RSC Advances
·
2016
·Vol. 6
·期 39
·32967-32978
·
IF 3.289
Jianqun Gan,XiaoXiao Guan,Jian Zheng,Huilong Guo,Kun Wu,Liyan Liang,Mangeng Lu
A series of novel thermoresponsive biodegradable hydrogels (TBHs) was prepared from N-isopropyl acrylamide (NIPAM) and two biodegradable crosslinkers, poly(ε-caprolactone) dimethacrylate (PCLDMA) and bisacryloylcystamine (BACy). The morphology, thermal behavior, swelling/deswelling kinetics, compression properties, in vitro drug delivery and biodegradation were investigated. The results indicated that the properties of the TBHs strongly depended on temperature and the feeding molar ratio of the PCLDMA to BACy components. Levofloxacin (LVF)-loaded hydrogels were prepared to explore their stimuli-responsive release process. The cumulative release profile of LVF-loaded TBHs exhibited a thermo-induced slow sustained drug release and a reduction-induced fast release. At a physiological pH, TBHs could be biodegraded slowly in glutathione (GSH) at 37 °C. Due to their homogeneous pore diameter, highly interconnected architecture, degradable chemistry and thermoresponsive properties, the TBHs developed herein are highly attractive with respect to tissue engineering scaffold applications.
研究领域:
材料科学
·
药剂学
·
生物医学工程
·
药物递送系统
✓ 已验证
DOI
高影响因子
BURNS
·
2024
·
IF 3.2
Ning Liu,Baoxia Xue,Wei Cheng,Yong Liu,Mei Niu,Yongzhen Yang,Shiping Yu,Li Zhang
Dressings play a crucial role in the management of burn wound. In this study, the cotton bandage was modified with the Poly (N-isopropylacrylamide) / graphite oxide/nano silver (PNIPAM/GO-Ag) hydrogel to obtain a novel dressing (PNIPAM/GO-Ag/COT). The healing effect of the PNIPAM/GO-Ag/COT dressing on deep second-degree burn wounds in rats and the changes of related inflammatory factors were explored and analyzed systematically. The deep second-degree burn model was established by the steam scald method in Sprague–Dawley (SD) rats. The granulation tissue, collagen deposition, the expressions of tumor necrosis factor-α (TNF-α), and basic fibroblast growth factor (bFGF) of the wound were evaluated by means of the HE staining, Masson staining, ELISA, and immunohistochemistry methods. The results showed that, compared with the blank group (rats without the dressing treatment), the PNIPAM/GO-Ag/COT dressing reduced the expression of TNF-α by approximately 18 % and promoted the bFGF expression in wound tissue. Compared to the control group (rats with the gauze treatment), the wound healing rate in the PNIPAM/GO-Ag/COT dressing group was 58 % on the 14th day, with an increase of 30 %. These results demonstrated that the PNIPAM/GO-Ag/COT dressing primarily promoted burn wound healing by reducing inflammatory reactions, promoting collagen deposition, and enhancing the expression of bFGF.
