ChemistrySelect
·
2025
·Vol. 10
·期 28
·e00823
·
IF 2
Xian-Yi Jin,Jia Luo,Hang Cong,Jiang-Lin Zhao
Graphical The enantioselective analysis of levamisole hydrochloride was achieved by a synergic electrochemiluminescence (ECL) system, in which a chiral macrocycle CycHemiQ[6] was employed as the recognition host, and the emitter of HemiQ[6]-based CQDs in the electrolyte provided high sensitivity and selectivity. A chiral macrocycle, cyclohexylhemicucurbit[6]uril (CycHemiQ[6]), is employed as the recognition host, to construct a chiral electrochemiluminescence (ECL) sensor system, with the emitter of hemicucurbituril-based carbon quantum dots (CQDs) and the co-reactant of Na 2 S 2 O 8 for the detection of levamisole hydrochloride ( L -LV), a drug with immunomodulatory and anticancer activities. The host–guest interaction between the chiral macrocycle and the guest molecule L -LV is considered to achieve high selectivity and high sensitivity detection of L -LV. The detection limit of 0.0075 µM is achieved in the linear range of 0.01–10 µM. The system exhibits strong anti-interference ability to other small molecules, with good stability, reproducibility, and recoveries. The established method provides an effective approach for monitoring L -LV drug residues, which could prevent adverse effects such as hematotoxicity and granulocytopenia caused by excessive accumulation.
研究领域:
分析化学
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生物电化学
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纳米技术
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手性识别
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药物分析
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DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Xinwen Jia,Mengyun Lu,Wenjing Zhang,Wuduo Zhao,Ajuan Yu,Shusheng Zhang
Chiral carbon quantum dots (CQDs) with –SH, –NH 2 functional groups were grafted onto a metal–organic cage (Zn-MOC) with unsaturated metal sites through coordination bond, and then a novel bichiral composite Zn-MOC@CQDs was constructed for the chiral discrimination of LA enantiomers. Zn-MOC@CQDs exhibited a high fluorescence detection sensitivity for L -LA instead of D -LA, and the enantioselectivity coefficient for LA enantiomers was 2.34. Zn-MOC@CQDs exhibited more excellent enantioselectivity than the single components of CQDs and Zn-MOC, and the key reason may be the chiral synergistic effect between the different chiral building blocks.
研究领域:
化学
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材料科学
·
分析化学
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DOI
高影响因子
CERAMICS INTERNATIONAL
·
2018
·
IF 3.057
Zhaoying Guo,Qi Wang,Tao Shen,Xianjie Hou,Jianlei Kuang,Wenxiu Liu,Wenbin Cao
A novel CQDs/TiO 2 hierarchical structure with enhanced photocatalytic properties was achieved by uniformly decorating urchin-like and yolk-shell TiO 2 microspheres (UYTMs) with carbon quantum dots (CQDs) through an environmentally friendly hydrothermal process. The CQDs were firstly synthesized by the electrochemical method, and the TEM, Raman and PL characterizations strongly indicated that the as-prepared CQDs exhibited good dispersion, high crystallinity and unique up-conversion properties. The UYTMs synthesized by a NaOH-assisted hydrothermal process showed stable 3D hierarchical structure and large surface area, which was beneficial for light absorption and contacting with contamination. The good combination of CQDs and UYTMs was further successfully achieved during the hydrothermal process, and demonstrated by a series of tests. The photocatalytic experiments suggested that the CQDs/UYTMs exhibited better photocatalytic activities than the pure UYTMs and P25 under both visible and UV light irradiation. The CQDs/UYTMs combining with 6 wt% of CQDs showed the best photocatalytic efficiency, while excessive CQDs tended to inhibit the photocatalytic activity. According to the results and discussions, a possible mechanism in improving the photocatalytic efficiency of the CQDs/UYTMs is significantly proposed. The up-conversion property of CQDs can broaden the absorption spectrum of CQDs/UYTMs to the visible light. Moreover, the CQDs, as the electron reservoirs, are efficient to separate the electrons and holes, leading to an improved photocatalytic activity of CQDs/UYTMs.
