ACS Nano
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2025
·
IF 16
Yuge Wu,Qi Wang,Xin Li,Ke Li,Dehua Huang,Kehan Zou,Zhehua Zhang,Yongchao Qian,Congcong Zhu,Xiang-Yu Kong,Liping Wen
Human sweat has the potential to be sufficiently utilized for noninvasive monitoring. Given the complexity of sweat secretion, the sensitivity and selectivity of sweat monitoring should be further improved. Here, we developed an olfactory-inspired separation-sensing nanochannel-based electronic for sensitive and selective sweat monitoring, which was simultaneously endowed with interferent separation and target detection performances. The special separation-sensing strategy imparts functional composite membranes with a high sensitivity of 113 mV dec–1 for potassium detection. The excellent mechanical properties and conformability of the Kevlar aramid nanofiber layer bring well-wearing performances to realize continuous wireless sweat monitoring. The recognition between functional molecules and target ions is proved at the molecular level in detail in the article. The replacement of functional molecules proves the universality of the strategy for performance enhancement in intricate biofluid analysis systems.
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PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2024
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IF 4.3
Shen Zhang,Xin Nie,Yan Ren,Yuyu Guo
Due to the excellent characteristics, fluorescent copper nanoclusters (Cu NCs) have aroused great interest in recent years. Herein, the simple prepared, environmentally friendly fluorescent Cu NCs were synthesized by using trypsin as the stabilizer and applied for the determination of tetracycline. Uniformly dispersed Try-Cu NCs were obtained with average size of 3.5 ± 0.3 nm and some excellent merits of good water solubility, UV light stability and salt stability. Emission peaks around 460.0 nm were visibly quenched by tetracycline based on static quenching mechanism and inner filter effect (IFE). Two excellent linear relationships were observed between ln(F 0 /F) and tetracycline concentrations in the range of 1–100 μM and 100–300 μM with limit of detection (LOD) of 0.084 μM. Meanwhile, this nanoprobe exhibited an apparent selectivity for tetracycline detection. Moreover, Try-Cu NCs were successfully employed to determine tetracycline in serum and milk samples after facile pretreatment with satisfactory recovery rates and credible standard deviation. The results suggested that this as-prepared Try-Cu NCs had excellent application prospects in the future.
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PubMed
高影响因子
IEEE SENSORS JOURNAL
·
2024
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IF 4.3
Xuanxu Nan,Lingyi Xu,Li Yang,Yue Cui
The development of sensors for the detection of albumin concentrations in urine is essential for the long-term detection and treatment of kidney disease. Albumin is an important biomarker for kidney diseases. However, albumin concentrations in patient urine are often too high (more than 0.15 mg/mL), causing competitive lateral flow immunoassays to exceed detection ranges. In this work, we report for the first time a one-step, fluorescent lateral-flow quantification of human urine albumin using an in-situ minipump and clinical evaluation in renal patients, eliminating the need for external sample dilution. The device is constructed by integrating a lateral flow immunoassay strip and an in-situ minipump that sits above the sample/conjugate pad of the strip. The detection is based on competitive immunoassay by using fluorescent nanoparticles as the probe, and the in-situ pump performs on-chip dilution. The linear detection range with this device is 0.1-10 mg/mL for a 1000-fold dilution of the sample with the pump, and 1-100 mg/mL for a 10,000-fold dilution. The device can be used for the direct quantification of albumin in the urine of patients with clinical kidney disease. We anticipate the work can open up exciting new opportunities for the quantification of protein biomarkers, and their wide range of applications in clinical and home-settings.
