Tungsten
·
2025
·
IF 11.2
Pei Jing-Jie,Li Wen-Bin,Wang Ni,Li Dong-Yang,Cao Gui-Qiang,Dong Qi,Yi Yuan-Jie,Wang Jing-Jing,Li Xi-Fei
Heterostructures, consisting of metal selenides and metal sulfides, have been extensively reported as hosts for sulfur (S), aiming to address three significant challenges confronted by S cathodes in lithium-sulfur batteries. To answer the key question—whether a heterostructure of metal selenides or metal sulfides is a better choice as the host for an S cathode —two types of zeolitic imidazolate framework (ZIF)-8-derived ZnSe@VSe 2 and ZnS@VS 2 polyhedra are designed and successfully synthesized. Results show that ZnSe@VSe 2 /NC (nitrogen-doped carbon) host possesses stronger anchoring and catalytic conversion abilities (Li 2 S precipitation capacity: 178.97 mAh·g −1 ) to polysulfides than ZnS@VS 2 /NC host (107.79 mAh·g −1 ). Meanwhile, ZnSe@VSe 2 /NC@S cathode presents fast S redox and Li + diffusion kinetics, superior charge-discharge stability, and low electrochemical polarization. As a result, ZnSe@VSe 2 /NC@S cathode exhibits significantly better cycling performance (525 mAh·g −1 at 1C after 300 cycles) and rate capability than ZnS@VS 2 /NC@S cathode (378 mAh·g −1 ). These advantages are primarily attributed to the synergistic effects arising from the built-in electric field at the ZnSe@VSe 2 heterointerface (directed from VSe 2 to ZnSe), the lower electronegativity of Se compared to S, and the higher electrical conductivity of ZnSe/VSe 2 relative to ZnS/VS 2 . Graphical
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ACTA PHARMACOLOGICA SINICA
·
2025
·
IF 8.4
Zhao Man,Jin Zu-yi,Fan Wei-zhen,Qiang Peng-fei,Zheng Zhi-hua,Li Guo-feng,Hong Liang,Li Min
The stimulator of interferon genes (STING) is a crucial pattern recognition receptor that activates innate immunity, particularly in response to pathogen infection and various stimuli. Notably, activation of STING exhibits remarkable potential in enhancing anti-tumor immunity, underscoring the significance of discovering STING small molecule agonists. Recently, zinc pyrithione (ZPT), a marketed antifungal small molecule, has been reported to possess anti-tumor activity through various mechanisms. Our preliminary screening of STING agonists revealed that ZPT could significantly induce STING activation. In this study, we investigated whether ZPT exerted anticancer effects as a small molecule activator of STING. We showed that ZPT bound to the STING protein in vitro with K D value of 2.72 μM, and ZPT (1–16 μM) dose-dependently activated the STING-TBK1-IRF3 signaling axis in THP-1 cells. In MC38 tumor-bearing wild-type C57BL/6 mice with normal immune systems, administration of ZPT (5, 10, or 20 mg/kg, i.p., every two days for 14 days) dose-dependently inhibited the tumor growth, activated CD45 + , CD3 + , and CD8 + T cells in both tumors and spleens, and significantly elevated IL-6 secretion in the peripheral blood. These results highlight the potential of ZPT as an immunotherapeutic agent targeting STING.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-12
·
IF 15.7
Sun Yulu,Xu Ruoyao,Dai Jinfei,Tang Hebing,Wang Jungang,Cai Weilun,Li Peizhou,Xu Jie,Yuan Fang,Jiao Bo,Li Jingrui,Wu Zhaoxin,Dong Hua
Achieving uniform and stable hole transport layers (HTL) is crucial for large-area perovskite solar cells (PSCs). However, current self-assembled monolayer (SAM)-based HTL suffer from weak interfacial adhesion, poor film uniformity, and limited stability, constraining their scalability. Our study proposes an integrated HTL strategy with in situ SAM anchoring during NiO x synthesis, forming a type of scalable, high-performance, and durable HTL. This strategy significantly enhances molecular ordering, energy level alignment, and charge extraction, leading to a more pronounced performance improvement in large-area slot-die coating modules. PSCs with this HTL achieved a champion PCE of 26.02% (with an active area of 0.0655 cm 2 ), while large-area modules reached 22.80% at 23.25 cm 2 , 21.45% at 87.45 cm 2 , and 20.21% at 749.276 cm 2 (certified at 19.50%), showing superior scalability. Moreover, the irradiation and thermal stability, key concerns for commercial applications, were significantly improved. The encapsulated industrial-scale modules successfully passed the three module quality tests (MQTs) in the IEC 61215-2-2021 standard: outdoor exposure (MQT 08), UV pre-conditioning (MQT 10), and wet-high temperature operating life (MQT 13) tests.