Chemical and Biological Technologies in Agriculture
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2026
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IF 5.2
Chen Yao,Li Dongyang,Liu Yan,Cheng Yongjia,Zhang Juan,Li Chaojie,Lei Zhiwei,Yang Wen
Background Plants synthesize and emit a wide variety of volatile compounds that serve different defense-related functions in response to both abiotic and biotic stresses. Results In this study, 1-nonanol was identified as the most active volatile against Epicoccum sorghinum among those co-up-regulated in the tea cultivar of ‘Qianmei 601’ infected by three strains of E. sorghinum. Its antifungal results in vitro indicated that the minimum inhibitory concentration and the minimum bactericidal concentration were 0.1 mg/mL and 0.15 mg/mL, respectively. Scanning electron microscopy, transmission electron microscopy, calcofluor whiteand and propidium iodide staining solutions demonstrate that 1-nonanol inhibited the normal growth of E. sorghinum mycelia by affecting the cell membrane and cell wall structure of E. sorghinum mycelia. Additionally, exposure to 1-nonanol resulted in increased levels of intracellular malondialdehyde, soluble proteins, and chitinase, while superoxide dismutase content decreased. Transcriptome analysis revealed that regulatory genes associated with 1-nonanol were involved in starch and sucrose metabolism, glycerophospholipid metabolism, and fatty acid synthesis pathways. Treatment with 1-nonanol significantly up-regulated genes linked to exo-1,3- β -glucanase and hexokinase, while genes related to chitin synthase, aminophospholipid translocase, 3-oxoacyl-[acyl-carrier-protein] synthase, and mitochondrial 2-enoylthioester reductase were down-regulated. Conclusions These results indicate that 1-nonanol disrupts the integrity of cell walls and cell membranes, inhibiting the growth of normal hyphae and potentially causing cell death. This study is the first to confirm that 1-nonanol is a crucial component of the defense-related volatile compounds produced by ‘Qianmei 601’ in response to stress from E. sorghinum . We discussed these results and emphasized the importance of this interaction in plant–microbe interactions. Graphical abstract
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Nature Communications
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2026
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IF 15.7
He Chengxuan,Yang Ruijie,Zhong Chenggui,Ye Zhicheng,Dong Yuan,Chen Weihao,Chen Lingyun,Wang Zhihan,Wu Shiqun,Zhang Jinlong
The simultaneous utilization of methane and carbon dioxide via dry reforming holds promise for sustainable syngas production, yet conventional thermocatalytic processes suffer from energy-intensive operation and catalyst deactivation. Here, we report a light-driven methane dry reforming strategy utilizing sinter-resistant nano-island alloys catalyst, which are dynamically evolved from partially oxidized NiIr nanoclusters anchored on TiO 2 under photoexcitation. In situ characterization reveals interfacial charge oscillations on the catalyst induce a support-Ni-Ir electron transfer pathway, stabilizing oxidized Ni linkages while electronically modulating surface Ir sites. This dual functionality promotes CH x O* intermediate formation, suppressing coking during 100-h operation under intermittent illumination. By decoupling photoelectric and photothermal contributions, we demonstrate that localized photogenerated electrons dominate balanced syngas production, whereas photothermal effects enhance molecular vibrations. The optimized catalyst achieves a syngas rate of 10841 mmol g cat -1 h -1 with 25.0% light-to-fuel efficiency, establishing a design paradigm for solar-driven alloy catalysts in greenhouse gas valorization.
