TALANTA
·
2017
·
IF 4.162
Yaoyao Zhou,Bo Ling,Hongqi Chen,Lun Wang
A novel fluorescence method for the determination of hydrogen peroxide (H 2 O 2 ) and uric acid (UA) was developed. The procedure was based on the hydroxyl radicals (·OH), which effectively quenched the fluorescence of the Mn 2+ -doped NaYF 4 :Yb,Er upconversion nanoparticles (UCNPs). Based on the property of Mn 2+ -doped NaYF 4 :Yb,Er upconversion nanoparticles, the Fenton reaction and enzymatic reaction of uric acid, this method could be used for highly sensitive detection of H 2 O 2 and uric acid. Under optimal conditions, we observed that the fluorescence quenching signal showed good linearity with the H 2 O 2 concentration in the range of 3.00 × 10 -8 M ~ 6.00×10 -5 M, and the detection limit of this assay was 1.30×10 -8 M. Meanwhile, the linear concentration range for UA was 4.00 × 10 -9 M ~ 1.00×10 -5 M, and the lower limit of detection was 1.90×10 -9 M. Furthermore, the developed method was successfully used for the determination of UA levels in human serum with satisfactory results.
研究领域:
分析化学
·
生物化学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Chinese Physics B
·
2018
·Vol. 27
·期 9
·097301
·
IF 1.321
Ang Li,Jin-Lei Wu,Xue-Song Xu,Yang Liu,Ya-Nan Bao,Bin Dong
The W18O49 nanoflowers with a diameter of 500 nm are prepared by a facile hydrothermal method. The Er–Yb: NaYF4 nanoparticles are adsorbed on the petals (the position of the strongest local electric field on W18O49 nanoflowers). With a 976 nm laser diode (LD) as an excitation source, the selectively green upconversion luminescence (UCL) is observed to be enhanced by two orders of magnitude in Er–Yb: NaYF4/W18O49 nanoflowers heterostructures. It suggests that the near infrared (NIR)-excited localized surface plasmon resonance (LSPR) of W18O49 is primarily responsible for the enhanced UCL, which could be partly reabsorbed by the W18O49, thus leading to the selective enhancement of green UCL for the Er–Yb: NaYF4. The fluorescence intensity ratio is investigated as a function of temperature based on the intense green UCL, which indicates that Er–Yb: NaYF4/W18O49 nanoflower heterostructures have good potential for developing into temperature sensors.
研究领域:
材料科学
·
光学
·
纳米技术
·
温度传感
✓ 已验证
产品关联
DOI
高影响因子
Theranostics
·
2013
·
IF 7.806
Yun Sun,Juanjuan Peng,Wei Feng,Fuyou Li
Lanthanide upconversion nanophosphor (UCNP) has attracted increasing attention for potential applications in bioimaging due to its excellence in deep and high contrast imaging. To date, most upconversion imaging applications were demonstrated in dark surroundings without ambient light for higher signal-to-noise ratio, which hindered the application of optical imaging guided surgery. Herein, the new established NaLuF 4 -based UCNP (NaLuF 4 :Yb,Tm, ~17 nm) with bright upconversion emission around 800 nm as imaging signal was used to realize imaging under ambient light to provide more convenient for clinician. Moreover, due to the existance of heavy element lutetium (Lu) in the host lattice, the NaLuF 4 :Yb,Tm nanoparticles can also be used as an X-ray CT imaging agent to enhance the imaging depth and in vivo imaging resolution.
研究领域:
生物医学工程
·
纳米医学
·
医学影像学
✓ 已验证
DOI
PubMed
高影响因子
Journal of Physical Chemistry C
·
2021
·
IF 4.126
Sen Yang,Shunfa Gong,Zhilong Zhou,Lifang Wu,Minmin Zhang,Lilin Jiang,Wenzhi Wu
The optical and thermometric properties of bismuth (Bi) and ytterbium (Yb) codoped double perovskite Cs2Ag0.6Na0.4InCl6 microcrystals (MCs) are investigated, which possess high photoluminescence quantum yield and stable broadband spectra from visible to near-infrared (NIR) region. Thermal quenching and dynamic properties are shown using temperature-dependent steady-state photoluminescence (PL) and time-resolved PL (TRPL) techniques, which reveal the transition mechanism from self-trapped excitons (STEs) to Yb dopants. Taking advantage of the diverse thermal quenching of distinct PL between STEs and Yb3+ emissions, an optical thermometer based on the fluorescence intensity ratio is designed in the visible and NIR region, which can provide a self-referenced temperature with high sensitivity. The maximum absolute and relative sensor sensitivities are 0.113 K–1 and 1.66% K–1, respectively. These characteristics all demonstrate that Bi/Yb codoped Cs2Ag0.6Na0.4InCl6 MCs can be excellent and novel luminescent materials for non-contact temperature measurement.
