CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Chengdong Li,Lingfeng Li
PA/F127 co-assembly forms robust Si–O–P bonds and uniform microstructure in silica xerogels. • Xerogels integrate high strength, monolithicity, self-extinguishing ability, and thermal insulation. • PA's dual role enables rapid gelation, bypassing conventional slow acid-catalyzed growth. • Excellent fire resistance with minimal flame damage outperforms commercial silica aerogel sheets. • A green, additive-free strategy overcomes the flame-retardancy vs. mechanical-integrity trade-off. Conventional flame-retardant additives often raise environmental and health concerns due to their toxicity and persistence. Developing high-performance, inherently fire-resistant silica xerogel monoliths via scalable ambient pressure drying remains a significant challenge, as mechanical robustness, monolithic integrity, and flame retardancy are typically mutually exclusive. This study addresses this issue by introducing a green and synergistic strategy using bio-derived phytic acid (PA) and the amphiphilic block copolymer Pluronic F127 to direct the sol-gel co-assembly of a methyltrimethoxysilane/tetraethoxysilane (MTMS/TEOS) system. PA serves dual roles: as a potent biobased acid catalyst, it accelerates precursor hydrolysis, and as a non-toxic, multidentate cross-linker, it forms persistent Si–O–P bonds that chemically reinforce the silica network. F127 acts as a microstructure director, templating a homogeneous gel network with robust inter-particle connectivity. This cooperative action enables rapid gelation (within 1–20 min) and yields monolithic phosphorus-incorporated silica (P-silica) xerogels. The optimized material exhibits excellent mechanical performance (compression strength = 0.140 MPa, strain = 60.3%), outstanding thermal stability (90.3 wt% residual mass at 1000 °C), and superior fire resistance, showing immediate self-extinguishment and minimal damage upon direct flame impingement. It also provides effective thermal insulation, surpassing commercial silica aerogel sheets at a thickness of 3 mm. By replacing conventional hazardous flame retardants with benign, biobased PA and achieving a unique property synergy, this work presents a viable and environmentally sound design principle for advanced thermal insulation materials in fire-risk environments, contributing to safer and more sustainable material solutions. Download: Download high-res image (123KB) Download: Download full-size image
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高影响因子
ACS Applied Bio Materials
·
2024
·
IF 4.6
He Ren,Minchao Hao,Gengqi Liu,Jiexin Li,Zhen Jiang,Wenlu Meng,Yumiao Zhang
Photodynamic therapy (PDT) and ferroptosis show significant potential in tumor treatment. However, their therapeutic efficacy is often hindered by the oxygen-deficient tumor microenvironment and the challenges associated with efficient intracellular drug delivery into tumor cells. Toward this end, this work synthesized perfluorocarbon (PFC)-modified Pluronic F127 (PFC-F127), and then exploits it as a carrier for codelivery of photosensitizer Chlorin e6 (Ce6) and the ferroptosis promoter sorafenib (Sor), yielding an oxygen self-supplying nanoplatform denoted as Ce6-Sor@PFC-F127. The PFCs on the surface of the micelle play a crucial role in efficiently solubilizing and delivering oxygen as well as increasing the hydrophobicity of the micelle surface, giving rise to enhanced endocytosis by cancer cells. The incorporation of an oxygen-carrying moiety into the micelles enhances the therapeutic impact of PDT and ferroptosis, leading to amplified endocytosis and cytotoxicity of tumor cells. Hypotonic saline technology was developed to enhance the cargo encapsulation efficiency. Notably, in a murine tumor model, Ce6-Sor@PFC-F127 effectively inhibited tumor growth through the combined use of oxygen-enhanced PDT and ferroptosis. Taken together, this work underscores the promising potential of Ce6-Sor@PFC-F127 as a multifunctional therapeutic nanoplatform for the codelivery of multiple cargos such as oxygen, photosensitizers, and ferroptosis inducers.