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-24
·
IF 15.7
Liu Chuqi,Liu Dexiang,Zheng Xiang,Guan Jiali,Zhou Xinyan,Zhang Haikun,Wang Shen,Li Qiubai,Lu Gan,He Jun,Ma Cong
Tumor-derived exosomes carry programmed death-ligand 1 (PD-L1), which binds programmed cell death protein 1 (PD-1) on T cells, suppressing immune responses locally and systemically. However, the mechanisms governing exosomal PD-L1 sorting and secretion remain elusive. Here, we identify Munc13-4 as a crucial regulator of this process. Deletion of Munc13-4 in breast tumors enhances T cell-mediated anti-tumor immunity, suppresses tumor growth, and improves the efficacy of immune checkpoint inhibitors. Mechanistically, Munc13-4 collaborates with hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), Rab27, and SNAREs to facilitate PD-L1 sorting and secretion via exosomes. Cryogenic electron microscopy (cryo-EM) analysis of the Munc13-4–Rab27a complex provide structural insights into exosome secretion. Importantly, PD-L1 sorting relies on a ternary complex composed of Munc13-4, PD-L1 and HRS, which is regulated by interferon gamma (IFNγ) signaling. A designed peptide that disrupts Munc13-4–PD-L1 interaction impedes PD-L1 sorting, enhances antitumor immunity, and suppresses tumor growth, highlighting the therapeutic potential of targeting this pathway.
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WATER AIR AND SOIL POLLUTION
·
2025
·Vol. 236
·期 13
·1-19
·
IF 3
Zhang Xia,Zhou Mengqin,Wan Xiu,Liu Xi,Hao Shixiong,Cheng Chunru,Xiao Zhongming,Wang Yongfan
To address the challenges of titanium dioxide's low utilization of visible light, easy recombination of photogenerated charges, and insufficient interfacial contact when integrated with other semiconductors to form heterojunctions, a novel, simple, and easy hybrid MOF template-directed method was developed to enhance the interaction between oxide and support, thereby constructing In 2 O 3 @TiO 2 - x (IT- x ) composites with tightly contacted heterojunction interfaces. After 120 minutes of exposure to visible light, the IT-30% realized a 91.98% degradation rate for tetracycline in wastewater with an initial concentration of 30 mg/L, which is 1.46, 3.39, and 2.07 times higher than that of bare TiO 2 , bare In 2 O 3 , and Degussa-P25, respectively. After 5 cycles (10 h), the IT-30% photocatalyst still maintained high photocatalytic activity with a 14.47% decline in tetracycline degradation efficiency. The experiments on free radical trapping and electromagnetic spin resonance (ESR) revealed that the superoxide radical is the primary active substance in the tetracycline photocatalytic degradation. SEM, HRTEM, and XRD characterization techniques were utilized to demonstrate the successful preparation of hollow composites. The results of BET, UV-Vis DRS, XPS, photoluminescence (PL), and electrochemical impedance spectroscopy (EIS) indicate that the high photocatalytic activity of the prepared IT-30% composite is ascribed to its large specific surface area, strong capacity for visible light absorption, generate abundant oxygen vacancies generated in the composites, and efficient separation and migration of photogenerated carriers. In addition, a possible degradation pathway for tetracycline was proposed according to the HPLC-MS test results of intermediate products.
