INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2021
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IF 6.953
Xiang Xiao,Yurong Zhou,Cui Tan,Juan Bai,Ying Zhu,Jiayan Zhang,Xinghua Zhou,Yansheng Zhao
β-glucan is an important functional active component with relatively high content in barley. It is reported to possess various biological activities, including anti-oxidative stress, but its mechanism of action remains obscure. In the current study, C. elegans was used as an in vivo animal model to explore its anti-oxidative stress mechanism. We found that both RBG (raw barley β-glucan) and FBG (fermented barley β-glucan) could significantly reduce the ROS level in C. elegans under oxidative emergency conditions. In addition, both FBG and RBG had positive effects on SOD and CAT enzyme activity, and FBG treatment obviously reduced the MDA content in nematodes under oxidative stress. Moreover, FBG and RBG pretreatment could extend the median lifespan of C. elegans under oxidative stress. The CB1370 and CF1038 mutants further confirmed that daf-2 and daf-16 were necessary for FBG or RBG to participate in anti-oxidative stress, and the RT-PCR results also evidenced that β-glucans resist oxidative stress in C. elegans partially through the daf-2 / daf-16 pathway. In summary, barley β-glucan has high potential to defense oxidative stress as a natural polysaccharide.
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Journal of the Taiwan Institute of Chemical Engineers
·
2021
·
IF 5.876
Yue Teng,Guangqing Song,Rong Chen,Xiao Zhang,Yongjun Sun,Haixia Wu,Biming Liu,Yanhua Xu
Background Excessive nitrate and phosphate in water is a major cause for eutrophication. Methods Carboxymethyl β-cyclodextrin immobilized on hydrated lanthanum oxide (LaCD) composite was fabricated, using carboxymethyl β-cyclodextrin (CM-β-CD) to immobilize hydrated lanthanum oxide (HLO). LaCD can efficiently and simultaneously adsorb nitrate and phosphate. Significant findings Results disclosed that the adsorption capacity in sole system reached 37.50 mg N/g and 66.98 mg P/g, whereas the adsorption capacity in binary system reached 31.62 mg N/g and 64.05 mg P/g. LaCD can also maintain high and stable adsorption efficiency within a wide pH range (4–11). Characterizations indicated excellent adsorption efficiency of LaCD for nitrate and phosphate. This finding may be due to electrostatic interaction, hydrogen bonding of abundant oxygen-containing groups on CM-β-CD surface and host-guest interaction in β-cyclodextrin (β-CD) cavity. HLO on LaCD had specific adsorption to phosphate through Lewis acid-base interaction and ligand exchange. Ten cycles verified LaCD had excellent reusability in adsorption-desorption experiments. This study may provide a supplementary method for synchronous and efficient removal for nitrate and phosphate to solve water eutrophication problem.
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NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
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2023
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IF 3.6
Chen Min,Huang Shanjiao,Weng Shuoyun,Weng Junting,Guo Rongjie,Shi Bingbing,Liu Danjuan
Septic cardiomyopathy (SCM) is manifested by impairment of cardiac contractile function with myocardial mitochondrial dysregulation. Natural product, songorine (SGR), a diterpenoid alkaloid derived from the lateral root of Aconitum carmichaeli , has been reported for the treatment of heart failure. Here, the protective role of SGR in heart injury of SCM was investigated and its underlying action of mechanism was explored. Firstly, the mouse and cardiomyocytes (H9C2 cell) SCM model induced by LPS were established to evaluate the therapeutic effect of SGR. The in vivo results exhibited that SGR rescued the survival rate of SCM mice, restored the loss of ejection fraction (EF) and fractional shortening (FS), and reduced left ventricular systolic diameter and left ventricular diastole diameter (LVIDs, LVIDd) by echocardiography. SGR improved the mitochondrial biosynthesis and myocardial fiber structure and arranged them neatly by transmission electron microscope (TEM). Further, SGR inhibited inflammatory targets myeloperoxidase (MPO) and tumor necrosis factor (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), and plasminogen activator inhibitor-1 (PAI-1). And SGR activated the mitochondrial biosynthesis–related peroxisome proliferator–activated receptor-γ coactivator-1α (PGC-1α), β-catenin, and matrix metallopeptidase 2 (MMP2) proteins. Meanwhile, the in vitro results showed that SGR promoted the increased the myocardial H9C2 cell viability, and mitochondrial biosynthesis and structure. SGR also blocked the inflammatory factors and reversed PGC-1α, β-catenin, and MMP2 in vitro, while SGR alleviated the myocardial cell apoptosis via flow cytometry. The findings indicate that SGR mitigates sepsis-caused myocardial damage by Wnt/β-catenin signaling pathway–mediated mitochondrial biosynthesis. SGR may be a promising candidate for treatment of SCM. Graphical Abstract
