查找使用阿拉丁产品的科研文献

Nano zero-valent iron-mediated sodium alginate/polyacrylic acid composite hydrogel: evaluation of hemostatic effects on post-extraction bleeding in anticoagulated mice

Zhao Fang-bing,Xu Yong-kang,Zhang Jing-wen,Cheng Yu-lin,Geng Yuan-ming,Shen Xiao-qing

Objectives This study evaluated the hemostatic efficacy, biocompatibility, and wound healing promotion of a sodium alginate/polyacrylic acid composite hydrogel (SPI hydrogel) mediated by nano zero-valent iron (nZVI) in anticoagulated mice with post-extraction bleeding. Materials and methods Primary human gingival fibroblasts were cultured in media containing different concentrations (1%, 10%, 25%, 50% concentration) of SPI hydrogel extracts and tested for biocompatibility using the cck8 assay. CD-1 mice were modeled for anticoagulation using oral anticoagulants. After confirming modeling success via INR assessment, mice were divided into cotton (Control), gelatin sponge (GS), and hydrogel (SPI) groups. Experiments included tooth extraction hemostasis and tail amputation tests, alongside postoperative healing observation of extraction sockets and comparative histopathological analysis. Results The hydrogel extract at 50% concentration showed slight cytotoxicity and the remaining concentrations were biocompatible. Post-extraction bleeding volume in the SPI group (40 ± 21 mg) was lower than in the Control (265 ± 93 mg) and GS (133 ± 41 mg) groups. Following tail amputation, SPI group bleeding volume (7.90 ± 5.15 mg) was lower than the control group (22.70 ± 12.86 mg), and hemostasis time (1020 ± 115.11 s) was shorter than control group (1500 ± 151.24 s). HE and Masson test of wound tissue revealed superior healing, reduced inflammation, and normal collagen formation in the SPI group. Conclusion SPI hydrogel has acceptable biocompatibility, hemostatic efficacy and wound healing properties, surpassing conventional materials in treating anticoagulant-induced post-extraction bleeding. Clinical relevance It provides a potential alternative for managing anticoagulant-induced bleeding after tooth extraction clinically. Graphical abstract

A cellulose carbamate–grafted sodium alginate semi-interpenetrating network fertilizer with enhanced water retention and controlled nutrient release for sandy soil improvement

Yan Zhang,Yonghao Yan,Wen Xiong,Xiang Si,Shengkai Yang,Dinghai Qi,Pingqiang Gao

To address agricultural water shortage and low fertilizer utilization efficiency, this study developed a biodegradable carbamate cellulose‑sodium alginate/urea-formaldehyde resin hydrogel (CCS-NaAlg/UF) with dual water retention and nutrient slow-release functions. The material was prepared via chemical crosslinking with citric acid combined with physical crosslinking by urea-formaldehyde resin. Its structure was characterized using FT-IR, XRD, XPS, and SEM. Water absorption kinetics, cyclic stability, and soil water retention were evaluated, while nitrogen slow-release characteristics were assessed through leaching experiments. Degradation performance and practical application effects were investigated via soil burial tests and millet pot experiments. Results showed that the hydrogel reached swelling equilibrium in deionized water within 40 min with a water absorption ratio of 35.38 g/g. At 3 wt% addition to sandy soil, the maximum water retention rate increased to 94.8%, with the effective retention period extended to three times that of blank soil. Nitrogen slow-release performance was excellent, with cumulative release rates of 48.9% in water and 35.6% in soil within 30 days, with both release profiles conforming to the Korsmeyer-Peppas model (R 2  > 0.93). Under drought stress, millet growth was significantly superior to the untreated group at both 7 and 14 days. The material achieved 43.07% soil burial degradation after 49 days with no microplastic residues. This work provides a green, efficient strategy for integrated water-fertilizer management in arid and semi-arid regions.

