JOURNAL OF CULTURAL HERITAGE
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2026
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IF 3.7
Ruofan Yang,Bei He,Simin Wang,Yimin Li,Zihuan Hou,Daodao Hu,Xiaolin Shang,Yuhu Li,Peng Tian,Junli Ren,Huiping Xing
Brittle fracture of GAW-treated Xuan paper occurs earlier than acidification. • Wet-heat alternations induce the rapid brittle fracture of gelatin-alum film. • Wet-heat alternations disrupt the coordination network in gelatin-alum film. • Gelatin-alum film is prone to oxidation due to the increase in random coil content. • The exposed Al 1 and Al 3+ are prone to hydrolysis and accelerates acidification. The deterioration of paper artworks treated with gelatin alum solution (GAW) is conventionally attributed to cellulose hydrolysis catalyzed by alum-derived protons. However, our observations and aging evaluation of GAW treated Xuan paper under alternating hygrothermal conditions revealed a discrepancy that mechanical properties declined faster than acidity accumulation, challenging this acid-centric view. To elucidate the underlying mechanism, this work focused on investigating the conformational changes of gelatin molecules under alternating hygrothermal conditions, as well as the presence or absence of alum. Results showed that gelatin-alum films (GAF) initially exhibited better flexibility than gelatin films (GF) due to the coordination crosslinking effect of Al 3+ species, which also inhibited the recovery of gelatin's triple-helix structure. However, after accelerated aging, the GAF underwent more pronounced brittle fracture. This is mainly attributed to the intense movement of molecular segments in hygrothermally sensitive gelatin, which disrupted the coordination cross-linking network, resulting in the formation of more disordered structures such as random coil and accelerated oxidation of gelatin. Subsequently, the exposed Al 3+ and Al(H 2 O) 6 3+ (Al 1 ) became more prone to hydrolysis and polymerization, yielding acidic species and [Al 30 O 8 (OH) 56 (H 2 O) 24 ] 18+ (Al 30 ), thereby accelerating acidification and brittle fracture. Thus, this work provides a more comprehensive perspective to understand the damage mechanism of GAW-treated Xuan paper, valuable for conservation and restoration of GAW-treated paper artworks. Download: Download high-res image (372KB) Download: Download full-size image
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高影响因子
Food Bioscience
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2026
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IF 6.2
Dingxuan Xu,Zilong Zhao,Hangwei Zhang,Xiaolin An,Nana Zhang,Bowen Yan,Yu Liu,Yang Zhang,Hongyuan Cheng,Daming Fan
Spirulina, a nutrient rich microalga, is predominantly utilized in powdered form, limiting its direct role in structuring food matrices. This study developed a Spirulina based printable system by incorporating κ-carrageenan and applying microwave 3D printing to achieve rapid solidification and high fidelity shaping. Rheological results showed that κ-carrageenan not only ensured the shear-thinning behavior of the slurry at high temperatures, but also imparted a modulus response that strengthened with decreasing temperature, thereby facilitating smooth extrusion and deposition during microwave 3D printing. Successful printing of complex structures was achieved at κ-carrageenan contents of 2% or higher and temperatures above 60 °C. The textural properties of the printed products, including gel strength, hardness and gumminess, increased with κ-carrageenan content and printing temperature. Meanwhile, the compressive stress increased markedly with both parameters, with distinct yielding behavior emerging under high-temperature conditions with ≥2% κ-carrageenan. Low-field NMR and scanning electron microscopy revealed that microwave-induced synergistic crosslinking further enhanced water binding and network crosslinking density. Finally, numerical simulations revealed the coupling of viscosity, temperature, and shear fields during extrusion, elucidating the synergistic mechanism of κ-carrageenan and microwave heating on the instant solidification and surface fidelity of the printed products.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Wenli Yang,Qiurong Liang,Ziqing Zeng,Kewen Yang,Weijing Shao,Xuecai Tan,Shaogang Liu,Rihui Su,Jun Yan
