INORGANIC CHEMISTRY COMMUNICATIONS
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2025
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IF 5.4
Wei Wang,Chunlai Liu,Na Wang,Shuai Bai,Yang Wang,Jianglei Hu,Junnan Wu
In this paper, thick-walled organosilicon nanotubes, bi-functionalized with Au nanoparticles and -SO 3 H have been synthesized for the first time in a facile approach using the mixture of Pluronic surfactants P104(EO 27 PO 61 EO 27 ) and F108(EO 132 PO 50 EO 132 ). The wall thickness is up to about 6.0 nm. More importantly, the Au nanoparticles are quite stable and uniformly distributed inside the nanotubes, and their size distributions are mainly around 3.0–4.5 nm. The organosilicon nanotubes, combined with the ultra-nanosized Au nanoparticles along with synergistic effect of oxidizing -HS to -SO 3 H, acting as a Brønsted acid, resulted in the optimal composite, i.e. , Au-HS 0.3 /SO 3 H-Si-NTs(T), with a catalytic conversion efficiency of 100.0 % in the hydration reaction of phenylacetylene without any organic solvents and acids, which makes them have good application prospects in green organic synthesis.
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International Journal of Nanomedicine
·
2025
·
IF 6.5
Ling-zhijie Kong,Dong Zhou,Guoyan Mo,Mingyue Shu,Wenyan Yu,Hao Cheng,Kaichun Li
Introduction: The therapeutic efficacy of nanomedicine in oncology is predicated on its capacity to enhance drug uptake by cells and control drug release. While targeted nanomedicines are highly regarded for their potential, they are not spared from issues of colloidal instability and uncontrolled drug release.Methods: The hybrid system (Au@SiO2-HA-DOX) was designed to enhance colloidal stability and facilitate controlled drug delivery by coating gold nanorods with silica shells and hyaluronic acid (HA) for tumor targeting. The nanoparticles were characterized for morphology, size, zeta potential, and photothermal properties. The loading efficiency of doxorubicin (DOX) and its release behavior in response to pH, reactive oxygen species (ROS), and NIR stimulation were evaluated.Results: Under NIR irradiation, the nanoparticles exhibited excellent photothermal stability and sustained temperature elevation. In vitro studies demonstrated that the nanoparticles possessed good biocompatibility (cell viability exceeding 90%) and colloidal stability (7 days). The loading efficiency of DOX was enhanced to 65.9%, with sustained release characteristics. Furthermore, Au@SiO2-HA-DOX exhibited selective targeting and stronger cytotoxicity towards cancer cells. The cellular uptake efficiency was 1.7 times higher than that of the Free DOX at 24 h, with an IC50 value of 1.36 μM, compared to 2.01 μM for Free DOX. In vivo experiments in a mouse breast cancer model revealed significant tumor growth inhibited with NIR-assisted therapy, while maintaining stable body weight and preserving good biocompatibility.Conclusion: This nanohybrid system represents a promising strategy for improving the efficacy of chemotherapy and reducing toxicity in cancer treatment. It enhances drug enrichment and release in tumor tissues while minimizing the impact on normal tissues.
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ACS Sensors
·
2026
·
IF 10.9
Runcheng Liu,Jie Yan,Shujun Zhang,Wen Yang,Juan Li,Xiaoyan Sun,Lutao Du,Mingshun Jiang
DNA methylation has emerged as a pivotal molecular biomarker for early cancer diagnosis. Nevertheless, existing detection strategies remain limited by complex workflows, poor efficiency in trace DNA capture, and the inability to resolve both absolute concentration and methylation ratio simultaneously. Herein, we engineer a tilted fiber Bragg grating (TFBG) biosensor functionalized with Au@zeolitic imidazolate framework-8 (Au@ZIF-8) core-shell nanoparticle arrays. This architecture overcomes the diffusion-limited capture of conventional biosensors through a powerful hydrodynamic−plasmonic synergy. First, hydrodynamic stagnation flow efficiently preconcentrates trace DNA molecules onto the sensing interface. Subsequently, plasmon-enhanced dielectrophoresis provides an active trapping force, precisely localizing these molecules onto sensing hotspots. To enable multiparametric methylation profiling, a dual-recognition strategy was developed by integrating sequence-specific DNA hybridization with 5-methylcytosine (5mC) antibody binding. This approach allows for rapid (<15 min), amplification-free quantification of both methylated DNA concentration and methylation ratio in complex biological samples, with an ultralow detection limit of 6.9 × 102 copies/μL. Clinical validation using patient-derived samples demonstrates excellent diagnostic accuracy, achieving a receiver operating characteristic (ROC) area under the curve (AUC) of 0.941 through multilocus methylation analysis. This study establishes a robust, amplification- and label-free biosensing platform that integrates microfluidic manipulation with plasmonic nanoengineering, offering a powerful strategy for high-throughput, clinically translatable DNA methylation analysis in early cancer detection.
