SENSORS
·
2026
·Vol. 26
·期 13
·4205
·
IF 4
Xiao Wu,An Wang,Xiao Cai,Fan-Li Zhang,Bing Pei
Urine pH is an important biomarker related to metabolic status and urinary system health, but reliable SERS quantification in real urine remains limited by matrix interference, heterogeneous hotspot distribution, and the narrow response range of single pH-responsive molecules. Here, we report a core–gap–shell Au@1,4-BDT@Au@4-MBA/MPY nanoprobe for ratiometric SERS detection of urine pH. 1,4-BDT was confined within the gap between the gold core and shell as an internal standard, while 4-MBA and 4-MPY were co-assembled on the outer gold shell to provide complementary protonation/deprotonation responses. The internal standard-corrected ratio I1004/I1400/I731reduced signal fluctuation and enabled segmented linear fitting over pH = 1.0–7.0 and pH = 7.0–10.0, with coefficients of determination of 0.98806 and 0.99989, respectively. The sensing platform also maintained stable ratiometric responses under different interference conditions. In real urine samples from five volunteers, SERS-predicted pH values agreed well with commercial pH meter measurements, with relative accuracies of 98.71–101.9% and RSD values below 2.1%. This confined internal standard and dual-molecule ratiometric strategy provides a feasible approach for urine pH sensing in complex biofluid matrices.
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高影响因子
DALTON TRANSACTIONS
·
2024
·Vol. 53
·期 42
·17200-17206
·
IF 3.5
Wang Zhao,Jiazheng Zhou,Linan Wang,Wenqi Jin,Yingying Kong,Yu Chu,Junjie Li
Pb-based chalcogenides display abundant structural diversity and distinguished properties. Based on a mixed anion and dimensional reduction combined strategy, a wide band gap Pb-based thiohalide, Pb6Ba3Si2S8I10, has been rationally designed and synthesized experimentally by the flux method. The compound crystallizes in the Rc space group with cell parameters a = 9.7925(2) Å, b = 9.7925(2) Å, and c = 70.628(3) Å and is composed of [SiS4] tetrahedra and unprecedented [PbI5S2] polyhedral units, resulting in a unique quasi-two-dimensional structure, which enriches the chemical and structural diversity of Pb-based thiohalides. The experimental band gap of Pb6Ba3Si2S8I10 was determined to be 2.80 eV. Based on statistical analyses and to the best of our knowledge, it is the largest experimental optical band gap among the known Pb-based thiohalides. The results demonstrate the feasibility of using highly electropositive Ba atoms to regulate the dimensions of the structural framework of thiohalides and give new insights into the structure and property modifications of thiohalides by the mixed anion and dimensional reduction combined strategy.
研究领域:
无机化学
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材料科学
·
固体化学
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功能材料
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半导体物理
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DOI
高影响因子
PHYSICAL REVIEW B
·
2026
·Vol. 113
·期 10
·104506
·
IF 3.9
Junkun Yi,Lihong Hu,Menghu Zhou,Binbin Ruan,Yadong Gu,Qingsong Liu,Shunli Ni,Lewei Chen,Jihai Yuan,Yunqing Shi,Haoyu He,Mingwei Ma,Fanming Qu,Guangtong Liu,Zhi-An Ren
Here, the authors report the crystal and electronic structures, and superconductivity of $h$-NbS single crystals with site-selective Nb vacancies. This compound has a noncentrosymmetric lattice structure and exhibits Nb vacancy dependent electronic structure. $h$-NbS is a two-gap $s+s$-wave superconductor with a moderate coupling strength. The broken inversion symmetry leads to a Pauli limit violation in this three-dimensional superconductor with very low anisotropy. These findings highlight the interplay between crystal symmetry, dimensionality, stoichiometry, and superconductivity in transition metal chalcogenide superconductors.
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高影响因子
INORGANIC CHEMISTRY
·
2019
·
IF 4.85
Jiannan Lin,Zheng Hu,Hui Li,Jianqiang Qu,Miao Zhang,Wenjie Liang,Shi Hu
Bismuth oxyhalide (Bi-O-X) is a group of layered semiconductors, which are promising candidates for photocatalysis due to their inherent internal electric field and adjustable band gap through composition and morphology control. Bismuth-rich Bi-O-X has improved stability and advantageous band structure compared to those of Bi-O-X and hence has attracted an increasing amount of research interest. In this work, ultrathin nanotubes of Bi5O7I with a 5 nm diameter and a 1 nm wall are obtained through a hydrothermal method while the phase and morphology of the products are regulated by the pH values and polyvinylpyrrolidone (PVP) concentration of the reaction system, of which the products can be tuned from BiOI nanosheets to Bi5O7I nanobelts and ultrathin Bi5O7I nanotubes. PVP and pH control is important to the formation of the nanotubes as formation occurs via a PVP-guided oriented attachment from primary nanoparticles of Bi5O7I. The poorly crystalline and porous structure of the resultant bismuth-rich ultrathin nanotubes not only exposes more surface atoms but also exhibits a highly reduced conduction band minimum. The resultant band gap of 2.39 eV (as compared to 3.20 eV for the nanobelts) arises from the undercoordinated bismuth centers brought about by the rich oxygen vacancies in the nanotubes. The largely reduced band gap effectively enhances visible-light absorption, while the short charge-diffusion length of the nanotubes further reduces the charge-carrier loss in recombination.