STF 4 stabilizes Tea Tree Oil with 84.2% encapsulation efficiency in emulsion. • STFEF 10 achieves 98% sterilization via photothermal synergy. • STFEF 10 had enhanced mechanical and UV/water vapor/oxygen barrier properties. • STFEF 10 can effectively prolong the shelf life of berries. Natural antimicrobial agents are both environmentally friendly and safe, and exhibit excellent biocompatibility. However, their instability and rapid release characteristics limit their application in food preservation packaging. In this study, a photothermal-responsive packaging film was developed by incorporating a Pickering emulsion of soy protein isolate-tannic acid-Fe 3+ (STF) nanoparticles stabilizing tea tree oil (TTO) into a chitosan (CS)/gelatin (Gel) matrix. The STF nanoparticles, synthesized via coordination-driven self-assembly, stabilized the Pickering emulsion and achieved an encapsulation efficiency of 84% for TTO. Under near-infrared (NIR) irradiation, STF nanoparticles transform light energy into thermal energy. On the one hand, the localized increase in temperature provides the film with a certain sterilizing effect. On the other hand, the film allows for the rapid, controlled release of tea tree oil as needed. Through the synergistic effect of localized thermal therapy and controlled release of essential oils, the film exhibits over 98% antibacterial activity against E. coli and S. aureus . Furthermore, the resultant film has outstanding mechanical strength, barrier properties, and antioxidant effects. Preservation experiments were ultimately carried out using strawberries and grapes as representative berries, and the results showed that the film can extend the shelf life by 3–8 days depending on the fruit type. These results demonstrate the application potential of this photothermal controlled-release film in the field of berry preservation. Download: Download high-res image (136KB) Download: Download full-size image
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Yuxin Xu,Gaofei Xiao,Zihan Du,Yun Hu
Elastomers are widely used in industrial, medical, and commercial fields. There is an urgent need for ideal elastomer that combine high toughness, recyclability, and degradability. However, their green and efficient preparation still faces severe challenges. This paper reports a simple one-pot in situ synthesis strategy utilizing biomass resources to produce bio-based elastomers. This process involves the in situ cross-linking of gelatin with ultra-low tannic acid content to form a homogeneous gelatin elastomer slurry. The resulting gelatin-based bioelastomer exhibits high mechanical performance, anti-ultraviolet capability, and soft characteristics. Furthermore, this material can safely biodegrade naturally, reducing environmental impact. These combined attributes position the bioelastomer as a strong candidate for emerging applications in flexible electronics, soft robotics, and biomedical engineering scaffolds, where mechanical durability, UV resistance, and environmental friendliness are concurrently required. By employing exclusively green and recyclable reagents, this one-pot strategy offers a practical pathway toward high-strength, degradable, and sustainable gelatin-based elastomers.
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MATERIALS & DESIGN
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2026
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IF 8.2
Chaorui Jiang,Yanan Yang,Zhuo Meng,Hao Wu,Kai Wang,Xufei Zheng,Minxiang Zhou,Lijing Zhao,Yanwei Du,Bo Liu,Zhihui Zhang
Graphene oxide enhanced hydrogel enables tunable mechanics. • Sustained Rh1 release promotes angiogenesis via VEGF/CD31 upregulation. • Hydrogel boosts anti-inflammatory cytokines (IL-4, IL-10) for faster healing. • The water gel dressing has an antibacterial rate of up to 98.69% against S. aureus . During the healing process of skin wounds, there are challenges such as slow tissue regeneration and bacterial infections. This paper has developed a drug-loaded composite hydrogel dressing that can promote angiogenesis, inhibit bacteria, and reduce inflammation. The hydrogel is composed of gelatin (Gel) and acrylamide (AM), and is formed into a biomimetic cell membrane structure through cross-linking. By adding different concentrations of graphene oxide (GO), the tensile strength of the hydrogel dressing can be significantly increased (from 57.54 KPa to 95 KPa), and the adhesion strength (shear strength) can be effectively enhanced (16.44 KPa). Additionally, Panax ginsenoside Rh1 has been successfully encapsulated in the hydrogel, achieving local controlled release. In vivo evaluation shows that the enhanced matrix by graphene oxide and the sustained release of Panax ginsenoside Rh1 have an antibacterial rate of up to 98.69% against S. aureus . It also stimulates the proliferation, migration, and tube formation of endothelial cells, thereby achieving strong vascularization at the wound site. Moreover, it can enhance the secretion capacity of anti-inflammatory factors (IL-4 from 19.54 to 105.61 pg/mL, IL-10 from 151.94 to 339.98 pg/mL), thereby accelerating the wound healing process. This hydrogel dressing provides a promising strategy for achieving high-quality wound repair. Download: Download high-res image (223KB) Download: Download full-size image