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高影响因子
FOOD RESEARCH INTERNATIONAL
·
2026
·
IF 8.8
Qingluan Li,Wenhui Geng,Yibin Ying,Lijuan Xie
Neonicotinoids (NEOs) pose significant threats to environmental safety and the food chain. To overcome the limitations of conventional nanozymes in achieving simultaneous pesticide discrimination and ultrasensitive quantification, a tunable platinum/gold@manganese dioxide (Pt/Au@MnO 2 ) nanozyme was developed. The material was engineered by synthesizing urchin-like Pt/Au nanoparticles via a two-step hydrothermal method, followed by electrostatic self-assembly onto MnO 2 nanosheets. By modulating the Pt/Au to β-MnO 2 ratio, the nanozyme's activity could be precisely switched between laccase-like (LAC) and peroxidase-like (POD) modes. The LAC mode enabled discriminative analysis of four NEOs through distinct colorimetric fingerprints analyzed by principal component analysis (PCA). For quantification, the POD mode was amplified by glutathione (GSH), which enhanced the signal through a nucleophilic reaction, resulting in a visible color gradient from dark green to light yellow. This strategy achieved highly sensitive detection of imidacloprid with a wide linear range (10 −8 –10 −4 M), a low detection limit of 4.42 × 10 −9 M, and high accuracy in real samples (recoveries: 96.2–104.0%). This dual-mode platform offers a robust and practical strategy for on-site NEO monitoring in food safety and agricultural control.
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Analytical Methods
·
2026
·
IF 3
Liansheng Ling,chen chen,Yingqing Li,xiaosong Yang,Ji Zhang
Here we report an ultrasensitive dynamic light scattering (DLS) immunosensor for cardiac troponin I (cTnI) leveraging a novel Self-cascading reaction synergistic amplification strategy by using metal organic frameworks (MOF) materials. This synergistic amplification system was designed within combined enzymatic (glucose oxidase, GOD) catalysis, acid-responsive MOF disintegration, Fenton reaction and gold nanoparticles (Au NPs) stability modulation. When the target cTnI was present, sandwich structure was formed between multifunctional probes (Ab-GOD/Fe-MOF) and Ab modified 96-well plates, subsequently occurring self-cascading reactions with further addition of glucose: the glucose was oxidized into gluconic acid (creating an acidic micro-environment) by O2 under the catalysis of MOF - conjugated GOD and produced H2O2, the acidic micro-environment triggered the breakdown of Fe-MOF and the release of Fe2+, reacting with H2O2 via the Fenton reaction to etch the protective DNA layer that modified on Au NPs, enable the salt-induced aggregation of AuNPs. Crucially, the DLS assay achieved a low limit of detection (LOD) of 1.5 × 10-13 g/mL, furthermore, this cascade amplification strategy realized the quantitative detection of cTnI in clinical samples with high sensitivity and specificity.
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IEEE SENSORS JOURNAL
·
2026
·
IF 4.5
Pengxia Li,Zhifei Cao,Bin Xie,Guowei Yang,Yifei Ma,Mei Wang,Suotang Jia,Xuyuan Chen,Zhaomin Tong
Gas sensors play a vital role in human health monitoring, particularly for detecting disease-related biomarkers in exhaled breath. However, conventional metal-oxide semiconductor gas sensors face limitations in wearable respiratory monitoring applications due to their inflexibility and high heat loss. Here, we fabricated an Au-ZnO fibre-based gas sensor for the detection of ammonia (NH3), an indicator of kidney dysfunction. The device is constructed from a composite flexible fibre comprising a liquid-metal core and a silica cladding, onto which an Au-ZnO gas-sensing layer is synthesised in situ. Liquid metal directly conducts thermal energy to the insulating cladding through Joule heating, providing thermal energy to the gas-sensing layer. This design enables low heat loss and low-current operation while generating sufficient thermal energy to enhance the gas-sensing response. The resulting Au-ZnO fibre sensor exhibits a stable high response to NH3 (response of 2.2 to 2 ppm NH3) even under bending (bending radius of 15 mm). The response time and recovery time are 153 s and 156 s at a working temperature of 280 oC. This demonstrates that the Au-ZnO fibre sensor has good flexibility and suitability for wearable respiratory monitoring. To showcase its practical utility, a real-time monitoring sensor system was developed by designing a signal detection circuit, and the concentration of NH3 was monitored in real time through different coloured light-emitting diodes. This work presents a practical, home-based approach for respiratory monitoring of NH3 and offers a simple, effective solution to distinguish between healthy individuals and patients with different stages of kidney disease.
