Materials Today Bio
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2026
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IF 10.2
Jingqiu Chen,Hegeng Li,Yanbing Tao,Wenjian Zhang,Xinyi Chen,Yunong Zhao,Lanpeng Guo,Qing Huang,Jianjun Chen,Huan Liu
Rhinitis is a common chronic respiratory disease that severely affects patients’ quality of life and may lead to serious complications, underscoring the need for rapid and portable diagnostic tools to support routine monitoring and clinical management. Here, we introduce a multiscale material platform based on colloidal quantum dots (CQDs) for the construction of electrochemical immunosensors enabling the rapid detection of eosinophil cationic protein (ECP) and neutrophil myeloperoxidase (MPO), two clinically relevant biomarkers of rhinitis. The platform leverages specific antigen–antibody recognition coupled with the electrical transduction and interfacial charge-transfer properties of CQDs, resulting in significant amplification of electrochemical signals and high detection sensitivity. To ensure translational applicability, we systematically examined key factors associated with real clinical samples—including hemolysis, storage duration, and preservation conditions in serum—and verified the method’s reliability through spiked recovery experiments. Importantly, the immunosensor was successfully applied to the detection of ECP and MPO in patient-derived nasal secretion samples, exhibiting strong concordance with enzyme-linked immunosorbent assay (ELISA) results. Collectively, this work demonstrates that the CQD-based materials platform offers a robust and clinically validated strategy for protein biomarker detection, and highlights its strong potential for point-of-care testing (POCT) and home-based diagnostics, providing valuable support for the early diagnosis and management of rhinitis.
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ELECTROCHIMICA ACTA
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2026
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IF 5.6
Sen Feng,Chengyuan Ni,Xiaoying Jiang,Mouhamadou Aziz Diop,Fengguo Liu,Jun Liu,Chengdong Xia,Junjie Zhang,Aimin Liu,Zhongning Shi
To achieve green and efficient production of high-purity magnesium, this work investigates the electrochemical reduction and deposition mechanism of Mg(II) in a NaCl-KCl-MgCl 2 molten salt system at 953 K. A combination of thermodynamic analysis and electrochemical techniques, including cyclic voltammetry, square wave voltammetry, chronopotentiometry, and potentiostatic electrolysis, was employed on a tungsten electrode. The reduction of Mg(II) to Mg(0) was confirmed to be a single-step, two-electron transfer reversible process controlled by ion diffusion. The diffusion coefficient of Mg(II) was determined to be 1.19 × 10 −8 cm 2 /s to 1.25 × 10 −8 cm 2 /s. Potentiostatic electrolysis at -1.68 V (vs. Ag/AgCl) successfully produced high-purity liquid magnesium, which was collected and solidified. X-ray diffraction and scanning electron microscopy with energy-dispersive X-ray spectroscopy analyses unequivocally identified the deposits as metallic magnesium with a purity exceeding 99.9 wt.%. The key innovation lies in simultaneously establishing the fundamental electrochemistry of Mg(II) and demonstrating its direct electrodeposition in a low‑cost, industrially scalable NaCl-KCl‑based electrolyte, providing a critical foundation for a continuous, green magnesium electrolysis technology.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 13.2
Liran Zhang,Yang Chen,Junhui Qiao,Shanshan Chen,Size Fan,Xinyue Zhai,Yuxuan Cheng,Tao Yang,Yue Zhang,Changhuan Zhang,Han Wu,Dongmin Wang
With the completion of many large-scale projects in coastal areas, the durability deterioration of reinforced concrete caused by various erosion factors has become increasingly prominent. Therefore, it is very important to develop in-situ, real-time and non-destructive monitoring technology for these ions. Here, we report a high-performance, flexible and all-solid-state chloride ion sensor fabricated by inkjet printing. Optimization of ink formulation, droplet-assisted printing, design of a unique functional interlayer interface structure, and precise control of active materials loading achieved excellent sensor characteristics. The sensor demonstrated excellent sensitivity, selectivity, repeatability, stability and quick response in chloride ion quantification. We confirmed the sensor's reliability and potential for on-site durability evaluation through successful real-time monitoring. The sensor accurately tracked the chloride ion concentration and distribution within the pore solution of cement specimens. The sensor design strategy also demonstrated the scalability for monitoring various erosion ions. This work provides a novel method that establishes a foundation for advancing the monitoring and maintenance of smart concrete infrastructure.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2026
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IF 4.6
Kaitao Xu,Wenqian Cao,Hongxu Chen,Xueqian Xia,Wenxin Lin,Yong Guo,Quan Hu
Arginine (Arg) has been recognized as a crucial biomarker for cystinuria, with its concentration levels markedly influencing human health. In this study, Eu-TATB were synthesized via a solvothermal method using 4,4′,4″- s -triazine-2,4,6-triyl-tribenzoic acid (H₃TATB) as the organic ligand and Eu ions. Eu-TATB, benefiting from its intrinsic photosensitive characteristics and the characteristic Eu 3+ emission at 618 nm, was utilized to construct a novel ratiometric fluorescent sensor. By harnessing the photosensitization of Eu-TATB under ultraviolet light irradiation, significant oxidation of arginine was catalyzed, leading to the emergence of a new blue fluorescence peak at 430 nm. The intensity of this blue fluorescence increased proportionally with the arginine concentration, while the red emission at 618 nm gradually decreased. Utilizing the cross response of this dual-emission intensity, Eu-TATB exhibits ratiometric fluorescence sensing property for arginine, with a broad linear range of 0.1–2 mM and a low limit of detection (LOD) of 3.22 μM, and validated the practicality of the proposed sensor through the quantitative detection of arginine in human serum. Notably, the variable luminescence colors that are visible to naked eye endow the feasibility of Eu-TATB for in situ visualization analysis of arginine.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 13.2
