Journal of Environmental Sciences
·
2022
·
IF 6.796
Mei Du,Jingzhang Liu,Fengbang Wang,Lei Bi,Chunyan Ma,Maoyong Song,Guibin Jiang
Bacterial infections have become a great threat to public health in recent years. A primary lysozyme is a natural antimicrobial protein; however, its widespread application is limited by its instability. Here, we present a poly (N-isopropylacrylamide) hydrogel inverse opal particle (PHIOP) as a microcarrier of lysozyme to prolong and enhance the efficiency against bacteria. This PHIOP-based lysozyme (PHIOP-Lys) formulation is temperature-responsive and exhibits long-term sustained release of lysozyme for up to 16 days. It shows a potent antibacterial effect toward both Escherichia coli and Staphylococcus aureus , which is even higher than that of free lysozyme in solution at the same concentration. PHIOPs-Lys were demonstrated to effectively inhibit bacterial infections and enhance wound healing in a full-thickness skin wound rat model. This study provides a novel pathway for prolonging the enzymatic activity and antibacterial effects of lysozyme.
研究领域:
生物材料学
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微生物学
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药剂学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2023
·
IF 5.9
Shushu Chao,Yiqiu Zhang,Shihong Cheng,Xinzhe Shao,Songlin Liu,Wenjuan Lu,Yanfeng Wang,Pingping Zhang,Qingqiang Yao
Based on the opportunities of ibuprofen administration innovation and challenges associated with the construction of transdermal drug delivery systems using medicated nanoparticles and electrospun nanofiber membranes, we developed a transdermal drug delivery system comprising ibuprofen-loaded ZnO nanoparticles/polyacrylonitrile electrospun nanofiber membranes (ZnO-ibuprofen/PAN), which was dual-stimulus responsive, wherein both pH and temperature triggered drug release. ZnO-ibuprofen nanoparticles with high drug loading capacity (17.7%) were prepared at room temperature by a one-step method involving 4,4′-((4-(4H-1,2,4-triazol-4-yl) phenyl) azanediyl)dibenzoic acid, Zn(NO3)2·6H2O, and ibuprofen, following which electrospinning was conducted to generate the ZnO-ibuprofen/PAN nanofibers. The transdermal drug release behavior of the ZnO-ibuprofen/PAN electrospun nanofiber membranes in the normal (pH = 7.4, 37 °C) and inflammatory (pH = 6.5, 42 °C) tissue environment exhibited increased drug release rate at higher ambient temperatures and decreased pH following 24 h of drug release. The cumulative drug release rate of ZnO-ibuprofen/PAN electrospun fibers through porcine skin under inflammatory conditions reached 71.35% ± 2.96% after 24 h, thereby demonstrating their favorable transdermal permeation behavior. The cytotoxicity assays revealed that the nanofibers possessed excellent biocompatibility. Thus, the dual stimulus-responsive ZnO-ibuprofen/PAN can be an effective transdermal drug delivery carrier.
研究领域:
药学
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纳米技术
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材料科学
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药物递送系统
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Yu Li,Chao Liu,Xiaoqian Gai,Chao Deng,Haiying Wei,Yuqian Liu,Huining Xiao
Extensively used agricultural mulch fabricated from nonbiodegradable polyolefin plastic causes tremendous environmental pollution. In this work, a paper-based mulch, composed of the cellulose fiber networks incorporated with Emamectin benzoate (EB)@sodium lignosulfonate (SL), has been developed with facile papermaking/coating methods. The spherical microcapsule loaded with pesticide EB has a desirable core-shell structure for better protection and sustained release of photosensitive EB. The loading rate and encapsulation efficiency reached 78.5 % and 52.3 %, respectively. Furthermore, microcapsules exhibited excellent slow-release behavior and resistance to photolysis. Natural carnauba wax was coated on the surface of the paper-based mulch to form a hydrophobic layer and increase the physical intertwinement of fibers in the mulch, thereby exhibiting superior performance, such as enhanced tensile strength , excellent hydrophobicity , high air permeability, and high light transmittance at reasonable level. Moreover, unlike conventional polyethylene mulch film, the functionalized paper-based mulch almost completely biodegraded after 75 days in the soil. Thus, multifunctional, eco-friendly mulch from lignocellulose is an innovative approach to obtaining the sustained release of agrochemicals, and it provides an excellent alternative to conventional agricultural plastic mulch.
