Scientific Reports
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2017
·Vol. 7
·期 1
·1-5
·
IF 4.259
Wang Xu-Ping,Zhou Peng-Fei,Li Zhi-Gang,Yang Bo,Hollmann Frank,Wang Yong-Hua
A Ser105Ala mutant of the lipase B from Candida antarctica enables ‘perhydrolase-only’ reactions. At the example of the chemoenzymatic Baeyer-Villiger oxidation of cyclohexanone, we demonstrate that with this mutant selective oxidation can be achieved in deep eutectic solvent while essentially eliminating the undesired hydrolysis reaction of the product.
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NANOTECHNOLOGY
·
2023
·
IF 3.5
Feitong Lu,Wei Wei,Qiang Shi,Ning Wang,Yi Xiao,Zibo Li
TiO2/graphene oxide (GO) nanocomposites with high contact interface were prepared with glycol 400 (PEG400) served as dispersant. This nanocomposite exhibits improved photocatalytic efficiency in contrast with the nanocomposite prepared without PEG400. In this work, the photocatalytic performance was investigated by observing the degradation rate of Rhodamine B (RhB). And it is found that the mass ratios of GO in nanocomposites plays an important role. When the mass ratio of GO reached 45%, the photocatalytic performance of the nanocomposites reached the highest, which is ~72%. Moreover, the photocatalytic mechanism was studied through theoretical calculations, which can be summarized as follows: 1. The presence of GO decreases the band gap of TiO2 nanoparticles. 2. GO inhibits the the recombination of photogenerated electron-hole pair. 3. GO improves the adsorption capacity of TiO2 nanoparticles for RhB. This work promoted the application of TiO2/GO nanocomposites in wastewater treatment.
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CERAMICS INTERNATIONAL
·
2026
·
IF 6
Xihao Wang,Yu Sun,Yuancheng Sun,Zihao Wang,Ailin Xia,Juan Liu
The effects of single B-site substitution (Co, Ti, Ta) and triple co-substitution (Co 1/3 Ti 1/3 Ta 1/3 , CTT) on the multiferroic properties of Bi 0.9 (La 1/4 Nd 1/4 Sm 1/4 Gd 1/4 ) 0.1 FeO 3 were systematically compared. PUND measurements reveal switching-current peaks for both the Co- and CTT-sub samples, confirming switchable ferroelectric polarization. The Co-substituted sample exhibits well-resolved switching peaks, supporting the reliability of its remanent polarization ( P r = 26.9 μ C/cm 2 ). The CTT-sub sample shows a larger PUND-supported P r (45.1 μ C/cm 2 ); however, its switching peaks are strongly merged, so the P r extracted directly from the merged peaks is less precise than that of the Co-sub sample. For the Ti- and Ta-sub samples, no PUND switching-current peaks are observed, indicating that their P r values are not reliable indicators of intrinsic ferroelectric properties. More importantly, Co substitution yields the highest remanent magnetization ( M r = 73.39 emu/mol), which is attributed to effective suppression of the helical spin structure via enhanced superexchange interactions. In contrast, the CTT-sub sample, despite its larger P ᵣ, exhibits only a moderate M r of 51.93 emu/mol. The relatively lower magnetic performance of triple co-substitution is due to dilution of magnetic Co ions by non-magnetic Ti 4+ /Ta 5+ and local lattice disorder from competitive B-site occupancy. After DC poling, the Co-sub sample exhibits a 52.5% increase in M r (to 111.91 emu/mol). Overall, Co substitution provides the most reliable ferroelectric switching and the best overall multiferroic performance, especially magnetization, whereas CTT substitution gives the largest PUND-supported polarization but with less well-resolved switching.