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ADVANCED ENGINEERING MATERIALS
·
2022
·Vol. 24
·期 8
·2101550
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IF 4.122
Jianhang Du,Weiye Liu,Zhanrong Kang,Bin Yu,Dejian Li,Huifeng Ding,Jianming Huang
3D-printed bioceramics derived from silicone resin are of great interest in bone tissue engineering owing to their simple processes and low cost. Herein, PCN-224, as a subclass of metal−organic frameworks (MOFs), is successfully fabricated and deposited on the surface of 3D-printed porous β-Ca 2 SiO 4 (C 2 S) scaffolds. The composite scaffolds possess uniform interconnected macropores (≈400 μm), with increased porosity and slower degradation. The results indicate that deposition of PCN-224 significantly promotes cell proliferation and the expression of osteogenesis-related genes. Moreover, the composite scaffolds significantly improve calvarial defect healing in rats, compared with C 2 S scaffolds. Therefore, the PCN-224-modified 3D-printed porous C 2 S composite scaffolds are promising candidates for bone tissue engineering.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
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2026
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IF 4
Lei Gong,Zhenghang Wang,Hao Chen,Kaili Xuan,Yuchen Ding,Junqiang Zhang,Mengqi Wang,Qingxi Wu,Yan Chen
BACKGROUND Cacumen Platycladi (CP), the dried twigs and leaves of Platycladus orientalis , is a food-related botanical with potential hair health-promoting activity. However, the principal bioactive constituent responsible for its anti-alopecia effect and the underlying mechanism remain unclear. This study aimed to identify the key anti-alopecia constituent of CP and investigate its mechanism of action against androgenetic alopecia. RESULTS Six major candidate compounds were identified from CP by fractionated extraction, gas chromatography–mass spectrometry, liquid chromatography–mass spectrometry, and network pharmacology analysis. Among them, amentoflavone showed the strongest anti-alopecia activity. In a testosterone-induced mouse model, amentoflavone increased mean hair length by 1.10-fold and hair density by 1.33-fold versus the model group, improved follicular morphology, reduced the proportion of vellus hair by 50.8%, and regulated serum hormone levels. Western blot analysis further showed that amentoflavone increased β-catenin and cyclin D1 expression while decreasing GSK-3β expression. CONCLUSION Amentoflavone was identified as the principal anti-alopecia constituent of CP. Its beneficial effect was associated with activation of the Wnt/β-catenin signaling pathway, suggesting that CP is a promising source of functional bioactive compounds for hair health-related applications. © 2026 Society of Chemical Industry.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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2019
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IF 4.833
Xiu-Fang Shi,Ming-Ming Wang,Shu-chao Huang,Jiang-Xue Han,Wen-Chao Chu,Chunling Xiao,En Zhang,Shangshang Qin
Metallo-β-lactamase (MBL)-producing carbapenem-resistant Enterobacterales (CRE) pose an emerging threat to public health worldwide. An effective inhibitor of MBLs is therefore urgently needed for clinical use. In this study, two acyclic pyridine-containing ligands, H 2 dedpa and compound 8, were discovered with excellent activities when combined with meropenem (MEM) against MBL ( bla NDM and bla IMP )-producing clinical isolates, including Escherichia coli , Citrobacter freundii , Proteus mirabilis , Enterobacter cloacae and Klebsiella pneumoniae . In particular, these two compounds improved the activity of MEM against E. coli harboring the bla NDM-4 gene by nearly 40,960 times. H 2 dedpa (IC 50 = 0.17 ± 0.04 μM) and compound 8 (IC 50 = 0.04 ± 0.02 μM) showed higher inhibitory activity against bla NDM-1 enzyme than the positive control ethylenediaminetetraacetic acid (EDTA, IC 50 = 28.84 ± 0.70 μM). A sterilization kinetics experiment showed that H 2 dedpain combined with MEM could kill 99.9% of bacteria within 24 h H 2 dedpa and compound 8 are therefore promising MBL inhibitors.