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CELLULOSE
·
2025
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IF 4.8
Zhang Haiping,Tian Haoye,Liu Shicheng,Dong Xia,He Jinxin,Zhao Qiangqiang
The water-soluble tetraphenylethylene derivatives bearing sulfonic acid groups, namely TPE1S, TPE2S, TPE3S, and TPE4S were synthesised. These derivatives exhibit aggregation-induced emission (AIE) behavior, and fluorescence is also detected in dilute aqueous solution under UV irradiation. Furthermore, these compounds display slightly photochromism in both dissolved and solid states. When applied to modified cotton fabric substrates, the compounds exhibit significant photochromic properties due to the interaction force with the fibers. The photochromic behavior of the material can be modulated by external stimuli such as light, temperature, and humidity. The material undergoes complete decolorization within least 3300 s under dark conditions, while green light irradiation accelerates the process to 20 s. A discernible change in imaging color occurs after 18 h of storage at − 20 °C. At 50 °C, the color fades completely within 60 s. These features endow the materials with the potential for light-activated multicolor fluorescent patterning, information encryption, anti-counterfeiting, and smart textiles. Graphical abstract
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JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-21
·
IF 12.6
Zhao Jinchao,Lei Lei,Zeng Cheng,Zhou Xianfei,Ding Junkang,Dai Wenbin,Jiang Angfeng,Zou Shaomin,Jin Qiao,Tang Zhe
Incomplete radiofrequency ablation (iRFA) of hepatocellular carcinoma (HCC) has the risk to exacerbate the tumor immunosuppressive microenvironment and promote lung metastasis. There is an urgent need to reverse the immunosuppressive microenvironment and reduce lung metastasis after iRFA. Herein, an iron-based metal-organic framework loaded with capmatinib (Fe-MOF/Cap) is employed to reverse the immunosuppressive microenvironment dominated by M2-like tumor-associated macrophages (TAMs) after iRFA and inhibit lung metastasis of HCC. On one hand, Fe-MOF/Cap repolarizes M2-like TAMs to M1-like TAMs and inhibits the expression of PD-L1 after iRFA, promoting CD8+ T cell infiltration. The infiltration of CD8+ T cells and the decrease of PD-L1 are conducive to enhance the immunotherapy after iRFA. On the other hand, Fe-MOF/Cap can inhibit lung metastasis of HCC via inhibiting the expression of c-MET. In vitro and in vivo experiments confirm that Fe-MOF/Cap is able to significantly inhibit the lung metastasis of HCC after iRFA by inhibiting the c-MET/STAT3/VEGF pathway. Fe-MOF/Cap provides a potentially promising strategy for HCC immunotherapy and anti-metastasis after iRFA, with favorable clinical prospects.Graphical
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Chinese Medicine
·
2025
·Vol. 20
·期 1
·1-23
·
IF 5.7
Xu Jin-Di,Gao Xiao-Qin,Zhong Rong-Ling,Zhou Jing,Wang Ting,Chen Can,Yao Wei-Feng,Geng Ting,Zhang Yi,Li Song-Lin,Zhang Li
Background Shi–Zao–Tang (SZT), a classical formula of Traditional Chinese Medicine orally used for treating malignant ascites effusion (MAE), is made by mixing the powder of Kansui Radix (KR), Euphorbiae Pekinensis Radix (EPR) and fried Genkwa Flos with the decoction of Jujubae Fructus. According to Chinese Pharmacopoeia, vinegar-processed KR and EPR should be used in oral administration. However, toxicity and efficacy of SZT containing vinegar-processed KR and EPR (VSZT) versus SZT in MAE rats, and the potential mechanisms of VSZT against MAE, remain unknown. Here, we comparatively studied the quality, toxicity and efficacy of SZT and VSZT, and explored the potential mechanisms of VSZT against MAE. Methods Main components in SZT and VSZT were quantified by liquid chromatographic coupled with triple quadrupole tandem mass spectrometry. The intestinal toxicity and efficacy of SZT and VSZT were comparatively investigated in MAE rats. Specially, intestinal toxicity was evaluated by intestinal barrier function, histopathology and oxidative damage. The efficacy was investigated