FOOD CHEMISTRY
·
2025
·
IF 9.8
Wenping Yang,Zufei Jin,Ying Yu,Guangyan Hao,Langjin Zhong,Yue Tang,Yuangen Wu
The presence of excessive nitrite in foodstuffs poses significant risks to human health, underscoring the critical importance of developing rapid detection methods. This study synthesizes a Mn₃O₄ vacancy-rich nanozyme exhibiting exclusive oxidase-mimicking activity, capable of catalyzing the oxidation of N-ethyl-N-(3-sulfopropyl)-3-methylaniline sodium salt (TOPS). Intriguingly, TOPS oxidation derivatives demonstrate nitrite concentration-dependent color variations through a diazotization-like phenomenon. Thus, we establish dual detection platforms incorporating both visual and smartphone-assisted sensing modalities. Mechanistic investigations reveal that both the catalytic oxidation and diazotization-like processes involve reactive oxygen species ( • O₂ − and 1 O₂). Sensitivity studies demonstrate a linear detection range of 20–160 μM, with calculated limits of detection (LOD) at 1.9 μM (visual) and 0.01 μM (smartphone), respectively. Comparative analysis with national standard methods validates the reliability and accuracy of our approach in real food matrices. This work presents a robust analytical platform combining operational simplicity with laboratory-grade precision for food safety monitoring.
研究领域:
分析化学
·
纳米技术
·
食品安全
·
生物传感器
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Biomedical Nanotechnology
·
2022
·Vol. 18
·期 11
·2484-2497
·
IF 3.641
Li Guiyin,Chen Min,Li Haimei,Li Xinhao,Yao Xiaoqing,Li Liuxun
Golgi protein 73 (GP73) is a novel biomarker for the detection of hepatocellular carcinoma. We prepare a colorimetric aptasensor for GP73 detection based on the catalytic performance of the H-rGO-Mn3O4 nanozyme. The H-rGO-Mn3O4 nanozyme serves
as a peroxidase mimetic which can enhance the reaction with the substrate (3, 3,’ 5, 5′-tetramethylbenzidine, TMB) and H2O2. The peroxidase-like activity of H-rGO-Mn3O4 features a 1.78-fold higher binding affinity value (Km
)
for TMB compared with that of horseradish peroxidase. The H-rGO-Mn3O4 nanozyme not only exhibits admirable peroxidase-like activities due to the synergistic effect of Mn3O4 NPs, rGO and hemin, but also has a large specific surface area to endow the
GP73 aptamer with specific recognition capabilities. A sandwich colorimetric aptasensor is formed to realize the visual detection of GP73 through catalyzing the H2O2-mediated oxidation peroxidase substrate TMB to oxidized TMB accompanied by a color change from colorless
to blue. Under optimal conditions, the logarithm of the GP73 concentration (0.05–50.0 ng/mL) shows a good linear relationship with the absorbance. The calibration equation is Y =−0.0383 lgC+0.4835, with R2 of 0.9964, and the lowest limit of detection is 36.94
pg/mL. Additionally, the content of GP73 in human serum samples is directly detected, and the relative standard deviation is 0.49–4.91%. Compared with the enzyme-linked immunosorbent assay method, the relative error is 0.23–3.61%. All in all, colorimetric aptasensor is demonstrated
to exhibit excellent specificity, stability, and reproducibility.
研究领域:
生物标志物研究
·
纳米技术
·
分析化学
·
癌症诊断
·
生物化学
✓ 已验证
DOI
高影响因子
Surfaces and Interfaces
·
2024
·
IF 5.7
Yufeng Gan,Yuxiang Yang,Shunyan Ning,Yimin Liu,Yuezhou Wei,Xinpeng Wang,Deqian Zeng
Developing heterojunction photocatalysts is a critical method to augment the photocatalytic activity of single semiconductors. However, the instability of their heterostructure poses a significant challenge. Herein, a unique 0D/2D Mn 3 O 4 /CdS p-n photocatalyst has been prepared by a simple one-pot in-situ hydrothermal approach for H 2 production and methylene blue (MB) degradation. The optimized MC-0.18 (18 at% Mn) nanocomposite showed remarkable photocatalytic properties, producing a significantly higher H 2 generation rate of 1291 μmol· g −1 · h −1 , which was 13.7 and 9.2 times higher than that of pristine CdS and ex-situ synthesized MC-0.18-ex photocatalysts, respectively. MC-0.18 displayed the highest reaction rate at 0.0435 min −1 for MB degradation, which was approximately 2.6 and 6.3 times higher than CdS and Mn 3 O 4 , respectively. Active species capture experiments and ESR identified •OH and •O 2 − as the main substances involved in MB degradation. Importantly, MC-0.18 demonstrated excellent stability and reusability in photocatalytic H 2 production and MB degradation cycle tests. The formation of unique p-n heterostructures results in enhanced photoactivity due to the matched band alignment between ultrafine Mn 3 O 4 nanoparticles and CdS nanosheets , leading to a high charge separation capacity. This study offers a facile route to design p-n heterojunctions that have remarkable charge transfer abilities to promote H 2 production and degrade organic dyes.
