COLLOIDS AND SURFACES B-BIOINTERFACES
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2023
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IF 5.8
Xiaoxiao Gu,Haoyang Yuan,Cailing Li,Lixian Xu,Shuang Li,Dinghua Yu
Photodynamic therapy has always been an antibacterial tool for solving multi-drug resistant bacteria problem, but the side effects and the low efficiency due to the high aggregation and low solubility of photosensitizers limit its application. Due to the anti-inflammatory effect of caffeic acid , two novel photosensitizers (CA-1-TBO, CA-TBO) were synthesized by conjugating caffeic acid with toluidine blue O (TBO). The structures have been characterized by 1 HNMR and high-resolution mass spectrometry . The UV–vis absorption, fluorescence spectra and the octanol-water partition coefficient of two photosensitizers were measured to evaluate their photophysical properties and hydrophilic/hydrophobic properties. Compared with parent TBO, the two modified photosensitizers have shown a higher quantum yield and kinetics constants of singlet oxygen, which has been supported by the simulation results of density functional theory . As drug-resistant representatives of gram-positive and gram-negative bacteria, respectively, S. aureus and P. aeruginosa have been used for in vitro antibacterial experiments. The sterilization efficiencies of the two modified photosensitizers far exceed that of parent TBO. The results of the octanol-water partition coefficient and fluorescence quantification showed that modified photosensitizers CA-1-TBO and CA-TBO could be more accumulated than parent TBO. Based on scanning electron microscopy images, protein gel electrophoresis , and the conductivity of the bacterial solution, the possible mechanism of improved antibacterial photodynamic efficiencies could be induced by membrane permeability due to the caffeic acid effect. The findings demonstrate the significant potential of natural phenolic compounds in the development of photosensitizer molecules with characteristics such as more efficient, biocompatible and less side effects.
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INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
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2023
·Vol. 64
·期 14
·30-30
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IF 4.4
Guodong Liu,Le Feng,Xiaoqiang Liu,Peng Gao,Fang Wang
Purpose:This study aimed to investigate the effects of O-linked N-acetylglucosamine modification (O-GlcNAcylation) on connexin43 (Cx43) expression and its subsequent effects on tight junction properties in diabetic retinopathy (DR).Methods:O-GlcNAcylation levels in primary human retinal vascular endothelial cells (HRVECs) and retinas from rats with diabetes were regulated by treatment with Thiamet G or alloxan. Immunoprecipitation was used to examine the relationship between O-GlcNAcylation and Cx43 expression. Stable overexpression and knockdown of Cx43 in HRVECs were achieved using lentivirus constructs; further, their effects on occludin and zonula occluden-1 (ZO-1) expression and tight junction barrier function were determined.Results:O-GlcNAcylation level increased significantly, whereas Cx43 expression decreased in retinas from rats with diabetes and HRVECs cultured under high-glucose conditions. Immunoprecipitation revealed that Cx43 was modified by O-GlcNAcylation and phosphorylation simultaneously. O-GlcNAcylation inhibition negatively regulated both total Cx43 and phosphorylated Cx43 expression, subsequently disrupting tight junction properties. Conversely, Cx43 overexpression reversed the disruption of tight junction properties and downregulated vascular endothelial growth factor expression. Consistently, Cx43 overexpression increased transendothelial electrical resistance values in HRVEC layers.Conclusions:O-GlcNAcylation negatively regulated Cx43 expression, contributing to the disruption of the blood retinal barrier. However, O-GlcNAcylation inhibition and Cx43 overexpression could reverse the tight junction disruption. Therefore, O-GlcNAcylation inhibition is a potential target for avoiding tight junction disruption through the Cx43 pathway in DR.
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Food Chemistry-X
·
2023
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IF 6.1
Huan Liu,Jingyu Li,Nazimah Hamid,Junke Li,Xuemei Sun,Fang Wang,Dengyong Liu,Qianli Ma,Shuyang Sun,Hansheng Gong
Smoked duck is a popular meat product in China. The aroma profile and key aroma compounds in smoked ducks were elucidated using solvent-assisted flavor evaporation-gas chromatography–olfactometry-mass spectrometry (SAFE-GC-O-MS), odor activity values (OAVs), aroma recombination and omission experiments, and sensory evaluation. The results indicated that the predominant aroma profiles of rice-, tea oil- and sugarcane-smoked ducks all contained strong smoky, roasty, fatty, meaty, and grassy aromas. A total of 31 aroma compounds were identified as important odorants by OAVs, including 8 aldehydes, 6 pyrazines, 5 phenols, and 2 sulfur compounds. The aroma recombination and omission experiments confirmed that 13 odorants were key aroma compounds in smoked ducks. Of these odorants, 2-methoxyphenol, 4-methylphenol, 5-ethyl-2,3-dimethylpyrazine, methional, 2-methyl-3-furanthiol, ( E, E )-2,4-decadienal, 1-octen-3-ol, and anethole significantly contributed to the aroma profile of smoked duck flavor ( p < 0.01).