Glycerol/NaCl-Regulated Poly(vinyl alcohol)/Sodium Alginate/Graphene Oxide Composite Gels with Low-Temperature Flexibility and a Strain-Dependent Resistance Response

Flexible gel sensors can lose mechanical compliance and electrical stability at low temperature or during solvent loss. A poly(vinyl alcohol) (PVA)/sodium alginate (SA)/graphene oxide (GO) composite gel was prepared by freeze–thaw cycling and post-treated in either aqueous NaCl or a NaCl-containing water/glycerol mixture (1:2,v/v). The water/glycerol–NaCl-treated gel (F-G/S/P/G) exhibited a maximum tensile stress of 428 ± 27 kPa and an elongation at break of 432 ± 27% at room temperature (n= 3), and remained visibly deformable after 24 h at −20 °C. During ambient storage, it retained approximately 89% of its initial mass after 35 days. The cycle-averaged peak ΔR/R0increased from 0.135 at 20% strain to 1.142 at 250% strain, and the 20–60% linear region gave a gauge factor of 1.01 (R2= 0.9988). Three independently prepared sensing elements gave a peak ΔR/R0of 0.710 ± 0.019 at 100% strain, with response and recovery times of 1.22 ± 0.07 and 1.04 ± 0.06 s, respectively. After 500 cycles at 100% strain, the normalized peak response retained 95.1% of its initial value. Overall, F-G/S/P/G combined low-temperature deformability, ambient-storage mass retention, and repeatable resistance sensing.

Preparation, optimization and in vitro activity analysis of PVA/gelatin/sodium alginate-based (PGS) hydrogels loaded with Gardeniae Fructus Preparatus (JZZ) extract

Chenhao Liu,Chuchu Shan,Zebin Yu,Changyi Ye,Yunqiu Shen,Chunmei Yuan,Yifeng Pan,Yuyan Zhang,Xingying Chen

In this study, polyvinyl alcohol (PVA) was introduced into the traditional gelatin (Gel)/sodium alginate (SA) system, and PVA/Gel/SA hydrogels (PGS) were prepared by freeze-thaw cycling and Cu2+ crosslinking. After screening, proper PVA/Gel ratios were found to significantly improve mechanical strength and flexibility, with all formulations showing high water content and swelling ratios. Among them, PGS4 (5% Gel, 3% PVA, 2% SA) and PGS6 (5% Gel, 7% PVA, 2% SA) showed optimal mechanical performance (321.65 and 428.80 kPa) and proper swelling behavior (swelling ratios of 13.80 and 12.65 at 24 h). After loading the extract of Gardeniae Fructus Preparatus (JZZ), the water content of JZZ-PGS4 and JZZ-PGS6 decreased slightly, while swelling behavior was basically unchanged. JZZ-PGS4 had favorable stability (37.21% degradation at 14 days), high encapsulation efficiency (82.73%) and effective drug release behavior. Both JZZ-PGS4 and JZZ-PGS6 exhibited strong antioxidant activity. PGS4 and PGS6 showed moderate antibacterial activity and good cytocompatibility, which were enhanced by JZZ extract. In conclusion, JZZ-PGS4, possessing balanced comprehensive properties, could serve as a drug-loaded hydrogel platform based on the PVA/Gel/SA system for chronic diabetic wounds.

Carboxymethyl chitosan/polyvinyl alcohol/sodium alginate hydrogels incorporating Fe3+/curcumin/tannic acid self-assembled nanocomplex with self-healing, antioxidant, and antibacterial properties

De Zhou,Zejian Xu,Tian Lan,Xiaonan Sui

Hydrogels, due to their excellent properties, were widely noted and held great potential for application in wound healing. However, conventional wound dressings are limited by insufficient antioxidant and antibacterial properties, which restricted their effectiveness in treating infected wounds. In this study, a multifunctional hydrogel (PCS/Cur@Fe&TA) was fabricated from carboxymethyl chitosan, polyvinyl alcohol, and sodium alginate via a freeze-thaw cycle method to evaluate its potential as a wound dressing. The hydrogel incorporated nanocomplex composed of curcumin, tannic acid, and Fe 3+ , which endowed the material with enhanced antioxidant and antibacterial properties. The resulting hydrogel exhibited excellent swelling capacity (400–800%) and water holding capacity (>62%), and a good degradation rate, enabling it to maintain a moist microenvironment conducive to wound healing. Moreover, after hydrogel treatment, the cell viability remained >80%, >99% hemocompatibility (hemolysis rate < 1%), and significantly enhanced antioxidant enzyme activities ( P  < 0.05). The hydrogel showed marked antibacterial activity, with inhibition zones of 1.03 cm against E. coli and 0.61 cm against S. aureus . Overall, the developed hydrogel exhibits considerable promise as a therapeutic material for accelerating wound healing. Download: Download high-res image (157KB) Download: Download full-size image

