FOOD HYDROCOLLOIDS
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2024
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IF 11
Qianzhu Lin,Xiaojing Li,David Julian McClements,Zhengyu Jin,Chao Qiu,Guanghua Li
Oral delivery systems for nutrients and nutraceuticals are required for personalized nutrition applications. In some applications, these delivery systems need to encapsulate both hydrophilic and hydrophobic bioactive agents. In this study, bigel beads (2 mm) were prepared using pea protein (PP) and sodium alginate (SA) to form the hydrogel phase, and glyceryl monostearate and soybean oil to form the oleogel phase. The hydrogel phase was crosslinked by using Ca 2+ ions to form electrostatic bridges between the alginate molecules. The bigel beads had an oil-in-water type structure consisting of an oleogel dispersed phase within a hydrogel continuous phase. These beads were used to encapsulate and control the release of model hydrophobic (curcumin) and hydrophilic (epigallocatechin gallate) nutraceuticals. The textural and microstructural characteristics of the bigel beads were evaluated by dynamic shear rheology, textural profile analysis, cryo-electron microscopy, and fluorescence confocal microscopy. As the concentration of SA increasing from 0.2 to 1.0%, the hardness of bigel beads increased from 306.75 g to 792.40 g. In vitro digestion experiments showed that most of the nutraceuticals were released in the small intestine, rather than the stomach. Nutraceutical release could be controlled by manipulating bead composition, with the extent of nutraceutical release decreasing with increasing alginate concentration. The bigel beads developed in this study could be used as easy-to-swallow carriers for the controlled release of hydrophilic and hydrophobic bioactive ingredients. These kinds of products may be especially useful for people with dysphagia.
研究领域:
食品科学
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营养学
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药剂学
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产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·Vol. 34
·期 34
·2400817
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IF 18.5
Zhuangjie Xu,He Xi,Xue Sun,Hongjie Liu,Jiaxin Liu,Yanshuang Ba,Dandan Chen,Guodong Zhang,Chunfu Zhang,Xiaohua Ma,Yue Hao
Metal halide perovskite (MHP) single crystals have shown great potential for high-performance X-ray detection due to their excellent carrier transport properties, tunable optical bandgap, and low-temperature fabrication process. However, 3D perovskite single crystals suffer from severe ion migration, limiting the stability and sensitivity of X-ray detectors. Herein, a lowing temperature crystallization (LTC) method for liquid-phase epitaxial growth of 2D (PEA) 2 PbBr 4 single-crystal (SC) film on 3D CsPbBr 3 substrate is demonstratedand a 2D/3D (PEA) 2 PbBr 4 /CsPbBr 3 SC heterojunction is successfully constructed. The epitaxial (PEA) 2 PbBr 4 layer shows a pronounced passivation effect on CsPbBr 3 SC with a low trap density of 2.27 × 10 10 cm −3 . As such, the prepared 2D/3D heterojunction X-ray detector achieves a record-low detectable dose rate of 3.05 nGy air s −1 and high sensitivity of 34496 µC Gy air −1 cm −2 in 120 keV hard X-ray detection, with a largely suppressed dark current drift of 2.49 × 10 −4 nA cm −1 s −1 V −1 . In addition, the heterojunction detector exhibits a self-driven sensitivity of 44 µC Gy air −1 cm −2 due to its built-in electric field. This work provides a simple strategy to controllable construct 2D/3D MHP SC heterojunction with excellent optoelectronic characteristic, which is conducive to promoting the development of MHP SC X-ray detectors and other optoelectronic devices.
研究领域:
材料科学
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光电子学
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辐射探测技术
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产品关联
DOI
高影响因子
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
·
2021
·
IF 3.575
Dequan Kong,Baoying Xie,Yuhang Li,Yaping Xu
Palmitoylethanolamide (PEA) offers a strong protection against BBB disruption and neurological deficits after cerebral ischaemic/reperfusion (I/R) injury. To date, these BBB protective effects of PEA are mainly attributed to PPARα-mediated actions. However, whether PEA protects against BBB disruption through direct regulation of cytoskeletal microfilaments remains unknown. Here, we identified PEA as a Rho-associated protein kinase (ROCK2) inhibitor (IC 50 = 38.4 ± 4.8 μM). In vitro data suggested that PEA reduced the activation of ROCK/MLC signaling and stress fiber formation within microvascular endothelial cells (ECs) after oxygen-glucose deprivation (OGD), and consequently attenuated early (0–4 h) EC barrier disruption. These actions of PEA could not be blocked by the PPARα antagonist GW6471. In summary, the present study described a previously unexplored role of PEA as a ROCK2 inhibitor, and propose a PPARα-independent mechanism for pharmacological effects of PEA.