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SEPARATION AND PURIFICATION TECHNOLOGY
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2023
·
IF 8.6
Cuizhu Sun,Zhenggang Wang,Hao Zheng,Shasha Zhao,Xianxiang Luo,Chenguang Li,Lingyun Chen,Fengmin Li
Phthalate esters (PAEs) widely used as plasticizers in industrial products are a major threat to human health and water ecological security. In this work, chitin-based sponges doped with oxygen-modified graphitic carbon nitride (O- g CN) (ChCN) demonstrated adsorption-photocatalytic synergistic ability for the efficient removal of two typical PAEs, diethyl phthalate (DEP) and dibutyl phthalate (DBP). The addition of O- g CN increased the sponge mechanical strength from 0.629 to 1.39 MPa, enabling materials with interconnected pores, excellent compressibility, and mechanical durability. The saturated adsorption capacities of DEP and DBP reached 37.41–42.93 mg g −1 for ChCN sponges, wherein the driving forces were hydrophobic interactions, hydrogen bonding, and π-π interactions. Notably, O- g CN significantly improved PAE removal by simultaneously enhancing the adsorption and photocatalytic effect of ChCN sponges due to its high catalytic activity, leading to 100% removal of DEP and DBP within 2 h. The degradation pathway of DEP was confirmed to be de-esterification. Finally, filtration columns assembled with ChCN sponges showed 87.8–90.9% PAE removal from water under natural light, and the removal efficiency did not significantly change even after three reuses, indicating stable removal performance and good reusability with potential for practical applications. The sponges also possessed good biocompatibility and biodegradability, as demonstrated through algal toxicity experiments and biodegradation tests. Therefore, this research presents a convenient method for preparation of compressible and reusable sponge materials from renewable biomass for efficient PAE removal from aqueous environments and has revealed the underlying mechanisms of such removal by the adsorption-photocatalysis synergistic effect.
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JOURNAL OF MOLECULAR STRUCTURE
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2023
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IF 3.8
Di-Ming Chen,Xue-Jing Zhang
Acetylene is an important industrial material for the production of acetaldehyde, acetic acid, benzene, synthetic rubber, synthetic fiber, etc., and its separation from the gas mixtures of C 2 H 2 /CO 2 is of great importance but a challenging task due to their similar physical properties and molecular sizes. In this study, taking the advantage of open-donor sites on the pore surface as the nano-traps for C 2 H 2 molecules, a new microporous metal-organic framework (MOF) formulated as {[C o 3 (OH) 2 (HCOO) 2 (CPT) 2 ](NMF) 2 (MeOH) 3 (H 2 O)} n ( 1 , NMF = N - methylformamide) has been prepared by virtue of a bifunctional organic ligand 4-(4H-1,2,4-triazol-4-yl)benzoic acid (HCPT), which showed discriminating sorption performance toward C 2 H 2 (113 cm 3 /g at 298 K and 1 bar) over CO 2 (33 cm 3 /g) under the same conditions. The different sorption behavior of {[C o 3 (OH) 2 (HCOO) 2 (CPT) 2 ]} n between C 2 H 2 and CO 2 results in a high uptake ration (3.4:1) and IAST selectivity (13) at 298 K and 1 bar. Furthermore, the force-field based grand canonical Monte Carlo (GCMC) simulation results demonstrate that the large electronegativity and polarizability of open O donor sites on the pore surface contribute to its high C 2 H 2 /CO 2 separation performance, leading to its more favorable C 2 H 2 uptakes than CO 2 .
