SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2021
·
IF 4.098
Yuanyuan Meng,Chunming Yuan,Chunhui Du,Ke Jia,Chunfang Liu,Kun-Peng Wang,Shaojin Chen,Zhi-Qiang Hu
Amines are widely used in many fields including agriculture, dyes, medicine and food processing. However, volatile amine vapors could initiate acute and serious damage to human bodies. Thus, highly efficient detection of volatile amine vapors has great importance for academic research as well as practical application. In this work, a turn-on type fluorescent sensor BZCO has been developed, which could be used to detect volatile amine vapors. The portable BZCO sensor can be easily prepared through immersing filter paper into its CH 2 Cl 2 solution and then evaporating it to dryness. This paper-based amine vapor sensor exhibits high sensitivity with a relatively low detection limit at 3.82 ppm. It also has good selectivity for discriminating amine vapors from volatile organic solvents. The detection mechanism has been confirmed by UV–vis spectral analysis. The practical applications of this paper-based BZCO sensor, such as detection of food spoilage and fluorescent security ink, have been investigated. This work has developed a new fluorescent sensor BZCO , which has broad applications in various fields, including amine gas detection, security and anti-counterfeiting materials.
研究领域:
分析化学
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环境科学
·
食品安全
·
材料科学
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DOI
高影响因子
Biomolecules
·
2026
·Vol. 16
·期 7
·1002
·
IF 5.6
Hui Liu,Lina Hu,Yalan Wang,Zheshan Quan,Zheng Liu,Shiben Wang,Qingkun Shen
The tryptophan–kynurenine pathway, mediated by indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO), is critically involved in the pathogenesis of depression. A series of novel morpholine–coumarin derivatives were designed and synthesized as dual IDO1/TDO inhibitors. Through in vitro enzyme screening, compound14dexhibited potent inhibitory activity with IC50values of 0.34 µM and 0.75 µM, respectively. In lipopolysaccharide (LPS)-stimulated BV2 microglial cells,14ddownregulated IDO1/TDO expression, suppressed pro-inflammatory cytokines (IL-1β, COX-2, iNOS, TNF-α), and upregulated the anti-inflammatory cytokine IL-10. In an LPS-induced acute depressive mouse model established in C57BL/6 mice, intraperitoneal administration of14d(20 mg/kg) significantly reduced immobility time in the forced swim and tail suspension tests, without affecting spontaneous locomotor activity. Mechanistic studies revealed that14dinhibited microglial activation in the hippocampal dentate gyrus, reduced cerebral kynurenine levels, increased serotonin content, and upregulated BDNF/PKA signaling. Molecular docking further predicted the binding interactions of14dwith the active sites of IDO1 and TDO. These findings suggest that14drepresents a promising dual IDO1/TDO inhibitor lead compound for the treatment of inflammation-associated depression through modulation of the kynurenine pathway and neuroinflammatory responses.
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Xiaoqiang Luo,Haobo Ruan,Zhongte Pei,Zitao Yang,Qianyu Wang,Anjia Zheng,Jiajun Feng,Feng Jiang
Sustainable fluorescent elastomers derived from cellulose, coumarin, and plant oil were designed. • The mechanical properties of cellulose graft copolymers can be systematically manipulated. • These sustainable elastomers show typical blue fluorescence emission under UV irradiation. The development of sustainable functional materials from renewable resources is a critical pursuit in modern materials science. In this work, we report a novel class of sustainable fluorescent elastomers fabricated by grafting a coumarin derivative, 7-acryloyloxy-4-methylcoumarin (AMC), as the fluorescent chromophores and a plant oil-based polymerizable monomer, lauryl acrylate (LA), from cellulose backbone via homogeneous reversible addition-fragmentation chain transfer (RAFT) polymerization. In this architecture, the rigid cellulose acts as the backbone, LA plays the role of soft segments to provide the stretchability, while AMC serves as the hard segments to enhance the tensile strength and endow the matrix with fluorescent performance. The resulting cellulose- graft -poly(7-acryloyloxy-4-methyl co umarin- co -lauryl acrylate) (Cell- g -P(AMC- co -LA)) copolymers exhibit tunable mechanical properties and strong fluorescence emission. This work demonstrates a feasible strategy for converting renewable natural cellulose into sustainable fluorescent elastomers by integrating coumarin and plant oil derivatives, providing new insights into the development of fluorescent materials from bio-derived resources.