研究领域:
材料科学
·
光学
·
温度测量
·
光致发光
✓ 已验证
产品关联
DOI
高影响因子
Catalysts
·
2021
·Vol. 11
·期 2
·184
·
IF 4.146
Huang Zhou,Fengjiao He
β-NaYF4:Yb,Er,Gd fluorescent nanorods were successfully coupled to a reduced TiO2(UCNPs@R-TiO2) nanocomposite and applied to visible-light catalytic sterilization under 980 nm near-infrared (NIR) light illumination. The UCNPs (β-NaYF4:Yb,Er,Gd) absorb the NIR light and emit red and green light. The visible light can be absorbed by the R-TiO2(Eg = 2.8 eV) for the photocatalytic reaction. About 98.1% ofEscherichia coliwere effectively killed upon 12 min of NIR light irradiation at a minimum inhibitory concentration (MIC) of 40 μg/mL UCNPs@R-TiO2nanocomposite. The bactericidal properties were further evaluated by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) analysis. We found that the high bactericidal activity was due to the synergistic effect between the UCNPs and R-TiO2. Moreover, the UCNPs show excellent upconversion luminance properties, and the introduction of visible-light-absorbed R-TiO2nanoparticles (2.8 eV) was conducive to the efficient separation and utilization of photogenerated electron-hole pairs.
研究领域:
材料科学
·
微生物学
·
光化学
✓ 已验证
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2018
·
IF 4.439
Lele Qiu,Yulin Yang,Guohua Dong,Debin Xia,Mengru Li,Xiao Fan,Ruiqing Fan
As for the solution-processed MAPbI 3 film, the pinholes and gaps are an inevitable and undesirable phenomenon, which can usually lead to serious interface charge recombination due to the penetration of hole transport materials in perovskite solar cells (PSCs). Herein, a hydrophobic β-NaYF 4 :Yb,Er up-conversion ultrathin layer with particle size ca. 6 nm was first applied to modify the MAPbI 3 film for optimizing the surface of perovskite film. Thereby, the corresponding PSCs yield a significantly enhanced power conversion efficiency of 15.17% compared with that (13.32%) of the pristine PSCs. Furthermore, the PSCs also have a good stability in air atmosphere (relative humidity ≤45%) because of the introduction of this hydrophobic material. After a series of detailed investigations and comparison, it can be easily concluded that the filled pinholes and gaps in perovskite films via β-NaYF 4 :Yb,Er nanoparticles is the main reason for the performance enhancement of the β-NaYF 4 :Yb,Er based PSCs, which can result in an enhanced hole extraction efficiency and reduced interface charge recombination. As a conclusion, it is a feasible and effective approach for improving the photovoltaic performance of PSCs by filling up the pinholes and gaps in perovskite films with up-conversion ultrathin layers.
研究领域:
材料科学
·
能源科学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Materials Express
·
2023
·Vol. 13
·期 11
·1915-1921
·
IF 0.7
Chen Sihan,Hu Huiqi,Jiang Wenting,Zhang Yuyun,Luo Xiaohu,Peng Jiayi,Li Le,Zhen Deshuai,Wang Hanqing
A novel near-infrared induced upconversion sensor for the detection of uranyl ions was successfully constructed using β-NaYF4: Yb, Tm, Gd upconversion nanoparticles (UCNPs) and specific DNAzyme. Characterization of the UCNPs@DNAzyme was conducted using XRD, TEM, FT-IR and
fluorescence testing, and it was shown that the β-NaYF4: Yb, Tm, Gd nanoparticles were successfully prepared (∼27 nm). Upon 980 nm excitation, the UCNPs@DNAzyme emitted green light at λ=475 nm. Furthermore, Förster resonance energy transfer was observed between
the UCNPs@DNAzyme (doner) and uranyl (acceptor) present on the substrate chain. This resulted in fluorescence quenching, which was used to quantify the concentration of uranyl. The developed method was found to be highly selective and sensitive, with a detection limit as low as 43 nM. This
method also demonstrated excellent specificity and sensitivity for the determination of uranyl in water samples, indicating its potential application in near-infrared fluorescence detection and imaging of uranyl in vivo.