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ACTA PHARMACOLOGICA SINICA
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2026
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IF 8.4
Li Hai-bo,Liu Yong-hui,Liu Hai,Li Yuan,Le Qiu-min,Wang Fei-fei,Ma Lan,Liu Xing
The high relapse rate of drugs is currently a therapeutic dilemma in the treatment of substance use disorder (SUD). Emerging evidence from preclinical animal models demonstrates that pretreatment with selective dopamine D 2 receptor (D 2 R) antagonists prevents reinstatement of drug-seeking. However, the role of D 2 R downstream signaling in regulating relapse behavior remains unclear. In this study, we investigated the roles of G α i -protein- and β-arrestin-dependent D 2 R signaling pathways in cocaine-primed reinstatement using cocaine self-administration (SA) mouse model treated with biased ligands. We found that treatment of D 2 R G α i -protein antagonists, but not β-arrestin antagonists, significantly attenuated cocaine-primed reinstatement of drug seeking without affecting locomotor activity or anxiety levels. Administration of D 2 R G α i -protein antagonists, but not β-arrestin antagonists, increased cyclic adenosine monophosphate (cAMP) levels in the nucleus accumbens (NAc). Furthermore, treatment of D 2 R G α i -protein antagonists, but not β-arrestin antagonists, suppressed cocaine-induced neuronal activation in the NAc. Our results demonstrate that G α i -protein-dependent D 2 R signaling plays a crucial role in cocaine-primed reinstatement and suggest that D 2 R G α i -protein-biased ligands may be promising pharmacotherapeutic targets for SUD treatment.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 12.6
Chaoran Liu,Wenyu Zhang,Qingbin He,Xinyu Ma,Jianfeng Qiu,Runxiao Zheng,Hongjin Xue
Catalyzing the glucose cascade reaction to impair tumor cell energy metabolism represents a promising strategy for tumor therapy. However, the application of natural enzymes as therapeutic agents remains limited by various challenges. Although nanozymes with multi-enzyme activities, including glucose oxidase-like (GOx-like) activity, have been reported, their development often involves complex material combinations and cumbersome synthesis processes. Here, we develop a nanozyme with GOx-, peroxidase (POD)-, superoxide dismutase (SOD)-, and NADH oxidase (NOX)-mimic activities by simply controlling the AuPt alloy ratio. The optimal cascade activity was observed for the nanozyme at an Au: Pt proportion of 13:7. Density functional theory (DFT) calculations revealed that Au sites drive glucose dehydrogenation (GOx-like), while Pt sites facilitate hydroxyl radical (•OH) generation (POD-like). Both in vitro and in vivo data indicated that Au 13 Pt 7 nanozymes disrupt tumor redox/metabolic homeostasis by depleting glucose and generating cytotoxic •OH, and impairing mitochondrial function via NOX-like, thereby inducing cell apoptosis. Notably, apoptotic immunogenic cell death (ICD) induces antitumor immunity and suppresses tumor metastasis. This study presents an innovative strategy for engineering nanozymes with multi-enzyme catalytic capabilities while demonstrating the promising application of alloy-based nanozymes in synergistic metabolic-immunotherapy.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 12.6
Jinming Tian,Zeyu Zhang,Chao Cheng,Fei Yu,Tao Wang,Bin Cui,Ye Peng,Shuang Qiu,Fuming Wang,Weijing Cheng,Rong Luo,Guorong Jia,Changjing Zuo
Transarterial radioembolization (TARE) with β-emitting radionuclides is widely used for hepatocellular carcinoma (HCC), but its clinical efficacy remains to be further improved. α-particle-emitting radionuclides possess high linear energy transfer (LET) and unique advantages in cancer therapy, motivating α-particle based composite platform. Accordingly, we engineer the first clinically mimetic α-TARE microsphere by in-situ ²²³Ra-doped calcium-alginate composite microsphere (²²³Ra/Ca-ALG MS) using a hydrogel matrix, in which alginate "egg-box" coordination captures Ra²⁺ to provide stable radiolabeling, delivered via selective hepatic arterial injection to HCC. The microspheres exhibited excellent radiolabeling stability (88% retention after 384 h) and potent, dose-dependent cytotoxicity against HCC cells under hypoxia. In an orthotopic rat HCC model, 223 Ra/Ca-ALG MS-based TARE achieves precise intratumoral localization and sustained retention on SPECT/CT; ¹⁸F-FDG PET/CT and histopathology indicate a robust antitumor response, while serum biochemistry and histology support a favorable safety profile. Moreover, ²²³Ra/Ca-ALG MS provide powerful immune-activating capacity. Transcriptomics reveals activation of DNA-damage response, immunogenic cell death, and antigen-presentation pathways, flow cytometry and immunohistochemistry show increased dendritic-cell maturation and CD8⁺ T-cell infiltration. Collectively, 223 Ra/Ca-ALG MS demonstrates hypoxia-tolerant cytotoxicity, immune-activating potential, offering new insights for the development of immune-based TARE strategies in HCC and showing promising prospects for clinical translation.
