SEPARATION AND PURIFICATION TECHNOLOGY
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2024
·
IF 8.1
Haitao Shi,Haijun Zhang,Yuan Gao,Jiajia Yang,Jiping Chen
Solid amine adsorbents are showing promise as effective adsorbents for the capture of CO 2 from various gas mixtures, including biogas and flue exhaust gas. In this study, we introduced a co-grafting strategy using 1,4-butanediol diglycidyl ether (BDDE) on the surface of P(DVB-D). This approach aimed to exploit the reaction involving the opening of epoxy groups with amine groups, forming covalent bonds between polyethyleneimine (PEI) and mesoporous organic polymers, along with the introduction of hydroxy groups to enhance adsorbent long-term stability and antioxidation ability. After an extensive assessment, P(DVB-D)@B-41.2 %PEI exhibited a maximum CO 2 capture capacity of 4.53 mmol/g at 50 °C and 50 % RH. Notably, its remarkable CO 2 adsorption performance persisted across a diverse temperature spectrum (30–90 °C) and an extensive concentration span (5–30 % vol.). In contrast to conventional adsorbents prepared solely through impregnation methods, P(DVB-D)@B-41.2 %PEI exhibited impressive long-term stability throughout 50 successive cycles and excellent resistance to oxidative degradation. These findings underscore the considerable potential of P(DVB-D)@B-41.2 %PEI in the realm of carbon capture and sequestration (CCS) technology.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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2015
·Vol. 16
·期 8
·17999-18017
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IF 2.862
Bin Li,Benguo Liu,Jiaqi Li,Huizhi Xiao,Junyi Wang,Guizhao Liang
Isoliquiritigenin (ILTG) possesses many pharmacological properties. However, its poor solubility and stability in water hinders its wide applications. The solubility of bioactive compounds can often be enhanced through preparation and delivery of various cyclodextrin (CD) inclusion complexes. The 6-O-α-d-maltosyl-β-CD (G2-β-CD), as one of the newest developments of CDs, has high aqueous solubility and low toxicity, especially stable inclusion characteristics with bioactive compounds. In this work, we for the first time construct and characterize the supermolecular structure of ILTG/G2-β-CD by scanning electron microscopy (SEM), ultraviolet-visible spectroscopy (UV), Fourier transform infrared spectroscopy (FT-IR), and X-ray diffractometry (XRD). The solubility of ILTG in water at 25 °C rises from 0.003 to 0.717 mg/mL by the encapsulation with G2-β-CD. Our experimental observations on the presence of the ILTG/G2-β-CD inclusion complex are further supported by the ONIOM(our Own N-layer Integrated Orbital molecular Mechanics)-based QM/MM (Quantum Mechanics/Molecular Mechanics) calculations, typically substantiating these supermolecular characteristics, such as detailed structural assignments, preferred binding orientations, selectivity, solvent effects, interaction energies and forces of the ILTG/G2-β-CD inclusion complex. Our results have elucidated how ILTG interacts with G2-β-CD, demonstrating the primary host-guest interactions between ILTG and G2-β-CD, characterized by hydrogen bonds, hydrophobic interactions, electrostatic forces, and conformational effects, are favored for the formation of the ILTG/G2-β-CD inclusion.Keywords:isoliquiritigenin;6-O-α-d-Maltosyl-β-CD;inclusion complex;ONIOM calculation
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Journal of Materials Chemistry A
·
2017
·Vol. 5
·期 24
·12144-12148
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IF 8.867
Qianqian Yang,Jie Zhou,Genqiang Zhang,Cong Guo,Meng Li,Yongchun Zhu,Yitai Qian
Sb nanoparticles encapsulated in 1-D N-doped porous carbon (denoted as Sb/NPC) have been fabricated by an in situ nanoconfined replacement reaction between SbCl3 and the intermediate Ni/NPC, in which Ni/NPC was obtained by annealing the hydrothermally synthesized nickel–nitrilotriacetic acid (Ni–NTA) precursor in an argon atmosphere. The Sb nanoparticles with a size of 10–20 nm were uniformly encapsulated in the 1-D N-doped porous carbon scaffolds. When the Sb/NPC composite was applied as an anode material in the batteries, it exhibited a high reversible capacity of 556 mA h g−1 at 200 mA g−1 after 100 cycles for Li-ion batteries (LIBs) and a reversible capacity of 400.9 mA h g−1 at 100 mA g−1 after 100 cycles for Na-ion batteries (NIBs). Such enhanced electrochemical performance of the designed Sb/NPC can be attributed to the synergistic effect between uniformly dispersed Sb nanoparticles and the 1-D N-doped porous carbon matrices.
