targeting and colon retention. Oxa@HMI promoted chemotherapy efficiency and activated antitumor immune responses by intervening in the microbial environment within the tumor tissue, providing a crucial clinical approach for the treatment of colorectal cancer that susceptible to microbial invasion.
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INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
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2018
·
IF 2.317
Dan-Ting Yin,Yu Fu,Xin-Huai Zhao
Inulin was fermented by adult faecal microbiota and 10 exogenous strains for 24 or 48 h. The contents of acetate, propionate, butyrate and lactate were quantified in the fermented products, and the growth-inhibitory and apoptosis-inducing effects on a human colon cell line (HCT-116 cells) were assessed. Most of these strains increased contents of acetate, propionate and butyrate, and promoted lactate conversion. Correlation analysis suggested that butyrate and lactate in the fermentation products were positively and negatively correlated with the measured inhibition ratios (p < .05). The results were mostly consistent with the verification trial results using standard acid solutions. The fermentation products could cause apoptosis via inducing DNA fragmentation and increasing total apoptotic populations in the treated cells. Moreover, the fermentation products with higher growth-inhibitory activities demonstrated the increased apoptosis-inducing properties. In conclusion, these strains could cooperate with adult faecal microbiota to confer inulin fermentation products with higher anti-colon cancer activity.
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FUEL
·
2018
·
IF 4.908
Tao Chen,Lincai Peng,Xin Yu,Liang He
A series of carbonaceous solid acid catalysts were prepared by facile carbonization and sulfonation of biorenewable feedstocks (i.e., glucose, sucrose, starch and cellulose), and employed for directly converting carbohydrates in ethanol medium to synthesize 5-ethoxymethylfurfural (EMF). The carbonization temperature of cellulose and starch (500 °C) was required to be higher than that of glucose and sucrose (400 °C) to realize high –SO 3 H density and EMF yield. Based on rich exploitability of cellulose and good activity of its derived carbonaceous catalyst, magnetic cellulose-derived carbonaceous solid acid (MCC-SO 3 H) was subsequently synthesized, which possessed a porous structure with BET surface area of 35.34 m 2 g –1 , high –SO 3 H density (1.28 mmol g –1 ) and sufficient magnetism for separation (1.99 emu g –1 ). By optimizing the process variables, a maximum EMF yield of 63.2% could be achieved from fructose at 120 °C, and ethyl levulinate formation was favored at elevated temperature. The MCC-SO 3 H catalyst could be readily separated from the reaction mixture by an external magnet with recovery rate of 92.6% after six successive runs, and reused repeatedly with little deactivation. Besides, this catalyst was efficient for the one-pot transformation of fructose-based polysaccharides into EMF, affording yields of 51.3% and 32.5% from inulin and sucrose, respectively. With glucose as the substrate, instead ethyl glucoside with a high yield of 86.5% was obtained.
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Food Bioscience
·
2024
·
IF 4.8
Zhi-Yuan Nie,Xue-Ying Li,Ying-Ying Chen,Yuan-Yuan Deng,Dan-Dan Kuang,Yu-Lin Sun,Huan-Huan Xiao,Qiang-Ming Li,Jian-Ping Luo,Xue-Qiang Zha
In this study, a novel self-assembled micelle (Myr-OSADS-CIn) based on OSA-debranched lotus root starch (OSADS) and cationic inulin (CIn) was successfully constructed to enhance the stability and bioavailability of myricetin (Myr). Firstly, lotus root starch and inulin were chemically modified. The results of Fourier transform infrared spectroscopy, X-ray diffraction, Nuclear magnetic resonance spectroscopy and Element analysis confirmed the successful synthesis of OSADS and CIn. When the optimal weight ratio of Myr/OSADS/CIn was 1:40:120, a stable Myr-OSADS-CIn composite micelle was successfully formed. The key characteristics of the micelle included a polydispersity index (PDI) of 0.321, a zeta-potential of +24.247 mV, and an encapsulation efficiency of 87.536%. Transmission electron microscopy analysis revealed unique core-shell structures within the Myr-OSADS-CIn micelle. The formation and stability of the composite micelle were primarily influenced by hydrogen bonds and electrostatic interactions. Notably, the Myr-OSADS-CIn micelle exhibited excellent biocompatibility, significant antioxidant activity and controlled release of Myr. Furthermore, in vivo bioavailability of Myr in the Myr-OSADS-CIn micelle was found to be 4.054 times higher compared to free Myr. In conclusion, the Myr-OSADS-CIn micelle shows promise as a delivery system for the effective use of Myr in the food industry.