Construction and performance evaluation of coaxial 3D-printed carboxylated Euglena gracilis polysaccharide/polyvinyl alcohol/sodium alginate composite small-diameter artificial blood vessels

Yuxuan Liu,Ruofeng Yang,Hao Xu,Zongyi Li,Yan Wei,Ziwei Liang,Weimo Han,Di Huang

The clinical translation of small-diameter artificial blood vessels (inner diameter 6 mm) remains severely impeded by acute thrombosis and deficient endothelialization. To address these bottlenecks, this study leverages the superior bioactivity of carboxylated Euglena gracilis polysaccharide (CEGP) to modify conventional polyvinyl alcohol/sodium alginate (PVA/SA) vascular scaffolds, aiming to simultaneously enhance their mechanical integrity, hemocompatibility, and endothelialization-promoting capability. Here, a hierarchical network-structured CEGP/PVA/SA composite artificial blood vessel was fabricated via coaxial extrusion 3D printing coupled with a dual-crosslinking strategy (ionic crosslinking and repetitive freeze-thaw cycles). The incorporation of CEGP significantly optimized the hydrogel's printability and structural robustness. Specifically, the elastic modulus of the 1CEGP/PVA/SA group reached 2.03 ± 0.11 MPa, markedly surpassing the pristine PVA/SA control (1.22 ± 0.07 MPa), while achieving a robust clinical-grade burst pressure of 264.5 ± 7.17 mmHg (P < 0.05). Due to the synergistic effects of a highly hydrophilic surface and a negative charge barrier, the composite graft effectively restricted platelet adhesion, with the adherence density plunging from nearly 260,000 to approximately 110,000 platelets/mm². Furthermore, in vitro CCK-8 and scratch assays confirmed that the CEGP matrix profoundly accelerated the proliferation and migration of human umbilical vein endothelial cells (HUVECs), maintaining cell viability above 80% at day 5 and achieving complete scratch closure within 2 days. Collectively, the engineered CEGP/PVA/SA composite vessel establishes an exceptional paradigm for small-diameter vascular reconstruction by balancing biomimetic mechanical stability with active endothelialization induction. Download: Download high-res image (159KB) Download: Download full-size image

Ultra-stretchable, self-adhesive, antifreezing polyacrylamide/sodium alginate/polydopamine@carbon nanotubes conductive hydrogel for human micro-expression, electrocardiographic and motion signal monitoring

Chen Kexin,Zhou Ronghao,Jin Zhibin,Gong Yue,Hu Yinchun,Tian Zenghui,Wei Yan,Huang Di

Flexible sensors are indispensable components in wearable electronic devices and have great potential for applications in human health monitoring, human–machine interfaces and robotics. Conductive hydrogels have emerged as key materials for flexible sensor fabrication due to their exceptional modulus, elasticity and conductivity. Polyacrylamide (PAM) and sodium alginate (SA) were employed as the base materials, while glycerin and water were used as a binary solvent, and polydopamine-modified carbon nanotubes (PDA-CNTs) acted as conductive fillers to enhance conductivity and improve the mechanical properties of the hydrogel. A sensitive, self-adhesive and super-stretchable conductive hydrogel was successfully synthesized, which was designated as glycerol–water–polyacrylamide/sodium alginate/polydopamine-modified carbon nanotubes (GW-PAM/SA/PDA@CNTs). Experimental findings demonstrate that this hydrogel exhibits excellent mechanical properties, tissue adhesion, antifreezing and heat-resistant properties, self-healing and long-term stability. Moreover, it facilitates the monitoring of human motion signals, facial micro-expressions and electrocardiographic (ECG) signals. This study proposes a novel design strategy for the development of a multifunctional conductive hydrogel.