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Fanyong Yan,Zhangjun Bai,Yuan Chen,Fanlin Zu,Xing Li,Jinxia Xu,Liang Chen
A novel FRET ratiometric fluorescent probe (CMH-GA-CDs) was designed for the detection of Cu 2+ in aqueous solution. The CMH-GA-CDs were prepared through grafting 7-diethylaminocoumarin-3-carbohydrazide (HCM) on the surface of glyoxylic acid-modified carbon dots (GA-CDs) by amidation reaction. In the absence of Cu 2+ , a FRET pair from the CDs to CMH units was established, in which the CMH-GA-CDs exhibited dual emission bands centered at 400 nm (CDs) and 458 nm(CMH), respectively, under optimal excitation wavelength of CDs (λ ex = 340 nm). Upon addition of 30 μM Cu 2+ to CMH-GA-CDs solution, Cu 2+ coordinated with the heteroatoms N and O, which caused the inhibition of FRET process and the change of fluorescence intensity ratio I 458 /I 400 from 1.95 to 0.91. The ratio of I 458 /I 400 exhibited a good linear relationship with the concentration of Cu 2+ in the range of 0–10 μM and the limit of detection was as low as 0.21 μM. Furthermore, The CMH-GA-CDs were used for the detection of Cu 2+ in tap water and lake water with satisfactory recovery ratio between 91% and 104%, demonstrating the promising applicability for detecting Cu 2+ in water samples.
研究领域:
分析化学
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材料科学
·
环境科学
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DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2015
·
IF 2.353
Liqiang Yan,Yan Zhou,Wenqi Du,Zhineng Kong,Zhengjian Qi
The probe CT was synthesized and investigated as a novel label-free chemosensor for Ga 3 + detection in water. Probe CT showed remarkable selectivity and sensitivity for Ga 3 + in Tris–HCl aqueous buffer solution (pH 7.0). The chemosensor responded rapidly to Ga 3 + with a 1:1 stoichiometry . Meanwhile, the unapparent changes of fluorescence lifetime decays suggest the turn-on process of probe CT by Ga 3 + which appears to be a static mechanism.
研究领域:
分析化学
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环境科学
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传感器与生物传感器
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无机化学
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DOI
高影响因子
Chemical Biology & Drug Design
·
2014
·Vol. 86
·期 2
·173-179
·
IF 2.507
Qianqian Qiu,Xin Deng,Lei Jiao,Tianxiao Zhao,Fanfei Meng,Wenlong Huang,Hai Qian
A novel coumarin-based fluorescence probe has been constructed for the selective and sensitive detection of hydrogen sulfide (H 2 S). This probe displays high sensitivity and linearity to H 2 S in degassed PBS buffers and fetal bovine serum. It reacts with H 2 S with high selectivity over Cys, GSH, and other anions. Meanwhile, successful detection of H 2 S in living cells was also demonstrated.