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RESEARCH ON CHEMICAL INTERMEDIATES
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2026
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IF 3.5
Xian Liang,Liu Shuxin,Tian Xiaoxia,Li Wei
This study constructed an electrocatalyst of ultrafine platinum nanoparticles (UPt NPs) loaded onto nitrogen-rich porous hollow carbon spheres (NC). Using ZnO as a sacrificial template, NC carriers with a high specific surface area (516.4 m 2 /g) and hierarchical pore structure were prepared via ZIF-8 coating and carbonization. Pyridine/pyrrole nitrogen doping significantly enhanced the strong mutual interaction (SMSI) between Pt and the carrier. Combined with a mild photo-induced approach, the hydrolysis pathway of the Pt precursor was controlled by adjusting the light wavelength (UV/blue-violet/green light), enabling in situ reduction of Pt on the NC surface and within its pore network at room temperature while effectively suppressing agglomeration. Electrochemical testing revealed that the NC/Pt-UV2 catalyst, synthesized using 2 mM Pt precursor combined with UV light, exhibited a mass-specific activity (1179.5 mA·mg Pt −1 ) and electrochemically active area (135.8 m 2 g −1 ) 4.96 and 5.17 times higher than commercial Pt/C, respectively, with superior activity retention compared to Pt/C after 3600 s of constant-potential testing. This work proposes a method for preparing nitrogen-rich hollow carbon spheres with high specific surface area and a novel strategy for the green, efficient synthesis of ultrafine Pt nanoparticles, offering new insights for the design of supported electrocatalysts.
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BRAZILIAN JOURNAL OF CHEMICAL ENGINEERING
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2026
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IF 1.5
Liang Jiashun,Cao Xiong
This paper investigates the ignition and combustion properties of DAP-4/W mixture samples. The mixture samples were prepared by artificial mixing, and the PBXs were prepared using F2602 as a binder. The morphology and composition of DAP-4/W mixture samples were investigated using SEM and XRD. The decomposition performance of DAP-4 and DAP-4/W mixture samples was characterized by DSC. The mixture samples and PBXs were ignited using electric and chemical ignition, respectively. The results showed that the composite material composed of DAP-4 and W particles could accelerate the decomposition of DAP-4 and increase the energy release. In combustion experiments, it was found that the involvement of W particles can effectively prolong the combustion time of DAP-4, which shows that W particles can carry out a long energy supply. This work carried out in this study could be of some reference value for research in DAP-4 composites.
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Nano-Micro Letters
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2026
·Vol. 18
·期 1
·132
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IF 36.3
Wang Qian,Na Zongxu,Gao Jianfei,Yu Li,Chen Yuanwei,Gao Peng,Ding Yong,Dai Songyuan,Nazeeruddin Mohammad Khaja,Yang Huai
Energy-saving buildings (ESBs) are an emerging green technology that can significantly reduce building-associated cooling and heating energy consumption, catering to the desire for carbon neutrality and sustainable development of society. Smart photovoltaic windows (SPWs) offer a promising platform for designing ESBs because they present the capability to regulate and harness solar energy. With frequent outbreaks of extreme weather all over the world, the achievement of exceptional energy-saving effect under different weather conditions is an inevitable trend for the development of ESBs but is hardly achieved via existing SPWs. Here, we substantially reduce the driving voltage of polymer-dispersed liquid crystals (PDLCs) by 28.1 % via molecular engineering while maintaining their high solar transmittance ( T sol = 83.8 %, transparent state) and solar modulating ability (Δ T sol = 80.5 %). By the assembly of perovskite solar cell and a broadband thermal-managing unit encompassing the electrical-responsive PDLCs, transparent high-emissivity SiO 2 passive radiation-cooling, and Ag low-emissivity layers possesses, we present a tri-band regulation and split-type SPW possessing superb energy-saving effect in all-season. The perovskite solar cell can produce the electric power to stimulate the electrical-responsive behavior of the PDLCs, endowing the SPWs zero-energy input solar energy regulating characteristic, and compensate the daily energy consumption needed for ESBs. Moreover, the scalable manufacturing technology holds a great potential for the real-world applications.
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Nano-Micro Letters
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2026
·Vol. 18
·期 1
·131
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IF 36.3
Fang Wei,Ou Zeping,Wang Yifan,Li Zhe,Huang Qian,Zhang Pengchi,Li Xinzhe,Zheng Yujie,Hu Lijun,Li Chen,Ouyang Jianyong,Sun Kuan
A novel Cu + /Cu 2+ redox couple was introduced to enable a thermosensitive crystallization process, significantly enhancing thermopower from 1.47 to 2.93 mV K ‒1 .
A readily fabricated etched carbon cloth electrode offered an enlarged electroactive surface area, demonstrating superior current density through improved kinetics.