研究领域:
肿瘤学
·
纳米医学
·
药剂学
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PubMed
高影响因子
COMPOSITES PART B-ENGINEERING
·
2025
·
IF 14.2
Hua Zhang,Yang Luo,Guanrong Li,Zeming Hu,Rong Xu,Tong Zhu,Xu Cao,Yudong Yao,Wei Jian,Jun Chen,Grodon G. Wallace,Jun Fu
Engineered tissues created through cell-laden hydrogel bioprinting offer a promising therapeutic approach for tissue regeneration. However, considerable challenges persist in the development of hydrogels that possess optimal gelling kinetics and viscoelastic properties, and sufficient stability to facilitate both the printing of biomimetic structures and the formation of engineered tissues. Herein, we present a rapidly gelling and long-term dynamic hyaluronate hydrogel achieved through the introduction of self-assembled F127 diacrylate (F127DA) micelles to modulate the kinetics of hydrazone crosslinking and the extent of dual-crosslinking network formation. The investigation demonstrates that the introduction of F127DA strengthens the interactions among the hyaluronate components, significantly accelerating gelation and increasing the mechanical stability of the optimal hydrogels. The rapidly formed ink permits low-shear mixing-injection printing, facilitating the construction of precise structures with high cell viability. The viscoelastic microenvironment fosters fibroblast spreading within the bioprinted matrices and supports the development of a biomimetic skin construct characterized by multilayer keratinocytes on the surface. Application of this dynamic hydrogel in a full-thickness mouse skin wound model accelerates tissue healing by inflammation suppression, angiogenesis and extracellular matrix promotion. This study demonstrates innovative modulation of gelation kinetics and viscoelasticity of dynamic hyaluronic hydrogels using block copolymer micelles for tissue engineering.
研究领域:
生物材料学
·
组织工程学
·
再生医学
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高影响因子
ACS Nano
·
2022
·
IF 18.027
Xi Hu,Yu Sun,Xiaoqi Zhou,Bo Zhang,Hanxi Guan,Fan Xia,Shuangying Gui,Xueqian Kong,Fangyuan Li,Daishun Ling
The rigidity of polymeric micelles plays an important role in their biological behaviors. However, how drug loading affects the rigidity of polymeric micelles remains elusive. Herein, the indomethacin (IMC)-loaded Pluronic F127 micelle is used as a model system to illustrate the impact of drug loading on the rigidity and biological behaviors of polymeric micelles. Against expectations, micelles with moderate drug loading show higher cellular uptake and more severe cytotoxicity as compared to both high and low drug loading counterparts. Extensive one- and two-dimensional nuclear magnetic resonance (NMR) measurements are employed to reveal that the higher drug loading induces stronger interaction between IMC and hydrophilic block to boost the micellar rigidity; consequently, the moderate drug loading imparts micelles with appropriate rigidity for satisfactory cellular uptake and cytotoxicity. In summary, NMR spectroscopy is an important tool to gain insight into drug loading regulated micellar rigidity, which is helpful to understand their biological behaviors.
研究领域:
药学
·
生物物理学
·
材料科学
·
核磁共振波谱学
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PubMed
高影响因子
Biomolecules
·
2022
·Vol. 12
·期 9
·1263
·
IF 6.064
Dengchao Xie,Xin Zhou,Bo Xiao,Lian Duan,Zhenhua Zhu
Oral nanoparticles have been considered a prospective drug delivery carrier against ulcerative colitis (UC). To enhance the mucus-penetrating capacity and aqueous solubility, and strengthen the anti-inflammatory effect of resveratrol (RSV), we fabricated RSV-loaded silk fibroin-based nanoparticles with the functionalization of Pluronic F127 (PF-127). The obtained PF-127-functionalized RSV-loaded NPs had an average particle size around 170 nm, a narrow size distribution (polydispersity index < 0.2), and negative zeta potential (−20.5 mV). Our results indicated that the introduction of PF-127 strengthened the mucus-penetrating property of NPs. In vitro studies suggested that NPs with PF-127 enhanced the suppression of the secretion of proinflammatory cytokine TNF-α and reactive oxygen species (ROS) from RAW 264.7 macrophages under lipopolysaccharide stimulation in comparison with other counterparts. According to the evaluation of macro symptoms and main inflammatory cytokines, we further report preferable therapeutic outcomes achieved by PF-127 functionalized-NP-treated dextran sulphate sodium (DSS) groups in the colitis model compared with blank silk fibroin NPs and RSV-loaded NPs without the functionalization of PF-127. Taken together, this work suggests that the fabricated PF-127 NPs via the oral route are promising and useful RSV-loaded nanocarriers for UC treatment.Keywords:silk fibroin;resveratrol;nanoparticles;ulcerative colitis
研究领域:
药学
·
纳米技术
·
炎症
·
药物递送系统
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DOI
PubMed
高影响因子
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
·
2026
·
IF 4.8
Yunxiang Qi,Zhenghua Zhang,Xuan Wang,Haitao Long,Lumei Pu,Weibing Xu
Smart nanopesticides demonstrates excellent potential in the prevention of tomato gray mold. Herein, temperature, pH and GSH triple responsive of pyraclostrobin nanopesticide (CDC-F127-P) is fabricated base on Pluronic F127 and cinnamaldehyde-derived liposome. The maximum fungicide loading of Pyr reaches 52.9%. The particle size and zeta potential are 143 nm and + 29 mV. The release of Pyr increases from 38% to 61% after 48 h as the temperature rises from 5 °C to 35 °C. The value increases from 62% to 87% when the concentration of oxalic acid rises from 0 to 20 mM, which increases from 10% to 37% as the concentration of GSH rises from 0 to 20 mM. The EC₅₀ of CDC-F127-P is 1.96 μg/mL. The inhibition rates of CDC-F127-P for mycelial growth and spore germination are 69.3% and 73.0% at 10 μg/mL. The nucleic acid and protein leakage reaches 124.8 μg/mL and 113.5 μg/mL. A spore mortality rate of 66.4% is arrived. Mitochondrial membrane potential reduces by 96% after treatment with 2 μg/mL. The CDC-F127-P shows a hemolysis rate of 1.8% and a tomato seed germination rate of 60% at 10 μg/mL. The contact angle on the tomato leaf is 74.0 o . A solution retention capacity of 27.5 mg/cm 2 is retained after simulated rainfall. The disease inhibition rates of 64.9% and 71.0% in detached-leaf and potted-plant assays after treatment with 10 μg/mL CDC-F127-P. The triple-responsive CDC-F127-P nanopesticide offers a highly efficient and safe strategy for gray mold control and presenting a novel approach for developing green nano-pesticides.