研究领域:
生物化学
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医学检测
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分子生物学
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DOI
PubMed
高影响因子
Polymers
·
2020
·Vol. 12
·期 10
·2268
·
IF 3.426
Song Feng,Junqin Wang,Lihua Zhang,Qin Chen,Wang Yue,Ni Ke,Haibo Xie
Currently, controlled release formulations (CRFs) of pesticides in response to biotic and/or abiotic stimuli have shown great potential for providing “on-demand” smart release of loaded active ingredients. In this study, amphiphilic biopolymers were prepared by introducing hydrophobic (7-diethylaminocoumarin-4-yl)methyl succinate (DEACMS) onto the main chain of hydrophilic carboxymethylchitosan (CMCS) via the formation of amide bonds which were able to self-assemble into spherical micelles in aqueous media and were utilized as light-responsive nanocarriers for the controlled release of pesticides. FTIR and NMR characterizations confirmed the successful synthesis of the CMCS-DEACMS conjugate. The critical micelle concentration (CMC) decreased with the increase in the substitution of DEACMS on CMCS, which ranged from 0.013 to 0.042 mg/mL. Upon irradiation under simulated sunlight, the hydrodynamic diameter, morphology, photophysical properties and photolysis were researched by means of dynamic light scattering (DLS), transmission electron microscopy (TEM), UV-vis absorption spectroscopy and fluorescence spectroscopy. Moreover, 2,4-dichlorophenoxyacetic acid (2,4-D) was used as a model pesticide and encapsulated into the CMCS-DEACMS micelles. In these micelle formulations, the release of 2,4-D was promoted upon simulated sunlight irradiation, during which the coumarin moieties were cleaved from the CMCS backbone, resulting in a shift of the hydrophilic–hydrophobic balance and destabilization of the micelles. Additionally, bioassay studies suggested that this 2,4-D contained which micelles showed good bioactivity on the target plant without harming the nontarget plant. Thereby, the light-responsive CMCS-DEACMS micelles bearing photocleavable coumarin moieties provide a smart delivery platform for agrochemicals.Keywords:carboxymethyl chitosan micelles;light-responsive;coumarin;2,4-D;controlled release;pesticide
研究领域:
材料科学
·
农业化学
·
药学
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产品关联
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2020
·
IF 3.862
Lei Wang,Xiaofeng Ma,Linlin Wu,Ye Sha,Bo Yu,Xiaoyu Lan,Yanlong Luo,Yijun Shi,Yan Wang,Zhenyang Luo
Fabrication strategies for photo-responsive ion gels have attracted attention owing to their precise spatial and temporal control with predetermined responses to light stimuli. In this work, a reversible light-driven method was introduced to devise photo-responsive ion gels by harnessing coumarin-based building blocks under 365 nm irradiation. A series of random copolymers composed of N, N -dimethylacrylamide (DMA) and 7-(2′-methacryloyloxyethoxy)–4-methylcoumarin (MAOEMC), namely P(DMA- r -MAOEMC), were synthesized through reversible addition-fragmentation chain transfer (RAFT) polymerization with sufficient molecular weight (≈100 kDa). The coumarin moieties in those polymers exhibited a reversible photo-induced dimerization and photocleavage behavior in 1-ethyl-3-methylimidazolium bis (trifluoromethylsufonyl) imide ([C 2 mim][NTf 2 ]). Those polymers - ionic liquid system at high polymer concentration (20 wt%) under suitable wavelength UV light irradiation led to sol–gel transition, which could be functionalized as photo-healable material and photo-controlled adhesion agents. Notably, the photo-controlled adhesiveness was reversible and can be mediated from 1.2 MPa to 0.2 MPa. This work opens new avenues to develop multifunctional ion gels using dynamic covalent bonds.
研究领域:
材料科学
·
高分子化学
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产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2018
·
IF 2.88
Yatong Sun,Yanyan Shan,Ning Sun,Zhipeng Li,Xiangwen Wu,Ruifang Guan,Duxia Cao,Songfang Zhao,Xun Zhao
A novel coumarin chalcone derivative 1 was designed, synthesized and characterized by nuclear magnetic resonance spectra and high resolution mass spectrum . The photophysical and recognition properties of the compound as red fluorescent probe for cyanide and biothiols including cysteine (Cys), homocysteine (Hcy) and glutathione (GSH) have been discussed systematically. Red fluorescence probe 1 was able to achieve rapid and selective identification for cyanide anion and biothiols in aqueous solutions with red fluorescence quench. In addition, the recognition mechanism of 1 was demonstrated by in situ 1 H NMR. The compound has two potential nucleophilic sensing sites including carbon-carbon double bond and 4-position of coumarin. The results indicate that cyanide anions can be bonded to these two sites to afford 2:1 bonding product. But biothiols only are bonded to carbon-carbon double bond by Michael addition reaction. The bonding of both cyanide and biothiols to the probe disrupts intramolecular charge transfer and leads to fluorescence quench.