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Coatings
·
2026
·Vol. 16
·期 10
·1168
·
IF 3.4
Yunqing Xia,Shaomu Wen,Ming Wen,Ying Xiong,Hongjie Li,Guochuan Tu,Aiwei Sun,Lifen Tong
In this study, we attempted to use the response surface methodology with temperature, pH and thiourea concentration as control variables by systematically varying the experimental parameters in order to find the optimal preparation process for electroless deposition of Ni-B coatings. A mathematical model of the effect of different experimental parameters on the impedance of Ni-B coating was constructed by selecting the Box–Behnken Design (BBD) design, and the optimum plating solution temperature, pH and thiourea concentration for electroless deposition of Ni-B coating were discussed through optimization analysis. The surface microstructure of the Ni-B coating was characterized by SEM. The chemical composition of the Ni-B coating was analyzed by XRD and EDS, and the corrosion resistance of the coating was characterized by EIS and potentiodynamic polarization techniques. The results showed that the best morphology and the best corrosion resistance of the coatings were achieved when the plating solution temperature was 69.31 °C, the plating solution pH was 6.06, and the concentration of thiourea was 0.0015 g/L. The predicted impedance value was 5828.77 Ω, while the impedance value of the prepared coating based on the experimental setup parameters was 6041 Ω.
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ARCHIV DER PHARMAZIE
·
2023
·Vol. 356
·期 8
·2300110
·
IF 5.1
Jun-Da Qi,Yu-Qing Meng,Jingxin Sun,Wan-Xin Li,Hou-Xiang Zhai,Changhao Zhang,Jishan Quan,Cheng-Hua Jin
Four series of novel pyrazole derivatives (compounds 17a – m, 18a – m, 19a – g , and 20a – g ) were synthesized, and their antibacterial and antifungal activities were evaluated. Most of the target compounds ( 17a – m, 18k – m , and 19b – g ) showed strong antifungal activity and high selectivity relative to both Gram-positive and Gram-negative bacteria. Among them, compounds 17l (minimum inhibitory concentration [MIC] = 0.25 µg/mL) and 17m (MIC = 0.25 µg/mL) showed the strongest antifungal activity, being 2- and 4-fold more active than the positive controls gatifloxacin and fluconazole, respectively. In particular, compound 17l showed little cytotoxicity against human LO2 cells and did not exhibit hemolysis at ultrahigh concentrations, as did the positive control compounds gatifloxacin and fluconazole. These results indicate that these compounds are valuable for further development as antifungal agents.
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DYES AND PIGMENTS
·
2016
·
IF 4.055
Xing Qian,Rucai Yan,Yongjie Hang,Yuezhen Lv,Lixin Zheng,Chong Xu,Linxi Hou
Four new metal-free organic dyes QX15 – 18 based on indeno[1,2- b ]indole have been successfully designed and synthesized. These D–π–A type dyes consist of an indeno[1,2- b ]indole donor and a benzene or thiophene π-bridge. In an attempt to tune their photoelectric properties, the effects of different acceptor groups including cyanoacrylic acid, rhodanine-3-acetic acid, and 2-(1,1-dicyanomethylene)rhodanine (DCRD) have been investigated. The dye QX15 with a cyanoacrylic acid acceptor exhibited a highest V oc of 813 mV and a high J sc of 11.0 mA cm −2 , generating a highest power conversion efficiency of 6.29%. Meanwhile, the dye QX18 with a DCRD acceptor and a thiophene π-bridge showed a significantly improved J sc of 11.9 mA cm −2 , which could be attributed to its red-shifted absorption spectra and high molar absorption coefficient.
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POLYMER SCIENCE SERIES A
·
2012
·Vol. 54
·期 4
·270-281
·
IF 0.838
Luo Yan-Ling,Zhang Li-Li,Xu Feng
Brush-like block copolymers with poly( t -butyl methacrylate) (PBMA) and poly( N -isopropylacrylamide) (PNIPAAm) as side arms, PBMA- b -PNIPAAm, were designed and synthesized via a simple free radical polymerization route. The chemical structure and molecular weight of these polymer brushes were characterized and determined by nuclear magnetic resonance ( 1 H NMR), Fourier transform infrared spectrometry (FTIR) and gel permeation chromatography (GPC). The micellar formation by these polymer brushes in aqueous solutions were detected by a surface tension technique, and the critical micelle concentration (CMC) ranged from 1.53 to 8.06 mg L −1 . The morphology and geometry of polymer micelles were investigated by transmission electron microscope (TEM) and dynamic light scattering (DLS). The polymer micelles assume the regularly-spherical core-shell structure with well-dispersed individual nanoparticles, and the particle size was in the range from 36 to 93 nm. The PNIPAAm segments exhibited a thermoreversible phase transition, so the resulting block polymer brushes were temperature-sensitive and the low critical solution temperature (LCST) was determined by UV-vis spectrometer at about 28.82–29.40°C. The characteristic parameters of the polymer micelles such as CMC, micellar size and LCST values were affected by their compositional ratios and the length of hydrophilic or hydrophobic chains. The evaluation for caffeine drug release behavior of the block polymer micelles demonstrated that the self-assembled micelles exhibited thermal-triggered properties in controlled drug release.