Hao-wen Zhang,Xiang Xu,Jie Lu,Wei-jin Li,Aming Xie,Hao Chen,Yang-sheng Wang,Ying Zhi,Zhe-sheng Feng,Yan Wang
With excellent conductivity, large specific surface area, and tunable surface properties, MXene is regarded as a promising material for research in humidity sensing technologies. Nevertheless, achieving the high response intensity, excellent response sensitivity, structural stability, and oxidation resistance in the MXene-based humidity sensors remains a formidable challenge. Herein, this work presents a NiFe layered double hydroxide modified MXene composite material as the humidity sensing material with superior sensing performance. By adding the composite material to the carboxymethyl cellulose solution, a humidity-sensitive functional ink was prepared with favorable printability. Besides, the screen-printing process was successfully adapted to prepare the mass-producible humidity sensor. Experimental results indicate that the humidity sensor in this research possesses exceptional sensitivity (1.10 s/7.89 s for response/recovery time) and satisfactory response intensity (90,843% at 97% RH), along with favorable physicochemical stability and functional durability. Eventually, the function of the humidity sensor for skin humidity sensing, real-time respiration monitoring, soil moisture, and temperature visualization has been evaluated, revealing significant potential in meteorological monitoring, industrial production, intelligent home, and personalized healthcare management.
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ANALYTICA CHIMICA ACTA
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2026
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IF 6
Tongfang Chen,Jingjie Liang,Weiqing Liu,Fengxia Zhou,Chanci Qiu,Yuhui Peng,Xie Zhou
Background Glutathione (GSH), the most abundant cellular non-protein thiol and a central antioxidant, plays essential roles in regulating redox homeostasis, signal transduction, and detoxification processes. Altered GSH levels are closely associated with various pathological conditions, including neurodegenerative disorders, and liver injury . Notably, tumor tissues exhibit markedly elevated GSH concentrations (up to 4-10 times higher than in normal cells), where it promotes tumor proliferation, invasion, and chemoresistance by sustaining a reduced microenvironment, these characteristics make GSH an important biomarker and therapeutic target in oncology. Results We developed a novel "switch-on" near-infrared (NIR) fluorescence nanoprobe, Ag 2 S-CH@Cu-TCPP, for the highly sensitive and selective detection and imaging of GSH. The nanoprobe was constructed by conjugating histidine-rich CH peptides to carboxyl-capped Ag 2 S quantum dots (Ag 2 S QDs), which were then self-assembled onto two-dimensional Cu-TCPP metal-organic framework (MOF) nanosheets via coordination between Cu 2+ and imidazole groups. In this design, Cu-TCPP acts as an efficient quencher for the Ag 2 S-CH fluorescence via a fluorescence resonance energy transfer (FRET) mechanism. Upon encountering GSH, the reduction of Cu 2+ to Cu + disrupts the FRET process, leading to the recovery of the NIR fluorescence signal. This nanoprobe demonstrated a low detection limit of 5.33 μM and a wide linear range from 0.625 to 10 mM for GSH quantification, with excellent selectivity, high reproducibility, and favorable biocompatibility. We successfully applied the platform for monitoring intracellular GSH levels and distinguishing between cancer cells and normal cells based on their differential GSH expression. Significance and Novelty The "switch-on" probe demonstrates excellent biocompatibility and is applicable for cellular imaging. It enables discrimination between normal and cancer cells while supporting semi-quantitative analysis of both endogenous and exogenous GSH. This work provides a novel and reliable strategy for tumor diagnosis and advanced investigations into GSH-related biological processes.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Hecheng Yao,Shuyi Li,Chaohuan Yang,Chenchen Liao,Yuchan Li,Zhimin Guo,Guoyong Wang,Yan Liu
With the growing emphasis on personalized health management, point-of-care testing has garnered significant interest, creating a pressing demand for biosensors that are both highly sensitive and user-friendly. Herein, we develop a dual-function sensor on a Janus fabric for monitoring sweat glucose and lactate. The Janus material provides the critical function of unidirectional sweat transport for efficient collection while also being endowed with antibacterial properties and breathability to ensure user comfort during extended wear. The electrochemical electrode was fabricated via a sequential process of screen-printing, electropolymerization of Prussian blue, and modification with MXene and specific enzymes. The incorporation of MXene significantly reduces the electrical impedance of the electrode, thereby enhancing its electrochemical performance. The sensor offers broad detection ranges (0–500 μM for glucose and 0–25 mM for lactate) with low detection limits (0.6 μM and 0.145 mM, respectively). Furthermore, the detection sensors exhibit outstanding long-term stability, excellent reproducibility, and strong anti-interference capability. Moreover, the integrated sensor successfully monitored changes in glucose and lactate concentrations in human sweat, demonstrating significant potential for applications in health management and exercise monitoring.