研究领域:
材料科学
·
纳米技术
·
光催化
·
半导体物理
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高影响因子
INORGANIC CHEMISTRY
·
2019
·
IF 4.85
Da Chen,Shiqiang Hao,Guojun Zhou,Chenkai Deng,Quanlin Liu,Shulan Ma,Christopher Wolverton,Jing Zhao,Zhiguo Xia
Low-dimensional organic–inorganic hybrid metal halides have emerged as broadband light emitters for phosphor-converted white light-emitting diodes (WLEDs). Herein, we report a new zero-dimensional (0-D) lead-free metal halide (PMA)3InBr6 [PMA+: (C6H5CH2NH3)+] that crystallizes in the monoclinic system with P21/c space group. The structure consists of slightly distorted [InBr6]3– octahedra surrounded by organic PMA+ cations. The direct band gap characteristic of (PMA)3InBr6 was demonstrated by density functional theory calculation, and its relatively wide band gap of 3.78 eV was experimentally determined. Upon 365 nm ultraviolet light excitation, (PMA)3InBr6 exhibited strong broadband orange luminescence with a full-width at half-maximum of ∼132 nm resulting from self-trapped exciton emission, and the photoluminescence quantum yield was determined to be ∼35%. A WLED fabricated by combining the orange-emitting (PMA)3InBr6, a green phosphor Ba2SiO4:Eu2+, and a blue phosphor BaMgAl10O17:Eu2+ exhibited a high color-rendering index of 87.0. Our findings indicate that the organic–inorganic hybrid (PMA)3InBr6 may have potential for luminescence-based applications.
研究领域:
材料科学
·
光学
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PubMed
高影响因子
NEUROCHEMICAL RESEARCH
·
2022
·Vol. 47
·期 12
·3761-3776
·
IF 4.414
He Junhui,Li Dongmei,Wei Jie,Wang Sheng,Chu Shifeng,Zhang Zhao,He Fei,Wei Dongmei,Li Yi,Xie Jiaxiu,Lai Kedao,Chen Naihong,Wei Guining
Depression has become an important disease threatening human health. In recent years, the efficacy of Traditional Chinese Medicine (TCM) in treating the disease has become increasingly prominent, so it is meaningful to find new antidepressant TCM. Mahonia fortune (Lindl.) Fedde is a primary drug in traditional formulas for the treatment of depression, and alkaloids are the main components of it. However, the detailed mechanism of Mahonia alkaloids (MA) on depression remains unclear. This study aimed to investigate the effect of MA on gap junction function in depression via the miR-205/Cx43 axis. The antidepressant effects of MA were observed by a rat model of reserpine-induced depression and a model of corticosterone (CORT)-induced astrocytes. The concentrations of neurotransmitters were measured by ELISA, the expression of Connexin 43 (Cx43) protein was measured by Immunohistochemistry and western-blot, brain derived neurotrophic factor (BDNF), cAMP-response element binding protein (CREB) proteins were measured by western-blot, the pathological changes of prefrontal cortex were observed by hematoxylin–eosin (H&E) staining. Luciferase reporter assay was performed to verify the binding of miR-205 and Cx43. The regulation effect of Cx43 on CREB was verified by interference experiment. Gap junction dysfunction was detected by fluorescent yellow staining. The results confirmed that MA remarkably decreased miR-205 expression and increased Cx43, BDNF, CREB expression in depression rat and CORT-induced astrocytes. In addition, after overexpression of miR-205 in vitro, the decreased expression of Cx43, BDNF and CREB could be reversed by MA. Moreover, after interfering with Cx43, the decreased expression of CREB and BDNF could be reversed by MA. Thus, MA may ameliorate depressive behavior through CREB/BDNF pathway regulated by miR-205/Cx43 axis. Graphical Abstract
研究领域:
药理学
·
神经科学
·
分子生物学
·
中药
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高影响因子
APPLIED SURFACE SCIENCE
·
2017
·
IF 3.387
Meiling Xie,Hekai Zhu,Minghao Fang,Zhaohui Huang,Yan’gai Liu,Xiaowen Wu
Ti 2 Nb 10 O 29 photocatalysts were successfully synthesized by three different methods. Ti 2 Nb 10 O 29 fabricated by the solvothermal method (ST-TNO) exhibited unique microspheres compared to the larger irregular particles observed for the samples annealed in air (Air-TNO) and Ar (Ar-TNO). X-ray Photoelectron Spectroscopy (XPS) results revealed that a partial reduction process from Ti 4+ into Ti 3+ occurs in Ar-TNO, because of the introduction of oxygen defects. Ar-TNO exhibited visible-light absorption with a band gap of 2.85 eV, while the absorption edges of Air-TNO and ST-TNO were approximately 400 nm. Under UV light irradiation (λ < 420 nm), Ar-TNO exhibited a photocatalytic activity 2.1 times greater than that of Air-TNO, corresponding to the highest activity. The results indicated that the preparation method is crucial for determining the band gap and photocatalytic activity of semiconductors. Moreover, the novel semiconductor photocatalyst can be further applied for constructing the heterojunction and designing the band structure.
