Materials Today Chemistry
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2024
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IF 6.7
Yulong Zou,Beibei Zhou,Wenqiang Guo,Zhijie Sun,Xili Lu,Li Li
PLLA based shape-memory polymer composites with multifunctions have attracted growing attention in biomedical applications. Generally, a single nanofiller has the problem of insufficient functionalization and easy aggregation. Therefore, we design and fabricate polydopamine (PDA) surface modified MWCNTs-ZnO hybrid nanostructure ((MWCNTs-ZnO)@PDA). The dispersion of (MWCNTs-ZnO)@PDA in PLLA is improved in comparison with the pristine MWCNTs or ZnO. The results indicate that the (MWCNTs-ZnO)@PDA nanosystem shows a synergistic effect on the mechanical properties and photothermal properties of the composites. Comparative analysis with neat PLLA demonstrates a remarkable 17% increase in tensile strength and a 19% increase in elongation at break for PLLA/(MWCNTs-ZnO)@PDA composite. Additionally, the composites exhibit excellent NIR light-induced shape memory effects with a shape recovery ratio reaching 100%. Moreover, PLLA/(MWCNTs-ZnO)@PDA composites show favorable antibacterial activity against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ). Furthermore, the polymer composites display good 3D printability, and the 3D-printed porous scaffold possesses high compressive strength and modulus. Also, the PLLA/(MCNTs-ZnO)@PDA scaffold can be compressed into a compact size and recover its original shape under NIR light irradiation. This work provides an approach to prepare novel shape-memory polymer composites with multifunctions including high strength, light-induced shape-recovery, antibacterial properties and printability.
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BIOSENSORS & BIOELECTRONICS
·
2025
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IF 10.5
Qing Hu,Fanyi Qin,Huijiao Qu,Huayu Xiong,Shengfu Wang,Xiuhua Zhang,Yan Xiao
Acute kidney injury (AKI) is a common kidney disease characterized by a sudden decline in renal function. It usually has no clear clinical symptoms in its early stages, but can easily progress to renal failure or even result in death. Real-time monitoring of AKI progression significantly enhances the prospects for early diagnosis and prompt intervention. However, there is no available to monitor AKI as developing a renal-clearable and reversibly responsive probe capable of long-term in vivo track biomarkers of AKI, such as reactive oxygen species (ROS), remains an extremely challenging task. Herein, we have constructed a redox-reversible second near-infrared (NIR-II) fluorescent probe based on Au nanoclusters (Au NCs) for long-term dynamic monitoring of AKI. The probe features NIR-II excitation and emission capabilities, along with effective kidney targeting and prolonged retention, facilitating renal enrichment and enabling long-term high-resolution renal imaging. Notably, it demonstrates rapid and reversible responsiveness to ROS with high sensitivity and selectivity, permitting real-time monitoring of redox fluctuations in vivo. Given its exceptional performance, the probe achieves unprecedented real-time dynamic tracking of AKI progression, providing crucial redox status information during the disease process. Additionally, the probe can serve as an effective new tool for screening of potential therapeutic drugs for AKI. This work may offer some substantial promotion for the diagnosis and treatment of kidney diseases.
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Nano Today
·
2022
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IF 18.962
Qi-Xian Wang,Yuan-Fan Yang,Xiang-Fei Yang,Yue Pan,Ling-Dong Sun,Wen-Yuan Zhang,Yulei Shao,Jie Shen,Jian Lin,Lele Li,Chun-Hua Yan
Heterostructures of NaLnF 4 and porphyrinic metal-organic frameworks (MOF) have been reported as a promising platform for near-infrared (NIR)-driven photodynamic therapy (PDT), while the energy transfer from NaLnF 4 to MOF greatly decreased the upconversion emissions. To develop NaLnF 4 and MOF heterostructures with significantly improved PDT and imaging simultaneously is important to track their location to implement therapy accurately. Herein, we constructed Er 3+ -doped NaLnF 4 @MOF [email protected] nanoparticles to integrate NIR-driven PDT and NIR-II imaging. NaLnF 4 nanoparticles are designed with upconversion and NIR emission simultaneously under a single 980 nm excitation, where the upconversion luminescence (UCL) overlaps well with the absorption of Zr-based porphyrin MOF, enabling efficient energy transfer from NaLnF 4 to the MOF shell to generate 1 O 2 . And the NIR luminescence, which gave out under a lower excitation power than that of UCL, could be used to track the location and distribution of the heterostructures via NIR-II imaging. Moreover, antiprogrammed death-ligand 1 (α-PD-L1) immunotherapy was introduced synergistically to improve antitumor immunity efficacy. The combination of NaLnF 4 @MOF and α-PD-L1 not only inhibited primary tumors but also suppressed distant one, leading to an effective tumor inhibition rate of 95%. This work provides an integrated nanoplatform for boosting NIR-II imaging-guided PDT/immunotherapy efficacy toward tumor treatment.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2025