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产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2023
·
IF 10
Sijie Wu,Gaodan Liu,Ping Shao,Xingyu Lin,Jiahao Yu,Hanchi Chen,Huiliang Li,Simin Feng
Drug delivery systems have become a research priority in the biomedical field. The incorporation of liposomes to hydrogels further forms more robust multifunctional systems for more effective and sustained topical drug delivery. In this study, carboxymethyl-modified chitosan/hyaluronic acid (CMC/HA, CMH) thermosensitive hydrogel is developed for sustained transdermal delivery of liposomes. Hydrogels are crosslinked by hydrogen bonding, hydrophobic interaction and electrostatic interaction. The gel properties can be regulated by substitution degree (DS), and when DS = 18.20 ± 0.67% (CMH2), the gel temperature is 37.8 °C, allowing rapid gelation at body temperature (315 s). Moreover, CMH2 hydrogel has suitable spreadability (17.7–57.2 cm 2 ), viscosity (2133.4 mPa s) and porous structure, which facilitated its adhesion and application on the skin and liposomes delivery. The hydrogel can retard the liposomes release, and the release rate of ascorbyl glucoside (AA2G) is 33.92–49.35% in 24 h. Hydrogel avoids the rapid clearance of liposomes from the skin and improved the skin retention, achieving the long-term release of bioactive components. Liposome-hydrogel system more efficiently promotes the anti-photoaging effect of AA2G on skin, reducing epidermal thickness, melanin deposition and lipid oxidative damage and increasing collagen density. Therefore, liposome-hydrogel systems are proposed as multifunctional delivery systems for sustained transdermal delivery.
研究领域:
生物医学工程
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药学
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材料科学
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化妆品科学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xiaoke Ma,Xiao Luo,Dongmei Zhou,Yuan Zhang,Lin Zhao,Yongkui Yang,Peizhe Sun
Chemical oxidation, a cornerstone for groundwater and soil remediation, continues to face two major challenges: the prolonged delivery time required for oxidant diffusion and competitive consumption of oxidants by coexisting reductants. Potassium ferrate (K 2 FeO 4 ) is a highly efficient and eco-friendly water treatment agent owing to its strong oxidizing properties. However, its practical application is hindered by self-decay and substrate interference. Therefore, this study presented a novel slow-release ferrate material (K 2 FeO 4 @SiO 2 ) that integrated the high oxidizing capabilities of ferrates with the structural stability and functional advantages of nanosized SiO 2 . Given the low heating (30–100 °C) process is currently used for the thermal activation of oxidant in in-situ groundwater and soil remediation, a temperature-responsive system (K 2 FeO 4 @SiO 2 -LA) was further developed using lauric acid as a phase-change material to achieve controlled release of ferrate active components. Characterization confirmed the effective encapsulation of K 2 FeO 4 in the temperature-controlled material. The effectiveness of this material for removing norfloxacin (NOR) from water and its underlying degradation mechanism were comprehensively investigated. The material exhibited a removal efficiency of 9.4 % at 30 °C, which increased to 76.4 % at 50 °C. It exhibited excellent degradation performance and precise temperature responsiveness across a broad pH range and maintained high efficiency. High-valent iron (Fe(VI), Fe(V), Fe(IV)) served as the active oxidizing agent in the K 2 FeO 4 @SiO 2 -LA system. The sustained-release mechanism of the SiO 2 core-shell structure effectively suppressed K 2 FeO 4 self-decay, enhancing the production of high-valent iron and the NOR removal efficiency. Moreover, temperature-controlled materials were applied for efficient antibiotic removal from practical waters, offering a novel strategy for managing antibiotic pollution.
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产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Xin Guo,Yong He,Lei Wang,Qian-Lan Wu,Jing Li,Tian-Le Mao,Kiran Thakur,Yi-Long Ma,Zhao-Jun Wei
Glycyrrhizic acid (GA) exhibits potent antiviral, anti-inflammatory, and hepatoprotective activities. However, its bioactivity is constrained by low stability under varying conditions, including pH and temperature. To improve its stability, GA was loaded into zein-Astragalus polysaccharides (APS) nanoparticles (zein-APS-GA NPs). The optimized nanoparticles had a diameter of 101.10 nm, a polydispersity index of 0.092, and an encapsulation rate of 91.70 %. Simulated digestion experiments revealed a bioaccessibility of 72.84 % for nanoparticles, compared to 30.70 % for free GA. The radical scavenging rates of the nanoparticles ranged from 66.23 % to 73.34 %, and retained over 40 % after 48 h at room temperature. Stability assays confirmed their robustness across a range of ionic strength, pH values, temperatures, and storage durations. Furthermore, zein-APS-GA NPs increased the viability of alcohol-injured AML-12 cells to 95.50 % at 100 μg/mL (containing 91.7 μg/mL GA), significantly surpassing that of free GA (63.29 %, 100 μg/mL), highlighting their enhanced stability and cytoprotective efficacy.