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Jia Xin Yu,Lu Yao Li,Yu Fan,Piao Zheng,Sha Yang,Qi Fang Liu,Cai Juan Huang,Ya Lin Cao,Yang You
Lignin-derived poly(phenol-imidazole) nanosheets (pims) were synthesized. • Pims served as a multi-task nanofiller in composite hydrogel. • Composite hydrogel showed a marked promotion of infected diabetic wound healing. The management of chronic wounds continues to pose a significant clinical challenge and remains a focal point of extensive research. In this study, we present a multifunctional composite strategy utilizing rationally engineered two-dimensional (2D) nanofillers for the fabrication of advanced wound dressings tailored to address the complex microenvironment characteristic of chronic wounds. Specifically, a biocompatible thermo-responsive hydrogel was integrated with a 2D nanofiller densely functionalized with phenolic hydroxyl and imidazole groups, thereby imparting four principal functionalities: enhanced and tunable mechanical properties, remotely controllable mechanical adaptability, photothermal antibacterial effects, and antioxidant activity. This multifunctional composite hydrogel dressing demonstrated a marked acceleration of wound healing in a diabetic infected wound model. Moreover, transcriptomic analyses revealed its capacity to modulate the host inflammatory response, underscoring its promising therapeutic potential for chronic wound management. The findings of this study are anticipated to contribute a paradigm for the advancement of functional nanomaterials intended for biomedical applications. Download: Download high-res image (52KB) Download: Download full-size image
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FOOD HYDROCOLLOIDS
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2026
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IF 13.8
Zhongcan Peng,Jifei Feng,Chaoqing Yang,Hong-Bin Wang,Hong-Lei Jin
Fingered citron is a pectin-rich citrus resource, but extraction of fingered citron pectin (FCP) using natural deep eutectic solvents (NADES) remains limited. This study combined conductor-like screening model for real solvents (COSMO-RS) prediction with experimental validation to screen NADES for FCP extraction. Thirty-five NADES systems were evaluated using monosaccharides and pectin fragments as molecular models, and five candidates were selected for ultrasound-assisted extraction. Betaine-maltose (Bet-Mal) achieved the highest yield (11.86%), followed by choline chloride-maltose (ChCl-Mal) (9.57%), both higher than water extraction (4.88%). Structural analyses showed that NADES changed the domain composition, molecular size, methyl esterification, surface charge, conformation, and aggregation behavior of FCPs. L-proline-maltose (LP-Mal), Bet-Mal, and choline chloride-fructose (ChCl-Fru) extracted galacturonic acid-rich pectins with high homogalacturonan proportions, whereas glucose-maltose (Glc-Mal) yielded a highly branched rhamnogalacturonan-I-rich fraction with the highest molecular weight (945.2 kDa), largest particle size, and strongest nanoscale aggregation. ChCl-Mal-extracted pectin showed the highest DPPH scavenging activity, while the water-soluble pectin (WSP) had the strongest superoxide anion scavenging activity. The κ-carrageenan composite gels prepared from pectins extracted with different solvents exhibited distinct textural, rheological, thermal, and microstructural characteristics. The LP-Mal-extracted pectin formed the strongest water-retentive gel, with hardness of 1.54 N and water holding capacity of 92.34%, whereas ChCl-Mal and ChCl-Fru showed higher small-deformation viscoelastic moduli. These results provide insight into the solvent-dependent structure–function relationships of FCP and offer a COSMO-RS-guided NADES extraction strategy for obtaining fingered citron pectins with distinct food-related functionalities.