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IF 4.6
Xiao Li,Chengqing Zhao,Zhiyuan Wang,Suntao Shi,Huiling Gao,Jiang Wu,Baoxin Zhang
Drug-induced liver injury (DILI) is widely recognized as a major threat to global public health, posing significant obstacles to clinical treatment and drug innovation. The core mechanism underlying DILI progression is the depletion of intracellular glutathione (GSH), which is widely regarded as a key marker of oxidative liver injury and an important biomarker for early-stage DILI. In this study, we developed IC-MAC , a novel near-infrared (NIR) fluorescent probe for the highly sensitive and selective detection of GSH, which exhibited excellent photostability, a large Stokes Shift, and a significant fluorescence enhancement upon reaction with GSH. The probe demonstrated high biocompatibility and enabled real-time imaging of intracellular GSH fluctuations under physiological and oxidative stress conditions. In a mice model of acetaminophen-induced DILI, IC-MAC enabled dynamic visualization of GSH depletion in the liver and its recovery following therapeutic intervention. Fluorescence intensity was significantly correlated with the degree of GSH depletion and treatment response, providing robust evidence for the quantitative assessment of liver injury severity and drug efficacy. Collectively, these findings highlighted the potential of IC-MAC as a powerful platform for early DILI diagnosis and in vivo redox monitoring.
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CERAMICS INTERNATIONAL
·
2025
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IF 5.6
Haonan Zhao,Cuilian Wen,Lijin Luo,Jiamin Qian,Xi Lin,Yang Xu,Zhongzhi Tang,Xinyi Wang,Rongtao Zheng,Baisheng Sa
The integration of osteogenic and antibacterial properties into biomaterials is crucial for addressing infected bone defects. Mesoporous bioactive glass (MBG) is widely recognized for its bioactivity and tunable porous structure, making it a promising candidate for bone repair. However, conventional MBG lacks inherent antibacterial properties, limiting its application in postoperative infection management. In this study, we have successfully developed Ti 3 C 2 T x MXene modified MBG (Ti 3 C 2 T x /MBG) nanocomposites with osteogenic and antibacterial properties. The results reveal that the incorporation of Ti 3 C 2 T x MXene significantly enhances the mineralization capability, as evidenced by accelerated hydroxyapatite formation in simulated body fluid within 7 days compared to pure MBG. Notably, the nanocomposite exhibits no cytotoxicity toward MC3T3-E1 cells and markedly upregulates key osteogenic genes, including Alp, Runx2, Col1a1, Opn, and Ocn . Moreover, Ti 3 C 2 T x /MBG nanocomposite displays remarkable photothermal antibacterial efficacy, achieving 99.6% inhibition of Staphylococcus aureus under near-infrared irradiation. This study proposes a versatile strategy to synthesize multifunctional MXene/MBG nanocomposites with enhanced apatite mineralization, osteogenic gene expression, and antibacterial activity, demonstrating great potential for bone tissue engineering and other biomedical applications.
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SENSORS AND ACTUATORS B-CHEMICAL
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2025
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IF 7.7
Zhongkun Wang,Rui Zhu,Chenrui Li,Weiwei Xu,Liangyou Zhao,Guangjin Gao,Weihao An,Xiang Dong,Qingqing Miao,Qing Li
Bacterial infections pose a significant global health challenge, further exacerbated by the emergence of antibiotic-resistant strains, thereby necessitating the development of alternative therapeutic strategies. Type I photosensitizers, as an emerging phototheranostic modality, hold great promise for antibacterial treatment but are limited by poor specificity. Herein, we report a hydrogen sulfide (H 2 S)-activatable theranostic probe (CyIN) that integrates near-infrared (NIR) fluorescence imaging and type I photodynamic therapy (PDT) functionalities into a single platform for the precise treatment of drug-resistant bacterial infections. CyIN is rationally constructed by masking the hydroxyl group of iodine-substituted hemicyanine with a H 2 S-cleavable 2,4-dinitrophenyl group, which efficiently quenches NIR fluorescence and suppresses reactive oxygen species generation. Such molecular configuration allows CyIN to turn on its NIR fluorescence signal and type I photodynamic action upon interaction with bacterial-derived H 2 S, achieving distinguishable detection of drug-resistant bacterial infection, potent bacterial clearance (>99 %), and accelerated healing of bacteria-infected wounds. Furthermore, histological analyses confirm that the CyIN treatment can reduce inflammation, enhance collagen deposition, and promote tissue regeneration without systemic toxicity. Thus, this work presents a promising H 2 S-responsive phototheranostic platform for precise bacterial detection and efficient photodynamic eradication of drug-resistant bacterial infections.