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ChemistrySelect
·
2023
·Vol. 8
·期 45
·e202303620
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IF 2.1
Wei Ming Liu,Hui Yun Zhou,Li Jun Ren,Jia Jia Yang,Pei Yan Hao,Jia Nan Tong,Ya Wei Chen,Jun Liang Chen,Hyun Jin Park
Graphical In this study, hydrosoluble Lysine-modified β-cyclodextrin (Lys-β-CD) was synthesized. Then Berberine hydrochloride Lysine-β-cyclodextrin inclusion complexes (BBH/Lys-β-CD IC) were prepared by the co-deposition method and optimized using the Box-Behnken design. The phase solubility and the release behavior of inclusion complexes were studied. The inclusion complexes were characterized by SEM, FTIR and NMR. Furthermore, the binding pattern of BBH with the Lys-β-CD was investigated by molecular docking study. Berberine hydrochloride (BBH) is an isoquinoline alkaloid, and its diverse bioactivities have been studied for decades. However, BBH exhibits poor solubility and low oral bioavailability, which hampers its potential therapeutic exploitation. In this study, hydrosoluble Lysine-modified β-cyclodextrin (Lys-β-CD) was synthesized. Then BBH-Lysine-β-cyclodextrin inclusion complexes (BBH/Lys-β-CD IC) were prepared by the co-deposition method and optimized using the Box-Behnken design. In addition, phase solubility was studied and showed that BBH and Lys-β-CD can form inclusion complexes in a stoichiometric ratio of 1 : 1. The morphological characterizations exhibited that the IC had an irregular sheet and layered structure. The results of FTIR and 1 H NMR revealed that BBH entered the Lys-β-CD cavity with non-covalent interactions between host-guest molecules. Furthermore, the binding pattern of BBH with the Lys-β-CD was investigated by molecular docking study. The release behavior of IC showed that BBH could be released slowly from the inclusion complex. Hence, the Lys-β-CD IC has broad application prospects in drug delivery and biomedical fields.
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AIP Advances
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2023
·Vol. 13
·期 12
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IF 1.6
Wang Ying,Yang Shuai,Li Xiang,Huang Wei,He Zheng-fa,Fu Xian-liang,Zhu Li,Xu Man
Developing a highly efficient water-splitting photocatalyst for hydrogen production under visible light is urgent. In this study, β-SiC nanowire photocatalysts loaded with 0.01–0.1 wt. % nickel were prepared. Their microstructure and hydrogen production activity were studied. The catalyst with 0.05 wt. % nickel and a sacrificial agent Na 2 S–Na 2 SO 3 shows the highest hydrogen production rate of 375.4 µ mol g −1 h −1 since the loaded nickel prohibits the recombination of photogenerated electron–hole pairs in the system, which enhances the photocatalytic activity.