研究领域:
材料科学
·
环境科学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2017
·
IF 6.216
Guijuan Wei,Xixia Zhao,Kun Du,Zhaojie Wang,Ming Liu,Shuo Zhang,Shutao Wang,Jun Zhang,Changhua An
To date, zero-dimensional carbon quantum dots (CQDs), as a new carbon nanomaterials, have attracted attention in the improvement of the electrical conductivity for electrode materials. However, few attempts have been made to the use of CQDs as the structure-directing agent for the assembly of functional micro/nanoelectrodes. Herein, we have developed a general, and simple strategy to fabricate 3D porous hierarchical carbon quantum dots (CQDs)/M x O y (M = Co, Ni) composite nanostructures from thermolysis of corresponding CQDs/M(OH) y , where CQDs play crucial role as a structure-directing agent in tuning the morphologies of the M(OH) y . With the merits of the large electroactive surface area, superior electronic conductivity of CQDs, and fruitful porous structure, the as-fabricated battery-type electrode materials present amazing supercapacitor performance. For example, the as-made porous hierarchical CQDs/Co 3 O 4 nanoarchitectures exhibited remarkable electrochemical performance with 1603 F g −1 at 1 A g −1 , excellent rate capacity of 70.6% from 1 to 100 A g −1 , superior cycling ability (97.0% capacity remained after 2000 cycles). Furthermore, the CQDs/Co 3 O 4 //AC hybrid supercapacitor (HSC) exhibits a high specific capacity of 210.4 F g −1 with 74.8 W h kg −1 . The present work can be enlarged for the design of other functional 3D hierarchical micro-nanostructures in the fields of energy storage, catalysis, and photo/electrocatalysis.
研究领域:
材料科学
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能源存储
·
纳米技术
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产品关联
DOI
高影响因子
DIAMOND AND RELATED MATERIALS
·
2022
·
IF 3.806
Dan Sun,Rongting Guo,Yiju Lv,Wei Li,Mingjun Lu,Qiumei Wei,Zheng Liu,Guo-Cheng Han
Na 2 MnPO 4 F and Ti 3 C 2 ‑carbon quantum dots (CQDs) nanocomposites were prepared by wet mixing method combined with spray drying method, and the two materials were further compounded by heat treatment to get different ratios of Na 2 MnPO 4 F/Ti 3 C 2 -CQDs cathode material (NTC), the effects of Ti 3 C 2 -CQDs on the structure and electrochemical performance of the composite of Na 2 MnPO 4 F as a lithium-ion battery cathode material were investigated. The results showed that Na 2 MnPO 4 F was uniformly attached to the surface and between layers of Ti 3 C 2 -CQDs. The initial specific discharge capacity of NTC-2 at 0.1C was 67.8 mAh·g −1 , and the reversible capacity after 100 cycles was 60.7 mAh·g −1 , the capacity retention rate was as high as 90%, which all showed that Ti 3 C 2 -CQDs can enhance the cycle performance, rate performance and capacity retention rate of Na 2 MnPO 4 F. It also showed good rate performance under high current density . After the high current test, the current returned to 0.1C, and the capacity can be restored to the original value, which showed that the material has good structural stability. Therefore, Ti 3 C 2 -CQDs doped Na 2 MnPO 4 F is an important way to improve the electrochemical performance of polyanionic compounds.
研究领域:
材料科学
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电化学
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电池技术
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DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2023
·
IF 7.7
Donghuan Meng,Ye Lei,Menghan Pang,Jianrong Qiu,Chenghua Fan,Yuyan Feng,Dongbo Wang
In the graphitic carbon nitride-based photocatalytic reaction, the redox ability and electron transport ability of photocatalyst have an important influence on its activity. The Photo-Fenton reaction system was constructed by modifying N-doped carbon quantum dots (N-CQDs) on the surface of supramolecular self-assembled carbon nitride and introducing Fe ions into the carbon nitride planar structure . The xFe/N-CQDs/MCN1 catalysts with different iron contents were prepared, which had significant degradation effect on organic pollutants . Among them, 0.2Fe/N-CQDs/MCN1 degraded 76% of ciprofloxacin (CIP) within 120 min. Various characterizations demonstrate that photocatalytic activity are enhanced due to the surface modification of N-CQDs enhancing electron transfer rate on the surface of photocatalysts and the doping of Fe ions providing active sites for Fenton reaction . At the same time, the formation of chemical bonds limits the leaching of iron and avoids secondary environmental pollution . These results indicate that the novel catalyst has excellent application potential in the field of environmental photocatalysis .
研究领域:
环境科学
·
材料科学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Shizong Wang,Jianlong Wang
This study firstly reported the regulation of PMS activation pathway via the novel catalyst (CQDs/Co@CN) that contained carbon quantum dots (CQDs) and confined nano Co dual active sites. CQDs/Co@CN showed superior catalytic activity for PMS activation due to the synergistic effect of CQDs and confined nano Co, and sulfamethoxazole degradation rate reached 0.661 min −1 , which was even higher than that obtained by single atom catalyst. The reactive species in the system of CQDs/Co@CN/PMS could be easily regulated by the visible light. In the absence of visible light, PMS was mainly activated to produce Co(IV) = O, while it was activated to simultaneously produce radicals and Co(IV) = O in the presence of visible light. Moreover, the yields of Co(IV) = O increased by about 10 %. Experimental results and DFT calculation demonstrated that CQDs played crucial role in the regulation of reactive species. This study could provide a way to modulate the reactive species by visible light.