Physicochemical properties, stability, and oxidation kinetics of Rosa roxburghii Tratt seed oil/β-carotene proliposomes modified with sodium alginate and chitosan bilayers

Lu Yanling,Bi Huimin,Feng Yiting,Yang Jiaojiao,Han Long,Guo Lei,Fan Fangyu

ObjectivesTo enhance the stability of proliposomes co-encapsulating Rosa roxburghii Tratt seed oil (RSO) and β-carotene (βC), sodium alginate (SA) and chitosan (CS) were utilized for bilayer surface modification. In this study, the proliposomes containing RSO and βC are referred to as Ps, while the modified formulations are denoted as sodium alginate–chitosan-modified proliposomes (SA-CS-Ps).Materials and methodsThe physicochemical properties, structural characteristics, thermal stability, microstructure, rheological behavior, storage stability, and oxidation kinetics of SA-CS-Ps were investigated and compared with those of unmodified Ps and CS monolayer-modified Ps (CS-Ps).ResultsThe particle size and turbidity of Ps increased with the addition of modification layers, reaching 563.73 nm and 0.697, respectively, for SA-CS-Ps. CS and SA formed a protective bilayer through electrostatic interactions, which preserved the spherical structure of Ps while enhancing its apparent viscosity and stress. Thermal stability analysis indicated that the phase transition temperatures of CS-Ps and SA-CS-Ps were elevated by 10.57 and 15.76 °C, respectively, compared with that of unmodified Ps. During storage, the retention rates (RRs) of RSO and βC followed the order SA-CS-Ps>CS-Ps>Ps, whereas malondialdehyde and peroxide values exhibited the opposite trend. Elevated temperatures accelerated oxidation, thereby compromising the protective effect of the carriers. After 24 d at 4 °C, SA-CS-Ps demonstrated superior stability, with malondialdehyde of 0.016 μg/mg, peroxide value of 2.697 mmol/kg, and RRs of RSO of 97.15% and βC of 96.37%. The oxidation kinetics conformed to a first-order reaction model.ConclusionsGiven its enhanced protection against degradation and stability, SA-CS-Ps represents a promising candidate for the delivery of sensitive bioactive compounds. This study provides a theoretical basis for the application of bilayer-modified proliposomes in functional food delivery systems requiring enhanced stability.

Sodium alginate-based eutectogel fibers with high-speed ion channels with extreme environmental resilience and high-resolution for multi-environmental stimuli responses

Siyuan Chen,Tingxuan Duan,Xinyue Lou,Yibo Sun,Ying Chen,Xingmei Wang,Tianyu Wang,Yiyan Gao,Guanghui Gao

Hydrogel fibers have attracted considerable attention in sports science and healthcare for their merits on natural flexibility and favourable conductivity. However, creating hydrogel fiber sensors with flexibility at cryogenic temperatures and high-resolution responses to various environmental stimuli is still a tough problem. In this study, the fibers were fabricated using sodium alginate as the matrix and gelatin as the reinforcing phase, while deep eutectic solvent (DES) was chosen as the conductive phase. The eutectogel fiber sensors capable of real-time detection of multiple environmental signals were obtained through a strategy of wet spinning combined with solvent exchange. The tubular fiber structure provides more binding sites for DES molecules, improving flexibility and electrical conductivity. The presence of numerous strong and dense hydrogen bond chains within DES prevents them from freezing at temperatures as low as −70 °C. The sensors accurately monitored subtle strains (0.1%) and minute external humidity variations while simultaneously tracking human joint motion and respiratory activity. The fibers demonstrated excellent tensile strength (2.9 MPa), high electrical conductivity (1.44 mS·cm −1 ), dehydration resistance and potential for large-scale production. This work presents a promising platform to the actualization of advanced motion monitoring and the next-generation wearable sensing applications.

