JOURNAL OF SOLID STATE CHEMISTRY
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2021
·
IF 3.498
Mei Yan,Wen-Dong Yao,Wenfeng Zhou,Wenlong Liu,Ru-Ling Tang
Inorganic gallates are attractive owing to their abundant structures and wide applications for nonlinear optics, magnetism , molecular sieve and catalysis. Herein, a new cesium cadmium gallate, CsCdGa 3 O 6 , has been synthesized by a solid-state reaction, which is the first I-II-III-O (I = alkali metals, II = divalent metals, III = Al, Ga, In) type oxide. It crystallizes in the centrosymmetric space group P 2 1 / c , and the three-dimensional Ga–O polyanionic framework is constructed by [Ga 4 O 14 ] 16− helical belts linked [Ga 6 O 6 ] 6+ and [Ga 8 O 8 ] 8+ cages. Thermal analysis indicates that it possesses high thermal stability. Various characterizations and results analysis including XRD , TG-DSC, IR, Raman spectrum , as well as electronic structure calculations were performed.
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Foods
·
2025
·Vol. 14
·期 8
·1292
·
IF 5.1
Chunxiao Li,Xiaolei Zhao,Xiaofei Yin,Shuting Zhang,Jinxing He
2-amino-1-methyl-6-phenyl-imidazo [4,5-b] pyridine (PhIP) is a harmful compound that is formed during the high-temperature processing of meat products, and the risk of cancer may be increased with the prolonged intake of foods containing high levels of PhIP. This study aimed to develop an innovative detection method specifically for PhIP in meat products. Utilizing hydrogel-molecular-imprinting electrochemical sensing technology, the preparation conditions of molecularly imprinted hydrogels (MIHs) were optimized. Consequently, a highly selective and rapid detection method for PhIP was successfully established, integrated with an electrochemical workstation. The results indicate that the prepared MIHs exhibit an excellent specific recognition performance for PhIP. The sensor exhibited a linear response within the concentration range of 1.0–200.0 ng/mL, with a detection limit of 0.07 ng/mL (S/N = 3) under optimized conditions. In addition, the accuracy and reliability of the method were verified by spiked recovery experiments, and the recoveries ranged from 75.9% to 108.8%, which demonstrated its high accuracy and potential for practical application.
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JOURNAL OF MEDICINAL CHEMISTRY
·
2019
·
IF 6.054
Deyu Kong,Tao Xue,Bin Guo,Jianjun Cheng,Shunyin Liu,Jianhai Wei,Zhengyu Lu,Haoran Liu,Guoqing Gong,Tian Lan,Wenhao Hu,Yushe Yang
P2Y12 antagonists are widely used as antiplatelet agents for the prevention and treatment of arterial thrombosis. Based on the scaffold of a known P2Y12 antagonist AZD1283, a series of novel bicyclic pyridine derivatives were designed and synthesized. The cyclization of the ester substituent on the pyridine ring to the ortho-methyl group led to lactone analogues of AZD1283 that showed significantly enhanced metabolic stability in subsequent structure–pharmacokinetic relationship studies. The metabolic stability was further enhanced by adding a 4-methyl substituent to the piperidinyl moiety. Compound 58l displayed potent inhibition of platelet aggregation in vitro as well as antithrombotic efficacy in a rat ferric chloride model. Moreover, 58l showed a safety profile that was superior to what was observed for clopidogrel in a rat tail-bleeding model. These results support the further evaluation of compound 58l as a promising drug candidate.
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FOOD CHEMISTRY
·
2022
·
IF 9.231
Zenghui Xie,Yuling Hu,Yanlong Chen,Gang Wu,Gongke Li,Qisheng Zhong
A core–shell magnetic sulfonatocalix[6]arene covalently cross-linked polymer was proposed as a magnetic adsorbent, combined with ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) for the enrichment and determination of epoxy derivatives in canned foods. The adsorbent has high density of host–guest recognition functional groups, abundant binding sites and suitable cavity size, showing good extraction performance for epoxy derivatives. Quantum chemical simulation calculations proved multiple interaction forces in the adsorption process. The extraction parameters were investigated. Under optimized experimental conditions, 13 kinds of target analytes showed low detection limits (0.0072–0.023 ng/g) and good precisions (RSDs of 0.8 %-9.4 %). This method has been successfully applied to the simultaneous determination of 13 kinds of epoxy derivatives in different food samples including canned beverage, fish, meat, and milk powder. Satisfactory recoveries (74.9 %–118 %) were obtained. The results showed the potential application prospects in the enrichment and detection of hazardous substances in food.
