NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Jie Song,Yingnan Zhou,Lijun Chen,Zhiwen Yuan,Yuhua Niu,Xi Li,Liangxian Huang
This study employed β-cyclodextrin (β-CD) for the hydrophilic modification of iron tetraoxide (Fe3O4) magnetic materials. Subsequently, potassium humate (KHA) and carboxymethyl cellulose (CMC) were used as raw materials. A β-CD@Fe3O4/KHA/CMC/AM/MAH hydrogel with magnetic properties which can be easily recycled was synthesized for the slow release of glyphosate (GLY). FTIR, XRD, TG and VSM analyses demonstrated that the hydrogel possesses good thermal stability and magnetic properties with a saturation magnetization strength of 29.77 emu g−1. The equilibrium solubility of the hydrogel in pH = 7.4 and pH = 8.5 buffer was 24.58 g g−1 and 25.83 g g−1, respectively. The maximum release of GLY was recorded at 63.31% and 67.78%, with the drug release behavior under different loading gels following the Fickian diffusion mechanism. A pot planting experiment indicated that the water content of plants treated with the β-CD@Fe3O4/KHA/CMC/AM/MAH drug-loaded gel decreased by 51.69%. Additionally, soluble protein levels decreased to 2.69 mg g−1, chlorophyll content decreased to 0.486 mg g−1, SOD levels decreased to 43.81 U g−1, and MDA increased to 4.02 μmol g−1, effectively inhibiting the growth of grass and providing a theoretical basis for achieving slow drug release.
研究领域:
材料科学
·
高分子科学
·
环境科学
·
农业化学
·
纳米技术
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DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Xinlin Jiang,Zipeng Wu,Xiaoru Tan,Yichen Lin,Hui Xing,Yinglin Xuan,Dong Ma,Xin Cui
Hyperuricemia-related diabetic wounds are notoriously difficult to treat due to elevated uric acid (UA) levels, excessive reactive oxygen species (ROS), and chronic inflammation. Current therapies often fail to address these underlying causes, underscoring the need for innovative approaches that not only clear UA but also mitigate inflammation and promote tissue regeneration. In this study, we developed a polyrotaxane-based microsphere (HPR MS) system conjugated with 4,5-diamino-2-thiouracil (DT) to achieve high-affinity UA clearance without increasing cytotoxicity. By leveraging the molecular motility of the polyrotaxane structure, featuring β-cyclodextrin (β-CD) shuttles along the F-127 axis, we significantly improved the molecular recognition between DT and UA for enhanced UA absorption efficiency. In vitro experiments confirmed that HPR/DT MS rapidly reduced UA levels compared to control groups. Using a type 2 diabetic wound model, HPR/DT MS treatment effectively reduced UA levels, suppressed COX-2 expression, and transformed the immune microenvironment from a pro-inflammatory to a regenerative state in vivo . This was accompanied by enhanced M2 macrophage polarization, angiogenesis, and improved blood perfusion, resulting in accelerated wound healing. Overall, these findings highlight HPR/DT MS as a promising therapeutic strategy for hyperuricemia-related diabetic wounds, targeting the core pathological factors to improve wound repair.
研究领域:
药学
·
生物医学工程
·
伤口愈合
·
糖尿病研究
·
炎症
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DOI
PubMed
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2019
·Vol. 166
·期 6
·B388
·
IF 3.12
Jingdang Chai,Jie Zhang,Yangping Wen,Lie Zou,Xinxin Zhang,Xing Xin,Muhan Zhou,Jingkun Xu,Ge Zhang
An electrochemical sensor based on PEDOT:PSS-β-CD-SWCNT-COOH/GCE for highly sensitive analysis of shikonin (SHI) in PBS buffer solution was reported. PEDOT:PSS-β-CD-SWCNT-COOH composite was obtained by using poly(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate) (PEDOT:PSS), β-Cyclodextrin (β-CD) and carboxylated single-walled carbon nanotube (SWCNT-COOH) to modify glassy carbon electrode (GCE) and characterized by scanning electron microscopy and electrochemical impedance spectroscopies. In optimized conditions, PEDOT:PSS-β-CD-SWCNT-COOH had a high sensitivity to SHI and it could detect SHI in linear ranges 6 nM to 30 μM with a low detection limit of 1.8 nM. And a series of experiments showed that the modified electrode exhibited good repeatability, reproducibility, and selectivity to electrochemical determination of SHI.