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BIOMEDICINE & PHARMACOTHERAPY
·
2023
·
IF 7.5
Chunxia Hu,Jinyong Zhang,Ruiqin Cui,Shiyi Liu,Ying Huang,Huan Zeng,Shumin Cheng,Guibao Zhou,Jingli Li,Longqin Sun,Yan Zhao,Xiao Wang,Jianhua Liu,Quanming Zou,Wei Huang
Given the important role of polymyxin B (PB) in the treatment of drug-resistant Gram-negative bacterial infections, the emergence of PB resistance poses a serious threat to public health. Adjuvant development is a supplementary strategy that can compensate for the lack of novel antibiotics by protecting PB. In this study, we found a small molecule named Lyb24 that showed weak antibacterial activity (minimum inhibitory concentration ≥ 10 μg/ml) but potentiated and revitalized the efficacy of PB against Gram-negative pathogens, including mcr-1 - and mgrB -deletion-mediated PB-resistant strains. Our results showed that Lyb24 inhibits the translational levels of genes associated with the modification of lipid A. In addition, Lyb24 increases the permeability, disrupts the integrity and induces the depolarization of the membrane. We further found that both Lyb24 and PB could directly bind to AzoR and inhibit its activity. Structural analysis showed that Lyb24 binds to the isoalloxazine ring of flavin mononucleotide (FMN) through pi-pi stacking and loop η4 of AzoR. A pneumonia model was used to confirm that the activity against clinical PB-resistant Klebsiella pneumoniae was enhanced due to Lyb24 on PB. In conclusion, we provide a potential therapeutic regimen by combining Lyb24 and PB to treat Gram-negative-resistant bacterial infections. Our findings not only explain the synergistic effect of Lyb24, but also expand our knowledge on the mechanism of action of PB.
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Scientific Reports
·
2016
·Vol. 6
·期 1
·1-9
·
IF 5.228
Hu Linzhen,Zhu Hucheng,Li Lei,Huang Jinfeng,Sun Weiguang,Liu Junjun,Li Hua,Luo Zengwei,Wang Jianping,Xue Yongbo,Zhang Yu,Zhang Yonghui
Two pairs of new enantiomers with unusual 5,5-spiroketal cores, termed (±)-japonones A and B [(±)- 1 and (±)- 2 ], were obtained from Hypericum japonicum Thunb. The absolute configurations of (±)- 1 and (±)- 2 were characterized by extensive analyses of spectroscopic data and calculated electronic circular dichroism (ECD) spectra, the application of modified Mosher’s methods and the assistance of quantum chemical predictions (QCP) of 13 C NMR chemical shifts. Among these metabolites, (+)- 1 exhibited some inhibitory activity on Kaposi’s sarcoma associated herpesvirus (KSHV). Virtual screening of (±)- 1 and (±)- 2 were conducted using the Surflex-Dock module in the Sybyl software and (+)- 1 exhibited ability to bind with ERK to form key interactions with residues Lys52, Pro56, Ile101, Asp165, Gly167 and Val99.