研究领域:
材料科学
·
化学工程
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高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2021
·
IF 5.316
Rong Zhang,Jian-Feng Sun
Along with the development of versatile trichromatic phosphors, the phosphors bridging the cyan gap between blue and green light have been an ongoing focus in simulating the full-visible-spectrum luminescence to satisfy the daily illuminating demands. Herein, an intriguing cyan-emitting phosphor Rb 2 CaPO 4 F:Eu 2+ belonging to the perovskite-type structural prototype was first time synthesized via the solid-state reaction. Structural analysis indicated that the typical Rb 2 Ca 0.90 PO 4 F:0.10Eu 2+ phosphor crystallizes in the orthorhombic structure with the space group of Pnma (62), and its cell parameters are equal to a = 12.913(5) Å, b = 5.989(4) Å, c = 7.440(1) Å, and V = 575.44(8) Å 3 . The fluorine-centered [FRb 4 Ca 2 ] octahedra interconnect with each other by sharing faces to build the one-dimensional perovskite-structure corrugated chains, which further connect with the [PO 4 ] tetrahedra to establish the structural framework of Rb 2 CaPO 4 F host. The electronic structure of Rb 2 CaPO 4 F matrix was studied by the first-principle calculation on the basis of the density functional theory, revealing an appropriate direct band of 4.76 eV. Pumped with the near-ultraviolet light, Rb 2 CaPO 4 F:Eu 2+ phosphor displayed a bright cyan emission covering from 400 to 600 nm with a broad FWHM of 142 nm. According to the Dexter theory, the concentration quenching mechanism of Eu 2+ -activated Rb 2 CaPO 4 F phosphor was classified as the dipole-dipole interaction. The Rb 2 CaPO 4 F:Eu 2+ phosphor not only exhibits a good thermal stability (I 443 K /I 298 K = 70%), but possesses a satisfactory internal quantum efficiency of 68% which is superior to most of the previously reported cyan-emitting phosphors. Consequently, it turns out that our perovskite-type Rb 2 CaPO 4 F:Eu 2+ phosphor can be considered as a promising candidate to fill the cyan gap toward the full-visible-spectrum light. The present work also demonstrates a great possibility for exploring the novel phosphors inspired by the mineral-type structural prototypes.
研究领域:
材料科学
·
光学
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Muhua Chen,Shang Wei,Jiayi Wu,Jingrun Li,Bo Fu,Xinbao Zhu
Visible light driven antibiotic degradation with metal-organic frameworks (MOFs) has been regarded as a feasible and efficient approach. Herein, Bi-based MOF (CAU-17) was synthesized and used for tetracycline (TC) removal. To enhance the photocatalytic performance, sulfur (S) element was doped on CAU-17 through solvothermal process. Characterization results verified that S element was successfully doped on CAU-17 and distributed uniformly. The introduction of S element could boost the generation of oxygen vacancies and tune the band gap of CAU-17. By optimizing the S content, the band gap energy (E g ) of CAU-17–0.02 S sample (0.02 g thiourea was added during the synthesis) reduces from 3.57 to 3.37 eV compared to pristine CAU-17. In addition, the visible light response was enhanced and the charge transfer resistance was reduced. TC removal tests demonstrated that CAU-17–0.02 S exhibited a removal efficiency of 62.9%, and the degradation rate constant is 1.44 times than that of bare CAU-17. Reactive species trapping experiment indicated h + ,·OH and·O 2 - all promoted the degradation of TC, following the order of h + >·OH> ·O 2 - . Moreover, CAU-17–0 . 02 S presented a good reusability with slight performance loss after four cycles.