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BIOMATERIALS
·
2023
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IF 14
Zheng Zou,Zhen Zhang,Hui Ren,Xueliang Cheng,Xuesi Chen,Chaoliang He
Injectable antibacterial hydrogels have attracted considerable attention in wound management. However, the development of injectable hydrogels with excellent antibacterial activity , good biocompatibility , and strong tissue adhesion remains a challenge. In this study, an antibacterial tissue-adhesive hydrogel was developed based on a catalyst-free o -phthalaldehyde (OPA)/amine reaction by simply mixing OPA-terminated four-arm poly(ethylene glycol) (4aPEG-OPA) and ε-poly- l -lysine (ε-PLL) solutions. The hydrogel showed tunable gelation time, storage moduli , and degradation rate depending on the polymer concentration and 4aPEG-OPA/ε-PLL mass ratio. The hydrogel exhibited nearly 100% bacterial inhibition rates in-vitro against Gram-negative E. coli and Gram-positive S. aureus , while maintaining good biocompatibility. The hydrogel matched well in shape and tightly adhered to the tissue after in-situ formation at the wound sites. Following the treatment of rat models of full-thickness skin incisions and round wounds, the hydrogel effectively closed the wounds and promoted wound healing. Moreover, after administering to S. aureus infected full-thickness skin wounds, the hydrogel exhibited remarkable efficacy in inhibiting wound infection with a bacterial inhibition rate over 99.94%, achieving a significantly accelerated wound healing compared with the commercially available Prontosan® gel. Therefore, the hydrogel exhibits great potential as a wound dressing for infection prevention and promotion of healing.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2023
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IF 9.9
Lu Tian,Dazhong Zhong,Tao Zhao,Yi Liu,Lu Hao,Qiang Fang,Xuelei Lang,Xin Zhao,Genyan Hao,Guang Liu,Jinping Li,Qiang Zhao
Developing highly efficient OER catalysts is essential for producing hydrogen from water electrolysis to compensate for conventional fossil fuel shortages. Here, the oxygen-vacancy-rich heterostructure grown on the Ni foam (NF) (Co 3 O 4 @Fe-B-O/NF) is fabricated. The synergistic effect between Co 3 O 4 and Fe-B-O has been proven effectively modulate the electronic structure and produce highly active interface sites, ultimately leading to enhanced electrocatalytic activity. Co 3 O 4 @Fe-B-O/NF requires an overpotential of 237 mV to drive 20 mA cm −2 in 1 M KOH, and 384 mV to drive 10 mA cm −2 in 0.1 M PBS, superior to most catalysts currently used. Moreover, Co 3 O 4 @Fe-B-O/NF as an oxygen evolution reaction (OER) electrode shows great potential in overall water splitting and CO 2 reduction reaction (CO 2 RR). This work may provide effective ideas for designing efficient oxide catalysts.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2023
·
IF 6.1
Zhengming Xu,Shuang Liu,Huining Lai,Lijun You,Zhengang Zhao
Arbutin, salidroside, polydatin, and phlorizin are typically natural bioactive phenolic glycosides. To improve the liposolubility and bioavailability, highly liposoluble derivatives including 6′-O-lauryl arbutin, 6′-O-lauryl salidroside, 6″-O-lauryl polydatin, and 6″-O-lauryl phlorizin were efficiently synthesized by enzymatic acylation in a green solvent 2-MeTHF. Their reaction conversions reached 84.4, 99.5, 99.8, and 89.1%, respectively, when catalyzed by Lipozyme 435 at 20 mg/mL at 50 °C. As expected, the derivatives had high log P (1.66–2.37) and retained good antioxidant activity, making them potential alternatives to butylated hydroxytoluene (BHT) and tert-butyl-hydroquinone (TBHQ) in lipid systems. Then, the intestinal permeability characteristics and metabolism of phenolic glycosides and their derivatives were investigated based on Caco-2 monolayers. The permeability of polydatin and phlorizin was mainly through active transport, but that of arbutin and salidroside involved both passive diffusion and active uptake. The acylated derivatives suffered from severe CES-mediated hydrolysis but exhibited a larger transported amount than phenolic glycosides.
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FUEL PROCESSING TECHNOLOGY
·
2023
·
IF 7.5
Mengjiao Fan,Yuewen Shao,Kai Sun,Yuchen Jiang,Shu Zhang,Yi Wang,Song Hu,Jun Xiang,Xun Hu
Bio-oil as a carbon source can be used to prepare hybrid metal@carbon material while the polymerization of which generally prevents metals from exposure. In this study, melamine was used as a structural regulating agent for preparing Co/N/C catalyst via heating the mixture of cobalt nitrate, melamine and bio-oil for hydrogenation of o-chloronitrobenzene (o-CNB). The results showed that the Co species was encapsulated in the carbon structure from cross-polymerization of melamine and bio-oil at 600 °C. The further heating to 900 °C led to decomposition of melamine-derived substance, and meanwhile cobalt oxide was reduced and confined in the resulting carbon structure. The formed metallic Co catalyzed the growth of long carbon nanotube with cobalt on the tip, forming the Co/N/C catalyst of higher specific surface area (128.2 m 2 /g) and metallic Co dispersion (3.7%), rendering the superior activity for hydrogenation of o-CNB with the yield of o-chloroaniline up to 90.2%. The encapsulation or exposure of Co species was closely related to relative ratio of bio-oil and melamine in the catalyst precursors. Additionally, leaching of cobalt, due to dechlorination of o-CNB, was found to be an issue of Co/N/C catalyst but not for that of Ni/N/C catalyst.
