Science of Advanced Materials
·
2019
·Vol. 11
·期 1
·105-111
·
IF 1.158
Di Huang,Long Yanju,Luo Lijun,Li Lingxin,Zhang Sifeng,Wang Lulu,Jiang Fengzhi
N-doped Bi2O3 with hierarchical structure was synthesized using precipitation/calcination method. In this method, ethylenediamine was used as both the nitrogen source and morphology controller besides the P123 triblock copolymer as main structure directing agent,
to control the texture and morphology of the catalyst. The microstructure and chemical composition of N-doped Bi2O3 photocatalyst were characterized with XRD, XPS, SEM-EDS, DR UV-vis, and N2 physisorption. The prepared hierarchical N-doped Bi2O3
was used for the photocatalytic degradation of 17β-estradiol (E2) under visible light. The absorption edge of prepared N doped Bi2O3 appeared an obvious red shift comparing with pure phase Bi2O3. This would help photocatalyst make full
use of light source to degrade E2. Under the same conditions of the photocatalytic reaction, the rate constant of degradation of E2 over N-doped Bi2O3 was 6.3 times of that obtained over Bi2O3. The stability of N-doped Bi2O3
and the mechanism of the photocatalytic degradation of E2 under visible light were studied.
研究领域:
环境科学
·
材料科学
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DOI
高影响因子
Science of Advanced Materials
·
2015
·Vol. 7
·期 6
·1021-1027
·
IF 2.598
Yu Jin-Gang,Chen Na,Jiao Fei-Peng,Liu Qi,Jiang Xin-Yu,Jiang Jian-Hui,Chen Xiao-Qing
A novel and facile method for preparing iodinated carbon nanotubes, with iodine and hydrogen simultaneously covalently bound to the surface of nanotubes, has been developed. The functionalized carbon nanotubes were fully characterized using Fourier transform infrared spectroscopy, X-ray
photoelectron spectroscopy, Raman spectroscopy, energy-dispersive X-ray (EDX) spectroscopy and thermogravimetric analyses. This is the first report on the successful functionalization of single-walled carbon nanotubes using hydroiodic acid.
研究领域:
材料科学
·
化学
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DOI
高影响因子
Science of Advanced Materials
·
2019
·Vol. 11
·期 1
·116-127
·
IF 1.158
Sun Qiang,Zheng Huaili,Zheng Xinyu,Hu Xuebin,An Yanyan,Liu Hongxia,Zhao Chuanliang
In this study, a kind of novel dual flocculants system was prepared by premixing polydopamine (PDA) with anion polyacrylamide (APAM) to remove nickel ions and methylene blue from aqueous solutions. Polydopamine was prepared by oxidant-induced self-polymerization of dopamine. Anion polyacrylamide
was synthesized by acrylamide, acrylic acid and 2-acrylamido-2-methyl-1-propanesulfonic acid under ultraviolet irradiation. Various analytical methods were applied to characterize and exhibit the successful synthesize of polydopamine and anion polyacrylamide. The flocculation performance was
evaluated and results indicated that chelation reaction and π–π stacking effects of PDA, meanwhile adsorption and bridging effects of APAM for nickel ions and methylene blue molecules removal were dominant in neutral and alkaline condition, whereas charge neutralization
of APAM was favored in weak acidic condition. The maximum removal efficiency of nickel ions and methylene blue was 99.2% and 96.7% under the optimum condition, respectively. This work provides a scientific basis and a platform for the application of polydopamine-anion polyacrylamide to remove
heavy metal ions and dyes from aqueous environment.
研究领域:
环境科学
·
材料科学
·
化学工程
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DOI
高影响因子
Science of Advanced Materials
·
2020
·Vol. 12
·期 1
·144-151
·
IF 1.117
Xu Hai-Tang,Liao Hua-Zhen,Zou Meng-Jun,Zhao Yan-Zhi,Lei Fu-Hou,Huang Qin,Dong Mengyao,Zhang Jiaoxia,Guo Zhanhu,Fan Jincheng,Wang Chao,Zhou Ju-Ying
This study investigates the antioxidant, antibacterial and antiproliferative properties of the ethyl acetate, chloroform, ethanol and n-butanol extracts from Chloranthus henryi. Total flavonoid content (TFC) and total phenol content (TPC) values for the extracts could
be investigated. The TPC value for extracts changed from 4.36 to 19.64 milligram gallic acid equivalents per gram of dry material, and the TFC of extracts changed from 3.13 to 9.99 milligram rutin equivalents per gram of dry material. The antioxidant properties were evaluated and their antimicrobial
activity was tested against bacterial strains Staphylococcus aureus, Klebsiella pneumonia, Pseudomonas aeruginosa, Group A Streptococcus and Monilia albican. The results showed that all extract displayed moderate or great potential of antioxidant and antibacterial
activity. Strong correlations were observed between TPC and antioxidant activity. Five compounds could be separated from n-butanol extract, which showed high content of TPC and significant antioxidant activity. They are (1) gallic acid, (2) caffeic acid, (3) 4-hydroxybenzoic acid, (4)
rosmarinic acid and methyl rosmarinate (5). Antiproliferative activity was tested using HepG2, Hela and MCF-7 cells. The study suggested that components of Chloranthus henryi possessed fine antioxidant property, therefore can be applied for antioxidant, antibacterial and antiproliferative
agents in the food or drug industries.