研究领域:
生物医学工程
·
伤口愈合
·
材料科学
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2022
·Vol. 139
·期 27
·e52444
·
IF 3.057
Yulin Jiang,Jing Wang,Juehan Wang,Yi Zhuang,Lin Qi,Ganjun Feng,Li Zhang
In this research, we successfully prepared a new kind of core-shell microspheres (PNIPAM@GO) composed of hydrophilic poly (N-isopropyl acrylamide) (PNIPAM) nanoparticles as the core and amphiphilic graphene oxide (GO) nanosheets as the shell through hydrogen bonding and self-assembly in organic solvent. The temperature-sensitive behavior of the PNIPAM core made its average size decrease from 888.3 nm to 630.3 nm with temperature increasing from 25°C to 50°C. And the GO shell could give PNIPAM@GO microspheres remarkable photothermal effects in water under NIR laser irradiation (808 nm) for 20 min. Further, doxorubicin (DOX) and 5-fluorouracil (5-FU) were loaded into the core and the shell with loading efficiency of 81% and 11%, respectively. By turning on/off NIR irradiation, the PNIPAM@GO microspheres could respond to the heat generated from GO shell by volume shrinkage, thus on-demand controlling the drug release. The in vitro biological assessment verified that the samples prepared here were biocompatible. The developed platform shows a potential application in chemo-photothermal therapy of cancers in the future.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
·
药学
·
癌症治疗
✓ 已验证
产品关联
DOI
高影响因子
Polymer Chemistry
·
2018
·Vol. 9
·期 29
·4063-4072
·
IF 4.927
Yan Chen,Yuting Gao,Lucília P. da Silva,Rogério P. Pirraco,Mengdi Ma,Liming Yang,Rui L. Reis,Jie Chen
The aim of this research was to develop thermo- and pH-responsive hydrogels based on H-bonds for the sustained release of the small-molecule model drug Methylene Blue (MB). The thermo- or pH-sensitive triblock copolymer based on PNIPAM or PAA was synthesized by sequential RAFT polymerization and hydrolysis. By tuning the temperature or pH, the copolymer was able to form diverse nanostructures, including core–shell micelles, electronegative or uncharged core–shell structures and 3D networks with the hydrophobic forces of PNIPAM or H-bonds between PAA and PNIPAM. Furthermore, the reversible sol–gel transition of the copolymers was modulated by temperature (∼37 °C), pH (∼5) and concentration (∼7 wt%). The drug release potential was evaluated via in vitro injection of copolymer hydrogels into a simulated human body device. The copolymer hydrogels exhibited a sustained drug release behavior and a low instantaneous drug concentration. The MTT studies revealed that there is no noticeable cytotoxicity of NDB or NDA hydrogels against cells. Thus, the tunable drug release efficiency suggests the possibility of PNIPAM- and PAA-based environment responsive hydrogels being applied as drug carrier systems.
研究领域:
材料科学
·
生物医学工程
·
药剂学
✓ 已验证
DOI
高影响因子
OPTICAL MATERIALS
·
2019
·
IF 2.687
Qiang He,Yongjuan Wang,Yuming Zhou,Man He,Ran Xu,Saichun Hu,Wenting Wu,Ruili Wang
Passively responsive thermochromic smart window, which can modulate indoor incident solar light automatically at relatively high outdoor temperature, is a practical energy-saving device for construction and automotive industries. In this paper, a thermochromic composite hydrogel film based on W-doped vanadium dioxide (W-VO 2 ), poly N-isopropyl acrylamide (PNIPAM) and polyacrylamide (PAM) is presented and this hydrogel film was prepared between two quartz substrates to form the sandwich structured smart window. In this thermochromic system, 2 wt% monoclinic W-VO 2 were dispersed in the hydrogel film with the thickness of 0.1 mm. The introduction of PAM changes the flow-state PNIPAM microgel to hydrogel, which dramatically improved the practicality of the PNIPAM-based smart window. When the outdoor temperature is higher than 40 °C, the solar modulation capacity of this passive smart window, with a high luminous transmittance of 72% at 25 °C, can reach 46.3%. The smart window possesses high solar modulation ability and more than 20% luminous transmittance even after 40 times high temperature durability tests.
研究领域:
材料科学
·
能源效率
·
智能材料
·
光学工程
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2014
·
IF 3.242
Houluo Cong,Jingang Li,Lei Li,Sixun Zheng
In this contribution, we reported the synthesis of poly(N-isopropylacrylamide)- block -poly(N-vinylpyrrolidone)- block -poly(N-isopropylacrylamide) (PNIPAM- b -PVP- b -PNIPAM) triblock copolymers through sequential reversible addition–fragmentation chain transfer/macromolecular design via the interchange of xanthate (RAFT/MADIX) process. The triblock copolymers have been characterized by means of 1 H nuclear magnetic resonance (NMR) spectroscopy, gel permeation chromatography (GPC) and differential scanning calorimetry (DSC). This ABA triblock copolymer displayed a typical thermoresponsive gelation behavior. In this work, the thermoresponsive gelation behavior was investigated by means of rheological measurements, micro-differential scanning calorimetry (Micro-DSC) and small angle X-ray scattering (SAXS). The thermoresponsive gelation behavior could endow the triblock copolymers with the potential application as injectable hydrogels.