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International Journal of Environmental Research and Public Health
·
2022
·Vol. 19
·期 14
·8683
·
IF 4.614
Xiang Guo,Lei Rao,Zhenyu Shi
Adsorption can quickly remove pollutants in water, while photocatalysis can effectively decompose organic matter. B-TiO2/g-C3N4ternary composite photocatalytic materials were prepared by molten method, and their adsorption–degradation capability under visible light conditions was discussed. The morphology of the B-TiO2/g-C3N4materials was inspected by SEM, TEM, BET, and EDS, and the results showed that close interfacial connections between TiO2and g-C3N4, which are favorable for charge transfer between these two semiconductors, formed heterojunctions with suitable band structure which was contributed by the molten B2O3. Meanwhile, the molten B2O3effectively increased the specific surface area of TiO2/C3N4materials, thereby increasing the active sites and reducing the recombination of photogenerated electron–hole pairs and improving the photocatalytic degradation abilities of TiO2and g-C3N4. Elsewhere, the crystal structure analysis (XRD, XPS, FTIR) results indicated that the polar -B=O bond formed a new structure with TiO2and g-C3N4, which is not only beneficial for inhibiting the recombination of electron holes but also improving the photocatalytic activity. By removal experiment, the adsorption and degradation performances of B-TiO2/g-C3N4composite material were found to be 8.5 times and 3.4 times higher than that of g-C3N4. Above all, this study prepared a material for removing water pollutants with high efficiency and provides theoretical support and experimental basis for the research on the synergistic removal of pollutants by adsorption and photocatalysis.Keywords:adsorption;degradation;B2O3;TiO2/C3N4;molten
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JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
·
2012
·
IF 2.625
Chi Ma,Di Pang,Zuochun Xiong,Wei Bai,Chengdong Xiong
Control of cellular responses is crucial for the use of electrospun membranes in biomedical applications, including tissue engineering or biomedical devices. However, it is still unclear whether adhesion and proliferation of fibroblasts is stimulated or inhibited on polyethylene glycol (PEG)-modified electrospun membranes. In this study, poly( L -lactide-co-glycolide) (PLLGA)–PEG copolymer and pure PEG were blended with PLLGA, and then electrospun onto nonwoven membranes. The effects of blending of PLLGA–PEG or pure PEG on the adsorption of proteins, and further on the adhesion and proliferation of L929 fibroblasts on the electrospun membranes were investigated. Addition of PLLGA–PEG or PEG significantly improved the hydrophilicity of the electrospun membranes. Pure PEG had no obvious effects on the growth of L929 fibroblasts; in contrast, PLLGA–PEG significantly inhibited the adsorption of proteins and the proliferations of the cells on the electrospun membranes. In response to diminished protein adsorption, mRNA expression of genes related to cell adhesion and migration was up-regulated. The limited effects of pure PEG were probably caused by its preferential dissolution, whereas membrane-confined PLLGA–PEG displayed excellent performance on the inhibition of protein adsorption and cell proliferation. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 100A:2897–2904, 2012.
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INORGANIC CHEMISTRY
·
2021
·
IF 5.165
Weiwei Cao,Xiaoyan Yang,Cécile Genevois,Mathieu Allix,Xiaojun Kuang
The new 8-layer twinned hexagonal solid solution Ba8Cr4–xTa4+0.6xO24 (x = 0.0–3.0) was isolated through the aliovalent substitution of Ta5+ for Cr3+ in Ba2CrTaO6, showing the widest B-site vacancy content range among the 8-layer twinned hexagonal perovskites. Ba8Cr4–xTa4+0.6xO24 forms a simple 8-layer hexagonal perovskite structure within 0.0 ≤ x < 2.4 and a tripled 8-layer hexagonal perovskite superstructure within 2.4 ≤ x ≤ 3.0. The latter shows expanded a and b axes by times in comparison to the simple 8-layer hexagonal perovskite structure owing to the partial face-sharing octahedral (FSO) B cation ordering along the ab plane. The B-cation and vacancy distributions in the tripled superstructure were characterized by neutron and X-ray powder diffraction and further confirmed by a scanning transmission electron microscopy–high angle annular dark field imaging and intensity profile analysis. The formation of 8-layer twinned hexagonal perovskites Ba8Cr4–xTa4+0.6xO24 in an extended solid solution range can be attributed to the presence of both covalent B–B and B–O–B bonding and B-site vacancies in the FSO sites. This work provides an effective way of combining covalent B–B and B–O–B bonding and vacancy creation as well as the cationic ordering in the FSO sites to reduce electrostatic repulsion, which could further enable the stabilization of new hexagonal perovskite compounds.
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