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高影响因子
Journal of CO2 Utilization
·
2021
·
IF 7.132
Zhongzheng Zhang,Shijian Lu,Guofei Shen,Yonghui Zhao,Tianyang Zhu,Qiang Gao,Nannan Sun,Wei Wei
The rapid synthesis of highly ordered nitrogen-doped mesoporous carbon single crystals with regular and tunable single-crystal morphologies were successfully realized via a controllable co-assembly strategy by using F127 as structure-directing template, 2-methylimidazole as nitrogen source and morphology-adjusting agent, and hexamethylenetetramine as formaldehyde source. Compared with other methods for carbon crystal growth, intricate pre-polymerization steps, taxing synthesis conditions, and long duration time are not requisite for this strategy. Detailed investigation on the effects of 2-methylimidazole dosage, hydrothermal temperature and time, and carbonization temperature on morphology, structure, and nitrogen content of carbon crystals were systematically conducted. Furthermore, one reasonable assembly mechanism was elucidated from both experimental and theoretical perspectives. It was found 2-methylimidazole actively involved in the formation of the polymer matrices via H-bonding to surfactant and chemical reactions with formaldehyde and resorcinol. As such, the introduced 2-methylimidazole not only acted as an effective nitrogen precursor to significantly promote the nitrogen content in resulted crystal carbons, but also served as a positive morphology-tuning agent. Its increasing use successfully achieved the morphology adjustment from hexagonal prisms to rhombic dodecahedrons and then spheres. With intrinsic enriched nitrogen content and large surface area, our synthesized carbon crystals show excellent CO 2 adsorption performance.
研究领域:
材料科学
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化学工程
·
环境科学
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DOI
高影响因子
CARBON
·
2019
·
IF 7.466
Hui Xie,Yajuan Zhao,Yong Tian,Xiufang Wang,Mingfang Yan
Owing to the shallow understanding of the formation mechanism of ordered mesoporous carbon nanoparticles (OMCNs), there are still many obstacles to the synthesis of OMCNs with controllable morphology by a simple and efficient method. Herein, we first propose a universal mechanism for OMCNs formation, that is, the composite micelle units self-assembly mechanism. Under the guidance of this mechanism, the inexpensive F127 was selected as the soft template, resorcinol and hexamethylenetetramine were used as the carbon source, and a series of dispersions were synthesized for the first time under acidic condition by the one-step aqueous solution method. Interestingly, OMCNs could be transformed from spherical to rhombic dodecahedron by adjusting the amount of F127. Moreover, the particle size of the obtained polymer nanoparticles (PNs) exhibited a linear relationship with the amount of F127 in a wide range ( W F127 = 0.25 g–0.70 g), and the linear equation is y = − 1523.6 x + 1055.8 (R 2 = 0.99), which can realize the customized synthesis of PNs. As a demonstration of their versatility, a simple and novel method was developed to prepare magnetic Fe-OMCNs by iron doping of PNs by oxidation reaction of iron. These findings have pioneering implications for promoting the development of OMCNs.
研究领域:
材料科学
·
化学工程
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DOI
高影响因子
CARBON
·
2026
·
IF 12.7
Gangyong Li,Yonghong Lu,Ruqin Zhang,Yongxiao Yang,Zhicheng Liu,Zhi Li,Yucan Zhu,Zhaohui Hou
Graphite-based materials are promising cathodes for rechargeable aluminum batteries (RABs) owing to their tunable electronic and structural characteristics; however, their performance is hindered by sluggish ion transport in conventional graphite cathode materials suffering from limited interlayer spacing and low surface activity. Herein, we develop a synergistic modification strategy combining Pluronic F127 self-assembly and Ar-plasma treatment to engineer graphite cathodes. The F127 soft template expands the interlayer spacing, while plasma etching introduces surface defects, synergistically optimizing ion transport pathways and electrochemical activity. The optimized cathode possesses an enlarged interlayer distance of 0.42 nm and delivers a high specific capacity of 135 mAh g −1 at 1 A g −1 , excellent rate capability, and 70.4% capacity retention over 10000 cycles. Kinetic analysis reveals a dominant pseudocapacitive contribution of 83.7%. This work demonstrates an effective interface engineering approach for designing high-performance carbon-based cathodes in RABs.