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Catalysts
·
2026
·Vol. 16
·期 5
·480
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IF 4.5
Qifan Zhao,Kaijie Li,Hongbo Yu,Hongfeng Yin
p-nitrophenol (p-NP) is a pollutant with environmental persistence, bioaccumulation potential, and significant health risks, and is widely dispersed in wastewater, so efficient removal ofp-NP is imperative. Among the various methods, the catalytic reduction ofp-NP top-aminophenol (p-AP) using sodium borohydride (NaBH4) is a particularly promising one and, herein, catalysts play a crucial role. Among the various metals, Au shows unique catalytic activity forp-NP reduction. However, nanosized Au often exhibit limited activity and stability due to their high surface free energy. To address this challenge, we designed and synthesized Au-SnOxhybrid nanoparticles confined within hollow mesoporous silica nanoreactors (Au-SnOx@hm-SiO2) via a soft-template-assisted co-adsorption strategy. The resulting bimetallic Au-SnOx@hm-SiO2nanoreactor showed significantly enhanced catalytic activity toward the NaBH4-mediated reduction ofp-nitrophenol (p-NP) compared with its monometallic Au@hm-SiO2counterpart, owing to the synergistic effect between Au and SnOx. Among various Au/Sn ratios, the catalyst with an Au/Sn molar ratio of 1:0.1 demonstrated the highest activity, achieving complete conversion ofp-NP within 5 min at ap-NP/Au molar ratio of 529:1—a tenfold improvement over Au@hm-SiO2. Moreover, the catalyst maintained high efficiency over six consecutive cycles, with only slight deactivation, benefiting from the protective silica shell.
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 6
·407
·
IF 5.4
Fan Lihua,Ou Zongyuan,Li Fan,Shi Yiheng,Wu Di,Wu Yongning,Li Guoliang
Sensitive and reliable quantification of Ochratoxin A (OTA) in food is essential for ensuring food safety and protecting public health. In this study, a dual-mode colorimetric and Surface-Enhanced Raman Spectroscopy (SERS) biosensor was developed by integrating DNAzyme-responsive hydrogel and Au@Pt@4-MBN nanozyme for signal amplification. Upon introduction of OTA, a specific cascade reaction was triggered, activating the generated DNAzymes and leading to the disintegration of the hydrogel network and the subsequent release of encapsulated nanozymes. The extent of hydrogel disintegration exhibited a positive correlation with OTA concentration, enabling straightforward quantitative detection. The biosensor demonstrated excellent sensitivity, with detection limits of 0.0668 ng mL⁻¹ (colorimetric) and 0.0342 ng mL⁻¹(SERS). When applied to spiked corn samples, it achieved high recoveries of 98.70%-100.93% (colorimetric) and 95.6%-104.27% (SERS), confirming its reliability. The method also demonstrated high practical applicability for authentic non-spiked samples, with a positive detection rate of 10% that was consistent with the results of the national standard method. This robust platform offers significant potential for sensitive mycotoxin monitoring in food and environmental safety. Graphical The alternative text for this image may have been generated using AI.
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Nanomaterials
·
2022
·Vol. 12
·期 15
·
IF 5.719
Asha Yadav,Bo Fu,Stephanie Nicole Bonvicini,Linh Quy Ly,Zhitai Jia,Yujun Shi
β-Ga2O3nanostructures, including nanowires (NWs), nanosheets (NSHs), and nanorods (NRs), were synthesized using thermally dewetted Au nanoparticles as catalyst in a chemical vapor deposition process. The morphology of the as-grownβ-Ga2O3nanostructures depends strongly on the growth temperature and time. Successful growth ofβ-Ga2O3NWs with lengths of 7–25 μm, NSHs, and NRs was achieved. It has been demonstrated that the vapor–liquid–solid mechanism governs the NW growth, and the vapor–solid mechanism occurs in the growth of NSHs and NRs. The X-ray diffraction analysis showed that the as-grown nanostructures were highly pure single-phaseβ-Ga2O3. The bandgap of theβ-Ga2O3nanostructures was determined to lie in the range of 4.68–4.74 eV. Characteristic Raman peaks were observed with a small blue and red shift, both of 1–3 cm−1, as compared with those from the bulk, indicating the presence of internal strain and defects in the as-grownβ-Ga2O3nanostructures. Strong photoluminescence emission in the UV-blue spectral region was obtained in theβ-Ga2O3nanostructures, regardless of their morphology. The UV (374–377 nm) emission is due to the intrinsic radiative recombination of self-trapped excitons present at the band edge. The strong blue (404–490 nm) emissions, consisting of five bands, are attributed to the presence of the complex defect states in the donor (VO) and acceptor (VGaor VGa–O). Theseβ-Ga2O3nanostructures are expected to have potential applications in optoelectronic devices such as tunable UV–Vis photodetectors.