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DYES AND PIGMENTS
·
2012
·
IF 3.126
Hongping Zhou,Jianqing Wang,Feixia Zhou,Dongling Xu,Yuanle Cao,Gang Liu,Lin Kong,Jiaxiang Yang,Jieying Wu,Yupeng Tian
A simple D-π-A type ligand ( L : 4′-(4-[4-(1H-[1,2,4]-triazolyl)styryl]phenyl)-2,2′:6′,2″-terpyridine) was designed and synthesized, which reacted with HgX 2 (X = Cl, Br, I, SCN) yielding a series of uncommon five-coordinated mercury (II) complexes ( Dyes 1–4 ). The ligand and Dye 4 were characterized by single crystal X-ray diffraction determination. Linear and nonlinear optical properties of the ligand and dyes were exhibited. Experimental results revealed that the two-photon absorption (TPA) cross-sections of the four dyes are considerably larger than that of the ligand. Density function theory (DFT) calculations performed on Dyes 1–4 showed that the halogens affect the accepting capability of the complexed metal due to different electron inductive effects , which finally influence the TPA cross-section values.
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Inorganic Chemistry Frontiers
·
2026
·
IF 6.2
Maxim V. Mikhailenko,Tatiana Yu. Astakhova,Elena N. Timokhina,Maxim A. Faraonov,Alexey V. Kuzmin,Salavat S. Khasanov,Denis V. Korchagin,Gennady V. Shilov,Akihiro Otsuka,Hiroshi Kitagawa,Dmitri V. Konarev
A series of anionic bi- and trinuclear complexes of CoII, FeII and MnII with hexaazatrinaphthylene (HATNA) and hexaazatriphenylenehexacarbonitrile (HAT(CN)6), incorporating paramagnetic Cp*2Fe+ cations (S = 1/2), were obtained. It was demonstrated that even a mild Cp*2Fe reductant can be used to reduce metal complexes of HAT-type ligands. Metal iodides were transferred from the pristine powder to the complexes in a non-coordinating solvent via complex formation with spiropyran or tetrabutylammonium iodide. The isostructural complexes (Cp*2Fe+)[(MIII2)2·HATNA]−·C6H4Cl2·0.5C6H14 (M = Co (1), Fe (2) and Mn (3)) contain monoanionic [(MIII2)2·HATNA]− units, which alternate in π-stacks with Cp*2Fe+ cations and also form π-stacked [(MIII2)2·HATNA−]2 dimers. Metal ion coordination is asymmetric, featuring one short and one long M–N bond. The short M–N bonds are 1.973(6) Å for CoII (1), 2.039(4) Å for FeII (2), and 2.115(4) Å for MnII (3); these are the shortest bonds reported to date among studied HAT-based complexes for CoII and FeII. These complexes exhibit very strong antiferromagnetic metal–radical coupling, which isolates their high-spin ground states at high temperatures. To the best of our knowledge, the exchange coupling value of −300 cm−1 observed for 3 is the highest among MnII-containing complexes based on a radical ligand with delocalized spin. Compound (Cp*2Fe+)[(FeIII2)3·HATNA]−·C6H4Cl2 (4) is unique due to its magnetic behavior, which is severely different from that previously observed for similar trinuclear radical FeII-containing HAT-based complexes. Instead of a smooth increase in the χMT value with a temperature decrease, attributed to the formation of a high-spin system, a rapid increase below 30 K is observed. Trinuclear trianionic species [(FeIII2)3·HAT(CN)6]3− are isolated in (Cp*2Fe+)3[(FeIII2)3·HAT(CN)6]3−·4C6H4Cl2 (5) and do not participate in intermolecular exchange coupling. The unusual magnetic behavior of 5 can only be described by a model implying different signs of D for metal ions in the complex. Such a feature arises from the substantial difference in the coordination geometry of one Fe1 ion compared to the other two Fe2 ions.