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DOI
高影响因子
Science of Advanced Materials
·
2022
·Vol. 14
·期 5
·911-919
·
IF 1.067
Zhu Chunxia,Ming Shenqiu,Qiu Bin,Zhong Hui
FePt nanoparticles were in this study prepared at varied concentrations to assess their mechanism in regulating DNA injury and inactivation of Hela cells through mitogen-activated protein kinase (MAPK) signal pathway. The cells were divided into following 5 group sets: 1st, 2nd, 3rd,
4th and 5th, which were randomly intervened by following varied concentrations of FePt nanoparticles; 0, 5, 10, 15 and 20 μg/mL. Their action on cellular toxicity, proliferation and inactivation of cells was detected with CCK-8 method, while apoptotic condition was detected with
flow cytometry (FCM). The degree of DNA double chains fracture was detected with neutral single cell gel electrophoresis and immunofluorescence staining. The protein expressions of of EKR1/2, p-ERK1/2, p38 MAPK and p-p38 MAPK in every set were detected with Western Blot assay, while proliferative
activity in the 4th and 5th sets was lower than in the 1st set, and inhibiting action in the 4th set was best. There was no notable difference between 4th and 5th sets, and apoptotic rate in the 1st set was lower than in the other sets. The DNA percentage in the Hela cells was reduced and
Tial length was lengthened along with increased concentration of adopted FePt nanoparticles. The proliferation of Hela cells was restrained by FePt nanoparticles through restraining of the MAPK signal pathway, but growth of Hela cells was not affected, and DNA double-strand break (DSB) was
increased. The FePt nanoparticles could therefore be adopted as one kind of effective anti-tumor drug through increased DNA DSB in tumor cells based on killing effect of tumor cells and good compatibility for normal cells.
研究领域:
纳米技术
·
癌症生物学
·
细胞信号传导
·
毒理学
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DOI
高影响因子
Science of Advanced Materials
·
2022
·Vol. 14
·期 1
·1-10
·
IF 1.067
Wei Zhili,Wei Li
Zirconia ceramics (ZiC) has become a biomaterial with good clinical application prospects due to its good biocompatibility, stability, and excellent mechanical properties. In this study, bioactive glass (BioS) was undertaken as the modifier, and the ZiC precursor solution was penetrated
on the surface of the ZiC body or the ZiC particles were coated with the BioS precursor solution, so as to obtain the ZiC with biological activity by introducing the BioS phase. While the material was characterized, its mechanical properties and biological activity were analyzed by simulating
the mineralization of the body fluid, including the cell adhesion, proliferation, and differentiation of the material. The ZiC was applied as an implant for restoration of patients with teeth loss caused by periodontal disease. In the test, after surface infiltration of BioS sol or coating
of ZiC particles, a very thin BioS phase can be formed on the surface of ZiC after high temperature sintering. The in vitro mineralization test showed that the activation of the grain boundary promoted the deposition of calcium and phosphorus layers on the surface of the sample. The
mechanical test revealed that the relative density, flexural strength, and fracture toughness of the material decreased with the infiltration and coating of BioS. However, under proper preparation conditions, the modified ZiC still showed good mechanical properties and can promote the spreading,
adhesion, and differentiation of mouse bone marrow mesenchymal stem cells (mBMSCs). Clinical trials proved that after the modified ZiC implant material was implanted in patients with teeth loss, the structure was not loose or broken, and the intraoral prosthesis could function normally. After
treatment, the level of IL-1β in the gingival crevicular fluid of the patient decreased obviously (P <0.05). In addition, the probing depth (PD), clinical attachment loss (CAL), and other indicators decreased greatly (P <0.05).