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RSC Advances
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2016
·Vol. 6
·期 76
·72439-72446
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IF 3.289
Jinyang Shen,Ye Jin,Hongli Tian,Yuan Wang,Xiaolin Yang,Zhonglin Yang,Changrun Guo,Fei Li
Akebia saponin D (ASD), a triterpenoid saponin with numerous pharmacological activities, is isolated from the rhizome of Dipsacus asper Wall. However, the poor oral bioavailability of ASD restricts its development and clinical use. The purpose of this research is to develop a solid dispersion (ASD-SD) to improve the oral bioavailability of ASD. Poloxamer 407 was employed to prevent ASD from aggregation and Cremophor® RH 40 was used to inhibit multidrug resistance associated protein (MRP) mediated efflux in several new formulations. The particle size was remarkably reduced from 380 nm (ASD) to 230 nm (ASD-SD1 [composition: ASD : Poloxamer 407 : Cremophor® RH 40; ratio: 5 : 9 : 1, w/w/w]). The cumulative release percentage of molecular ASD from dialysis bags was improved from 63.78% (ASD) to 97.12% (ASD-SD1). Single-pass intestinal perfusion studies showed that the absorption of ASD in ASD-SD2 (composition: ASD : Poloxamer 407; ratio: 5 : 9, w/w) was increased approximately 1.8-fold compared to ASD which was mainly due to the particle size reduction, and further promoted by ASD-SD1 about 2.1-fold compared to ASD-SD2 which might be through the MRP inhibition of Cremophor® RH 40. Furthermore, the oral bioavailability in rats was enhanced significantly to 156.9% and 233.1% by ASD-SD2 and ASD-SD1, respectively. Therefore, ASD-SD1 could be a promising drug delivery system to improve the oral absorption of ASD which might be by destroying self-micelles and inhibiting MRP-mediated efflux.
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NEUROCHEMICAL RESEARCH
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2013
·Vol. 38
·期 9
·1871-1879
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IF 2.125
Ruan Lin,Huang Huan-Sen,Jin Wen-Xiang,Chen Hai-Ming,Li Xiong-Juan,Gong Qing-Juan
Ischemic stroke is the most common type of stroke and brings about a big disease burden because of high mortality and disability in China. Tetrandrine, a bisbenzylisoquinoline alkaloid isolated from the Chinese herb Radix Stephania tetrandra, has been demonstrated to possess anti-inflammatory and free radical scavenging effects and even regulate astrocyte activation, but the possible role of tetrandrine in ameliorating cerebral ischemia/reperfusion injury of ischemic stroke remains unknown. The aim of this study was to determine the effects of tetrandrine on neurological injury and differential proteomic changes induced by transient reversible middle cerebral artery occlusion (MCAO) in mice. Male Balb/c mice were divided into sham (n = 30), MCAO + saline as control (n = 30), and MCAO + Tet as tetrandrine-treated (n = 30) groups. Mice in the control and tetrandrine-treated groups underwent 120 min of MCAO following reperfusion. Immediately and 2 h after MCAO, the mice received either normal saline (sham operated and control groups) or tetrandrine (tetrandrine-treated group) intraperitoneally. Neurological defects, brain water content, and infarct volume at 24 h after stoke were used to evaluate neurological injury extent. Treatment with tetrandrine not only mitigated cerebral neurological deficits ( P < 0.05) and infarct size ( P < 0.01), but also decreased brian edema in the ischemic brain ( P < 0.05). Then, fluorescence two-dimensional difference in gel electrophoresis was used to detect our systematic differential profiling of proteomic changes responding to tetrandrine administration. We validated that the expression of GRP78, DJ-1 and HYOU1 was associated with neuroprotective effect of tetrandrine in MCAO model by Western blotting. These findings indicate a potential neuroprotective role of tetrandrine for ischemic stroke and yield insights into cellular and molecular mechanisms of tetrandrine taking place in ischemic stroke.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2024
·
IF 3.3
Zirou Xiao,Shuang Wu,Hongshan Liang,Bin Li,Jing Li