研究领域:
环境科学
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化学工程
·
材料科学
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DOI
高影响因子
MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 11
·1-8
·
IF 5.479
Guo Ying,Zhang Juncai,Zhang Weihong,Hu Daodao
Brightly fluorescent carbon quantum dots coated with polyethylenimine (PEI-CDs) were prepared using malic acid and PEI as the precursors. The PEI-CDs have a high quantum yield (41%) and green emission (peaking at 502 nm under 430 nm excitation), both of which are not affected by high ionic strength. The PEI-CDs have a positive charge at physiological pH values and can electrostatically bind aptamers with their negative charge. This is shown for aptamers binding thrombin or ATP. Binding of aptamers results in quenching of fluorescence. If thrombin or ATP are introduced, the respective aptamer will bind them, and the complex is then released from the PEI-CDs. Fluorescence increases in proportion to the analyte concentration. Under optimized conditions, thrombin and ATP can be sensitively and selectively detected by fluorometry with lower detection limits of 1.2 and 13 nM, respectively. The assay was successfully applied to the determination of thrombin and of ATP in spiked serum samples.
Green fluorescent carbon quantum dots were functionalized with polyethyleneimine. They were applied to aptamer-based determination of thrombin and ATP. The PEI-functionalized carbon quantum dots (PEI-CDs) have bright green fluorescence are were synthesized by one-step hydrothermal treatment of malic acid and PEI. Employing the PEI-CDs, a fluorometric aptamer-based assay was developed for the determination of thrombin and ATP.
研究领域:
分析化学
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生物化学
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纳米技术
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分子生物学
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Ye Zhang,Congjun Zhang,Jing Chen,Li Liu,Mengyue Hu,Jun Li,Hong Bi
Multidrug resistance (MDR) has been recognized as a major obstacle to successful chemotherapy for cancer in the clinic. In recent years, more and more nanoscaled drug delivery systems (DDS) are constructed to modulate drug efflux protein (P-gp) and deliver chemotherapeutic drugs for overcoming MDR. Among them, d-α-tocopheryl polyethylene glycol succinate (TPGS) has been widely used as a drug carrier due to its capability of inhibiting overexpression of P-gp and good amphiphilicity favorable for improving permeation and long-circulation property of DDS. In the present work, a novel kind of mitochondria-targeting nanomicelles-based DDS is developed to integrate chemotherapeutics delivery with fluorescence imaging functionalities on a comprehensive nanoplatform. The mitochondria-targeting nanomicelles are prepared by self-assembly of triphenylphosphine (TPP)-modified TPGS and fluorescent carbon quantum dots (CQDs) in an n-hexane/H2O mixed solution, named CQDs-TPGS-TPP. Notably, although the drug loading content of doxorubicin (DOX) in the as-prepared nanomicelles is as low as 3.4%, the calculated resistant index (RI) is greatly decreased from 66.23 of free DOX to 7.16 of DOX-loaded nanomicelles while treating both parental MCF-7 cells and drug-resistant MCF-7/ADR cells. Compared with free DOX, the penetration efficiency of DOX-loaded nanomicelles in three-dimensional multicellular spheroids (MCs) of MCF-7/ADR is obviously increased. Moreover, the released DOX from the nanomicelles can cause much more damage to cells of drug-resistant MCs. These results demonstrate that our constructed mitochondria-targeting nanomicelles-based DDS have potential application in overcoming MDR of cancer cells as well as their MCs that mimic in vivo tumor tissues. The MDR-reversal mechanism of the DOX-loaded CQDs-TPGS-TPP nanomicelles is also discussed.
研究领域:
药学
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纳米技术
·
癌症研究
·
药物递送系统
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产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 2
·122015
·
IF 7.5
A. Al-Farraji,Saad H. Ammar,Hanan H. Abed,Zaid H. Jabbar
Photocatalytic ozonation is an advanced oxidation process (AOP) that has recently demonstrated its strong oxidation capabilities for efficient wastewater treatment using sunlight and air as the ozone source. Additionally, the spinning disc photocatalytic reactor (SDPR) has been widely adopted recently as an intensification approach for photocatalytic processes. Herein, an efficient approach has been adopted to enhance the degradation performance of photocatalytic ozonation process over CQDs/FeTiO 3 photocatalyst film in a SDPR for synergistically enhancing the degradation of diclofenac sodium (DCF). The DCF degradations were compared in different treatment systems in the SDPR, including ozonation, catalytic-ozonation, photocatalysis, and photocatalytic ozonation. High photocatalytic ozonation performance (99.3% degradation efficiency, 85.8% mineralization, and high stability after six runs) has been acquired over CQDs/FeTiO 3 photocatalyst film under visible-light exposure. The effective separation of photogenerated charge carriers due to CQDs deposition, and high generation of ORS resulting from the combined systems were responsible for the enhanced photocatalytic performance.