研究领域:
药剂学
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纳米技术
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药物递送
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天然产物
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生物高分子科学
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2025
·
IF 5.6
Siyu Du,Yi Zheng,Yabing Chen,Yijing Guo,Xinyue Kang,Lei Wang
The growing incidence of periodontitis demands innovative therapies, as current drug treatments are limited by short retention times, rapid clearance, and the risk of antimicrobial resistance. This study introduces a novel pH-responsive nano-miclle system for simvastatin (SIM) delivery. Its core innovation lies in being the first system ((SIM NP)n) of its kind to be stabilized by a cross-linked "outer shell," which significantly enhances its stability and controlled release capabilities. This "smart" system remains stable in a neutral environment (pH 7.4), preventing premature drug release. However, upon encountering the acidic inflammatory microenvironment of periodontitis, the shell degrades, triggering the sustained release of SIM directly at the site of inflammation. In vitro studies demonstrated that the SIM-loaded micelles possess potent immunomodulatory effects: they effectively suppressed pro-inflammatory M1 macrophage polarization (decreasing IL-1β, iNOS) while promoting anti-inflammatory M2 macrophage polarization (increasing Arg-1, IL-10). Mechanistic investigation confirmed this therapeutic effect is mediated by the PI3K/AKT/mTOR signaling pathway. More importantly, in a mouse model of periodontitis, the nano-micelles significantly reduced alveolar bone resorption, demonstrating potent anti-inflammatory and bone-protective efficacy in vivo. In conclusion, this "smart" pH-triggered delivery system for SIM offers a highly promising and effective strategy to overcome the limitations of traditional therapies, providing a new targeted path for the treatment of periodontitis.
研究领域:
纳米医学
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牙科
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药物递送
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炎症
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生物材料
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Qiao yuan Luo,Tianrui Zhou,Zhen Wang,Yuntong Liang,Lihua Fu,Chuanhui Xu,Bai Huang,Baofeng Lin
Eutectogels have emerged as promising materials for disinfection applications under complex environmental conditions, owing to their remarkable stability and adaptive properties. In this study, a deep eutectic solvent (DES)-activated eutectogel (PVA/CMC-ZE@NaClO 2 ) was developed through physical cross-linking of polyvinyl alcohol (PVA) and carboxymethyl cellulose (CMC) within a DES medium. The resulting gel exhibits dual-responsive behavior to both temperature (−20 to 50 °C) and humidity (55–90 % RH), enabling intelligent and sustained release of ClO₂ even under extreme environmental conditions. A key innovation lies in the role of DES as an activator, which reacts with NaClO₂ under moisture stimulation to continuously generate gaseous ClO₂. The eutectogel demonstrates high structural integrity across challenging environments—including cold, humid, and dry settings—maintaining stable ClO₂ release for over 20 days. This prolonged disinfectant delivery confers strong antibacterial efficacy, making the material suitable for broad public health applications. Additionally, the gel is readily reshapeable and reusable, while also being fully biodegradable within 20 days under ambient conditions. This work presents the first example of a eutectogel-based slow-release system for ClO₂, offering a new paradigm for designing intelligent, environmentally adaptive materials with extended release performance for disinfection in extreme settings.
研究领域:
材料科学
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环境化学
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抗菌技术
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智能响应材料
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可持续消毒
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Xuan Wang,Xu Meng,Tao Liang,Jiachun Song,Kamal Eldin Afaf,Hong Duan,Lingyan Zheng,Gang Chen
γ-Cyclodextrin (γ-CD) is one of the most widely used materials for encapsulating hydrophobic functional molecules due to its distinctive structural features, especially an internal hydrophobic cavity surrounded by external hydrophilic surface. However, its limited loading capacity, adsorption efficiency, and poor stability hinder its broader applications. To address this issue, γ-cyclodextrin-based metal-organic frameworks (γ-CD-MOFs) was formed by anchoring potassium ions with γ-CD through hydrothermal self-assembly. After loading different hydrophobic small molecule active substances, a multifunctional composite coating was prepared by embedding them into the chitosan (CS) matrix. The release kinetic model analysis confirmed that the release behavior of Cinnamaldehyde (Cia), 2-methoxycinamaldehyde (2-MCA), and Curcumin (Cur) from γ-CD-MOFs conformed to the Ritger-Peppas equation. Compared with CS, CS/γ-CD-MOF@Cia has a strong inhibitory effect on E. coli O157: H7 and S. aureus . Sprayed on green grapes, the shelf life is extended to 21 days. CS/γ-CD-MOF@2-MCA can significantly reduce the spoilage of milk caused by photooxidation. Furthermore, compared with CS, the oxidation and browning of banana peels were effectively delayed by CS/γ-CD-MOF@Cur, and complete blackening is not observed even after 11 days of storage. By combining the advantages of chitosan and γ-CD-MOF, the active molecules with different functions were encapsulated on the platform of γ-CD-MOF to achieve antibacterial, light-blocking, and antioxidant effects on food. The novel functional coating materials presented in this work offer a promising approach to effectively prolonging the shelf life of fresh foods products.