研究领域:
材料科学
·
环境科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
Advanced Healthcare Materials
·
2023
·Vol. 12
·期 15
·2202280
·
IF 10
Wenya Li,Rongtian Li,Qiang Ye,Yiming Zou,Xing Lu,Wenhua Zhang,Jinxiang Chen,Yinghua Zhao
Nanomedicine exhibits emerging potentials to deliver advanced therapeutic strategies in the fight against triple-negative breast cancer (TNBC). Nevertheless, it is still difficult to develop a precise codelivery system that integrates highly effective photosensitizers, low toxicity, and hydrophobicity. In this study, PCN-224 is selected as the carrier to enable effective cancer therapy through light-activated reactive oxygen species (ROS) formation, and the PCN-224@Mn 3 O 4 @HA is created in a simple one-step process by coating Mn 3 O 4 nanoshells on the PCN-224 template, which can then be used as an “ROS activator” to exert catalase- and glutathione peroxidase-like activities to alleviate tumor hypoxia while reducing tumor reducibility, leading to improved photodynamic therapeutic (PDT) effect of PCN-224. Meanwhile, Mn 2+ produced cytotoxic hydroxyl radicals (∙OH) via the Fenton-like reaction, thus producing a promising spontaneous chemodynamic therapeutic (CDT) effect. Importantly, by remodeling the tumor microenvironment (TME), Mn 3 O 4 nanoshells downregulated hypoxia-inducible factor 1 α expression, inhibiting tumor growth and preventing tumor revival. Thus, the developed nanoshells, via light-controlled ROS formation and multimodality imaging abilities, can effectively inhibit tumor proliferation through synergistic PDT/CDT, and prevent tumor resurgence by remodeling TME.
研究领域:
纳米技术
·
癌症治疗
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Asim Mushtaq,Xuehua Ma,Jabeen Farheen,Xiaoqing Lin,Muhammad Tayyab,M. Zubair Iqbal,Xiangdong Kong
Magnetic hydroxyapatite nanocomposites are promising candidates for various biomedical applications. However, the uncontrolled growth with the unfavorable size limits their widespread utilization in real-time applications. Herein, a facile method was utilized to fabricate uniform spherical-shaped nanocomposites of manganese oxide combined hydroxyapatite (Mn 3 O 4 -HAp) with an average size of about 28 nm. The structural characterization reveals the presence of Mn 3 O 4 in the crystalline phase, confined by HAp to give a composite structure. The biocompatibility and drug loading capability of Mn 3 O 4 -HAp nanocomposites are improved by surface modification using Food and Drug Administration-approved triblock copolymer Pluronic® F-127, followed by folic acid (FA) for targeting ability. Taking advantage of the surface properties of the polymer and the drug delivery potential of HAp, metformin was encapsulated in the prepared nanocomposites with a loading capacity of 98 %. The prepared nanocomposites indicate promising cell viability up to 87 % and an excellent drug release profile in an acidic atmosphere. Moreover, the magnetic component Mn 3 O 4 presents auspicious T 1 -Magnetic resonance imaging with notable r 1 relaxivity of 2.166 mM −1 s −1 . Further, the Mn 3 O 4 [email protected] nanocomposites demonstrate good cellular uptake and excellent reactive oxygen species (ROS) production under low-intensity UV irradiation , resulting in a remarkable photodynamic therapeutic effect. The results showed that the designed Mn 3 O 4 -HAp nanocomposites are promising targeted chemo-theranostic agents.