研究领域:
分析化学
·
材料科学
·
环境科学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2013
·
IF 5.437
Hongqi Chen,Fei Yuan,Shaozhen Wang,Juan Xu,YiYan Zhang,Lun Wang
In this work, we design a FRET system for sensitive and selective determination of thrombin in red region, in which NaYF 4 :Yb,Er upconversion nanoparticles (UCNPs) act as donor and gold nanorods (Au NRs) act as acceptor. NaYF 4 :Yb,Er UCNPs with a strong emission at 661 nm were successfully synthesized by tuning the doped ions ratio. Carboxyl-functionalized NaYF 4 :Yb,Er UCNPs and Au NRs were then prepared and conjugated with the thrombin aptamers, respectively. The fluorescence emission band of NaYF 4 :Yb,Er UCNPs ( λ max =661 nm) highly overlaps with the absorption band of Au NRs( λ max =666 nm), which benefits from the large tunability of the spectrum band of Au NRs. A FRET system was then formed when thrombin was added to the mixture of NaYF 4 :Yb,Er UCNPs and Au NRs, which were both modified thrombin aptamers. The fluorescence quenching efficiency of NaYF 4 :Yb,Er UCNPs was increased in a thrombin concentration-dependent manner, which built the principle of thrombin quantification. The linear range was 2.5–90 nM in an aqueous buffer, and 3.75–112.5 nM in spiked human serum samples for thrombin. It also demonstrates a high selectivity to other biological species due to the specific binding. The measurement of thrombin in human plasma is satisfying, suggesting that the FRET system is of practical value in a complex biological sample matrix in red region.
研究领域:
分析化学
·
生物传感
·
纳米技术
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2013
·Vol. 3
·期 33
·13915-13925
·
IF 2.562
Leyong Zeng,Lingchao Xiang,Wenzhi Ren,Jianjun Zheng,Tianhua Li,Bin Chen,Jichao Zhang,Chengwen Mao,Aiguo Li,Aiguo Wu
Due to non-invasive deep imaging and therapy, multifunctional agents of magnetic resonance (MR)/upconversion luminescence (UCL) imaging and photodynamic therapy (PDT) play an important role in clinical diagnosis and treatment of cancers, and also in the assessment of therapy effect. In this paper, tetra-sulfonic phthalocyanine aluminium (AlPcS4) photosensitizers-conjugated Fe3O4@NaYF4:Yb/Er (NPs-AlPcS4) nanocomplexes were synthesized for the T2-weighted MR/UCL imaging and PDT of cancer cells. The PEG-coated Fe3O4@NaYF4:Yb/Er nanoparticles (NPs) with a core–shell structure showed strong T2-weighted MR relaxivity (r2 = 42.131 mM−1 s−1) and UCL emission in the visible region (the bands at about 654–674 nm, 545 nm and 524 nm), and were conjugated successfully with AlPcS4 photosensitizer by electrostatic interaction. By direct observation of XFM and staining with Prussian blue, the element distribution and location of NPs in MCF-7 cells were characterized, respectively. Under irradiation from a 980 nm laser, the death ratio of MCF-7 cells incubated with NPs-AlPcS4 nanocomplexes could be up to about 70%. The results indicated that the as-prepared NPs-AlPcS4 nanocomplexes would be a potential candidate as multifunctional nanoprobes for the dual-modal T2-weighted MR/UCL imaging and PDT of cancers in the future.