研究领域:
食品科学与技术
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材料科学
·
纳米技术
·
活性包装
·
控释
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials
·
2019
·Vol. 12
·期 23
·4019
·
IF 2.972
Jun Yang,Wanyu Zang,Zheng Zhang,Peng Wang,Qing Yang
The sustained release of pesticides improves drug utilization efficiency and reduces their adverse effects. Activated carbon (AC) is an excellent adsorbent and promising soil conditioner. It has a rich, porous structure and thus can store and gradually release drugs. In this study, three AC materials with surface areas ranging from 800–2000 m2/g were used and two types of modified activated carbons were prepared, and their capacity as drug carriers was evaluated by using 2,4-Dichlorophenoxyacetic acid sodium (2,4-D sodium) as the model pesticide. The preparations were characterized by scanning electron microscopy, nitrogen physical analysis, and zeta potential. The five preparations showed an enhanced and tunable sustained release of drugs. AC1, with the highest specific surface area, possesses the best drug-loading capacity, reaching 679.18 mg/g, but the lowest drug release rate of 32.31% in 96 h. PDA-AC3 has the lowest specific surface area, showing limited drug-loading ability, 82.94 mg/g, but 100% drug release within 72 h. This study suggests that activated carbon has potent applications in agricultural pest control as an inexpensive, effective, controllable, and safe pesticide carrier.Keywords:activated carbon;sustained release;dopamine;nitrogen-doped activated carbon;pest control
研究领域:
农业科学
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环境科学
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材料科学
✓ 已验证
DOI
PubMed
高影响因子
CARBON
·
2012
·
IF 5.378
Dong Ma,Jiantao Lin,Yuyun Chen,Wei Xue,Li-Ming Zhang
Graphene oxide nanosheets were used to induce the in situ gelation of doxorubicin hydrochloride as an antitumor drug. When a very small amount of the graphene oxide was introduced into an aqueous solution of doxorubicin hydrochloride at room temperature, a strong and thixotropic gel was rapidly formed without any polymers or chemical additives. The gelation mechanism was investigated by fluorescence spectroscopy, X-ray diffraction and scanning electron microscopy. The encapsulated doxorubicin hydrochloride was found to show sustained release and antitumor efficacy.
研究领域:
药剂学
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材料科学
·
肿瘤学
✓ 已验证
DOI
高影响因子
ACS Applied Polymer Materials
·
2020
·
IF 0
Xuan Wang,Fanfan Li,Huanhuan Zhao,Yanwu Zhang
In order to improve the sustained release properties of carriers and explore the effect of copolymer sequence structures on sustained release, 5 groups of 12 block copolymers (12-BCPs) with different sequences were prepared using 4 monomers and the microstructure was controlled by changing the sequence of monomers. The results show that each polymer chain contains an average of 228 monomers and the proportion of 4 monomers basically conforms to 1:1:1:1. The release kinetics of fluorescein sodium (FS) as a drug model molecule was detected by UV–vis spectroscopy, and the result proves that sequence microstructures have great effect on their sustained release behaviors. The five groups of copolymers all show high initial loading (49.6–74.6 mg/g) and long sustained release time (18–30 days). The copolymer with the largest monodisperse self-assembly size (13.40 μm) in which the block sequence is 2-hydroxyethyl acrylate/styrene/4-vinylpyridine/tert-butyl acrylate has the optimal drug loading capacity (74.6 mg/g) compared with others. At the same time, it owns the most stable release state and the longest sustained release time (30 days).
研究领域:
高分子化学
·
药物传递系统
·
生物材料
✓ 已验证
DOI
危险品化学品经营许可证（带存储）