研究领域:
分析化学
·
生物医学工程
·
材料科学
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DOI
高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 5
·321
·
IF 5.4
Liu Shicong,Zhang Yuanyuan,Zhao Hongyang,Liu Junqiu,Hou Chunxi
A “turn-on” fluorescence sensor was developed for cholesterol detection on the basis of fluorescence resonance energy transfer (FRET) between the organic fluorophore 1-(4-(1,2,2-triphenylvinyl)phenyl)pyrene (TPE-Py) and a gold nanoparticle-β-cyclodextrin conjugate (AuNPs-β-CD). Mechanistically, the AuNPs-β-CD, an energy acceptor, was synthesized via Au–S bonding, and TPE-Py transferred energy to the AuNPs via FRET, resulting in fluorescence quenching of TPE-Py. In the presence of cholesterol, which has a stronger binding affinity for the β-CD cavity, TPE-Py was competitively displaced, enabling the recovery of the fluorescence signal. This sensor has high sensitivity for cholesterol, with a low detection limit of 66 nM and a linear range of 0.5–30 µM. Furthermore, the sensor was successfully used to determine the cholesterol content in food samples with satisfactory recoveries, revealing its potential for food analysis.
Section
Graphical abstract
The alternative text for this image may have been generated using AI.
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DOI
PubMed
高影响因子
JOURNAL OF AOAC INTERNATIONAL
·
2019
·Vol. 97
·期 1
·121-127
·
IF 1.201
Wang Lili,Deng Jian,Ji Xuezhen,Liu Wanbin,Liang Jun,Yan Xiaona,Chen Dan,Xie Jie
A novel derivative β-cyclodextrin (β-CD) bonded silica gel (β-CD/SiO2) was prepared via carbodiimide activation and used as a chiral stationary phase (CSP). The β-CD/SiO2 CSP was characterizedby X-ray photoelectron spectroscopy and FTIR spectroscopy to prove the successful immobilization of β-CD onto the surface of the silica gel.The thermal behavior of the CSP was studied by differential scanning calorimetry and then used forthe chiral separation of racemic naproxen using HPLC. Several factors affecting the separation efficiency of naproxen enantiomers were investigatedsystematically. The following parameters were selected: methanol–0.01 M phosphate buffer solution (85 + 15, v/v, pH 3.5) was the mobile phase, the flow rate was 1.0 mL/min, and the column temperature was 35°C. Under optimal conditions, the racemic naproxen was efficiently separated with a resolution factor (RS) of 1.70 and a separation factor (α) of 1.25. This method was successfully used for the enantiomeric separation and purity assessment of naproxen in commercial naproxen sustained release tablets.
研究领域:
分析化学
·
药学
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产品关联
DOI
PubMed
高影响因子
npj Science of Food
·
2023
·Vol. 7
·期 1
·1-10
·
IF 6.4
Qiu Chao,Zhang Zhiheng,Li Xiaojing,Sang Shangyuan,McClements David Julian,Chen Long,Long Jie,Jiao Aiquan,Xu Xueming,Jin Zhengyu
In this study, composite nanoparticles consisting of zein and hydroxypropyl beta-cyclodextrin were prepared using a combined antisolvent co-precipitation/electrostatic interaction method. The effects of calcium ion concentration on the stability of the composite nanoparticles containing both curcumin and quercetin were investigated. Moreover, the stability and bioactivity of the quercetin and curcumin were characterized before and after encapsulation. Fluorescence spectroscopy, Fourier Transform infrared spectroscopy, and X-ray diffraction analyses indicated that electrostatic interactions, hydrogen bonding, and hydrophobic interactions were the main driving forces for the formation of the composite nanoparticles. The addition of calcium ions promoted crosslinking of the proteins and affected the stability of the protein–cyclodextrin composite particles through electrostatic screening and binding effects. The addition of calcium ions to the composite particles improved the encapsulation efficiency, antioxidant activity, and stability of the curcumin and quercetin. However, there was an optimum calcium ion concentration (2.0 mM) that provided the best encapsulation and protective effects on the nutraceuticals. The calcium crosslinked composite particles were shown to maintain good stability under different pH and simulated gastrointestinal digestion conditions. These results suggest that zein–cyclodextrin composite nanoparticles may be useful plant-based colloidal delivery systems for hydrophobic bio-active agents.