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Frontiers in Pharmacology
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2025
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IF 4.8
Sha Li,Si-Ming Yan,Li-Wei Zhang,Xiao-Yan Yang,Zhong Guo
Introduction: Polydopamine nanoparticles (PDA NPs) exhibit numerous outstanding characteristics, including simple preparation, broad light absorption, drug binding ability, excellent biocompatibility and adhesive properties, making them suitable for biomedical application. However, the limited information on their hemocompatibility may hinder their progression from laboratory research to clinical application.Methods: In this study, we investigated comprehensively the hemocompatibility of PDA NPs, assessed the effects of PDA NPs on red blood cells (RBCs) morphology and lysis, fibrinogen structure and conformation, blood coagulation, platelet activation, complement system activation, and organ toxicity.Results: The results indicated that PDA NPs can induce morphological changes and hemolysis in RBCs in a concentration-dependent manner. Interactions with fibrinogen suggested a disturbance in the protein’s microenvironment without significantly altering its secondary structure. This study also revealed that PDA NPs have a concentration-dependent effect on blood coagulation, platelet activation, and complement system activation. Additionally, PDA NPs showed no significant acute toxicity after intravenous injection.Conclusion: The findings offer important insights into the hemocompatibility of PDA NPs, which is essential for their safe and effective clinical use. Understanding their interactions with blood components is key to ensuring their compatibility in biomedical applications. These results are vital for guiding the development of PDA NPs for medical use, particularly in blood-contacting applications.
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GREEN CHEMISTRY
·
2012
·Vol. 14
·期 9
·2506-2512
·
IF 6.32
Jianjian Wang,Jiawen Ren,Xiaohui Liu,Jinxu Xi,Qineng Xia,Yanhong Zu,Guanzhong Lu,Yanqin Wang
5-Hydroxymethylfurfural (HMF) is a very important intermediate in the fine chemical industry. This study aims to investigate the direct conversion of glucose or glucose-based carbohydrates, such as sucrose, cellobiose, inulin, starch and cellulose, to HMF by using a Sn-Mont catalyst. With the use of this catalyst, a HMF yield of 53.5% was achieved from glucose in a mono-phase medium of tetrahydrofuran (THF)/dimethylsulfoxide (DMSO) at 160 °C for 3 h. The success of one-step conversion of glucose to HMF is attributed to the Sn-Mont catalyst containing two types of acid sites, Lewis acid and Brønsted acid sites. The former one plays a crucial role in the isomerization of glucose to fructose and the latter one is active in the dehydration of generated fructose to HMF. Furthermore, Sn-Mont catalyst also demonstrated excellent activity in the conversion of disaccharides and polysaccharides and as high as 39.1% HMF was directly obtained from cellulose in a THF/H2O–NaCl bi-phasic system.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2017
·
IF 9.446
Hu Li,Wenfeng Zhao,Zhen Fang
Liquid furanic hydrocarbons, a class of biomass-based fuels and chemicals, are typically required to achieve moderate product selectivity and yield under harsh conditions (e.g., high temperature and H 2 pressure) involving multi-step processes over different catalysts. In this study, a single-step catalytic process was developed for direct conversion of various saccharides to furanic biofuels such as 2,5-dimethylfuran and 2-methylfuran with high yields (>95%) at 110–130 °C. The negatively charged hydride (H − ) of readily available polymethylhydrosiloxane (PMHS) acting as green H-donor over hydrophobic Pd nanoparticles did not obstruct upstream reactions (e.g., hydrolysis, isomerization and dehydration) for the in situ formation of furanic aldehydes/alcohols from sugars, and could selectively facilitate the subsequent hydrodeoxygenation of carbonyl and hydroxyl groups other than the furanic ring in one pot, as clarified by deuterium-labeling study. Importantly, the unreduced Pd(II) nanocatalysts also exhibited comparable performance in the selective hydrodeoxygenation reaction. Moreover, the catalytic strategy was extended to various carboxides for quantitative production of corresponding furanic/aromatic hydrocarbons at room temperature that were more pronounced than previously reported results, and the optimal Pd/MIL-53(Al) coated with polydimethylsiloxane (Pd/MIL-53(Al)-P) was highly stable with little deactivation and Pd leaching for at least five consecutive cycles.