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高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
·
IF 4.1
Yi Jintao,Fu Nani,Zhong Wenhui,Liu Xia,Zhou Anqi,Li Xun
Amoxicillin (AMO), a penicillin antibiotic, and ciprofloxacin (CIP), a quinolone antibiotic, are widely used to combat bacterial infections and are frequently co-administered to enhance therapeutic efficacy. However, improper use of AMO and CIP may lead to antibiotic residues in the environment, posing serious threats to human health. The visual detection of AMO and CIP remains significant challenges. Herein, the Eu-DPA@CQDs was used for the dual-mode detection of AMO and CIP, which was synthesized by CQDs doped in europium-DPA metal-organic framework. In the colorimetric mode, the catalase-mimicking Eu-DPA@CQDs oxidized TMB to blue oxTMB. Upon addition of AMO, the oxTMB was reduced, causing color fading. Subsequent introduction of CIP restored nanozyme activity, regenerating the blue signal and enabling dual-analyte antibiotic detection. In the fluorescence mode, the Eu-DPA@CQDs probe exhibited dual emission at 440 nm and 613 nm. Upon AMO addition, the fluorescence at both wavelengths was quenched, accompanied by a color change from red to purple. In the presence of CIP, the emission at 440 nm increased and redshifted to 490 nm, while the signal at 613 nm was quenched, resulting in a multicolor transition from red to cyan. The Eu-DPA@CQDs sensor enabled rapid and dual-mode detection of AMO and CIP. The colorimetric method exhibited wide linear ranges of 0.005–25 μM for AMO and 0.007–4.25 μM for CIP, with detection limits of 1.67 nM and 3.75 nM, respectively. A visible color transition from dark blue to colorless was observed with increasing AMO concentration, while the addition of CIP reversed the signal back to dark blue. Similarly, the fluorescence detection achieved wide linear ranges from 0.005 to 30 μM for AMO and 0.005 to 15 μM for CIP, with detection limits as low as 4.74 nM and 3.11 nM, respectively, also within only 1 min. As the concentration of AMO increased, the color shifted from red to purple. In contrast, increasing CIP concentration induced a color transition from red to cyan. These color transitions were both clearly visible to the naked eye. The sensor demonstrated excellent selectivity and anti-interference capability, providing a reliable platform for accurate, sensitive, and quantitative determination of both antibiotics in real samples. Graphical abstract
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PubMed
高影响因子
ADVANCED MATERIALS
·
2026
·
IF 29.1
Che Liu,Kaiyang Guo,Yan Liu,Huiyin Zheng,Jun Ma,Zhuosen Wang,Xinwei Cui,Yapeng Tian
Efficient proton transport in 2D confined electrodes critically depends on the flexibility of interfacial hydrogen-bond networks. However, the interfacial issue becomes more pronounced in the 2D confined space. The strong hydrogen bonds between confined water molecules and surface ─O terminations of MXenes immobilize protons and hinder charge storage kinetics. Here, we introduce an edge-coordination strategy to achieve precise electronic delocalization modulation in Ti 3 C 2 T x MXene by anchoring carboxyl-functionalized carbon quantum dots (CQDs) at positively charged edges. The CQDs induce substantial electron delocalization on surface ─O sites, which simultaneously weakens rigid hydrogen bonds and facilitates interfacial charge transfer. This regulation establishes a dynamic hydrogen-bond network that supports continuous Grotthuss-type proton migration within the confined channels. Consequently, the optimized CQDs@MXene electrode delivers a volumetric capacitance of 2507.2 F cm −3 , retains 65.8% at 1000 mV s −1 , and maintains nearly 100% stability over 10 000 cycles. In situ vibrational spectroscopy and density functional theory reveal that the electron delocalization drives the weak hydrogen-bond interface and charge transfer coupling governs proton transport kinetics. This work establishes electronic delocalization as an effective paradigm for manipulating hydrogen-bond dynamics and interfacial charge transport for ultrafast ion transport in confined electrochemical systems.
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PubMed
高影响因子
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