by amount of ascites, indices in excretion, intestinal motility and inflammation. The potential mechanisms of VSZT treats MAE were explored through integration of metabolomics, 16S rRNA and Western blotting analysis. Results VSZT contains less 3- O - EZ and more ingenol than SZT. VSZT showed reduced intestinal toxicity than SZT in MAE rats. Both SZT and VSZT indiscriminately decreased the amount of ascites and ascitic inflammatory cytokines, promoted urination and defecation, increased fecal water content and intestinal motility. VSZT reversed endogenous metabolism and gut microbiota disorders, down-regulated colonic cAMP, PKA, p-CREB/CREB and AQP3, as well as mesenteric p-VEGFR2/VEGFR2, p-SRC/SRC, and p-VE-cadherin/ VE-cadherin in MAE rats. Conclusion VSZT preserved the efficacy of SZT on MAE with lower intestinal toxicity. VSZT increased water excretion and decreased MAE formation to alleviate MAE through regulating gut microbiota, restoring tryptophan and tyrosine metabolism disorders, and affecting cAMP-PKA-CREB-AQP3 and VEGFA-VEGFR2-SRC-VE-cadherine pathway.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-12
·
IF 15.7
Liu Chenchen,Liu Xueming,Chen Bing,Li Zifan,Ou Xinwen,Lu Yaobin,Liu Yuhao,Wu Chongbei,Yao Shan,Liu Yunhai,Ye Liqun,Han Bin,Yang Zhifeng
Photocatalytic oxygen reduction reaction offers a sustainable approach for hydrogen peroxide (H 2 O 2 ) synthesis, while the efficiency is limited by the challenge of synergistically optimizing the supply of oxygen, protons, and electrons. Here, by elaborately developing squaric acid-based zwitterionic covalent organic framework (STT COF), we propose a triple synergy strategy for boosting H 2 O 2 photosynthesis. The as-prepared STT COF delivers a high H 2 O 2 yield of 14356.5 μmol g –1 h –1 in pure water, with a notable apparent quantum yield of 40.0% at 420 nm, roughly 7.9 times that of its charge-neutral counterpart and outperforming other documented systems. Under natural sunlight irradiation, a 5 L H 2 O 2 solution (~400 μM) is produced in a continuous flow membrane reactor equipped with STT COF and gas diffusion layers. Mechanism studies demonstrate that STT COF induces a strong donor-acceptor (D-A) interaction to promote electron transfer, undergoes spontaneous hydrogenation for continuous protons and facilitating oxygen uptake in a favorable configuration, collectively creating a triple synergy to boost H 2 O 2 photosynthesis.
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FIBERS AND POLYMERS
·
2025
·
IF 2.3
Zhang Shuo,Guo Mengyao,Wu Jiaqing,Wang Ying,Zhang Xin
A novel spinning method that integrates electrospun nanofiber strips into yarn structures has been developed to produce multifunctional yarns. The resulting yarn exhibited a core-sheath structure, with a core composed of tannic acid-modified magnesium hydroxide/thermoplastic polyurethane (TA@MH/TPU) nanofiber strip, sheathed by either pure cotton or cotton/sodium alginate blended fibers. The TA modification improved the dispersion of MH within the TPU matrix, leading to enhanced membrane strength compared to unmodified MH/TPU at equal loadings. The film containing 7% TA@MH/TPU demonstrated optimal mechanical properties (breaking strength of 1.43 MPa, elongation of 122.93%), flame retardancy (limiting oxygen index of 27.1%), and antibacterial efficacy killing ratios of 80.87% against E. coli and 85.07% against S. aureus . Yarns fabricated with this film, the TA@MH/TPU-cotton (CMSCY) retained the antibacterial functionality (67.48% against E. coli and 79.05% against S. aureus ), and the TA@MH/TPU-cotton/sodium alginate (C/SAMSCY) achieved the flame retardancy with a limiting oxygen index of 27.8%. Notably, the CMSCY yarn showed a high tensile strength of 1.53 MPa, which was 15 times that of the TA@MH/TPU nanofiber film, addressing the application limitations of nanofiber membranes caused by their low mechanical strength. Given that electrospun membranes can be readily functionalized, this spinning method offers a promising strategy for producing composite yarns, particularly for developing multifunctional textile fabrics.