研究领域:
神经科学
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药理学
·
细胞生物学
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DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2026
·
IF 10.4
Guocong Ma,Mingwu Qiao,Dan Hai,Yan Ma,Ge Bai,Peijun Zhao,Xianqing Huang,Xinyu Sun,Lianjun Song
FA-SA conjugate with excellent antioxidant activity was prepared. • FA-SA-PP NPs exhibited good antioxidant and DPP-IV inhibit activity. • SA-based HBs achieved the intestinal-targeted release of FA-SA-PP NPs. • NPs provide I-level defense system and HBs provide II-level defense system for PP. Pea peptides (PP) with hypoglycemic activity were prone to decrease activity due to their sensitivities to pH, temperature and enzymes. Herein, ferulic acid modified sodium alginate conjugate was prepared and employed as the carrier for fabricating FA-SA-PP NPs with the PP encapsulation efficiency (EE) of 99.69%, which formed the I-level fence for protecting PP. Further, SA-based hydrogel beads loaded with FA-SA-PP NPs (EE: 99.87%) were prepared for forming the II-level fence to protect PP. Results showed that FA-SA-PP NPs@SA HBs had good stability in SGF, and gradually swelled and released FA-SA-PP NPs in SIF. Besides, the digested products of FA-SA-PP NPs@SA HBs still showed good antioxidant and DPP-IV inhibitory activities. Overall, the “double fence” effect protection mechanism can achieve the combination of antioxidant and hypoglycemic functions, and realize the intestinal-targeted release of PP, which shows great application potential in reducing oxidative stress damage and nutrition intervention to diabetes. Download: Download high-res image (162KB) Download: Download full-size image
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DOI
PubMed
高影响因子
Journal of Energy Chemistry
·
2021
·
IF 9.676
Yuan Cai,Jialun Wen,Zhike Liu,Fang Qian,Chenyang Duan,Kun He,Wenjing Zhao,Sheng Zhan,Shaomin Yang,Jian Cui,Shengzhong (Frank) Liu
The replacement of small cations with bulkier organic cations containing long alkyl chains or benzene rings to form a thin two-dimensional (2D) perovskite passivation layer on three-dimensional (3D) perovskite (2D/3D) has become a promising strategy for improving both the efficiency and stability of perovskite solar cells (PSCs). The 2D layer defines the interfacial chemistry and physics at the 2D/3D bilayer and endows the 2D/3D structure with better chemical and thermal stability. Herein, 2D/3D (CF 3 -PEA) 2 FA 0.85 MA 0.15 Pb 2 I 7 /FA 0.85 MA 0.15 PbI 3 planar heterojunction perovskite was produced using a facile interfacial ion exchange process. The 2D (CF 3 -PEA) 2 FA 0.85 MA 0.15 Pb 2 I 7 capping layer can not only passivate the FA 0.85 MA 0.15 PbI 3 film but also act as super-hydrophobic layer to inhibit water diffusion and significantly enhance the stability. The 2D capping layer can also establish a unique graded band structure at the perovskite/Spiro-OMeTAD interface and lead to p-type doping for Spiro-OMeTAD layer which is beneficial for efficient charge transport. Optimized PSCs based on this 2D/3D heterojunction yield a champion power conversion efficiency (PCE) of 23.1% and improved stability. The device maintains 84% output for 2400 h aging under ambient environmental conditions without encapsulation, and maintains 81% for 200 h under illumination with encapsulation. This work will inspire the design of more fluorinated 2D perovskite interfaces for advanced photovoltaics and beyond.
研究领域:
材料科学
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光伏技术
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化学工程
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产品关联
DOI
高影响因子
Food Packaging and Shelf Life
·
2022
·
IF 8.749
Xiwen Jia,Xin Li,Jinhai Zhao,Baohua Kong,Hao Wang,Qian Liu,Hui Wang
In this study, pea protein isolated/pullulan electrospun nanofiber films (PPI/PUL NFs) were successfully cross-linked by heating through Maillard reaction . PPI/PUL NFs were characterized by scanning electron microscopy (SEM), fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and water contact angles (WCAs). The morphological analysis illustrated that the cross-linking degree of these NFs varied with the glucose content, and the maximum glucose content was 3.0% (w/v). The fiber structure was broken down when the glucose content exceeded 3.0% (w/v), which was attributed to partial swelling and fusion of nanofibers after cross-linked by glucose. FTIR results indicated that the Maillard reaction occurred between the PPI and glucose during the thermal crosslinking process. Cross-linking dramatically improved the thermal stability, WCAs, insolubility and barrier properties of PPI/PUL NFs, which were needed to be solved urgently in biobased food packaging material. The cross-linked PPI/PUL NFs with a 2.0% glucose showed the most hydrophobic surface (WCAs of 104.5° and water vapor transmission rate of 29.3%). The antimicrobial activity of allicin-loaded PPI/PUL NFs (PPI/PUL-AC NFs) was evaluated, and the maximum size of the inhibition zone of cross-linked PPI/PUL-AC NFs against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) was 16.5 mm and 12.8 mm, respectively. This study not only offered an effective pathway to protect the biological activity of allicin under heating conditions by electrospinning but also provided a reference on novel crosslinking approach of PPI/PUL NFs, which allowed PPI/PUL-AC NFs to be a highly promising platform for antimicrobial food packaging.