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高影响因子
MICROCHEMICAL JOURNAL
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2024
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IF 4.9
Yan Chen,Xiaojuan Yang,Zhonggang Liu,Guohua Liu,Zheng Guo
Resolving the issue of poor conductivity and easy aggregation of MOFs is recognized as one important factor for their successful applications in electrochemical sensors and electrocatalysis. In this work, we propose an assembly of NH 2 -MIL-101(Fe) onto a nanoporous gold (NPG) microelectrode surface. The nanoporous gold could greatly improve the conductivity and reduce the aggregation of NH 2 -MIL-101(Fe). The proposed NH 2 -MIL-101(Fe)/NPG microelectrode was developed for the electroanalysis of ascorbic acid (AA) and uric acid (UA). It exhibited excellent electrochemical performance for the individual and simultaneous sensing of AA and UA in a 0.1 M PBS solution (pH 7.4). High sensitivities (2.03 μA μM −1 cm −2 for AA; 29.30 μA μM −1 cm −2 for UA) were achieved in the simultaneous analysis process. The improved electrochemical performance was attributed to the electrocatalytic properties and large specific surface area of NH 2 -MIL-101(Fe)/NPG, as well as the electrostatic interaction between NH 2 -MIL-101(Fe) and analytes. Moreover, the NH 2 -MIL-101(Fe)/NPG microelectrode was successfully used for the simultaneous detection of AA and UA in complicated environment (human sweat and advanced DMEM). This work shows great promise for the simultaneous detection of AA and UA and extends the applications of MOFs in electrochemical devices.
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高影响因子
Journal of Energy Storage
·
2024
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IF 8.9
Bairui Tao,Xiaoyan Feng,Fengjuan Miao
In order to solve the problem of glucose detection in medical development and meet the urgent demand for new energy storage devices, this paper proposes a new material suitable for glucose sensing and capacitive properties. The sensor was fabricated by depositing Co 3 O 4 nanoparticles onto nickel foam with integrated r-GO via the hydrothermal method, followed by the synthesis of CuO nanoparticles using electroplating. The detection range of the sensor is 0.3–11.3 mM. The sensor's sensitivity is 1000.3 μA mM −1 cm −2 , indicating its responsiveness to changes in analyte concentration. In electrochemical test systems, Signal-to-Noise Ratio (SNR) usually represents the relative intensity of the effective current signal and the background noise, reflecting the accuracy and reliability of the measurement. When the SNR is three, the minimum detection limit is 0.431 μM, highlighting its ability to reliably detect analytes at low concentrations amidst background noise. According to electrochemical workstation tests, the sensor demonstrates robust stability. Furthermore, the electrode material proves suitable for asymmetric supercapacitor devices, when the current density is 2 Ag −1 , the specific capacitance is 660.5 Fg −1 . At the same time, we also explore the cyclic stability of the device, which can retain 92.3 % of its initial specific capacitance after 5000 cycles, showing its remarkable long-term stability. In addition, the prepared nanocomposites can also light the red LED light. The results show that the synthesized CuO/Co 3 O 4 /r-GO/NF electrode can be used for electrochemical glucose sensing and supercapacitors, and plays an important role as a multi-functional material in the fields of medical, food, electronics, transportation and energy, providing key technical support for a variety of applications.
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高影响因子
ChemistrySelect
·
2025
·Vol. 10
·期 6
·e202405285
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IF 2
Rao Ma,Xin Xiao,Ziwei Feng,Ke Jiang,Rong Hu,Shuang Meng,Tong Yang,Long Huang
Graphical This study reports a simple hydrothermal method for synthesizing copper oxides (CuO x ) with varied Cu + /Cu 2+ ratio. It turns out that the surface Cu + species are highly active sites for glucose electro-oxidation. The glucose electrochemical sensor using as-synthesized CuO x -FA as catalyst exhibits wide detection range with low detection limit and quick response. Detecting glucose levels in food & beverages and body fluids is crucial for health management and disease diagnosis. Developing a highly efficient and durable catalyst is essential for glucose electrochemical sensor. Herein, we reported copper oxides with tuned structure as catalyst for glucose electro-oxidation by simple hydrothermal method. Formaldehyde, trisodium citrate, and ascorbic acid were adopted as reductant for the synthesis of copper oxides. The surface structure and glucose electro-oxidation activity of as-synthesized copper oxides were carefully studied. The surface valence of copper was greatly influenced by the reductant, and the enhanced Cu + content in the surface was believed to account for the improved activity toward glucose electro-oxidation. When using formaldehyde as reductant, the resulted CuO x -FA exhibited the best activity toward glucose electro-oxidation with the detection limit as low as 0.1 µM and showed a wide linear detection range of 0.1 µM ∼ 1 mM. The CuO x -FA also showed fast response, good anti-interference ability, and excellent durability, which makes it a promising catalyst for glucose electrochemical sensor.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