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Advanced Healthcare Materials
·
2025
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IF 9.6
Chaofan Yao,Yu Zhao,You Wu,Haoming Wang,Hongbin Li,Jinmei He,Li Liu,Yudong Huang,Feng Cheng
Bacterial infections remain a critical challenge in wound care, demanding advanced multifunctional materials for effective treatment. Here, this work presents a 3D-printable hydrogel (STFWA) integrating a Schottky heterojunction and dual-network architecture for synergistic photothermal and photodynamic antibacterial therapy. The hydrogel incorporates W18O49-x@Au nanostructures, where Au nanoparticles are in situ grown on oxygen-deficient W18O49-x (bandgap ≈1.5 eV), forming a Schottky junction that enhances carrier separation and reactive oxygen species (ROS) generation. The dual-network matrix, composed of silk fibroin and tannic acid-Fe3+ (TA/Fe3+), exhibits robust mechanical integrity and hemostatic capability, while silk fibroin enables high-resolution digital light processing (DLP) 3D printing. The co-existence of W18O49-x and Au induces dual localized surface plasmon resonance (LSPR), while TA/Fe3+ contributes to deep coloration, collectively boosting photothermal conversion. Upon near-infrared (NIR) irradiation, the hydrogel exhibits potent antibacterial efficacy against Staphylococcus aureus and Escherichia coli through combined photothermal and photodynamic mechanisms. In vivo studies using a rat model of infected wounds demonstrate accelerated healing, enhanced angiogenesis, and regulated inflammation. This work highlights a nanostructure-enabled hydrogel platform for NIR-activated, synergistic antibacterial therapy with clinical potential in infected wound management.
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iScience
·
2025
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IF 4.1
Wenhui Zhang,Min Zhao,Leqiang Wang,Jiaqi Wang,Xiaoguang Ge,Junzhi Liu,Bin Chen,Shi Gao,Jingbin Lu
Metal-organic frameworks (MOFs) based on nanomaterials have attracted attention for tumor microenvironment (TME)-responsive therapy. However, they lack intrinsic imaging capabilities to monitor drug release and predict therapeutic outcomes. Herein, metal-phenolic nanosheets (Cu/EA-MOF) with photoacoustic (PA) imaging property in the second near-infrared window were constructed to achieve diagnosis and treatment for H 2 S-enriched tumors. Endogenous H 2 S triggers the decomposition of Cu/EA-MOF into the ellagic acid (EA) and copper sulfide (Cu 2-x S), which can be used for chemotherapy and chemodynamic therapy, respectively. Moreover, EA can enhance the efficiency of chemodynamic therapy by boosting superoxide dismutase activity. Importantly, the degradation of Cu/EA-MOF can be indicated via the change of ratiometric PA signal intensity. Furthermore, the NIR-II fluorescent molecule benzobisthiadiazole (BBT) was further introduced into Cu/EA-MOF to investigate the degradation process and drug release. As a promising theranostic nanomaterial, Cu/EA/BBT-MOF is successfully used to achieve effective synergistic therapy and predict therapeutic outcomes.
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CHEMICAL ENGINEERING JOURNAL
·
2025
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IF 13.2
Rui Jiang,Jie Zhao,Yifei Qiao,Bo Tan,Jialin Yin,Zhenyu Dai,Shiliang Mei,Wanlu Zhang,Ruiqian Guo
Near-infrared (NIR) emission has garnered significant attention owing to its broad application potential in next-generation optoelectronics. Among various candidates, indium phosphide (InP) quantum dots (QDs) have emerged as particularly promising candidate due to their environmentally benign composition and relatively facile synthesis. However, the synthesis of NIR-emitting InP-based QDs exhibiting high luminescence efficiency remains a critical challenge. The inherent difficulties primarily stem from insufficient core nucleation and the complex shell growth processes essential for achieving high-performance QDs. Herein, we report an expeditious synthetic strategy for achieving NIR-I emissive core-only InP QDs with tunable emission ranging from 683 to 742 nm, mediated by the synergistic effect of ZnCl 2 and NH 4 PF 6 . Under the competitive adsorption between ZnCl 2 and NH 4 PF 6 , high-covalent InP QDs with sizes of approximately 6 to 10 nm can be obtained within 5 min. During the later stages in this dual-salt system, PF 6 − effectively eliminates surface oxides while zinc ion enrichment establishes a negatively charged surface. This Zn-related configuration promotes subsequent adsorption and defect passivation by NH 4 + . The final core-only QDs exhibit bright NIR-I emission with a photoluminescence quantum yield of up to 74 % in solution. Furthermore, the application potential of these core-only QDs is demonstrated through simple patterning. This work establishes a straightforward, post-treatment-free synthesis of high-performance NIR-I core-only InP QDs, highlighting their substantial promise for next-generation optoelectronic devices.