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Advanced Science
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2026
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IF 14.1
Junzhe Fu,Fan Jia,Yixian Mu,Wanzhe Liu,Dingqi Tang,Qiao Jin,Jian Ji,Youxiang Wang
Hypertrophic scars (HS) are sustained by a self‐perpetuating extracellular matrix (ECM)–fibroblast feedback loop, in which activated fibroblasts drive excessive ECM deposition, while the resulting matrix stiffening in turn reinforces fibroblast activation. Although advanced fibroblast‐suppression strategies are being actively developed, this matrix‐driven profibrotic feedback remains poorly integrated into HS therapeutic strategies and insufficiently targeted. Here, we introduce an enzyme–nitric oxide (NO) co‐regulatory system for HS: enzymatic degradation of pre‐existing ECM relieves aberrant mechanical cues, while NO‐mediated modulation of fibroblast phenotypes restrains excessive collagen synthesis, thereby inducing mutually reinforcing remodeling across the ECM–fibroblast axis. Specifically, a microneedle platform is developed for localized co‐delivery of the thermosensitive protease bromelain (Bro) and NO‐donor‐functionalized polydopamine nanoparticles (PDA‐NO). Upon near‐infrared irradiation, precise photothermal stimulation further enhances Bro activity and accelerates NO release, enabling controlled amplification of the co‐regulatory effect. In vivo studies demonstrate that this system alleviates HS and restores balanced fibrotic remodeling, as evidenced by coordinated suppression of YAP signaling and the TGF‐β1/α‐SMA/Collagen I axis, supporting effective interruption of the fibrotic feedback loop. Distinct from existing fibroblast‐centric approaches, this study establishes pathological ECM–fibroblast crosstalk as a key mechanistic entry point for HS, advancing a mechanism‐driven, materials‐enabled framework for antifibrotic strategy design. An enzyme–nitric oxide (NO) co‐regulatory strategy reprograms pathological extracellular matrix (ECM)–fibroblast crosstalk in hypertrophic scars. Enzymatic degradation of pre‐existing ECM relieves aberrant mechanical cues, while NO‐mediated fibroblast phenotypic modulation restrains excessive collagen synthesis. Supported by photothermal amplification and localized microneedle delivery, this strategy interrupts the fibrotic feedback loop and restores balanced remodeling to alleviate hypertrophic scarring.
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PubMed
高影响因子
JOURNAL OF BIOMECHANICS
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2026
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IF 2.9
Li-Ming Zhou,Yan Luo,Jiazi Gao,Wenyu Jin,Junhee Lee,Seok-Jo Yang,Meiling Quan,Yuan-Zhu Xin
Bone tissue exists in a dynamic equilibrium maintained by bone resorption and formation, a state regulated by mechanical stimulation. Skeletal structures adapt their architecture and function dynamically in response to applied loads to meet varying biomechanical demands, a property termed mechanical adaptability. Research indicates that the intensity of adaptive responses correlates closely with load gradients, such as strain rate. To investigate the effects of varying load gradients on pre-osteoblast adaptive behavior, this study employed a sodium alginate-gelatin composite hydrogel containing rat MC3T3-E1 pre-osteoblasts as an in vitro model. Under fixed conditions of frequency (2 Hz) and loading duration (3 min/day), an autonomously constructed loading apparatus was used to apply static loads (0 g/cm 2 , 2 g/cm 2 ) and dynamic loads (0–4 g/cm 2 , 1–3 g/cm 2 ), thereby simulating mechanical environments with varying gradients. Through a series of assays examining cellular proliferation and differentiation, the study systematically investigated the effects of load gradients on pre-osteoblast function, with particular emphasis on cellular adaptation characteristics under short-cycle mechanical stimulation. The results showed that low gradients of loads had promoted the proliferation and differentiation of pre-osteoblasts.
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Small
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2026
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IF 11.8
Na Hong,Yanping Song,Zhao Li,Wenjie Shao,Jun Kang,Shuai Han,Shihao Wang,Zhiyuan Yang,Zhuang Miao,Shudong Zhang,Cui Liu,Min Xi,Nian Li,Zhenyang Wang
Silicon-based anodes are limited by severe volume fluctuations and sluggish charge-transfer kinetics. Although metallic coatings can improve electronic conductivity, continuous dense coatings may impede electrolyte access, and lithium-ion transport. Herein, a soft-hard synergistic bicontinuous conductive network strategy is proposed to fabricate a SiO x /nitrogen-doped laser-induced graphene/Cu (SiO x /NLIG/Cu) composite. Deep eutectic solvent (DES)-derived nitrogen-doped active sites combine with super-lyophilic NLIG matrix to spatially guide the electrodeposition of an interconnected percolation network, rather than an ionic blocking layer. This bicontinuous configuration decouples electronic and ionic transport. The porous NLIG framework serves as a strain buffer and a low-tortuosity ion conduit, while the interpenetrating Cu network maintains electrical continuity and structural integrity. This conductive framework is associated with the formation of a stable, LiF-rich solid electrolyte interphase, enhancing the lithium-ion diffusion coefficient by one order of magnitude. The binder-free anode delivers an initial lithiation capacity of 1820.6 mAh g −1 with an initial Coulombic efficiency of 86.3% at 0.1 A g −1 . It also exhibits enhanced durability, achieving 86.4% capacity retention after 1000 cycles at 2.0 A g −1 . Full cells assembled with LiNi 0.8 Co 0.1 Mn 0.1 O 2 cathodes achieve an active-material-level gravimetric energy density of 614.7 Wh kg −1 . This soft-hard synergy strategy provides a versatile solution to high-performance lithium-ion batteries.