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DOI
高影响因子
ELECTROCHIMICA ACTA
·
2018
·
IF 5.116
Ying Liu,Lingyang Liu,Yongtao Tan,Lengyuan Niu,Lingbin Kong,Long Kang,Fen Ran
Supercapacitors receive numerous attentions for their high charging/discharging rate and robust cycle life, while vanadium nitride with a wide work potential window and comparable specific capacitance promotes the rapid development of negative materials for supercapacitors. In this paper, we report an in-situ preparation for nanohybrid material of carbon nanosphere@vanadium nitride (CNS@VN) derived from metal-organic framework assembled by chitosan, NH 4 VO 3 and F127. The biomass of chitosan is used as carbon source, amphiphilic block copolymer of F127 is used as guiding agent, and the vanadium-based compound of NH 4 VO 3 is used as precursor. The prepared CNS@VN showed an outstanding specific capacitance as high as 300.4 F/g and the estimated one for VN can reach 1241.3 F/g. Furthermore, a hybrid supercapacitor device of CNS@VN||Co 3 O 4 is assembled by using CNS@VN and Co 3 O 4 as the negative and positive electrode materials . The device exhibits an excellent energy density of 18.8 Wh/Kg at the power density of 800 W/kg and a prior cycle stability of 77.3% retention. This kind of hybrid material with advanced structure architecture and good electrochemical performance may open up a new design thought for negative electrode materials of supercapacitors.
研究领域:
材料科学
·
电化学
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DOI
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2021
·Vol. 21
·期 6
·2100055
·
IF 4.979
Peihong Li,Yanlong Sui,Xueyan Dai,Qiangsheng Fang,Haofei Sima,Chunling Zhang
Dynamic hydrogels constructed with dynamic chemical bonds often have mechanical strength and self-healing properties. In this paper, tannic acid is combined with lysine-containing F127 through Schiff base. A series of FLaT hydrogels cross-linked by hydrogen bonds and dynamic chemical bonds is prepared, and the influence of Schiff base amount on the performance is discussed. The FLaT hydrogel exhibits reversible sol–gel transition, self-healing, injectability, and pH sensitivity. Increasing the amount of Schiff base can improve the strength, stability, and self-healing ability of the hydrogel. Owing to their low cytotoxicity, linear release pattern, and pH-controlled release rate, the FLaT hydrogels show potential use in drug delivery systems for cancer treatment.
研究领域:
材料科学
·
生物医学工程
·
药剂学
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DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2018
·Vol. 16
·期 1
·1-15
·
IF 5.294
Fu Ji-jun,Chen Ming-yue,Li Jie-xia,Zhou Jun-hua,Xie Sheng-nan,Yuan Ping,Tang Bo,Liu Cheng-cheng
Background In order to explore the possibility of treating breast cancer by
local photo-therapy, a photothermal agents loaded in situ hydrogel was
established. In detail, The
Cu2MnS2 nanoplates were
prepared by one-pot synthesis and, the thermosensitive Pluronic F127 was used as
the hydrogel matrix. The Cu2MnS2
nanoplates and the hydrogel were characterized by morphous, particle size, serum
stability, photothermal performance upon repeated 808 nm laser irradiation as
well as the rheology features. The therapeutic effects of the
Cu2MnS2 nanoplates and the
hydrogel were evaluated qualitatively and quantitatively in 4T1 mouse breast
cancer cells. The retention, photothermal efficacy, therapeutic effects and
systemic toxicity of the hydrogel were assessed in tumor bearing mouse
model.Results The Cu2MnS2 nanoplates
with a diameter of about 35 nm exhibited satisfying serum stability, photo-heat
conversion ability and repeated laser exposure stability. The hydrogel
encapsulation did not negatively influence the above features of the
photothermal agent. The nanoplates loaded in situ hydrogel shows a phase
transition at body temperature and, as a result, a long retention in
vivo.Conclusion sThe photothermal agent embedded hydrogel played a promising
photothermal therapeutic effects in tumor bearing mouse model with low systemic
toxicity after peritumoral administration.
研究领域:
肿瘤学
·
纳米医学
·
生物医学工程
·
材料科学
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DOI
PubMed
高影响因子
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