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Materials Science & Engineering C-Materials for Biological Applications
·
2017
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IF 4.164
Beibei Hou,Weitao Yang,Chunhong Dong,Bin Zheng,Ying Zhang,Jing Wu,Hanjie Wang,Jin Chang
How to encapsulate and transport the payload of multiple therapeutic compounds avoiding premature leakage, and simultaneously co-release them rapidly at specific lesions still remains the major concern in clinic. Herein, we designed the UCN@mSiO 2 -(Azo + RB) (azobenzene groups and Rose Bengal) nanoimpellers, which used the multicolor-emission capability of the core-shell upconverting nanoparticles (UCNs) at a single excitation wavelength to co-release anticarcinogen doxorubicin (Dox) and reactive oxygen species (ROS) for combined chemotherapy and photodynamic therapy (PDT). The nanoimpeller was formed from UCN inner core, mesoporous silica shell, and light triggers Azo and RB molecules. The UCNs emitting UV/blue and green/red multiband light were used to activate the photoresponsive Azo and photosensitizer RB molecules; The mesoporous silica shell offered the possibilities to load anticancer drug and conjugate the light triggers; As there are strong charge interaction and hydrogen bonds between Dox and surface silanols of mesoporous silica, the azobenzene molecules worked as “gatekeeper” and “molecular stirrer” to precisely trap and propel the release of Dox under the external stimuli. The time-dependent drug release analysis, ROS production test and PDT test suggested that the nanoparticles may serve as a useful multifunctional nanoplatform for synergistic therapy and cancer diagnostic.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2025
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IF 6.3
Hua Yu,Zhexuan Gao,Huanping Wang,Shilong Zhao,Degang Deng,Shiqing Xu
Developing phosphor-converted light-emitting diodes (pc-LEDs) for portable near-infrared (NIR) spectroscopy applications has generated significant demand for NIR-II phosphors. However, developing a NIR-II phosphor with both broadband emission and good thermal stability remains a significant challenge. Herein, we report a novel Ni 2+ -doped Mg 4 Nb 2 O 9 (MNO) phosphor that exhibits a full-width at half maximum (FWHM) of 213 nm, covering a wavelength range of 1100–1700 nm, with a peak at 1319 nm when excited by 405 nm ultraviolet (UV) light. The optimized phosphor exhibited an internal quantum efficiency (IQE) of 38.31 %. By combining first-principles calculations with experimental analysis, we established that Ni 2+ ions occupy the three octahedral cation sites in the MNO host. Notably, the MNO: 0.004Ni 2+ phosphor maintains 102 % of its initial emission intensity at 423 K compared to room temperature (RT), exhibiting a zero-thermal-quenching property, which can be attributed to the thermal energy transfer from oxygen vacancy defects to activator ions, large thermal energy barrier, as well as the high rigidity of the MNO host. An NIR-II pc-LED device was constructed by encapsulating the optimized phosphor within a UV LED chip. The application of nondestructive NIR spectroscopy in detection, night vision, and bioimaging further demonstrates the potential of this device.
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2025
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IF 5.6
Mengyao Zhang,Xin Hu,Yudai Huang
Compared to the first near-infrared (NIR-I) window (650–1000 nm), the second near-infrared (NIR-II) window (1000–1700 nm) is more valuable for photothermal treatment (PTT) due to its deeper tissue penetration and lower phototoxicity. However, the therapeutic efficacy of PTT remains suboptimal owing to the inherently low photothermal conversion efficiency (PCE) of existing materials. Therefore, the development of nanomaterials with high PCE is a promising strategy for improving anti-tumor therapy. In this study, hollow semimetal PtTe 2 nanorods were synthesized. Their unique electronic properties and hollow structure contribute to achieving high PCE under NIR-II irradiation, while simultaneously promoting reactive oxygen species (ROS) generation. Additionally, PtTe 2 catalyzed the endogenous conversion of hydrogen peroxide (H 2 O 2 ) into oxygen (O 2 ) and hydroxyl radicals (•OH), further enhancing anti-tumor effects via chemodynamic therapy (CDT). In vivo experiments confirmed the excellent biocompatibility of PtTe 2 , and laser treatment following PtTe 2 administration significantly inhibited tumor growth, demonstrating its favorable therapeutic efficacy. This study establishes a new nanoplatform for the treatment of malignant tumors through photothermal/photodynamic/chemodynamic therapy, providing valuable insights for future research on multifunctional cancer therapies.
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