Sodium Alginate Modification as a Promising Strategy for Inducing Oral Immune Tolerance to Fish Gelatin-Based Cell Scaffolds to Control Allergenic Risks

Shuya Wang,Mengqing Shi,Ya Li,Lei Qin,Shuqi Jia,Xiuhan Chen,Siqi Hou,Songyi Lin,Na Sun

Abstract The allergenic risks of fish gelatin-based cell scaffolds remain an unresolved issue. The study proposed a sodium alginate modification strategy to solve allergenic risks by inducing oral immune tolerance. The strategy significantly reduced antibody production, mast cell degranulation, inflammatory mediator release, and Th2 immune response. Peptidomics and bioinformatics prediction revealed that the strategy protected CD4+ T cell epitopes (FTGASGLPG) and CD8+ T cell epitopes (e.g., GATGPTGL). Additionally, intestinal barrier function, integrity, and Th1/Th2/Th17/Treg immune balance were restored. Notably, compared with the positive control group, RORγt expression was suppressed by 73.42%, and FOXP3 expression was increased by 5.34-fold in the 1% group. Gut microbiota analysis suggested that sodium alginate modification significantly downregulated the abundance of Faecalibaculum and Lactobacillus, while increasing Prevotella. It regulates the intestinal microbiota, thereby contributing to immune tolerance induction. Overall, sodium alginate modification represents a promising strategy to promote immune tolerance.

Regulation of the encapsulation, protection, and controlled release properties of naringin by sodium alginate oxidized hydrogel as a steady-state delivery system

Shuxian Bai,Lei Chen,Hui Teng,Hesham R El-Seedi,Junyan Yu,Chao Ai

Introduction Addressing the application challenges of low oral bioavailability and poor chemical stability associated with the citrus flavonoid naringin, hydrogels featuring unique three-dimensional network structures have garnered significant attention in the field of bioactive compound delivery. Methods In this study, a natural polysaccharide hydrogel delivery system based on dynamic imine bonds was designed and constructed. By regulating the oxidation degree of oxidized sodium alginate (OSA), hydrogels with distinct pore sizes were engineered to achieve stable encapsulation and controlled release of naringin. Dynamic covalent crosslinking between the aldehyde groups on OSA chains and the amino groups of carboxymethyl chitosan (CMC) endowed the hydrogels with exceptional adaptability. Results Research indicates that increasing the oxidation state of OSA can form a denser cross-linked network, thereby significantly regulating the swelling behavior, biodegradation rate, and drug release kinetics of hydrogels. Among these, 6OSA-Hy exhibits the most ideal sustained-release properties, enabling continuous and controlled release of naringin in simulated environments. In vitro cell experiments confirmed that this delivery system exhibits excellent biocompatibility, and its released active components effectively promote cell migration, with the 6OSA-Hy group achieving a scratch closure rate of 43.5%. Discussion The above studies demonstrate that the hydrogel system developed in this research provides a sustained-release stabilization strategy for enhancing the delivery of bioactive compounds such as naringin. This approach holds potential for improving bioavailability and is expected to find applications in the development of functional foods and nutritional supplements.

Fabrication of chitosan-sodium alginate/polyvinyl butyral composite layers with synergistic oleophobic-hydrophobic properties for eco-friendly water/oil-barrier paper coating

Jing Wang,Xiuwu Wang,Yingying Han,Chenyang Zhang,Chengjun Shao,Dongming Qi,Tao Chen

To address the inherent deficiencies in the water and oil barrier properties of paper-based packaging and the environmental risks posed by traditional coatings, this study developed a fluorine-free water/oil-barrier coating using bio-based chitosan (CHI) and sodium alginate (SA), together with polyvinyl butyral (PVB), as raw materials. A two-step modification strategy of cross-linked network construction and hydrophobic capping enhancement was employed. A dense cross-linked polysaccharide network underlayer was fabricated on the paper substrate via electrostatic interactions between CHI and SA combined with Ca 2+ -mediated crosslinking, which filled the substrate pores and imparted oil resistance. This was followed by the introduction of a PVB-based hydrophobic capping layer. The synergistic hydrogen bonding between PVB and polysaccharides significantly enhanced the coating's water resistance and structural stability. The composite coating exhibited excellent water and oil resistance, superior water vapor barrier performance, effectively improved the mechanical strength of the paper substrate, and demonstrated good tolerance to common solvents such as ethanol, hexane, and xylene. Furthermore, the excellent biodegradability of the coating was demonstrated through soil burial tests. The study presents a feasible technical solution for producing green, high-performance water/oil-barrier paper, effectively advancing the application of paper-based packaging in the food industry.