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产品关联
DOI
高影响因子
ACS Applied Polymer Materials
·
2022
·
IF 4.855
Shuaishuai Liu,Yanyan Wang,Chao Xiao,Miao Jiang,Xin Ding,Hui Zhang,Kang Zheng,Lin Chen,Xingyou Tian,Xian Zhang
Owing to superior comprehensive performance, polyimide film (PI) has been extensively used as flexible substrate to support and fix electronic components. However, the current PI film has inferior thermal conductivity, especially in the vertical direction, causing failure of electronic devices in overheating conditions. Herein, an electrically insulating pea-pod-like filler with high thermal conductivity in both horizontal and vertical directions was prepared by encapsulating interconnected carbon microsphere (CM) with graphene-like carbon nitride (g-C3N4). The resultant thermal conductivity of PI film in horizontal and vertical directions has been improved by 11 (1.98 W m–1 K–1) and 2.4 (0.43 W m–1 K–1) times at 30 wt % CM@g-C3N4 loading, respectively. Furthermore, benefiting from satisfactory light absorption of CM@g-C3N4, the PI/CM@g-C3N4 film displays rapid heating capability under illumination. Meanwhile, the PI/CM@g-C3N4 film keeps intrinsic electrical insulation, thermal and dimensional stabilities. This work provides an effective method to solve the bottleneck of the current PI film in inadequate thermal conductivity.
研究领域:
材料科学
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纳米技术
·
热工程
·
高分子科学
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产品关联
DOI
高影响因子
FOOD HYDROCOLLOIDS
·
2023
·
IF 10.7
Yulin Li,Xin Qi,Liyuan Rong,Jinwang Li,Mingyue Shen,Jianhua Xie
The improvement of heat-induced pea protein isolate (PPI) gel with weak gel properties has attracted research interest in recent years. In this study, gellan gum (GG) was used to regulate the rheology, gelling, and structural properties of PPI gel. The related properties of GG-PPI gels were significantly improved by the addition of GG, including gel strength, water holding capacity , and rheological properties. GG also slightly decreased the surface hydrophobicity of the PPI gel, but it was still higher than that of pure PPI without heat treatment. The zeta potential of GG-PPI composite gels increased from 27.2 to 30.0 with the addition of GG, and the turbidity increased from 0.42 to 0.52 accordingly. The crystal diffraction peaks of GG disappeared after forming the composite gels between GG and PPI, indicating that there might be interactions between GG and PPI. Scanning electron microscopy revealed that the presence of GG promoted the formation of a dense and homogeneous gel network structure. In conclusion, GG effectively improved the gel properties of PPI, which can provide some fundamental basis for the potential applications of PPI.
研究领域:
食品科学
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材料科学
·
生物物理学
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DOI
高影响因子
Current Research in Food Science
·
2023
·
IF 6.3
Jun Yan,Sheliang Zhao,Xingfeng Xu,Fuguo Liu
Pea protein has attracted widespread attention due to its high nutritional value, low allergenicity, non-GMO status, and broad availability. However, compared to animal proteins, pea protein has inferior functional properties, which limits its application in the food industry. This study used pea protein isolate (PPI) as the main raw material and investigated the effects of high-pressure homogenization (HPH), ultrasonic treatment (US), and the combination of the two in different orders on the structure and function of PPI. The results showed that HPH or US promoted the transformation of PPI insoluble suspension into a uniform protein dispersion, significantly reducing particle size, unfolding the spatial structure, exposing more hydrophobic amino acid residues. These structural changes resulted in a substantial increase in the solubility, foaming capacity and emulsifying activity of PPI. Moreover, the combined treatments further impacted the properties of PPI, largely depending on the order of the processing steps; the combination of HPH-US exhibited the best functional characteristics.