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ACTA PHARMACOLOGICA SINICA
·
2025
·
IF 8.4
Chen Yu-qi,Ye Jun-rui,Wang Sha-sha,Peng Ye,Zhou Run,Yuan Ruo-lan,Wang Wen-fei,Chu Shi-feng,Zhang Zhao,Chen Nai-hong
Selective serotonin reuptake inhibitors (SSRIs) are characterized by delayed therapeutic onset largely due to their reliance on the desensitization of 5-HT 1A autoreceptors (5-HT 1A R auto s) within the dorsal raphe nucleus (DRN). It has been shown that dissociation of serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS) interaction selectively modulates 5-HT 1A R auto s, thereby facilitating fast-onset antidepressant responses. Targeting the atypical disk large/ZO-1 (PDZ) domain has been implicated in the SERT-nNOS interaction. In this study, we established a drug screening system based on mBRET combined with biological tests to find SERT-nNOS interaction blockers (SNIBs). During screening the compound libraries, 9 top candidates were found to be capable of binding to the PDZ domain of nNOS. We then identified esflurbiprofen as a promising fast-onset antidepressant candidate. Pharmacodynamic studies revealed that esflurbiprofen effectively penetrated the DRN following systemic administration. Esflurbiprofen (10, 20, 40 mg/kg, i.p., once every 4 days) dose-dependently ameliorated depressive-like behaviors in mice subjected to chronic social defeat stress (CSDS) and chronic restraint stress (CRS). In rs-fMRI analysis, we found that esflurbiprofen enhanced the functional connectivity of emotion-related neural networks in CSDS mice. We further demonstrated that esflurbiprofen disrupted the SERT-nNOS complex in the DRN, augmented membrane-associated SERT, and reduced the concentration of 5-HT in the extracellular space of the DRN. This cascade subsequently enhanced serotonergic neuronal firing through the inhibition of negative feedback mediated by 5-HT 1A R auto s, culminating in an augmented release of 5-HT from serotonergic neurons projecting to the prefrontal cortex and hippocampus. These results highlight the potential of esflurbiprofen to induce rapid antidepressant effects by targeting the SERT-nNOS interaction within the DRN.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-8
·
IF 16.6
Liu Changhao,Zhang Ningsi,Li Yang,Fan Rongli,Wang Wenjing,Feng Jianyong,Liu Chen,Wang Jiaou,Hao Weichang,Li Zhaosheng,Zou Zhigang
Durability is one prerequisite for material application. Photoelectrochemical decomposition of seawater is a promising approach to produce clean hydrogen by using solar energy, but it always faces the problem of serious Cl − corrosion. We find that the main deactivation mechanism of the photoanode is oxide surface reconstruction accompanied by the coordination of Cl − during seawater splitting, and the stability of the photoanode can be effectively improved by enhancing the metal-oxygen interaction. Taking the metastable β -Fe 2 O 3 photoanode as an example, Sn added to the lattice can enhance the M–O bonding energy and hinder the transfer of protons to lattice oxygen, thereby inhibiting excessive surface hydration and Cl − coordination. Therefore, the bare Sn/ β -Fe 2 O 3 photoanode delivers a record durability for photoelectrochemical seawater splitting over 3000 h.
研究领域:
材料科学
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光电化学
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可再生能源
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