研究领域:
生物医学工程
·
肿瘤学
·
材料科学
·
影像医学
✓ 已验证
DOI
高影响因子
MATERIALS RESEARCH BULLETIN
·
2024
·
IF 5.3
Shuang Li,Caixia Deng,Pran Gopal Karmaker,Kaijing Yang,JiaYu Wang,Wei Liu,Xiupei Yang
Bismuth oxybromide (BiOBr) is a common photocatalyst for degrading organic pollutants. Due to its low charge separation efficiency and narrow band gap, it is difficult to achieve good results in practical applications. By doping ytterbium ions (Yb 3+ ) into BiOBr , its absorption and utilization of visible light can be improved, thereby enhancing the photocatalytic performance. In this study, a simple one-step hydrothermal method was used to prepare Yb-doped BiOBr photocatalysts with enhanced oxygen vacancies (OVs). Yb 0.4 /BiOBr excites molecular oxygen and has a low band gap and a high charge separation efficiency. When tetracycline hydrochloride (TCH) is used for photocatalysis, the degradation efficiency can reach 89.38% within 100 min, and the reaction rate constant is 1.47 times that of BiOBr without Yb doping. Finally, the possible degradation pathways and intermediates of TCH were investigated by liquid chromatography–mass spectrometry (LC–MS). This study provides a new approach for improving the photocatalytic activity of BiOBr.
研究领域:
环境科学
·
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 60
·37929-37937
·
IF 3.108
Yang Luo,Sinan Du,Wei Zhang,Zhengfang Liao,Fang Zuo,Shengtao Yang
Core@shell structures of Fe3O4@Mn2+-doped NaYF4:Yb/Tm nanoparticles (NPs) with multifunctional properties were prepared using a hydrothermal route with a seed-growth procedure. The effect of Mn2+ ions on the phase, shape, and upconversion luminescence (UCL) of Fe3O4@Mn2+-doped NaYF4:Yb/Tm NPs was explored using X-ray diffraction, transmission electron microscopy, dynamic light scattering, and photoluminescence spectroscopy. Furthermore, hydrophobic to hydrophilic surface modification of the Fe3O4@Mn2+-doped NaYF4:Yb/Tm NPs was achieved by coating the NPs with an amphiphilic polymer (poly(maleic anhydride-alt-1-octadecene) (C18PMH)) modified with amine-functionalized methyl ether poly(ethylene glycol). Then, the NIR-to-NIR UCL ascribed to the Tm3+ ions, T1-weighted MRI ascribed to the Mn2+ ions, and T2-weighted MRI ascribed to the Fe3O4 core of the hydrophilic Fe3O4@Mn2+-doped NaYF4:Yb/Tm NPs were evaluated. The results indicate that Mn2+ doping is an effective method to control the size/shape and improve the UCL intensity of Fe3O4@Mn2+-doped NaYF4:Yb/Tm NPs, which are promising as imaging agents for NIR-to-NIR UCL and T1/T2-weighted MRI in biomedical research.
研究领域:
生物医学工程
·
材料科学
·
影像医学
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry B
·
2018
·Vol. 6
·期 21
·3586-3599
·
IF 4.776
Xiaoqin Chen,Jing Sun,Huan Zhao,Ke Yang,Yuda Zhu,Hongrong Luo,Kui Yu,Hongsong Fan,Xingdong Zhang
For synchronous theranostic systems, there are two areas of focus. These are: excellent in vivo imaging and a multi-drug resistance (MDR) reversing ability for chemotherapy. Upconversion nanoparticles (UCNPs) exhibiting bright red emission in the “optical window in biological tissue (600–1100 nm)” could be a very useful candidate, although there have only been a few reports on UCNP-based conjugates with a MDR reversal ability explored for chemotherapy. Herein, we report an innovative theranostic system (D-UNT) via binding of an antitumor drug (DOX) and a MDR reversal agent (TPGS) to NaY(Mn)F4:Yb/Er UCNPs (UN) with synthetic optimized red emission and properties. The in vitro study demonstrated that the D-UNT was uptaken into drug-resistant MCF-7/ADR cells via caveolin dependent endocytosis and overcame P-gp mediated efflux. The cytotoxicity was significantly promoted to be much higher than that of free DOX. Accordingly, our D-UNT illustrates an enhanced reversal ability for chemotherapy. Our in vivo study further indicated that the D-UNT had excellent therapeutic efficacy against MDR tumors with minimal organ toxicity detected. In vivo deep-tissue imaging showed that the D-UNT accurately diagnosed MDR tumors at a 1.5 cm depth with high-contrast luminescent signals. Thus, the D-UNT is an effective theranostic system for the diagnosis and therapeutic treatment of MDR tumors. The present work opens new pathways to engineering powerful theranostic agents to simultaneously target, image and kill deep-tissue MDR tumor cells.
研究领域:
纳米技术
·
癌症研究
·
药学科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）