研究领域:
生物医学工程
·
纳米技术
·
材料科学
·
癌症治疗
·
医学影像
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2024
·Vol. 59
·期 9
·3930-3946
·
IF 3.5
Miao Xin,Wang Liying,Shi Yunxin,Chen Guohua,Liu Yunfei,Wu Gaoqi,Cao Zhenzhu,Zhang Yongfeng
Microsphere 3D structure of Cu/Mn 3 O 4 @SC composite was fabricated by pyrolyzing the bimetallic CuMn-MOF, which was composed of Cu 2+ , Mn 2+ and sulfur-containing ligand 2,5-thiophene dicarboxylic acid (H 2 TDC). The composite of Cu/Mn 3 O 4 @SC is used as a high-performance anode material for the lithium-ion batteries cycle exhibiting stable capacities of 715 mAh g −1 after 100 cycles at 200 mA g −1 and outstanding long cycle performance with a reversible capacity of 508 mAh g −1 at 0.5 A g −1 after 500 cycles. The superior performance for the Cu/Mn 3 O 4 @SC anode is mainly attributed to the mutual supporting characteristics of heterojunction synergistic effect, thus avoiding damage in the process of energy storage process. In addition, the kinetic analysis based on CV reveals that the transport kinetics mechanism of the Cu/Mn 3 O 4 @SC is synergistically controlled by the surface capacitive and pseudocapacitive behaviors. The EIS proves that the introduction of Cu enhances the conductivity of the material and the rate of lithium-ion diffusion. Graphical abstract Cu- and S-doped multielement microspheres was fabricated by pyrolyzing CuMn-MOF supported by 2, 5-thiophene dicarboxylic acid.
研究领域:
材料科学
·
电化学
·
纳米技术
·
能源存储
·
无机化学
✓ 已验证
DOI
高影响因子
ELECTROANALYSIS
·
2021
·Vol. 33
·期 6
·1646-1656
·
IF 3.223
Ya-Mu Xia,Xiang Ou,Yan Zhao,Meng Xia,Dong Chen,Wei-Wei Gao
A facile synthesis strategy of reduced graphene oxide (RGO)-octahedral Mn 3 O 4 (oct-Mn 3 O 4 ) nanocomposites using in situ one-pot hydrothermal reaction was reported. The RGO-oct-Mn 3 O 4 nanocomposites were drop-casted onto the surface of glassy carbon electrode (GCE) to obtain RGO-oct-Mn 3 O 4 /GCE. DPV results revealed that the performance of RGO-oct-Mn 3 O 4 /GCE towards metronidazole displayed a linear ranging from 0.1 to 9.5 μM with a detection limit of 0.037 μM. For sulfamonomethoxine, it exhibited a linear ranging from 1 to 95 μM with a detection limit of 0.27 μM. Moreover, the proposed sensor had good anti-interference capability, high stability, satisfactory reproducibility, and was successfully applied in real samples.
研究领域:
材料科学
·
分析化学
·
纳米技术
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
·
2023
·
IF 14
Yuquan Li,Junxu Yang,Xiaoming Chen,Hao Hu,Nihan Lan,Jinmin Zhao,Li Zheng
Mitochondrial reactive oxygen species (mROS) play a crucial role in the process of osteoarthritis (OA), which may be a promising target for therapy of OA. In this study, novel mitochondrial-targeting and SOD-mimic Mn 3 O 4 @PDA@Pd-SS31 nanozymes with near-infrared (NIR) responsiveness and synergistic cascade to scavenge mROS were designed for the therapy of OA. Results showed that the nanozymes accelerated the release of Pd and Mn 3 O 4 under NIR irradiation, exhibiting enhanced activities of SOD and CAT mimic enzymes with reversed mitochondrial dysfunction and promoted mitophagy to effectively scavenge mROS from chondrocytes, modulate the microenvironment of oxidative stress, and eventually inhibit the inflammatory response. Nanozymes were excreted in vivo through intestinal metabolic pathway and had good biocompatibility, effectively reducing the inflammatory response and relieving articular cartilage degeneration in OA joints, with a reduction of 93.7 % and 93.8 % in OARSCI scores for 4 and 8 weeks respectively. Thus, this study demonstrated that the mitochondria targeting and NIR responsive Mn 3 O 4 @PDA@Pd-SS31 nanozymes could efficiently scavenge mROS, repair damaged mitochondrial function and promote cartilage regeneration, which are promising for the treatment of OA in clinical applications.
研究领域:
生物医学工程
·
纳米技术
·
骨科
·
药学
✓ 已验证
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Shuangju Zhu,Yue Tang,Bin Shi,Wenying Zou,Xueli Wang,Chunxiao Wang,Yuangen Wu
Colorimetric detection of pathogenic bacteria in food still faces many challenges. Herein, a novel label-free and ultrasensitive colorimetric aptasensor was firstly established for the detection of food-borne pathogenic like Staphylococcus aureus ( S. aureus ) based on oligonucleotide-mediated the oxidase-mimicking activity of octahedral Mn 3 O 4 nanoparticles (NPs). The study confirmed that the common oligonucleotide such as SA31 aptamer can adsorb on the surface of octahedral Mn 3 O 4 NPs, and significantly inhibit the oxidase-mimicking activity by blocking their electron transfer to 3,3′,5,5′-tetramethylbenzidine. In the presence of S. aureus , aptamers will preferentially bind to bacterial cell, resulting in the recovery of oxidase-mimicking activity. The naked eye can easily recognize the color change from green to yellow, with the increase concentration of S. aureus from 10 CFU·mL −1 to 2 × 10 5 CFU·mL −1 . The colorimetric aptasensor shows a low detection limit of 3 CFU·mL −1 (S/N = 3). This strategy has excellent selectivity whether the presence of other competitive bacteria, and has been successfully applied to the non-enrichment detection of S. aureus in milk and pork samples.