研究领域:
食品科学
·
生物化学
·
药物递送
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DOI
PubMed
高影响因子
Materialia
·
2025
·
IF 2.9
Jiaxuan Wang,Jun Pan,Han Wu
This study aims to develop PVDF composite membranes with excellent comprehensive performance by hydrophilic modification of PVDF membranes. Specifically, polyvinylpyrrolidone (PVP) was used as a porogen and dispersing agent, while β-cyclodextrin (β-CD) and chitosan (CS) served as hydrophilic modification agents. A novel β-CD/CS/PVDF composite membrane was prepared using a blending phase transformation method. This membrane exhibits excellent hydrophilicity, underwater superoleophobicity, mechanical strength, self-cleaning ability, antibacterial performance, high separation performance, and biocompatibility. The experimental results indicate that the modified membrane with the optimal ratio (MF-β/C-2/3) achieved a pure water flux of 721.79 L·m −2 ·h −1 ·bar −1 , an underwater oil contact angle exceeding 140°. The membrane exhibited exceptional retention and separation capabilities for various concentrations of MB, MG, RB, MO, Pb 2+ , and Cr 6+ . It achieved a separation efficiency exceeding 99% for both oil-water mixtures and oil-water emulsions, and also demonstrated excellent separation performance when treating simulated wastewater containing multiple pollutants. In addition, ten cycles of separation experiments were conducted for organic dyes, heavy metal ions, oil-water mixtures, oil-water emulsions and simulated wastewater respectively. The results showed that after ten cycles of reuse, the modified membrane retained good separation efficiency and water flux, demonstrating exceptional separation stability. Research has shown that PVDF composite membranes have a promising prospect in the treatment of printing and dyeing wastewater. They can simplify the process flow, reduce costs, efficiently intercept pollutants, increase operational stability, and improve treatment efficiency. They have important practical significance in promoting the resource utilization of printing and dyeing wastewater.
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DOI
高影响因子
ELECTROPHORESIS
·
2015
·Vol. 36
·期 17
·2120-2127
·
IF 3.028
Lu Yangfang,Wang Hui,Xue Yun,Gu Xue,Wang Yan,Yan Chao
Submicron, non-porous, chiral silica stationary phase has been prepared by the immobilization of functionalized β-CD derivatives to isocyanate-modified silica via chemical reaction and applied to the pressurized capillary electrochromatography (pCEC) enantio-separation of various chiral compounds. The submicron, non-porous, cyclodextrin-based chiral stationary phases (sub_μm-CSP2) exhibited excellent chiral recognition of a wide range of analytes including clenbuterol hydrochloride, mexiletine hydrochloride, chlorpheniramine maleate, esmolol hydrochloride, and metoprolol tartrate. The synthesized submicron particles were regularly spherical and uniformly non-porous with an average diameter of around 800 nm and a mean pore size of less than 2 nm. The synthesized chiral stationary phase was packed into 10 cm × 100 μm id capillary columns. The sub_μm-CSP2 column used in the pCEC system showed better separation of the racemates and at a higher rate compared to those used in the capillary liquid chromatography mode (cLC) system. The sub_μm-CSP2 possessed high mechanical strength, high stereoselectivity, and long lifespan, demonstrating rapid enantio-separation and good resolution of samples. The column provided an efficiency of up to 170 000 plates/m for n -propylbenzene.
研究领域:
分析化学
·
色谱技术
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产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Xiao Tang,Kun Wang,Zihan Liu,Xu Luo,Ming Wu,Hui Ding,Gang Liu,Qian Du
Ulcerative colitis (UC) remains a major challenge in clinical treatment due to its multivariate pathology. Developing an oral formulation that encapsulates and delivers multiple active ingredients to target colon tissues by suppressing intestinal inflammation and restoring the intestinal barrier is crucial for effectively treating UC. Here, we developed rhubarb-derived nanovesicles (RNs) and a supramolecular hydrogel platform formed by furfural-functionalized chitosan-mannose polymer and synthesized 3-maleimide HP-β-CD, with kaempferol (Kae) integrated into the hydrophobic cavity. The hydrogel's cross-linking network effectively encapsulates RNs, forming the Kae/CMCHD@RNs system. Rheology, SEM, TGA, degradation behavior, in vitro drug release, and a macrophage-targeted permeability test were performed. The results indicate that the hydrogel utilizes pH/enzyme sensitivity to ensure sustained release in the colon, while also facilitating targeted delivery to macrophages. In vivo imaging further reveals a prolonged local drug retention time in the colon. Moreover, both in vitro and in vivo studies demonstrate RNs and Kae exhibit synergistic therapeutic effects for UC, including inflammation reduction, oxidative stress alleviation, M1-to-M2 macrophage repolarization, and restoration of the intestinal barrier. Consequently, this study underscores the potential of Kae/CMCHD@RNs as a promising therapeutic approach for managing UC.