研究领域:
高分子化学
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
INTEGRATED FERROELECTRICS
·
2017
·
IF 0.457
Qian-Qian Song,Zhong-Min Geng,Bing Yu,Hai-Lin Cong,Jian-Qiang Yu
We report a new strategy for the preparation of Inverse colloidal crystal (ICC) membranes by using SiO2 particle. The thermo-reponsive N-isopropylacrylamide (NIPAM) was polymerized to fabricated the smart ICC column. In this contribution, newly developed inverse colloidal crystal membranes that have uniform pores, high porosity. The permeability of the smart micro/nano filtration membrane was carried out by the KCl diffusion tests.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Energy & Environmental Materials
·
2020
·Vol. 3
·期 2
·192-201
·
IF 0
Hao Li,Youzeng Li,Qun Xu,Ali Zhang
Functional hydrogel is becoming a frequently used material in various fields, especially in biological and medical applications. In order to overcome the barriers of low uniformity of structure and lack of energy dissipation effect in common hydrogel, in this work a strategy of doping plasmonic H x MoO 3 quantum dots into PNIPAM (poly (N-isopropylacrylamide)) hydrogel to proceed its multifunctionalization is developed. This quantum dots-induced tactic could effectuate the enhancement of photothermal conversion, mechanical property, adhesion, and self-healing performance simultaneously. In particular, for adhesion performance, the toughness value could be elevated to over 2500 J m −2 efficiently. Further, the enhancement mechanism behind the extraordinary adhesion performance is studied, and it can be contributed to the synergistic effect of pore structure regulation and abundant hydrogen bond, which are both beneficial to the interaction between composite hydrogel and solid surface. Subsequently, based on its extraordinary adhesion and self-healing performance, the applicability of H x MoO 3 /PNIPAM hydrogel as a MØ growth substrate is investigated on wound dressing, and the experimental result demonstrates its excellent MØ growth-promoting activity.
✓ 已验证
DOI
International Journal of Electrochemical Science
·
2023
·Vol. 13
·期 8
·7347-7355
·
IF 1.5
Libo Deng,Jiaxiang Chen,Zhipeng Zhang,Weijia Zeng
Flexible and wearable electronics capable of detecting the temperature, the motion and the stress in the body have been developing recently. Such devices rely heavily on the stimuli-responsive materials. Particularly, flexible materials which can give electrical response to the change of temperature are crucial for wearable healthcare electronics, and thus have received great research interests recently. Herein, a thermo-responsive copolymer was prepared by copolymerization between N-isopropylacrylamide (NIPAm) and N-methylol acrylamide (NMA). AgNO 3 was mixed with the P(NIPAm-co-NMA) solution to fabricate nanofibers by electrospinning, which was then converted into Ag by in-situ reduction with sodium borohydride. The electrical resistance of the composite nanofiber showed high sensitivity to the change of temperature. Furthermore, the composite nanofibers exhibited excellent stability during repeated heating-cooling cycles.