研究领域:
材料科学
·
口腔医学
·
生物医学工程
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DOI
高影响因子
Science of Advanced Materials
·
2016
·Vol. 8
·期 5
·1145-1153
·
IF 1.812
Ma Wang,Yi Shengen,Lin Liangwu,Huang He,Peng Tao,Liu Zhongtao,Liu Zhipeng,Pei Dongni,Miao Xiongying,Wen Yu,Chen Wei,Xiong Li
To synthesize a novel photosensitizer loaded into hollow titanium dioxide nanoparticles (HTNP) and evaluate the efficacy of its anticancer effects on Panc-1 pancreatic cancer cells in vitro. DLS measurements showed that the size of the particles ranged from 80 to 1,000 nm, with
an average diameter of 120 nm. The PDI of the Photosan-loaded HTNP was 0.112 ± 0.01, indicating that the samples have excellent quality with a narrow size distribution in monomodal systems. The photodynamic effects were positively related to the photosensitizer concentration, the light
dose, and the incubation duration. Using the same parameters, photodynamic therapy induced with Photosan-loaded HTNP had a more severe inhibition effect on cancer cell growth than that induced using free Photosan. Moreover, the nano-Photosan groups produced effects within a shorter duration
than free Photosan. Neither the Photosan-loaded nanoparticles nor free Photosan affected H6C7 cells cultured from a normal pancreas. The flow cytometry results demonstrated that laser-induced cell death with Photosan-loaded HTNP was substantially more severe than that induced with free Photosan.
Photosan-loaded HTNP are safe and stable and exhibit faster and more effective tumoricidal effects than free Photosan in the inhibition of Panc-1 cell growth.
研究领域:
肿瘤学
·
纳米医学
·
细胞生物学
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2019
·Vol. 11
·期 6
·893-901
·
IF 1.158
Zhang Zhongtao,Zhang Guangkun,Ji Jingtian,Gao Zhonghui
Nuclear magnetic resonance imaging (MRI) has high image resolution and is widely used in the medical field, but it has the problem of inadequate sensitivity. Therefore, contrast material is needed to enhance the image clarity and accuracy of MRI. In order to further improve the cell
resolution of magnetic resonance imaging (MRI), a new contrast agent, BaYbF5/BaGdF5-Tm, Yb, is obtained by using BaYbF5 and BaGdF5 as the main raw materials and using high temperature thermal decomposition method. A layer of polyethylene glycol (PEG) is added to the material
from the point of view of biocompatibility. TEM and XRD are used to characterize the material, and MTT is used to test the cytotoxicity of the material. The material is used in the imaging process of stem cell-Danhong in the treatment of cerebral infarction. Bioluminescence imaging, immunofluorescence
testing and autoradiography are carried out. A large number of tests have confirmed that the material has low cytotoxicity and is similar to the existing contrast agents in MRI imaging. In bioluminescent imaging experiments, using BaYbF5/BaGdF5-Tm, Yb contrast agent can enhance the optical
density of imaging. In autoradiography test, using BaYbF5/BaGdF5-Tm, Yb contrast agent can clearly show the changes of various tissues. In immunofluorescence test, using BaYbF5/BaGdF5-Tm, Yb contrast agent can find more vascular proliferation cells survive. The new contrast agent proposed
in this study can enhance the imaging ability of MRI. Compared with conventional contrast agents, it has higher cell resolution and lower cytotoxicity. It has positive significance for future disease detection in medicine.
研究领域:
医学影像学
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神经病学
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材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2020
·Vol. 12
·期 5
·725-732
·
IF 1.117
Yu Fangfang,Li Jiaping,Yang Yan,Cheng Yueyue,Ni Xianwei,Wei Kaineng,Liu Zhe
By using an organic framework to fabricate functional biomaterials, novel design and advanced biomedical applications of polymeric microbubbles for in vivo targeting and disease-oriented imaging of tumor vascularization can be developed. The present study describes novel synthetic
protocols to fabricate RGD (Arginine-Glycine-Aspartic)-tagged αvβ3-targeted ultrasound microbubbles. The microbubbles were synthesized by emulsion polymerization techniques. Two types of microbubbles (MBs-1 and MBs-2) were obtained via biotin-streptavidin conjugation
to poly(butyl cyanoacrylate) microbubbles (MBs-0) obtained by one-step synthesis in reverse order. The size distributions and surface zeta potentials were characterized. The results showed that the sizes of the MBs-2 were larger than that those of the MBs-1, and the MBs-2 showed decreased
charge compared to MBs-1. In cell targeting studies, MBs-2 exhibited relatively stronger targeting affinity for αvβ3 integrins, while MBs-1 showed weaker targeting capability. Furthermore, in vivo mice imaging using MBs-2 for intravenous injection exhibited
an obvious and sustained signal increase, which revealed the accumulative of MBs-2 anchoring in tumor. Hence, MBs-2 have been proven to be a promising candidate for using as ultrasound contrast agents for the early diagnosis of αvβ3-overexpressing malignant tumors,
including breast cancer.