研究领域:
化学
·
生物分析
·
荧光探针研究
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产品关联
DOI
PubMed
高影响因子
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
·
2017
·
IF 2.466
Huanan Wang,Wenqing Xu
Due to higher transmembrane potential of tumor cells, enhanced accumulation of cationic drugs in tumor mitochondria has been attributed to a higher (more negative inside) mitochondrial transmembrane potential compared with normal cells, emerging researchers are focus on developing mitochondria-targeted antitumor drugs. Coumarins showed great potential on antitumor, but mitochondria-targeted coumarin derivatives have not been reported. In the present study, we synthesized mitochondria-targeted-methyl coumarin (mito-methyl coumarin) through coupling 6-methyl coumarin to TPP. We confirmed that mito-methyl coumarin inhibited HeLa cells proliferation selectively, induced ROS generation, reduced mitochondrial membrane potential , promoted mitochondria Ca 2+ accumulation, decreased mitochondria mass and induced HeLa cells apoptosis, but methyl coumarin did not. These results demonstrate that we succeed in synthesizing a novel mitochondria-targeted drug, mito-methyl coumarin, which is effective in inhibiting HeLa cells proliferation and inducing HeLa cells apoptosis through promoting ROS generation and mitochondria Ca 2+ accumulation.
研究领域:
药理学
·
肿瘤学
·
细胞生物学
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产品关联
DOI
PubMed
高影响因子
MATERIALS RESEARCH INNOVATIONS
·
2015
·
IF 0.83
J. Cao,W. M. Zhang,T. Wu,J. L. Pu
In this paper, a copolymer containing photosensitive group was used as photo-alignment film through linearly polarised ultraviolet irradiation to a varying heating rate for an investigation of liquid crystal orientation. When the polymer film is exposed to linearly polarised ultraviolet, it can generate a polarisation-axis selective photoreaction. Then the thin film underwent thermally enhanced photoinduced molecular reorientation followed by subsequent annealing. Fixed exposure energy was 324 mJ cm−2 and annealing temperature was 98°C, heating rates varied from 5 to 30 S °C−1, a large anisotropy was generated. According to the method mentioned in the paper to calculate the enhanced ratio, the best heating rate is 20 S °C−1.
研究领域:
材料科学
·
光学
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产品关联
DOI
高影响因子
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
·
2022
·
IF 3.322
Zhiming Wang,Yuedong He,Lijing Liao,Yuhao Zhang,Yucheng Zhao,Yibei Xiao,Xuefei Jiang,Fei Qiao
A glycosyl transferase , isolated from Angelica decursiva a medical herb rich in coumarin , shows C-glycosyl transferase activity by in vitro activity assay using 5,7-dihydroxycoumarin as substrate, producing a C-glycosylated product at position C′8 along with the main product at C′6 position. Catalytic promiscuity assay shows that Ad CGT also displays O- or C-glycosylation activity to other coumarins and flavonoids . When phloretin and 2,4,6-trihydroxyacetophenone were fed as substrates, Ad CGT catalyzed the formation of di-C-glycosides. Therefore, Ad CGT is a multifunctional glycosyltransferase with a broad substrate acceptability. This work highlights the potential of Ad CGT as a catalyst for glycosylation of coumarin and reveals a new regio-selective C-glycosyltransferase, providing a basis for exploring the mechanism of coumarin glycosylation.
研究领域:
生物化学
·
生物催化
·
药物化学
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）