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Materials Horizons
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2023
·Vol. 11
·期 4
·1023-1031
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IF 13.3
Weichen Song,Jiankun Sun,Qian Wang,Han Wu,Kunpeng Zheng,Binbin Wang,Zhong Wang,Xiaojing Long
Organic semiconductor (OSC) gas sensors with good mechanical flexibility have received considerable attention as commercial and wearable devices. However, due to poor resistance to moisture and low conductivity, the improvement in the sensing capability of individual OSCs is limited. Reported here is a promising pathway to construct a series of conjugated organic polymers (COPs) with well-defined pyrimidine (Py-COP) or boron β-diketone (BF-COP) units. Unlike traditional metal- or carbon-based hybrid materials, the developed COPs can provide abundant absorption sites for gaseous analytes. As a result, the as-prepared BF-COP results in an excellent sensing response of over 1500 (Ra/Rg) toward 40 ppm of NH3 at room temperature, which is the highest value among those of pristine COPs as n-type sensing materials. Notably, they can maintain their initial sensing responses for two months and 90% relative humidity resistance. Combining the results of in situ Fourier transform infrared spectroscopy and theoretical calculations, the β-diketone skeleton is found to activate the surface electronic environment, verifying that the electron-deficient B ← O groups are adsorption centers. The B/N-heterocyclic decoration effectively modulates the redox properties and electronic interactions, as well as perturbs charge transfer in typical π-conjugated COPs. These results offer insight into developing highly efficient OSC gas sensors, which potentially have broadened sensing applications in the areas of organoboron chemistry.
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BIOMACROMOLECULES
·
2023
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IF 6.2
Juanli Shen,Shiyu Fu,Xiaohong Liu,Shenglong Tian,Detao Liu,Hao Liu
β-Cyclodextrin (β-CD) is often used as a drug carrier for biomedical materials due to its unique cavity structure. Herein, β-CD was modified by acryloyl chloride and further copolymerized with N-isopropylacrylamide (NIPAM) and acrylic acid (AA) to obtain PNIPAM-co-β-CD-AC. The results showed that the critical phase transition temperature of PNIPAM/β-CD-AC could be controlled at 19 °C, and the fast sol–gel phase transition was realized in 2–10 s. The hydrophobic drug carried in this hydrogel can constantly be released for more than 6 days at pH values (pH 5.5–8), and the duration may match the recovery of the wound. As a dressing hydrogel, its rapid gel formation and inversion as well as shear-thinning behavior prevent secondary wound damage. The β-CD-based hydrogel also has good biocompatibility and antioxidant properties, which provide a good potential choice for wound dressings, especially for exposed wounds in winter.
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MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Chao Chen,Jiayue Ren,Pengcheng Zhao,Jin Zhang,Yongjun Hu,Junjie Fei
Dopamine (DA) is an important neurotransmitter in human’s brain, which has direct connection to diseases like Parkinson’s disease, schizophrenia, etc. Therefore, the sensitive and rapid quantitative detection of DA is essential for medical diagnosis and disease prevention. To construct a novel electrochemical sensor for DA detection, nickel-based metal–organic frameworks (Ni–MOF) were synthesized through a hydrothermal method and combined with β-cyclodextrin. Under optimal experimental conditions, the sensor exhibited a wide linear detection range (0.7–310.2 μM) and a low detection limit (0.227 μM). Furthermore, the sensor exhibited satisfactory stability and accuracy in an electrochemical study involving human serum and dopamine hydrochloride injection samples containing DA, and the redox mechanism of the sensor was elucidated. Overall, this study presents a novel electrochemical sensor based on cyclodextrins and MOFs for DA detection.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2023
·
IF 6.2
Shenghai Xin,Xiaoping Dong,Duolong Jin,Liying Yang,Dandan Su
Aqueous zinc-ion batteries (RZIBs) are one of the favorable complementary candidates for lithium-ion batteries. The cathode material determines the whole performance. Herein, β-MnO 2 /3D GPE-CNTs hybrid cathode materials were fabricated by intermittent high-energy vibratory ball milling method. It delivered a higher specific discharge capacity of 313.31 mAh·g −1 and excellent cycling stability compared to the bare β-MnO 2 sample. Morphological characterizations revealed that the enhanced electrochemical performance of the β-MnO 2 /3D GPE-CNTs hybrid was mainly attributed to the three-dimensional framework structure, large specific surface area, and good conductivity of GPE-CNT, as well as its resulting particle refinement with uniform dispersion and partial suppression of grain amorphization . This article provided a new sight of fabricating Mn-based materials/conducting carbon material hybrid for good performance cathode in RZIBs.
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