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FOOD CHEMISTRY
·
2023
·
IF 8.8
Jianming Zhang,Daiyao Liu,Chengcheng Zhang,Haiyue Niu,Xiaoting Xin,Juan Chen,Huaxi Yi,Daqun Liu
Co-culture fermentation is a novel technology for enhancing fermentation quality and promoting gamma-aminobutyric acid (GABA) yield. The purpose of this study was to evaluate the effects of Levilactobacillus brevis YSJ3 and Lactiplantibacillus plantarum JLSC2-6 co-culture on GABA yield, volatile and non-volatile metabolite profiles, and antioxidant activity in cauliflower byproducts. It was found that co-culture had the highest GABA yield (35.00 ± 1.15 mg/L) in fermented cauliflower stems. In total, 111 and 1264 volatile and non-volatile metabolites, respectively, were identified, of which 59 metabolites were significantly upregulated after co-culture fermentation. The results showed that 24 key upregulated metabolites were positively associated with hydroxyl radical-scavenging activity. Notably, Levilactobacills were positively correlated with the yield of GABA and key upregulated metabolites. Thus, these results suggest that Levilactobacillus brevis and Lactiplantibacillus plantarum can improve in key metabolites, GABA yield, and antioxidant activity following co-culture. This study provide a theoretical basis for developing GABA-rich cauliflower byproducts.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2023
·
IF 4.5
Kangdi Guan,Ziwei Zhang,Qiang Zhang,Pinghua Ling,Feng Gao
Herein, this paper reports a simple and label-free photoelectrochemical (PEC) sensor based on the organic semiconducting conjugated polymer-polyfluorene derivative, poly[(9,9-dioctylfluorenyl-2,7-diyl)-co-(6-{4-ethyl-piperazin-1-yl}-2-phenyl-benzo{de}isoquinoline-1,3-dione)] (PFNA). The PFNA was designed and obtained the lowest unoccupied molecular orbital (LUMO)/highest occupied molecular orbital (HOMO) values via spectral characterizations. The PFNA modified electrode produced a stable and enhanced photocurrent signal under white light irradiation at a bias of −0.1 V in phosphate buffer solution. A sensitive increment of the photocurrent was observed with the addition of p -phenylenediamine ( p -PD). A possible mechanism for this photoelectrochemical process including the photoexcitation of the polymer, electron injection from polymer toward the electrode, and the hole-scavenging process by the reductants were studied. The π bond in the polymer might facilitate the photoelectrochemical process owing to the enhanced electronic coupling between the polymer and the reductants. A PEC analysis on p -PD has been carried out to evaluate the photoelectrochemical performances of the modified electrode, which presents the wide linear ranges of 0.2–400 μM, with a lower detection limit of 0.13 μM. This work reports the PEC performance of organic semiconducting conjugated polymer-polyfluorene derivative, which would promote more efficient photoelectrochemical design of sensors and devices.
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Food Chemistry-X
·
2025
·
IF 8.2
Mantong Zhao,Zhongyuan Liu,Mengyin Zha,Ying Sun,Haohao Shi,Xueying Zhang,Chuan Li,Guanghua Xia
The effect of aldehydes from lipid oxidation on the generation of heterocyclic amine 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP) during pan-frying of golden pompano fillets was investigated. It was observed the aldehydes that contribute to thiobarbituric acid reactive substances (TBARS) value significantly promoted PhIP generation ( p < 0.05). The defat treatment of fresh fish tissue significantly reduced the PhIP formation in pan-fried products ( p < 0.05). During pan-frying, massive aldehydes were generated in a time-dependent manner with acrolein, propanal, hexanal, 4-hydroxy-nonenal (HNE), and 2,4-decadienal (DDE) as the abundant species. In the established chemical model, these aldehydes congruously promoted PhIP formation with the increased concentration, especially acrolein, HNE and DDE. Therefore, aldehydes could significantly enhance the PhIP generation under processing. However, except for propanal and hexanal, the promoting effect was slightly decreased with high levels of aldehydes addition due to the strong electrophilic properties and participation of reaction with the amino group of phenylacetaldehyde, creatinine, even PhIP.