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Innovative Food Science & Emerging Technologies
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2026
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IF 6.9
Tao Li,Lang Guo,Kang Yang,Yong Guo,Xinhui Wang,Jing Li
Photooxidation and microbial contamination are two major factors responsible for postharvest deterioration of fresh fruits, and active packaging offers an effective strategy for shelf-life extension. In this work, multifunctional and eco-friendly nanocomposite films were fabricated from polyvinyl alcohol/gelatin (PVA/GEL) incorporated with branched polyethyleneimine (PEI)-grafted carbon dots (CDs) and citral Pickering emulsions (CIT-PE) stabilized by β-cyclodextrin (β-CD) particles. Fourier-transform infrared (FTIR) spectroscopy and X-ray diffraction (XRD) analysis suggested physical interactions between the PVA/GEL matrix and the incorporated active components. The incorporation of CIT-PE and CDs significantly enhanced the UV-shielding, antibacterial, and antioxidant properties of the films. In particular, the PG/E8/C0.8 film exhibited complete UV-blocking ability in the UV region (200–400 nm), strong antibacterial activity against E. coli (18.05 ± 0.20 mm) and S. aureus (55.54 ± 0.87 mm), and high DPPH radical scavenging activity (84.49 ± 3.47%). In cherry tomato preservation experiments, the PG/E8/C0.8 film effectively delayed quality deterioration, maintaining a vivid appearance, lower weight loss (4.24%), and better retention of total soluble solids and titratable acidity after 16 days of storage compared with the control group. Overall, this work provides a feasible strategy for developing multifunctional active packaging materials for postharvest food preservation.
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ADVANCED FUNCTIONAL MATERIALS
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2026
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IF 19.9
Hua Wei,Houchao Jing,Zhijun Xu,Tongkun Guo,Yaqing Liu,Jingcheng Hao
Conductive hydrogel-based bioelectrodes, featuring superior biocompatibility and soft tissue-conformal elasticity and adhesion, enable precise monitoring of subtle physiological signals while minimizing motion-induced interference. However, persistent strong interfacial adhesion may cause tissue anaphylaxis and serious damage during peeling, especially in the practical scenarios requiring long-time epidermal monitoring and possible intraoperative electrode reposition. Herein, we developed a smart hydrogel-based electrode that integrates gelatin alongside an upper critical solution temperature (UCST)-type polymer. Benefiting from a reversible temperature-controlled phase-transition, the hydrogel exhibits strong adhesion at body temperature and gentle detachment after cooling (e.g., with an ice bag for several seconds). This thermo-switchable adhesion ensures robust interfacial contact that reduces electrode-tissue impedance and enhances the signal-to-noise ratio, while allowing atraumatic removal from skin and subcutaneous tissues. The hydrogel electrode can accurately capture electromyography (EMG) signals of hand muscles, enabling high-fidelity gesture recognition for non-contact remote control of robotic devices. The electrode is suitable for high-precision monitoring of deep subcutaneous muscle activity. Under simulated intraoperative conditions, it reliably recorded both spontaneous and evoked EMG signals from subcutaneous muscles. The proposed hydrogel-based electrodes enables multimodal electrophysiological recording, including epidermal and subcutaneous healthcare sensing, thereby validating their promising application scenarios under wearable and implantable conditions.
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危险品化学品经营许可证（带存储）