研究领域:
生物医学工程
·
药学
·
癌症研究
·
超声成像
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2023
·Vol. 15
·期 2
·256-266
·
IF 0.9
Li Wenqin,Zou Chuanxin
Since there are many problems in the clinical application of traditional chemotherapy drugs for gastric cancer (GC), including poor water solubility and insufficient targeting, the preparation of docetaxel nanoparticles (NPs) with chitosan (CS) as the carrier under nanotechnology can
improve its water solubility and targeting and thus improve the bioavailability and antitumor effect. GX1 was used as a GC target molecule, N-deoxycholic acid (DCA) hydroxyethyl CS was used as a nanodrug carrier, and docetaxel was used as an antitumor angiogenesis drug to fabricate GC target
NPs. The physical characterization was analyzed, the sustained release performance was further analyzed, and the anticancer performance was tested from in vitro and in vivo perspectives. After the NPs were transfected into GC cells, Prdx6 protein level in the cancer cells was
determined by western blotting, and the survival rate of GC cells was determined by cholecystokinin octapeptide (CCK-8). Experiments showed that the encapsulation efficiency and drug loading rate of GC-targeted NPs reached 51.8% and 24.3%, respectively. The average particle size was 148.7
nm, and the surface showed smooth and homogeneous aggregation. docetaxel in the NPs belongs to pH-responsive sustained release, and the drug diffusion type belongs to non-Fickian diffusion. in vitro tests showed that GX1 can improve the uptake rate of the NPs by gastric vascular endothelial
cells, and in vivo tests showed that the NPs can greatly limit the growth rate of GC tumors in nude mice (P < 0.01). Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) results of tumor sections showed that NPs could induce a large amount of tumor
cell apoptosis. The expression of Prdx6 protein in GC cells was decreased after transfection with NPs (P < 0.05), and NPs notably inhibited the proliferation of GC cells (P < 0.01).
研究领域:
肿瘤学
·
药剂学
·
分子生物学
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DOI
高影响因子
Science of Advanced Materials
·
2019
·Vol. 11
·期 7
·1008-1018
·
IF 1.158
Pan Hongtao,Zhang Yanjie,Zhao Xiangkun,Zhou Hongsuo
In this study, glutamic acid and sugar are selected as raw materials to produce glutamic acid-sucrose fluorescent carbon dot material (CDs-N) according to a certain proportion. In order to prolong the time of biological detection, CDs-N-PEG is modified by PEG. Considering that melanoma
will enter the brain, Angiopep-2 ligand and RGD circulating ligand are selected to further obtain CDs-N-PEG-ANG and CDs-N-PEG-RGD. The material is characterized, the fluorescence spectrum is tested, the tyrosinase detection test is designed, the B16F10 cells in vivo are selected for
the biotoxicity test, and the tyrosinase and melanoma detection are extended to the organism. In this study, mice and zebrafish are selected as the research objects. The experimental results show that the fluorescent carbon dots designed in this study can detect tyrosinase well. With the increase
of concentration and reaction time, the fluorescent carbon dots fluorescence intensity corresponding to the site will continue to increase. In the toxicity test of B16F10 cells, the fluorescent carbon dot material shows little toxicity, indicating that the material has good biocompatibility.
Tyrosinase activity is well detected in zebrafish. By comparing B16F10 cells and Hela cells expressed with different tyrosinases, melanoma in mice is preliminarily detected. In this study, tyrosinase is used to detect melanoma and tyrosinase-based biomarkers are used to provide a feasible
method for the preliminary diagnosis of melanoma.
研究领域:
生物医学
·
材料科学
·
肿瘤学
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2022
·Vol. 14
·期 2
·263-271
·
IF 1.067
Fan Jing,Wu Dan,Zhao Depeng,Hu Rui,Fu Zhihong,Li Xuemei
In this study, a novel small molecule estradiol guanidine derivative (Guanidoestradiol, GDT) for female reproductive system targeting and nitric oxide (NO) release has been constructed by conjugating 17β-estradiol and L-arginine through an esterification reaction. After
intraperitoneal administration in female mice, the serum Griess assay and immunohistochemical analysis of ovary and uterus were performed. GDT effectively increased NO concentration in the blood and produced some bio-effects that are beneficial to the reproductive system. The specific advantages
are as follows: (1) the introduction of guanidine groups and amino groups improves the water solubility and bioavailability of estradiol and is expected to exert other biofunctions; (2) the estradiol residue of GDT gives the NO donor the ability for ovarian and uterine targeting; (3) combined
administration of estradiol and NO to the uterus and ovary promoted endometrial thickening and expression of vascular proliferation markers; (4) the abundance of iNOS in tissues was reduced after treatment with NO donors. We suggest that Guanidoestradiol is a promising small-molecule drug
to enhance normal endometrial and ovarian function and may play a role in promoting reproduction.
研究领域:
药理学
·
生殖生物学
·
内分泌学
✓ 已验证
DOI
高影响因子
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