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INTERNATIONAL IMMUNOPHARMACOLOGY
·
2017
·
IF 2.956
Zhaoxiao Yu,Chenhui Zhang,Mingliang Zhou,Qiming Li,Hui Li,Wei Duan,Xue Li,Yonghong Feng,Jianping Xie
Tuberculosis (TB), caused by Mycobacterium tuberculosis , remains a formidable threat to global public health . The successful intracellular persistence of M . tuberculosis significantly contributes to the intractability of tuberculosis. Proline-glutamic acid (PE) and proline-proline-glutamic acid (PPE) are mycobacterial exclusive protein families that widely reported to be involved in the bacterial virulence , physiology and interaction with host. Rv2770c (PPE44), a predicted virulence factor , was up-regulated upon the infected guinea pig lungs. To investigate the role of Rv2770c, we heterologously expressed the PPE44 in the nonpathogenic fast-growing M . smegmatis strain. Subcellular location analysis demonstrated that Rv2770c is a cell wall associated protein, suggestive of a potential candidate involved in host-pathogen interaction. The Rv2770c can enhance M . smegmatis survival within macrophages and under stresses such as H 2 O 2 , SDS, diamide exposure, and low pH condition. M . smegmatis expressing Rv2770c is more virulent as testified by the increased death of macrophages and the increased expression of interlukin-6 (IL-6) and interlukin-12p40 (IL-12p40). Moreover, Rv2770c altered the secretion of IL-6 and IL-12p40 of macrophages via NF-κB, ERK1/2 and p38 MAPK axis. Taken together, this study implicated that Rv2770c was a virulent factor actively engaged in the interaction with host macrophage.
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CHROMATOGRAPHIA
·
2021
·Vol. 84
·期 11
·1065-1075
·
IF 2.044
Zhang Zixin,Wang Zhida,Zhang Ying,Zhang Yi,Han Lifeng,Tian Fei
We present a facile approach for the direct attachment of cross-linked poly(2-thiopheneacetic acid) onto the surface of magnetite nanoparticles with one single carbon layer (Fe 3 O 4 @1C NPs) via self-assembly oxidative polymerization. The functional Fe 3 O 4 @1C NPs combined with poly(2-thiopheneacetic acid) [Fe 3 O 4 @1C@ poly(Th) NPs] was successfully prepared and used for magnetic solid-phase extraction (MSPE). The influence of the preparation conditions and extraction conditions were investigated in detail. The morphology and size distribution of the monolithic materials were characterized by transmission electron microscopy. Under the optimized experimental conditions, the prepared Fe 3 O 4 @1C@ poly(Th) NPs showed good extraction efficiency for canthin-6-one alkaloids. Furthermore, the results indicated that the binding specificity and selectivity of the Fe 3 O 4 @1C@ poly(Th) NPs might be attributed to electrostatic interactions and pore structure. A MSPE–HPLC method was also developed for quantitative analysis of canthin-6-one alkaloids. The developed method showed good linearity, low limit of detections, low limit of quantifications, and good reproducibility over a wide linear range. To further prove the utility, Fe 3 O 4 @1C@ poly(Th) NPs-MSPE was also used to extract canthin-6-one alkaloids from Eurycoma longifolia stems, with a recovery rate of 87.9–114%. Thus, this method is potentially applicable for the extraction of similar alkaloid compounds from medicinal herb samples.
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JOURNAL OF MEDICINAL CHEMISTRY
·
2023
·
IF 7.3
Jing Liao,Jun Yang,Xiaobo Li,Chenghong Hu,Weiwei Zhu,Ying Zhou,Yu Zou,Mi Guo,Zhichao Chen,Xiang Li,Jintian Dai,Yuye Xu,Zhiwei Zheng,Pan Chen,Won-Jea Cho,Guang Liang,Qidong Tang
Acute lung injury (ALI) and sepsis are both serious and complex conditions associated with high mortality, yet there are no effective treatments. Herein, we designed and synthesized a series of diphenyl 6-oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide analogues exhibiting anti-inflammatory activity. The optimal compound J27 decreased the release of TNF-α and IL-6 in mouse and human cells J774A.1 and THP-1 (IL-6 IC50 = 0.22 μM) through the NF-κB/MAPK pathway. J27 demonstrated remarkable protection against ALI and sepsis in vivo and exhibited good safety in subacute toxicity experiments. Pharmacokinetic study indicated that J27 had good bioavailability (30.74%). To our surprise, J27 could target JNK2 with a totally new molecular skeleton compared with the only few JNK2 inhibitors reported. Moreover, there is no report that JNK2 inhibitors could apply for ALI and sepsis. Therefore, this work provides a new lead structure for the study of JNK2 inhibitors and a new target of JNK2 to treat ALI and sepsis.
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