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Molecular Catalysis
·
2023
·
IF 4.6
Zong-Pin Fu,Yun-Peng Zhao,Fa-Peng Wu,Jin-Xuan Xie,Le-Le Qiu,Jian Xiao,Jing Liang,Yong-Hui Bai,Fang-Jing Liu,Jing-Pei Cao
The selective hydrogenolysis of C O bonds is critical for the effective valorization of lignin. Herein, we synthesized a series of highly efficient Ni x Co y Al-T catalysts by a coprecipitation-calcination-reduction method and evaluated their catalytic hydrogenolysis performance towards the C O bonds of lignin-derived aryl ether, using isopropanol as the hydrogen donor source. The results revealed that the Ni 0.5 Co 1.5 Al-600 catalyst displayed superior activity and its catalytic performances were strongly influenced by the Ni/Co molar ratios and calcination temperatures. The enhanced dispersion of metal particles and the electron transfer from Ni to Co in Ni 0.5 Co 1.5 Al-600 catalyst facilitated the cleavage of C O bonds in lignin model compounds. Furthermore, the β-benzyl-H atom in 2-phenoxy-1-phenylethanol (PPE) also contributes to the cleavage of C aliphatic -O bonds. Under optimized reaction conditions (180 ℃, reaction time 2 h), PPE was completely converted over the Ni 0.5 Co 1.5 Al-600 catalyst, and the yield of ethylbenzene and cyclohexanol reached 95.91wt% and 85.73wt%, respectively. These findings demonstrate that the Ni x Co y Al-T catalytic system holds great promise for the production of valuable chemicals from lignin under mild conditions.
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PLANT PHYSIOLOGY
·
2023
·
IF 7.4
Liao Zhenkun,Liu Xiaojuan,Zheng Juan,Zhao Chenning,Wang Dengliang,Xu Yang,Sun Chongde
Polymethoxylated flavones (PMFs) have received extensive attention due to their abundant bioactivities. Citrus peels specifically accumulate abundant PMFs, and methylation modification is a key step in PMF biosynthesis; however, the function of reported O-methyltransferase (OMT) in citrus is insufficient to elucidate the complete methylation process of PMFs. In this study, we analyzed the accumulation pattern of PMFs in the flavedo of the sweet orange (Citrus sinensis) cultivar “Bingtangcheng” at different developmental stages. We found that accumulation of PMFs was completed at the early stage of fruit development (60-d after flowering). Furthermore, we characterized a true caffeoyl-CoA O-methyltransferase (named CsCCoAOMT1) from C. sinensis. Functional analysis in vitro showed that CsCCoAOMT1 preferred flavonoids to caffeoyl-CoA and esculetin. This enzyme efficiently methylated the 6-, 7- 8-, and 3′-OH of a wide array of flavonoids with vicinal hydroxyl groups with a strong preference for quercetin (flavonol) and flavones. The transient overexpression and virus-induced gene silencing experiments verified that CsCCoAOMT1 could promote the accumulation of PMFs in citrus. These results reveal the function of true CCoAOMTs and indicate that CsCCoAOMT1 is a highly efficient multifunctional O-methyltransferase involved in the biosynthesis of PMFs in citrus.
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Energy Storage Materials
·
2023
·
IF 20.4
Chengyao Zhao,Yiming Lin,Qiaoyan Lin,Qi Liu,Yujing Liu,Zhongqiu Liu,Anguo Ying
Aqueous zinc-ion hybrid capacitors (ZIHCs) are a promising new type of energy storage device, but there is a plight that the unsatisfactory Zn 2+ storage capability of carbonaceous cathodes limits further application. To address this issue, desolvation strategy is employed to tailor the solvation sheath of Zn 2+ in the ultra-micropores (0.59 nm) nanospheres , where H 3 PO 4 acts as phosphorus source for forming C-P bonds and enhancing C=O bonds to further reduce the desolvation energy barrier. In practical application, a quasi-solid-state flexible ZIHC is constructed, which provides a battery-level energy density (293.4 Wh kg −1 ) at a power density (180 W kg − 1 ) and a remarkable capacity retention of 93.4 % after 10 000 cycles. Electrochemical analyses, DFT calculations and structural characterization reveal that ultra-microporous is proved to be a prerequisite for C-P/C=O that are expected to further deplete solvent molecules within a Zn 2+ solvation sheath. Also, the coupling effect between the strong adsorption of Zn 2+ by C-P/C=O and the hydrophobic effect of C-P play an important role in facilitating desolvation process. This work creates a precedent for the application of ultra-microporous carbon materials in ZHICs and provides a brand-new approach for breaking the bottleneck of the low energy density and poor lifespan of ZHICs.
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