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FOOD CHEMISTRY
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2026
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IF 9.8
Suozhu Wu,Hao Wu,Guojuan Zhang,Hongyuan Guo
3-Monochloropropane-1,2-diol (3-MCPD) is a common contaminant generated during the heating process of foods. Because of the potential carcinogenic and toxic effects, measuring 3-MCPD is greatly significant to guarantee food security. Here, we developed a molecularly imprinted polyphenylboronic acid/carboxylated graphene (MIPPBA/CG)-based electrochemical sensor to determine 3-MCPD. The MIPPBA/CG composites were prepared by in-situ electrochemical deposition, and CG and MIPPBA were respectively used for electrical signal amplification and specific recognition of 3-MCPD. 3-MCPD was tested by square wave voltammetry utilizing the potassium ferricyanide probe. Under the optimal experimental conditions, our results showed that this sensor had the advantages of simplicity, rapidity, wide response range (1.0 × 10 −12 –1.0 × 10 −3 M), low detection limit (1.4 × 10 −13 M), good reproducibility, excellent stability, and high selectivity, and could detect the 3-MCPD content in different soy sauce samples with satisfactory results, which provided a promising approach for testing the food processing contaminant.
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Nanoscale
·
2026
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IF 5.1
Limeili Tian,Miaomiao Yang,Jing Wang,Shuai Yang,Chunxu Han,Yangyang Huang,Qingqiang Meng,Aiping Wu
Photocatalytic degradation is an eco-friendly method for decomposing tetracycline hydrochloride (TC), yet it faces challenges such as slow photogenerated carrier transfer, poor separation efficiency, and limited active sites. Semiconductor composites offer a promising solution to enhance catalytic efficiency. In this context, a novel 0D/2D BiOCl 0.7 I 0.3 /Bi 2 MoO 6 (BOCI-BMO) direct Z-scheme photocatalyst was synthesized via a solvothermal method, featuring 0D BiOCl 0.7 I 0.3 quantum dots anchored on 2D Bi 2 MoO 6 nanosheet. The composite photocatalyst with an optimal BOCI to BMO mass ratio of 7:3 (50 mg), achieved over 94% removal of TC (10 ppm) in 40 minutes, demonstrating excellent cyclic stability and broad applicability. Both theoretical calculations and experimental results confirm that the photogenerated carrier transport between semiconductors follows a Z-scheme mechanism, significantly enhancing carrier separation efficiency while preserving strong redox capabilities. Moreover, the unique 0D and 2D structures provide a large specific surface area, offering abundant active sites and reducing carrier transport distance, thereby boosting photocatalytic performance. This study provides theoretical and experimental insights for designing and synthesizing novel visible light-responsive photocatalysts.