BACKGROUND Growing public concern over the health risks of high-sugar diets has led to a consensus on the necessity of sugar reduction. This research evaluated the effects of oligosaccharides (OS), sodium carboxymethyl cellulose (CMCNa) and d -allulose as a compound improver on the quality of sugar-reduced bread, aiming to assess the feasibility of substantial sucrose reduction at the same time as maintaining desirable bread characteristics. RESULTS Compared to bread with a 90% sugar reduction, the improved formulation increased specific volume by 50.14% and reduced hardness by 66.69%. It exhibited a homogeneous structure and crust color closely resembling that of full-sugar bread. Low-field NMR analysis revealed better moisture control, delaying water loss and starch retrogradation, with relative crystallinity and retrogradation enthalpy decreased by 45.31% and 59.96%, respectively. Additionally, the combination of XOS and d -allulose boosted volatile compound production, increasing the abundance of aldehydes, esters and heterocyclic compounds, enriching the flavor with fruity and baked aromas. CONCLUSION The improvers enhanced the texture, appearance, flavor and storage stability of sugar-reduced bread, yielding qualities that are comparable to or even surpass conventional bread. These findings provide a new insight for the development of quality improvers designed for sugar-reduced bakery products. © 2024 Society of Chemical Industry.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2024
·
IF 5.8
Liwei Liang,Songlin Cai,Lan Zhang,Ke Sun,Ziying He,Libin Zhang,Ciyuan Huang,Min Long,Hongxiang Zhu,Bingsuo Zou,Tao Liu,Shuangfei Wang
Phenol has various applications in industry, due to its hazardousness, solubility, and volatility, it persists in water and poses a risk to human health. People are excited by the progress of photodegradation technology that facilitates water pollution treatment. The effect of side-chain engineering is proven to enhance photodegradation performance by improving optoelectronic properties. Therefore, here is a strategy that introduces functional groups to change the electron cloud density, achieving excellent optoelectronic properties evidenced by efficient exciton dissociation, separation, and fine-tuned energy level. Subsequently, by coupling of photocatalysis and adsorption, the donor/acceptor (D/A) heterojunction photocatalysts (PBDB-T: BTTIC-TT, PBDB-T: BTTIC-Ph) are designed via loading on coconut-shell carbon to process phenol. The results indicate that the champion photocatalyst PBDB-T: BTTIC-TT possesses superior optoelectronic properties, which can be attributed to the stronger electron-withdrawing ability of thieno[3,2- b ]thiophene than benzene. Consequently, the synergistic efficiency of adsorption and photocatalysis of phenol (10, 20 mg/L) are removed within 10 mins over 90 % which is still valid after twenty cycles. Surprisingly, a high concentration of phenol (100 mg/L) also exhibited excellent removal efficiency of over 80 % within 60 min.
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JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
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2024
·
IF 2.8
Wenchan Deng,Chundan Ye,Wei Wang,Rongrong Huang,Cheng Guo,Yuanjiang Pan,Cuirong Sun
Colorectal cancer (CRC) is a common malignant tumor in the gastrointestinal tract. Changes in amino acid metabolites have been implicated in tumorigenesis and disease progression. Biomarkers on the basis of chiral amino acids, especially D-amino acids, have not been established for early diagnosis of CRC. Quantification of chiral amino acids, especially very low concentrations of endogenous D-amino acids, is technically challenging. We report here the quantification of L- and D-amino acids in urine samples collected from 115 CRC patients and 155 healthy volunteers, using an improved method. The method of chiral labeling, liquid chromatography, and tandem mass spectrometry enabled separation and detection of 28 amino acids (14 L-amino acids, 13 D-amino acids and Gly). Orthogonal partial least squares discriminant analysis identified 14 targeted variables among these chiral amino acids that distinguished the CRC from the healthy controls. Binary logistic regression analysis revealed that D-α-aminobutyric acid (D-AABA), L-alanine (L-Ala), D-alanine (D-Ala), D-glutamine (D-Gln) and D-serine (D-Ser) could be potential biomarkers for CRC. A receiver operating characteristic curve analysis of combined multi-variables contributed to an area under the curve (AUC) of 0.995 with 98.3 % sensitivity and 96.8 % specificity. A model constructed with D-AABA, D-Ala, D-Gln, and D-Ser achieved an AUC of 0.988, indicating important contributions of D-amino acids to the association with CRC. Further analysis also demonstrated that the metabolic aberration was associated with age and the development of CRC, D-methionine (D-Met) was decreased in CRC patients with age over 50, and D/L-Gln in patients at stage IV was higher than patients at stage I. This study provides the signature of D-amino acids in urine samples and offers a promising strategy for developing non-invasive diagnosis of CRC.