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2025
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IF 3.9
Lu Yan,Liu Qingcui,Pang Xinxin,Tang Chenyang,Yan Zihan,Peng Banghua,Yu Feng
Ultrathin two-dimensional (2D) metal–organic framework (MOF) materials have become a research hotspot due to their ultra-large specific surface area and efficient charge transport, but their controllable preparation is still challenging. In this study, using molybdate anion, a small molecular modulation strategy is offered to precisely modulate the structure of cobalt-imidazolium MOF by liquid-phase reaction to successfully obtain ultrathin 2D MoCo-MOF shreds. High-valence molybdenum modulates the electronic structure and oxidation state of cobalt in MOFs, which in turn influences the growth of crystalline and morphology, leading to ultrathin MoCo-MOF structure. Synergism for molybdenum and cobalt in MoCo-MOF significantly enhanced the electrocatalytic activity of oxygen evolution reaction (OER) in 1M KOH. Meanwhile, the material also exhibited excellent uric acid (UA) detection performance with high sensitivity and wide detection range (4–800 μM). Our study verifies the effectiveness of oxometallate anion for structural modulation, provides a new way for material morphology modulation, and develops the potential of ultrathin 2D MoCo-MOF shreds for water electrolysis and UA detection.
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APPLIED ORGANOMETALLIC CHEMISTRY
·
2024
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IF 3.7
Zixuan Zhou,Yuhan Jiang,Xin Luo,Ying Zhang,Lei Wang,Yaguang Sun,Jingwei Liu,Mingchang Zhu,Jinchao Cao,Shuangyan Wu
Milk, owing to its nutritional value, is a staple commodity in daily life. Ensuring its integrity and authenticity is paramount for researchers and the food industry. To evaluate spoilage and adulteration of milk, we proposed a robust and reliable optical method to guarantee milk quality by utilizing riboflavin as an internal biomarker. By precisely controlling the content of Eu 3+ , Tb 3+ , and Gd 3+ ions, a two-dimensional ratiometric luminescence lanthanide coordination polymer (Ln-CP) with adjustable emission centers was synthesized for the detection of riboflavin (RF), leveraging a Förster resonance energy transfer (FRET) and photoinduced electron transfer (PET) process. This method demonstrates high sensitivity and selectivity towards RF and has been successfully applied to the detection of RF in both milk and calf serum.
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高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
He Huang,Qinqin Yang,Yu He,Gongwu Song
Phenolic pollutants are commonly employed in industries such as petrochemicals, dyeing, textiles, and pesticides, which cause great harm to our living environment and food safety. In this paper, the MXenes-based metal composites (M/MXenes, M = Cu, Co, Ni, Zn, Fe, Mn) with multi-enzyme mimic activity were prepared by a facile molten salt method. The M/MXenes have mimic catalytic activity of peroxidase (POD), ascorbic acid oxidase (AAO), catalase (CAT), superoxide dismutase (SOD) and laccase. The catalytic properties of M/MXenes were analyzed and discussed in detail. In addition, M/MXenes still have excellent catalytic performance and stability in harsh pH and high temperature environments, making them very suitable for practical applications. Due to the excellent laccase mimic activity of M/MXenes, a simple colorimetric sensor was constructed for the detection and degradation of phenolic pollutants. Because obvious color changes can be observed during the catalytic process of phenolic pollutants by M/MXenes, M/MXenes were fixed into sodium alginate (SA) to form a simple hydrogel-based sensing platform for 2, 4-chlorophenol, methoxyphenol, 4-bromophenol, 3-bromo-4-methoxyphenol, 3-bromo-4-methylphenol, hydroquinone and 1,8-naphthol. By introducing different concentrations of phenolic compounds, a series of color changes on the gel carrier can be observed by naked eyes. Then, the red (R), green (G) and blue (B) values matching with the color change of the hydrogel were read out by the color recognition application in the smartphone, and the RGB value was converted into the concentration of phenolic compounds, which offered a convenient and reliable method for the rapid detection of phenolic compounds. Thus, the strategy offers the potential in rational design of nanozymes with the advantages of multi-enzyme mimic activity, simple preparation, low cost and good stability.