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Analytical Methods
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2026
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IF 2.6
Ruochen Wu,Li Lu,He Jiang,Dali Hu,Hepeng Su
Circulating tumor cells (CTCs) are critical biomarkers of breast cancer metastasis, yet their low abundance and phenotypic heterogeneity present formidable challenges for reliable detection. Here, we report the design and validation of an electrochemical biosensor based on three-dimensional gold nanodendrites (AuNDs) functionalized with dual aptamers targeting epithelial cell adhesion molecule (EpCAM) and Mucin 1 (MUC1). The AuND platform, synthesized via potentiostatic electrodeposition, exhibited a mesoporous dendritic morphology with a specific surface area of 172.2 m²/g and crystalline Au(111) facets, confirmed by SEM, TEM, XRD, BET, and XPS analyses. Stepwise assembly of the aptamer-modified electrode produced distinct electrochemical signatures, with charge transfer resistance (Rct) increasing from ~50 Ω for bare AuNDs to ~2000 Ω after BSA blocking. Optimization identified 1.0 µM aptamer concentration and 60 min incubation as optimal sensing conditions. The sensor achieved an exceptionally low detection limit of 3 cells/mL and displayed a wide dynamic range from 10 to 10⁶ cells/mL, with a linear regression equation of ΔI (µA) = 5.8 log[Ccell] + 2.5 (R² = 0.998). Selectivity tests showed negligible responses (<5%) toward HeLa and Jurkat cells, while reproducibility across five electrodes yielded a relative standard deviation of 3.5%. Stability evaluation demonstrated retention of 92.5% activity after 28 days of storage at 4 °C.Recovery studies in 10% human serum spiked with MCF-7 cells showed excellent accuracy (96.5-104.2%) with RSD ≤ 4.5%.These results underscore the potential of the AuND/dual-aptamer biosensor as a robust and ultrasensitive platform for clinical CTC detection in early-stage and metastatic breast cancer.
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Nature Protocols
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2026
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IF 16
Wu Yongmeng,Liu Xinyu,Huang Yanmei,Meng Nannan,Zhang Bin
The construction of carbon‒nitrogen (C‒N) bonds is an essential transformation for synthesizing value-added organonitrogen compounds, including the raw materials for fertilizers, synthetic materials and pharmaceuticals. Electrocatalytic C‒N bond construction has emerged as an alternative strategy to traditional thermochemical routes, avoiding harsh and energy-intensive processes. This protocol describes an electrocatalytic C‒N bond construction strategy to synthesize organonitrogen from nitrogen oxides in water under ambient conditions, with a focus on several vital chemicals, such as urea, formamide, cyclohexanone oxime, amino acids and 15 N-labeled amino acids. Here, we provide detailed procedures for catalyst and reaction device design, electrosynthesis, product quantification and measurements for investigating the reaction mechanisms. Four catalysts, namely, vacancy-rich ZnO, core-shell Cu@Zn, AgRu alloy and low-coordination Ag, are synthesized as cathode catalysts. Two types of electrolyzers, an H-type cell and a flow cell, are used for the electrocatalytic reaction. Characterization techniques such as electrochemical in situ Raman spectroscopy, in situ attenuated total reflectance–Fourier transform infrared spectroscopy, ex situ electron paramagnetic resonance and scanning flow cell-differential electrochemical mass spectrometry have been adopted to study the reaction mechanism. The synthesis amount of urea is at the micromole level, while the synthesis amounts of formamide, cyclohexanone oxime and amino acids are at the millimole level. The catalyst synthesis protocol requires 0.5–1.5 d, the electrosynthesis requires ≤11 h and the in situ characterization requires 0.5–1.5 h.
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JOURNAL OF MEMBRANE SCIENCE
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2026
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IF 9
Yihao Song,Qieyuan Gao,Junwei Li,Yuepeng Li,Yulong Cheng,Daliang Xu,Mian Wu,Zhao Wei,Xiaoqi Sun,Yaowen Xing,Bart Van der Bruggen,Zirui Lin,Xiahui Gui
Polyamide (PA) membranes are promising nanofiltration (NF) materials for Li + -Mg 2+ separation in lithium extraction from salt-lake brines. However, their limited water permeance and reliance on acidic environments to maintain protonated electropositive surfaces hinder overall performances. Herein, we introduced a carboxyl doped PA NF membrane, hereafter referred to as GLY/PA-PDA (GLY = glycine; PDA = polydopamine). The hydrophilic ultrathin rough GLY/PA rejection layer and PDA interlayer enabled an exceptional water permeance of 17.2 L m −2 h −1 bar −1 . More importantly, carboxyl groups acted as unique Mg 2+ catchers to functionalize surfaces, resulting in enhanced surface positive charge intensity and sustained ion selectivity. The GLY/PA-PDA membranes achieved an impressive Li + -Mg 2+ separation coefficient of 30.5 in mixed-cation feeds. During a 3-stage separation process, the membrane demonstrated continuously increasing separation coefficients of each stage, obtaining an ultra-low-Mg 2+ extraction solution of 0.06 ppm. Our work proposes a direction for improving selectivity by utilizing guest metal cations within NF systems.
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