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SENSORS
·
2018
·Vol. 18
·期 5
·1448
·
IF 2.475
Han Song,Zhijie Luo,Mingyao Liu,Gang Zhang,Wang Peng,Boyi Wang,Yong Zhu
In the present work, centrifugal deposited Au-Pd core-shell nanoparticle (NP) film was proposed for the room-temperature optical detection of hydrogen gas. The size dimension of 44, 48, 54, and 62 nm Au-Pd core-shell nanocubes with 40 nm Au core were synthesized following a solution-based seed-mediated growth method. Compared to a pure Pd NP, this core-shell structure with an inert Au core could decrease the H diffusion length in the Pd shell. Through a modified centrifugal deposition process, continues film samples with different core-shell NPs were deposited on 10 mm diameter quartz substrates. Under various hydrogen concentration conditions, the optical response properties of these samples were characterized by an intensity-based optical fiber bundle sensor. Experimental results show that the continues film that was composed of 62 nm Au-Pd core-shell NPs has achieved a stable and repeatable reflectance response with low zero drift in the range of 4 to 0.1% hydrogen after a stress relaxation mechanism at first few loading/unloading cycles. Because of the short H diffusion length due to the thinner Pd shell, the film sample composed of 44 nm Au-Pd NPs has achieved a dramatically decreased response/recovery time to 4 s/30 s. The experiments present the promising prospect of this simple method to fabricate optical hydrogen sensors with controllable high sensitivity and response rate at low cost.
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 4
·233
·
IF 5.4
Gao Xiang,Hou Yujiao,Lin Fang,Wen Limei,Guo Yali,Kong Weijun,Hu Junping,Yang Jianhua
An electrochemical (EC) molecularly imprinted polymer (MIP) sensor for therapeutic drug monitoring of olanzapine (OLZ) has been developed. A “rime-like” gold-platinum nanostructured film (Au-Pt NF) was fabricated on a screen-printed carbon electrode (SPCE) via an one-step hydrogen bubble dynamic template (HBDT) method, followed by electropolymerization of a polyaniline-based MIP. The Au-Pt NF/SPCE served as an ideal three-dimensional conductive substrate with a large active area and enhanced electron-transfer capability, endowing the specific MIP sensor with high sensitivity. Using [Fe(CN) 6 ] 3−/4− as a redox probe, the sensor quantified OLZ by the decrease in differential pulse voltammetry current caused by target binding. It exhibited two linear ranges (0.005–0.4 µM and 0.4–10 µM) with a detection limit of 0.94 nM, and demonstrated high selectivity, reproducibility, and stability. The sensor achieved recoveries of 96.7–102.7% for OLZ in tablets, urine, and whole blood. This work provides a reliable, all-EC sensing platform with strong potential for rapid OLZ monitoring in clinical settings.
Section
Graphical
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SENSORS AND ACTUATORS A-PHYSICAL
·
2026
·
IF 5.1
Yingjiao Zhai,Junjie Yu,Xuanyu Chen,Fujun Liu
The urgent need for reliable blood glucose monitoring has driven the development of advanced sensing platforms such as surface enhanced Raman scattering (SERS). However, traditional SERS substrates are plagued by inconsistent hotspots and limited signal strength. We solved this problem by constructing a heterojunction substrate with a precisely designed gold nanoarray (Au NA) on a single-layer MoS 2 . Due to the structural characteristics of the substrate, a uniform plasma coupling network and efficient charge transfer channels have been constructed. The uniform intensity and charge transfer efficiency of LSPR were optimized through the design of the structure, and the enhancement mechanism was systematically studied physically. When functionalized with 4-MPBA, our sensor achieved an ultra sensitive glucose detection limit of 10 −12 M and long-term stability within 15 days, with relative enhancement factors of 6.29 and 13.98, respectively. It demonstrates excellent recognition ability for glucose molecules in anti-interference detection. This fully demonstrates the transformative potential of ordered nanoarray design in the field of biosensing.
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