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高影响因子
BIOELECTROCHEMISTRY
·
2024
·
IF 4.8
Mengjie Su,Wenjing Peng,Zhengyuan Ding,Yaqiu Zhou,Hui Gao,Qiyu Jiang,Chunmei Yu
The levels of monoamine neurotransmitters (MNTs) including dopamine (DA), adrenaline (Adr), norepinephrine (NE) and 5-hydroxytryptamine (5-HT) in cells are useful indicators to explore the pathogenesis of MNTs-related diseases such as Alzheimer’s disease, Parkinson’s disease and depression. Herein, we constructed a novel electrochemical sensing platform based on multi-walled carbon nanotubes (MWCNTs)-amine functionalized Zr (IV) metal–organic framework (UIO-66-NH 2 ) nanocomposite for the detection of multiple MNTs including DA, Adr, NE and 5-HT. The synergistic effect between MWCNTs and UIO-66-NH 2 endowed the nanocomposite with high specific surface area, low interface impedance and superior electrocatalytic activity, which effectively enhance the electrochemical performance of the sensor. The MWCNTs-UIO-66-NH 2 nanocomposite-based sensor exhibited satisfied sensitivity for the quantitative measurement of DA, Adr, NE and 5-HT, as well as low detection limit. The outstanding biocompatibility of the constructed sensor permitted it to be successfully implemented for the real-time monitoring of DA released by PC12 and C6 cells, providing a promising strategy for clinical diagnosis of MNTs-related disorders and diseases.
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高影响因子
Aggregate
·
2024
·Vol. 5
·期 4
·e542
·
IF 13.9
Xiaomin Ye,Chaoyu Yang,Li Wang,Qihui Fan,Luoran Shang,Fangfu Ye
Adsorbents with high adsorption efficiency and excellent biosafety for biomedical applications are highly required. MXene is a promising candidate owning these advantages, yet pristine MXene faces dilemmas including insufficient utility of surface site as well as limited processibility. Here, we develop MXene-encapsulated porous microcapsules via microfluidics. The microcapsules have a biomass hydrogel shell that provides robust support for MXene in the core, by which the microcapsules are endowed with high MXene dosage and remarkable biosafety. Additionally, the MXene nanoflakes assemble into a three-dimensional network via metal ion-induced gelation, thereby avoiding restacking and significantly improving surface utilization. Moreover, a freeze-pretreatment of the microcapsules during preparation results in the formation of a macroporous structure in the shell, which can facilitate the diffusion of the target molecules. These features, combined with additional magneto-responsiveness rendered by the incorporation of magnetic nanoparticles, contribute to prominent performances of the microcapsules in cleaning uremia toxins including creatinine, urea, and uric acid. Thus, it is anticipated that the MXene-encapsulated microcapsules will be promising adsorbents in dialysis-related applications, and the combination of microfluidic encapsulation with metal ion gelation will provide a novel approach for construction of hybrid MXene materials with desired functions.
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高影响因子
VACUUM
·
2024
·
IF 3.8
Bairui Tao,Xiangru Ren,XiaoJie Liu,Fengjuan Miao
The ZIF-67/NiS composite electrode was prepared on nickel foam (NF) matrix by hydrothermal method . NiS has been widely studied in sensors and supercapacitors due to its good electron transfer ability and good pseudocapacitor performance. Therefore, we prepared ZIF-67/NiS composite electrode. The synthesised ZIF-67/NiS composite electrode not only has certain electrochemical performance of battery type electrode, but also is sensitive to lactic acid (LA), and can be used as a non-enzymatic LA sensor and a dual-function material for supercapacitors . The detection limit of LA concentration in alkaline solution is 0.8 μM, and the sensitivity is 1.34 μA μM −1 cm −2 . Indicating that the electrode has good electrochemical sensing performance. The GCD test results show that the charging capacity of the ZIF-67/NiS is 2.5 times that of the ZIF-67. The ZIF-67/NiS composite has good cyclic performance, and the capacitance retention rate of the ZIF-67/NiS composite is 87% at 10 A/g current density .
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