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Journal of Functional Foods
·
2024
·
IF 3.8
Jiahao Liao,Jianyu Huang,Xiaoyi Chi,Xiaoqiong Li,Jian Kuang,Jianqiang Li,Xiangyu Bian,Jinzhu Pang,Jinjun Li,Weiwei Wang
In this study, D-mannose-modified nanoliposomes (MLipo@OVA) were developed to facilitate the targeted delivery of ovalbumin (OVA) to macrophages. The subsequent anti-inflammatory, antioxidant, and macrophage-polarizing effects of OVA were investigated. The nanoliposomes were designed with DSPE-PEG and DPPC to enhance the bioavailability and stability of OVA. In vitro analysis showed that MLipo@OVA significantly increased macrophage uptake, with D-mannose further enhancing this effect. MLipo@OVA reduced pro-inflammatory cytokines (TNF-α, IL-1β) and increased anti-inflammatory IL-10 levels in LPS-induced macrophages, primarily via the inhibition of the TLR4/NF-κB pathway. Furthermore, ROS levels were decreased, SOD and GSH activity was enhanced, the Nrf2/HO-1 pathway was activated, and the compound exhibited strong antioxidant activity. MLipo@OVA also promoted M2 macrophage polarization by upregulating CD206 and Arg-1 and downregulating iNOS. Overall, these results indicate that MLipo@OVA could be used as a nanomedicine to facilitate targeted anti-inflammatory and antioxidant therapies.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
·
IF 9.4
Yang Liu,Kun Wang,Lei Jin,Yahan Li,Guanyu Chen,Hui Xu,Jie Chen,Guangyu He
Transition metal sulfides (TMSs) catalysts with high catalytic oxygen evolution reaction (OER) activity have been extensively studied, especially Fe and Co-based sulfides. Fe and Co active sites with a strong synergistic effect, which can adjust the electron density distribution and effectively improve the electrocatalytic OER activity. However, TMSs have poor stability in alkaline environment caused by metal ions and sulfur elements are facilitated to dissolve. In this work, TMSs was modified by polyaniline (PANI) to inhibit the precipitation of iron, cobalt, and sulfur elements and enhance its stability under alkaline conditions. Moreover, π-d structure can also be formed by the coating of PANI, which can further adjust its own electronic structure on the basis of stabilizing the TMSs structure, so as to improve the electrochemical performance, rendering them to stably operate at harsh environment for more than 90 h. These findings offer new guidance for improving the electrocatalytic stability of TMSs.
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Foods
·
2024
·Vol. 13
·期 4
·622
·
IF 4.7
Qian Li,Rui Li,Fanxing Yong,Qiaoli Zhao,Jing Chen,Xing Lin,Ziyu Li,Zhuo Wang,Baojun Xu,Saiyi Zhong
Pickering emulsions (PEs) have been regarded as an effective approach to sustaining and preserving the bioactivities of essential oils. The aim of this research is to prepare a PE stabilized by chitosan/alginate nanoparticles (CS-SA NPs) for the encapsulation and stabilization of D-limonene. In this work, the influence of calcium ions (Ca2+) on the morphology and interaction of nanoparticles was studied, and then the preparation technology of CS-SA/Ca2+NPs was optimized. The results showed that the presence of Ca2+reduced the size of the nanoparticles and made them assume a spherical structure. In addition, under the conditions of 0.2 mg/mL CaCl2, 0.6 mg/mL SA, and 0.4 mg/mL CS, the CS-SA/Ca2+NPs had the smallest size (274 ± 2.51 nm) and high stability (−49 ± 0.69 mV). Secondly, the PE was prepared by emulsifying D-limonene with CS-SA/Ca2+NPs, and the NP concentrations and homogenization speeds were optimized. The results showed that the small droplet size PE could be prepared with 2 mg/mL NP and a homogenization speed of 20,000 r/min, and it had excellent antibacterial and antioxidant activities. Most importantly, the emulsion showed higher activity, higher resistance to ultraviolet (UV) and a higher temperature than free D-limonene. This research provides a feasible solution for the encapsulation, protection and delivery of essential oils.Keywords:homogenization speed;thermal stability;ultraviolet stability;antibacterial activity;antioxidant activity
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Xinyang Xu,Jiawen Liu,Yixin Sun,Zhonghua Li
Among the various advanced photocatalytic materials, the organic conjugated microporous polymer (CMP) photocatalysts have garnered significant interest due to their exceptional efficiency in photogenerated electron transfer and their structural versatility. In this study, we developed two novel donor-acceptor 1 -acceptor 2 CMP systems through varying the electron donor unit. Pyrene (P) and triphenylamine (T) were acted as donor units (D), respectively, meanwhile dibenzothiophene-S,S-dioxide (BTDO, A 1 ) and 3,4-ethylenedioxythiophene (EDOT, A 2 ) as their acceptors to construct two D−A 1 −A 2 type CMP photocatalysts, P-BTDO-EDOT and T-BTDO-EDOT. Their photocatalytic performances were compared and studied through photocatalytic hydrogen production. The findings show that P-BTDO-EDOT possesses higher photocatalytic hydrogen production activity (87.21 mmol g −1 h −1 ) than T-BTDO-EDOT (66.25 mmol g −1 h −1 ) under visible light, attributing to its stable conjugated architecture, larger specific surface area, exceptional optoelectronic capability, wider light absorption, donor unit pyrene with strong electron-donating and efficient charge separation ability. This work not only highlights the potential for designing innovative CMP molecular structures with D−A 1 −A 2 system, but also opens up a new pathway for developing high-efficiency photocatalysts.
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