研究领域:
食品科学
·
蛋白质工程
·
生物技术
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Jiayu Zheng,Wenqing Zhao,Xinyue Liu,Wei Liang,Yue Zheng,Xiangzhen Ge,Huishan Shen,Wenhao Li
Electron beam irradiation (EBI) is an environmentally friendly physical modification technology. In this study, pea starch nanocrystals (SNC) were prepared by EBI-assisted pretreatment, and investigated the effects of EBI on the multiscale structure and physicochemical properties of SNC. EBI-assisted pretreatment didn't change the particle morphology, crystalline type and FT-IR spectra of SNC. However, EBI-SNC's relative crystallinity and short-range orderliness index (R 1047/1022 ) significantly increased with increasing irradiation dose (5 KGy-20 KGy). In addition, EBI-assisted pretreatment caused the long chains of SNC's amylopectin to break into short chains. Moreover, EBI-assisted treatment significantly reduced the mean size, molecular weight, apparent amylose content, swelling power and SDS + RS content of SNC, while increasing the solubility, zeta potential and RDS content. Furthermore, the flow properties of the EBI-SNC samples were increased. The results show that EBI effectively changed the structural and functional properties of SNC, and the excellent functional properties are expected to broaden the application range of SNC.
研究领域:
食品科学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Chanchan Sun,Xv Qin,Miaomiao Huang,Xiaoru Wang,Bin Liang,Xiulian Li
The impact of interfacial structure on lipid digestion of emulsions remains controversial, presenting a key limitation in developing technologies for precise regulation of nutritional characteristics through rational food structure design. This study employed pea protein isolate (PPI) microgel particle (PPM) and PPI-κ-carrageenan (κ-CG) composite microgel particle (PPCM) as a model system. The mixing ratio of these macromolecules was adjusted, which changed the interaction of protein and polysaccharide molecules, as well as the interfacial structure of PPCM. Subsequent analysis of structural changes and emulsion digestion in an in vitro simulated digestion model elucidated the regulatory mechanism of interfacial structure on lipid digestion of Pickering emulsions (PPM-E and PPCM-E). The results demonstrated that free sulfhydryl and hydrophobic groups embedded in PPI became exposed during the heat-shearing process of microgel preparation, facilitating disulfide bond formation. The κ-CG gel associated with PPI gel through non-covalent bonds, effectively shielding the exposed hydrophobic groups of PPI. Based on the thickness of the interface, the amount of adsorbed protein, and the protein concentration at the interface, and the surface dilatational modulus, it was found that the deformability of microgel particles at the interface varies. This variation leads to differences in the interfacial structure: PPM formed thick but sparsely distributed interfacial layers due to its limited interfacial deformability; PPCM1 and PPCM2 formed thinner and denser interfacial layers with exposed κ-CG gels on the surface owing to because of their greater deformability compared to PPM; PPCM3, PPCM4, and PPCM5 exhibited the thinnest and densest interfacial layers among the microgel particles, with the exposed κ-CG interconnected to form a polysaccharide network surrounding the oil droplets. Compared with PPM-E, the κ-CG outside the interfacial layer of PPCM1-E and PPCM2-E promoted the expansion of the interfacial microgel in the simulated intestinal fluid and enhanced the hydrolysis by trypsin and lipase, resulting in higher free fatty acid (FFA) release than PPM. In contrast, the κ-CG network outside the interfacial layer of PPCM3-E, PPCM4-E, and PPCM5-E impeded the trypsin and lipase activity, thereby inhibiting the lipid digestion and resulting in lower FFA release than PPM.
研究领域:
食品科学
·
胶体与界面化学
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营养生物化学
·
功能食品
·
生物高分子工程
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Minjie Liao,De Pang,Xin Yuan,Jiahao Li,Lingjun Ma,Fang Chen,Xiaosong Hu,Junfu Ji
Despite their potential as sustainable plant protein sources, the functionality of pea vicilin (7S) and legumin (11S) globulins is often limited by their compact structures. Covalent modification with chlorogenic acid (CGA) represents a promising strategy for functional enhancement. In this study, a comparative analysis was conducted to elucidate the covalent binding mechanisms of CGA with pea 7S and 11S, revealing their divergent impacts on fibrillation capacity. The results indicated that the 1′-H group of CGA served as the grafting site, covalently docking to LysB30 of 7S and CysA318 of 11S to form C N and C S bonds, respectively. The binding amount of CGA was concentration-dependent, reaching a maximum of 70.2 μM/g for the 11S-CGA covalent complex and 46.2 μM/g for the 7S-CGA covalent complex. Regarding fibrillation properties, covalent binding of CGA inhibited the fibrillation of both pea globulins by suppressing fiber elongation and reducing surface hydrophobicity, thereby decreasing the viscosity of the fiber networks. Moreover, covalently bound CGA endowed both protein fibers with enhanced antioxidant capacity in a concentration-dependent manner. Overall, these results demonstrate that covalent polyphenol modification can effectively regulate the fibrillation properties of pea 7S and 11S globulins, thereby expanding the functionality of pea protein derived products.
研究领域:
食品科学与技术
·
植物蛋白
·
蛋白质化学
·
功能食品
·
多酚-蛋白质相互作用
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）