研究领域:
分析化学
·
食品科学
·
生物传感器
·
微生物学
✓ 已验证
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Zhijian Fu,Jiayu Ying,Xuri Yang,Manyu Zhang,Zijian Zhang,Rui Chen,Chenghan Yang,Xuyu Wang,Yubo Zhou,Hongbing Ji
Exploring room temperature treatment of formaldehyde (HCHO) is a crucial area of ongoing research, with transition metal catalysts showing promise for future development due to their cost-effectiveness. However, the challenge lies in the limited ability of these catalysts to activate oxygen efficiently and maintain stable catalytic oxidation of HCHO. The Mn 3 O 4 catalyst doped with Cr, Cu, Zn, and Co was synthesized via hydrogen reduction in this study. Cr/Mn 3 O 4 showed exceptional catalytic performance by completely converting HCHO at 30 °C and 200 ppm, while maintaining excellent stability during a 75-hour durability test. The characterization techniques revealed that the incorporation of transition metal Cr into the Mn 3 O 4 lattice resulted in an increased number of oxygen vacancy defects on its surface, thereby significantly enhancing its ability to activate oxygen. Furthermore, Cr doping substantially augmented the specific surface area and abundance of mesoporous structures in the catalyst, which provided ample active sites and facilitated efficient mass transfer for substrate oxidation by promoting diffusion to these active sites. These enhancements ultimately led to a heightened activation of oxygen and H 2 O into reactive oxygen species, consequently reducing the dominance of side reaction pathways caused by intermediates occupying active sites.
研究领域:
催化
·
环境化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2020
·Vol. 10
·期 23
·13687-13695
·
IF 3.119
Wenhua Zhan,Xiaoxia Cai,Hairui Li,Getao Du,Hao Hu,Yayan Wu,Lin Wang
Multidrug resistance (MDR) is a huge challenge for gastric cancer chemotherapy. Therefore, MDR accurate monitoring is of great significance for the treatment of gastric cancer. GMBP1, an extracellular internalization peptide, can target MDR gastric cancer cells through specific binding to GRP78, which is an MDR-related protein that is overexpressed in gastric cancer cells. Herein, we constructed GMBP1 conjugated Mn3O4 nanoplates (Mn3O4@PEG-GMBP1 NPs) for in vivo monitoring of MDR gastric cancer through magnetic resonance imaging (MRI). The generated Mn3O4@PEG-GMBP1 NPs had a size of about 11 nm and exhibited a good colloidal stability in PBS and in 10% FBS medium. Serial in vivo MRI studies in mice demonstrated that the magnetic resonance signal intensity, at the tumor site, reached a peak at 3 h after tail vein injection of Mn3O4@PEG-GMBP1 NPs. The specific targeting ability of MDR gastric cancer cells (SGC7901/ADR) by Mn3O4@PEG-GMBP1 NPs was authenticated in vitro, in vivo and by immunofluorescence analysis experiments. The systematic safety evaluation indicated that the toxicity of Mn3O4@PEG-GMBP1 NPs in mice was negligible. Therefore, the GMBP1 conjugated Mn3O4 nanoplates can be clinically used for accurate imaging and monitoring of MDR gastric cancer.
研究领域:
生物医学工程
·
肿瘤学
·
分子影像学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2021
·Vol. 168
·期 11
·116518
·
IF 4.316
Peipei Li,Dan Cheng,Xiaohua Zhu,Meiling Liu,Youyu Zhang
Compared with the traditional Haber-Bosch process, electrochemical N2 to NH3 reduction affords an eco-friendly and sustainable alternative to ambient NH3 synthesis with the aid of efficient electrocatalysts. In this work, partial oxidation of MnS to obtain the MnS-Mn3O4 is proved as a promising noble-free electrocatalysts of N2 to NH3 fixation at ambient conditions. When tested in 0.1 M Na2SO4, the electrochemical N2 reduction reaction performance of MnS-Mn3O4 is improved comparing with the MnS, which achieves large NH3 yield of 16.74 μg h–1 mgcat.–1 and a high Faradaic efficiency of 5.72%. It also exhibits excellent selectivity of N2 to NH3 and strong long-term electrochemical stability.
研究领域:
化学
·
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）