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RSC Advances
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2017
·Vol. 7
·期 42
·26487-26493
·
IF 3.108
Ying Duan,Jun Zhang,Dongmi Li,Dongsheng Deng,Lu-Fang Ma,Yanliang Yang
Tetrahydro-2,5-furandimethanol (THFDM) was obtained directly from a wide variety of carbohydrates by the combination of niobic acid and a hydrophobic ruthenium catalyst. Fructose, glucose, and polysaccharides consisting of fructose or glucose could be converted to THFDM in one-step. The selectivity to THFDM was kept around 60% while the glucose conversion varied from 9% to 49%. The as-synthesized niobic acid was characterized by TEM, N2 adsorption/desorption, XRD, NH3-TPD and FT-IR spectra of adsorpted pyridine. The niobic acid was proved to have medium and strong acid sites with a high Brönsted/Lewis ratio, which played a great role for keeping high THFDM selectivity using glucose as a substrate.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Xiangbiao Li,Hu Li,Qingmei Ge,Wenfeng Zhao,Hang Cong
The efficient transformation of cellulose from renewable biomass into the fuel additive methyl levulinate remains a significant challenge. Herein, the hydrothermal post-synthesis method was employed to synthesize a series of tin-based bimetallic Beta zeolites with multifunctional properties, Sn-M-Beta-SO 3 H (M = Al 3 + , In 3+ , Ti 4+ , and Zr 4+ ), for the direct conversion of cellulose to ML. The as-prepared Sn-M-Beta-SO 3 H catalysts were systematically analyzed via XRD, SEM, TEM, UV-Vis, XPS, FT-IR, NH 3 -TPD, and Py-IR techniques. The results revealed that the synergistic interaction between Sn and M influences the composition of acidic sites and the physical properties of these multifunctional zeolites. Notably, Sn-Al-Beta-SO 3 H, with an optimal balance of Lewis and Brønsted acidic sites, achieved an impressive ML yield of 69.7 % at 180 °C within 6 h—one of the highest reported values among heterogeneous catalysts to date. Furthermore, based on experimental findings, a potential reaction pathway for cellulose conversion over Sn-Al-Beta-SO 3 H was proposed, with fructose identified as a key intermediate.
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GREEN CHEMISTRY
·
2025
·
IF 9.2
Yanjuan Yang,Yuhuan Li,Liang Deng,Shangzhi Xie,Chuang Gao,Zixu Yang,Jing Xu
The production of 5-hydroxymethylfurfural (5-HMF) from saccharide conversion has fallen short of industrial expectations due to low reaction efficiency and high costs. Herein, we fabricated a series of LaPO4 catalysts with controlled crystal structures and tuned acidity via a facile hydrothermal method. The hexagonal LaPO4-120 catalyst exhibited a high glucose conversion of 99.9% and a remarkable 5-HMF yield of 90.1% at 150 °C for 60 min. Additionally, the hexagonal LaPO4-120 catalyst showed promising activities in converting various saccharides including fructose, glucose, cellobiose, sucrose, and inulin. A series of characterization studies and DFT calculations revealed that the hexagonal LaPO4-120 catalyst possessed low-coordination La sites and abundant zeolitic water stored in the open and oxygen-lined channels, which provided Lewis acid sites and a dynamically local Brønsted acid environment to respectively facilitate glucose isomerization and the subsequent dehydration. A plausible reaction mechanism involving a synergetic proton transfer via hydrogen bonding is proposed. This study offers insights for the design of low-cost and heterogeneous catalysts with finely tuned Lewis and Brønsted acid sites for 5-HMF production.
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