研究领域:
环境科学
·
材料科学
·
光催化
·
水处理
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高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2023
·
IF 10.8
Hezhen Xu,Shiyi Zuo,Danping Wang,Yu Zhang,Wenxiao Li,Lingxiao Li,Tian Liu,Yuanhao Yu,Qingzhi Lv,Zhonggui He,Jin Sun,Bingjun Sun
The clinical application of cabazitaxel (CTX) is restricted by severe dose-related toxicity, failing to considering therapeutic efficacy and safety together. Self-assembled prodrugs promote new drug delivery paradigms as they can self-deliver and self-formulate. However, the current studies mainly focused on the use of straight chains to construct self-assembled prodrugs, and the role of branched chains in prodrug nanoassemblies remains to be clarified. In this study, we systematically explored the structure–function relationship of prodrug nanoassemblies using four CTX prodrugs that contained branched chain aliphatic alcohols (BAs) with different alkyl lengths. Overall, CTX-SS-BA 20 NPs with the proper alkyl length exhibited significant improvements in both antitumor efficacy and biosafety. Furthermore, compared with straight chain (SC) modified prodrug nanoassemblies (CTX-SS-SC 20 NPs), CTX-SS-BA 20 NPs still hold great therapeutic promise due to its good biosafety. These findings illustrated the significance of BAs as modified chains in designing prodrug nanoassemblies for narrowing the efficacy-to-safety gap of cancer therapy.
研究领域:
药学
·
纳米技术
·
癌症研究
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PubMed
高影响因子
Bioactive Materials
·
2023
·
IF 18.9
Xianhao Dong,Yueyue Yang,Zheheng Bao,Adam C. Midgley,Feiyi Li,Shuxin Dai,Zhuangzhuang Yang,Jin Wang,Lihua Liu,Wenlei Li,Yayuan Zheng,Siyang Liu,Yang Liu,Weijian Yu,Jun Liu,Meng Fan,Meifeng Zhu,Zhongyang Shen,Gu Xiaosong,Deling Kong
Peripheral nerve injuries may result in severe long-gap interruptions that are challenging to repair. Autografting is the gold standard surgical approach for repairing long-gap nerve injuries but can result in prominent donor-site complications. Instead, imitating the native neural microarchitecture using synthetic conduits is expected to offer an alternative strategy for improving nerve regeneration. Here, we designed nerve conduits composed of high-resolution anisotropic microfiber grid-cordes with randomly organized nanofiber sheaths to interrogate the positive effects of these biomimetic structures on peripheral nerve regeneration. Anisotropic microfiber-grids demonstrated the capacity to directionally guide Schwann cells and neurites. Nanofiber sheaths conveyed adequate elasticity and permeability, whilst exhibiting a barrier function against the infiltration of fibroblasts. We then used the composite nerve conduits bridge 30-mm long sciatic nerve defects in canine models. At 12 months post-implant, the morphometric and histological recovery, gait recovery, electrophysiological function, and degree of muscle atrophy were assessed. The newly regenerated nerve tissue that formed within the composite nerve conduits showed restored neurological functions that were superior compared to sheaths-only scaffolds and Neurolac nerve conduit controls. Our findings demonstrate the feasibility of using synthetic biophysical cues to effectively bridge long-gap peripheral nerve injuries and indicates the promising clinical application prospects of biomimetic composite nerve conduits.
研究领域:
生物医学工程
·
神经科学
·
组织工程
·
再生医学
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PubMed
高影响因子
MATERIALS LETTERS
·
2023
·
IF 3
Caichao Wang,Yan Zhu,Kang Xu,Shuhong Sun,Mingrong Dong,Jinkun Liu,Yongmao Hu
Semiconductors Ag 8 SnS 6 (ATS) nanoparticles were synthesized by a simple one-pot method. Meanwhile, Se was added to the ATS process to form semiconductors Ag 8 SnS 6-x Se x (ATSSe) (x = 0.0, 0.2, 0.4, 0.6, 0.8) nanoparticles. The prepared ATS nanoparticles were mainly triangle in shape with grain sizes ranging from 15 ∼ 60 nm, and ATSSe nanoparticles were formed after the addition of Se during the synthesis process. Phase transformation of the synthesized nanoparticles rhombohedral crystalline ATS to cubic ATSe was observed for Se substitution ratios x in the range of 0.2 ∼ 0.8. The band gap of ATSSe nanoparticles was in the range of 1.16 ∼ 0.85 eV. This finding suggests that Se substitution is an effective method to regulate the band gap and structure of ATS.
研究领域:
材料科学
·
化学
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高影响因子
危险品化学品经营许可证（带存储）