The optimized Cu + /Cu 2+ system, achieved through synergistic enhancements in thermodynamic and kinetic performance, delivered an outstanding normalized power density P max ( ΔT ) ‒2 of 3.97 mW m ‒2 K ‒2 .
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JOURNAL OF POLYMER RESEARCH
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2026
·Vol. 33
·期 1
·18
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IF 2.8
Hu Minglei,Zhang Wei,Hu Bin,Chu Fuqiang,Yang Haicun,Cao Zheng
To enhance both the adhesive strength and cohesion of the adhesive resin, attapulgite (ATP) was chemically modified by peroxy groups to parepared ATP with initiation function (ATP-CPO). Subsequently, a series of high density polyethylene/ATP composites (HDPE/ATP) functionalized with maleic anhydride and vinyl trimethoxysilane were prepared via surface-initiated graft copolymerization. The effects of ATP-CPO dosage on the mechanical, thermal, rheological, and morphological characteristics of the composites were evaluated in detail. It was found that the surface functionalization and reactive extrusion process contributed to the nano-scale dispersion of ATP in the HDPE matrix, forming well-compatibilized nanocomposites consisting of HDPE-g-(MAH-co-VTMS), ATP-g-(MAH-co-VTMS), and more complex MAH/VTMS synergistically functionalized ATP-g-HDPE. When the ATP-CPO content was 4%, the composite exhibited significantly enhanced tensile strength, 180° peel strength, and shear strength, which were 1.4, 26.3, and 21.7 times higher than those of pure HDPE, respectively. Concurrently, the composites displayed higher melting and crystallization temperatures. However, the crystallinity decreased slightly, while the thermal stability was significantly improved. The melt exhibited more pronounced non-Newtonian behavior. Compared to the loss modulus, the storage modulus increased more significantly in the low-frequency region, and a non-terminal effect was observed, which enhanced the structural stability of the system under low-frequency shear stress.
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Humanities & Social Sciences Communications
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2024
·Vol. 11
·期 1
·319
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IF 3.7
Jing Yuhui,Wang Haoming,Chen Xiaojiao,Wang Chengliang
The emergence of ChatGPT has sparked new expectations for AI-empowered educational transformation. However, it remains unknown which factors affect its effectiveness in empowering learners to solve programming problems. Therefore, this study employed a quasi-experimental research design and used Python graphing in programming education as an example to investigate the factors influencing the effectiveness of learners in applying ChatGPT to problem-solving. Findings: AI literacy significantly influences learners’ effectiveness in using ChatGPT to solve problems, with AI awareness and AI usage being key factors. The knowledge base of programming language significantly affects learners’ effectiveness in applying ChatGPT to solve programming problems. Learners’ cognitive level of ChatGPT significantly influences their effectiveness in applying ChatGPT to problem-solving, while usage intention does not have a significant impact. However, learners’ intention to use ChatGPT significantly improves after application. Based on these findings, this study proposes that in the process of empowering education with Artificial Intelligence Generated Content (AIGC) products, the focus on learners should shift from cultivating their AI usage to AI literacy, laying the foundation for empowering learning with AIGC products. It is suggested to shift from mastering specific knowledge to graph-based rules as a method for empowering learning with AIGC products. Additionally, the focus should shift from enhancing learners’ intention to use the technology to strengthen their technological awareness, thereby creating practical pathways for empowering learning with AIGC products.
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Scientific Reports
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2017
·Vol. 7
·期 1
·14478
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IF 4.259
Wang Jin-Feng,Zhu Lei,Zhao Ben-Guang,Zhao Yu-Long,Song Jian,Gu Xiu-Quan,Qiang Ying-Huai
It is critical to prepare smooth and dense perovskite films for the fabrication of high efficiency perovskite solar cells. However, solution casting process often results in films with pinhole formation and incomplete surface coverage. Herein, we demonstrate a fast and efficient vacuum deposition method to optimize the surface morphology of solution-based perovskite films. The obtained planar devices exhibit an average power conversion efficiency (PCE) of 13.42% with a standard deviation of ±2.15% and best efficiency of 15.57%. Furthermore, the devices also show excellent stability of over 30 days with a slight degradation <9% when stored under ambient conditions. We also investigated the effect of vacuum deposition thickness on the electron transportation and overall performance of the devices. This work provides a versatile approach to prepare high-quality perovskite films and paves a way for high-performance and stable perovskite photovoltaic devices.
研究领域:
材料科学
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光伏技术
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表面工程
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可再生能源
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