研究领域:
药剂学
·
炎症性肠病研究
·
生物材料科学
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DOI
PubMed
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2019
·
IF 2.606
Qi Lan,Donghua Di,Siling Wang,Qinfu Zhao,Yikun Gao,Di Chang,Tongying Jiang
The aim of this study was to develop a novel ocular drug delivery system based on the hydroxypropyl beta cyclodextrin (HP-β-CD) inclusion complex coated with the synthesized chitosan-N-acetyl- l -cysteine conjugate (CS-NAC) for the hydrophobic drug quercetin . The inclusion complex was prepared by the solvent evaporation method, and the concentration of HP-β-CD and CS-NAC was optimized by isolated corneal penetration test. The optimized concentration of HP-β-CD and CS-NAC was 20% (w/v) and 0.1% (w/v), respectively. The CS-NAC/quercetin-HP-β-CD had the effect on improving the ocular penetration with little ocular irritation and could increase the ocular distribution significantly. Meanwhile, Coumarin-6 (C6) labelled CS-NAC/C6-HP-β-CD possessed enhanced fluorescence and located deeper into the epithelium of cornea at the same time point compared with the uncoated one. It could also transport drug through the corneal epithelium by intracellular routes except for intercellular routes. Furthermore, it could delay the occurrence of cataract about 1 d when administrated with full-dosage quercetin. The HP-β-CD inclusion complex coated with CS-NAC is a safe and promising ocular drug delivery system for improving the bioavailability and corneal penetration of hydrophobic drug like quercetin.
研究领域:
药剂学
·
眼科学
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产品关联
DOI
高影响因子
POLYMER INTERNATIONAL
·
2023
·Vol. 72
·期 7
·664-670
·
IF 3.2
Bin Li,Mengjing Zhou,Xiaojia Xu,Jizhen Liu,Wenrui Hao,Aolin Wu
Choline chloride, acrylamide (AM) and acrylic acid (AA) were used as raw materials to prepare deep eutectic solvent, and β-cyclodextrin (β-CD) was used as filler to prepare β-CD/P(AM- co -AA) composite hydrogel by frontal polymerization. The composite hydrogel was characterized by Fourier transform infrared spectroscopy and scanning electron microscopy. The pH response, mechanical properties and self-healing of the hydrogel were studied. The results show that AA contains easily ionized –COOH, which makes the composite hydrogel have excellent pH response and super-high swelling ratio under alkaline conditions. With the addition of β-CD, due to the increase of hydrogen bonds and the combination of β-CD and polymer chains the mechanical properties of the hydrogel are obviously improved and the tensile strength and compressive strength are increased by 4.12 and 2.26 times respectively. The introduction of β-CD can improve the self-healing performance of the composite hydrogel. With the increase of β-CD content, the healing rate and healing speed of the composite hydrogel show an upward trend. In this study, a simpler and faster method is proposed to prepare self-healing composite hydrogel with excellent mechanical properties and pH responsiveness. The self-healing property and the existence of a hydrophobic cavity of β-CD make β-CD/P(AM- co -AA) composite hydrogel have potential application in wound healing. © 2023 Society of Industrial Chemistry.
研究领域:
材料科学
·
生物医学工程
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2016
·
IF 3.299
Wei Liu,Zhaoliang Wu,Yanji Wang,Huijie Zheng,Hao Yin
At present, the large scale application of batch foam fractionation is still in confrontation with many problems and difficulties, especially for the enrichment of non-surface-active materials. It is difficult to select a suitable surfactant as the collector when a non-surface-active material can only form a stable association with the expensive surfactants or has not any interactions with the commercially available surfactants. The objective of this work was to investigate the feasibility of batch foam fractionation for recovering such a non-surface-active material, puerarin. Yam mucilage, an abundant byproduct from the manufacture of yam starch, was used to generate a stable foam phase based on its good foamability. According to the properties of puerarin and yam mucilage, β -cyclodextrin ( β -CD) was selected as a basic material to establish an association between them. The results of fluorescence sensitization experiments indicated that puerarin could form an equimolar inclusion complex with β -CD and the inclusion constant was 405.8. Subsequently, β -CD was modified by introducing carbon disulfide and copper (Cu) ion. Then, puerarin could be adsorbed on the gas-liquid interface in the form of ternary complex with modified β -CD-Cu ion complex and glycoprotein molecules (see Fig. 7). Batch foam fractionation was carried out by using the crude extracting solution as the initial feeding solution, in which the concentration of puerarin was as high as 4.6 g/L. Under the suitable conditions of temperature 50 °C, pH 6.0, loading volume of feed solution 400 mL, the pore diameter of gas distributor 0.450 mm, additive volume of yam mucilage 30 mL and volumetric air flow rate 100 mL/min, the enrichment ratio and the percent recovery of puerarin were 4.3 and 82.3%, respectively. This strategy could be generalized to the separation of various non-surface-active materials due to the low cost and the diversiform cavity dimension of cyclodextrins.
研究领域:
植物化学
·
分离工程
·
天然产物开发
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DOI
高影响因子
危险品化学品经营许可证（带存储）