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry C
·
2025
·
IF 5.1
Shuming Liu,Kai Yao,Jiakui Xu,Zhenhui Hu,Xianglong Zeng,Longhao Xiao,Zheng Fang,Yuwei Hu,Xi Chen,Yongsheng Yang,Wenxin Li,Yujie Ke
Energy-efficient windows are considered as one of the most promising energy saving strategies for buildings. An ideal thermochromic smart window should possess high stability, high transmittance and outstanding mechanical properties. However, existing smart window technologies could not meet these requirements simultaneously. Herein, composite hydrogels containing hydroxyethyl methyl cellulose and thermoresponsive poly(N-isopropylacrylamide) were synthesized and applied to smart windows. These hydrogels exhibited excellent solar modulation (ΔTsol = 74.97%), luminous transmittance (Tlum = 84.98%), and mechanical properties with a reversible compression ratio of up to 74%. Besides, they offered faster response time and superior thermal stability compared to traditional hydrogels. It was demonstrated that the composite hydrogels retained exemplary optical properties after 80 heating–cooling cycles, and PNIPAM/HEMC smart windows showed superior indoor temperature control capability. Compared with normal glass, a typical office building with the produced sample was calculated to show annual energy reductions of 19.2, 28.2, 74.8, and 49.7 kW h m−2 in Beijing, Hong Kong, Bangkok, and Kuala Lumpur, respectively. This study demonstrated a reliable strategy for PNIPAM windows that is promising to save building energy.
研究领域:
材料科学
·
能源工程
✓ 已验证
产品关联
DOI
高影响因子
Petroleum Science
·
2023
·
IF 5.6
Shi-Hao Chen,Chuan-Lin Mou,Wen-Long Ma,Ya-Dong Li,Zi-Yu Tang,Hong-Bo Deng
Here, we report the construction of magnetic core-shell microparticles for oil removal with thermal driving regeneration property. Water-in-oil-in water (W/O/W) emulsions from microfluidics are used as templates to prepare core-shell microparticles with magnetic holed poly (ethoxylated trimethylolpropane triacrylate) (PETPTA) shells each containing a thermal-sensitive poly ( N -Isopropylacrylamide) (PNIPAM) core. The microparticles could adsorb oil from water due to the special structure and be collected with a magnetic field. Then, the oil-filled microparticles would be regenerated by thermal stimulus, in which the inner PNIPAM microgels work as thermal-sensitive pistons to force out the adsorbed oil. At the same time, the adsorbed oil would be recycled by distillation. Furthermore, the adsorption capacity of the microparticles for oil keeps very stable after 1st cycle. The adsorption and regeneration performances of the microparticles are greatly affected by the size of the holes on the outer PETPTA shells, which could be precisely controlled by regulating the interfacial forces in W/O/W emulsion templates. The optimized core-shell microparticles show excellent oil adsorption and thermal driving regeneration performances nearly without secondary pollution, and would be a reliable green adsorption material for kinds of oil.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
Soft Matter
·
2015
·Vol. 12
·期 3
·925-933
·
IF 4.029
Ge Wang,Peiyi Wu
The influence of two thermoresponsive polymers, poly(N-isopropylacrylamide) (PNIPAM) and poly(N-vinylcaprolactam) (PVCL), on the phase transition behavior of a thermoresponsive ionic liquid, tributylhexylphosphonium 3-sulfopropylmethacrylate ([P4,4,4,6][MC3S]), was investigated. An obvious distinction was observed in the LCSTs and morphologies of [P4,4,4,6][MC3S]–PNIPAM and [P4,4,4,6][MC3S]–PVCL aqueous solutions, indicating their large differences in dynamic transition processes. In general, PNIPAM can “break” the water structure of [P4,4,4,6][MC3S] to decrease the transition temperature, while PVCL can “make” the water structure to increase it. Surprisingly, [P4,4,4,6][MC3S] has an unusual over-hydration behavior before dehydration while PNIPAM experiences a two-step transition process in [P4,4,4,6][MC3S]–PNIPAM aqueous solution, which has never been reported so far. Further studies revealed that the formation of strong intra-/inter-molecular hydrogen bonds CO⋯D–N in PNIPAM is the driving force for the LCST phenomenon of [P4,4,4,6][MC3S]–PNIPAM solution, while it is the [P4,4,4,6][MC3S] that dominates the phase separation of [P4,4,4,6][MC3S]–PVCL solution.
研究领域:
化学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）