Journal of the American Chemical Society
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2026
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IF 16.6
Yu Liu,Xu Zhang,Xingfan Zhang,Mingdong Zhou,Xiaolong Li,Fumin Wang,Xubin Zhang,Alexey A. Sokol,You Lu,Thomas W. Keal,Weiwei Tang,C. Richard A. Catlow,Junbo Gong
Gas–liquid interfacial nucleation can influence organic crystallization, yet its mechanistic role in polymorph selection remains poorly understood. Here, we demonstrate that nucleation at the gas–liquid interface of flufenamic acid solutions governs polymorph selection and gives rise to a pronounced concentration-dependent polymorphism, wherein low initial concentrations favor the nucleation of form I, higher concentrations yield form III, and intermediate concentrations selectively produce the metastable form IV. In situ synchrotron-based grazing-incidence wide-angle X-ray scattering (GIWAXS) directly resolves the formation and evolution of prenucleation assemblies at the interface, revealing three distinct interfacial molecular evolution pathways correlated with the emergence of specific polymorphs. Molecular dynamics (MD) simulations combined with energy calculations within the hybrid quantum mechanics/molecular mechanics (QM/MM) embedded-cluster framework further reveal interfacial enrichment, orientational bias, and conformer-dependent stabilization of stacking motifs, providing a microscopic interpretation of the experimentally observed selectivity. Together, these results establish the gas–liquid interface as an active structural selector that reshapes molecular organization prior to nucleation, offering a mechanistic framework for understanding and controlling polymorphism in evaporation-driven crystallization.
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ACS Sustainable Chemistry & Engineering
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2026
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IF 7.6
Wei Wang,Lei Zhang,Jianan Liu,Yinxia Chang
Hydrothermal processing of lignocellulosic biomass generates aqueous streams enriched in phenolic and furanic intermediates, but these dissolved carbon species are commonly lost through oxidative degradation. Here, we developed an organic radical-mediated humification strategy driven by thermally activated persulfate, which redirects dissolved carbon into humic acid-like substances (HALs) with cross-linked aromatic−heterocyclic structures through phenol−furan coupling rather than oxidative mineralization to CO2. Under acid-alkaline pretreatment that enhances precursor release, the HAL yield reached 61.43%, significantly higher than the 6.32−7.78% obtained from single-condition pretreatments. This pathway retained 81.1% of biomass carbon in products, including 75.9% in HALs and 5.2% in coproducts, while only 18.9% was released as CO2. The process simultaneously enabled detoxification and carbon retention, removing 88−100% of benzenoid aromatics and 98−100% of furanic compounds while preserving 48.3−87.2% of bioavailable substrates. Ultrahigh-performance liquid chromatography−electrospray ionization−mass spectrometry resolved oligomer series indicative of chain-growth incorporation, and pyrolysis−gas chromatography−mass spectrometry confirmed aryl-furan connectivity, supporting the formation of π-conjugated, redox-active aromatic−heterocyclic networks. Density functional theory calculations showed that phenol−furan radical coupling lowers the activation barrier from 96.5 to 10.1 kcal mol−1, enabling efficient C−C/C−O bond formation and polymer growth. Process simulation at a biomass feed rate of 10,000 kg/h projected a HAL production of 6143 kg/h; technoeconomic analysis further indicated favorable economic performance, with an internal rate of return of 53.6%, a discounted payback period of 3.9 years, and a net present value of 15.0 billion CNY. These findings establish a carbon-retentive pathway that transforms hydrothermal wastewater from a waste stream into a precursor platform for functional carbon materials in circular biorefineries.
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DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
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2026
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IF 2.6
Yuxin Liu,Zhenlin Shang,Wenxin Hu,Dongxu Liu,Jun Zhu,Xiaojing Pei,Ze Zhang
Background Nanoemulsions (NEs) are promising delivery systems for lipophilic active ingredients. However, traditional preparation methods of NEs are energy-intensive, complex, and lead to poor stability and high costs.Objective This study aims to introduce a novel pre-nanoemulsions (PNEs) system to overcome the limitations of traditional NE preparation methods.Methods The PNEs, composed of an oil phase, surfactant, co-surfactant, and aqueous phase, form thermodynamically stable isotropic mixtures. The optimized PNEs were characterized in terms of particle size, zeta potential, and polydispersity index (PDI). Comprehensive stability tests, including centrifugation, dilution, and long-term storage, were conducted. Turbiscan analysis was also performed to further assess their stability. Additionally, the sustained release and transdermal absorption capabilities of the PNEs were evaluated.Results The optimized PNEs exhibited a particle size of 115.8 ± 2.6 nm, zeta potential of −40.4 ± 2.4 mV, and PDI of 0.15 ± 0.02, with high encapsulation efficiency for lipophilic substances. Comprehensive stability tests, including centrifugation, dilution, and long-term storage, demonstrated robust performance, which was further confirmed by Turbiscan analysis. The PNEs also showed enhanced sustained release and transdermal absorption capabilities.Conclusions This universal PNEs system provides a simple, low-cost, and efficient solution for delivering lipophilic active ingredients. It addresses the key challenges of traditional NEs and offers significant potential for practical applications across various industries.
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Journal of Inorganic and Organometallic Polymers and Materials
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2026
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IF 6
Wang Haixia,Sun Yilei,Liu Chuang,Meng Zeda D.,Oh Won-Chun
A series of graphene-modified copper–metal–organic framework composites (G-Cu-MOF-0.3, G-Cu-MOF-0.5, G-Cu-MOF-1) were fabricated via a solvothermal method. Structural characterizations verified that graphene was successfully composited without damaging the Cu-MOF crystalline framework, among the four materials, G-Cu-MOF-0.5 exhibits the largest specific surface area and pore size. Electrochemical results showed that G-Cu-MOF-0.5 displayed the best CO₂ electroreduction performance, with a current density of − 11 mA cm⁻², a double-layer capacitance (Cdl) of 4.97 mF cm⁻² and a Tafel slope value of 36.5 mV dec⁻¹. At − 1.5 V vs. RHE, the total Faradaic efficiency for CH₄ and CO reached 24% with stable operation over 12 h. Graphene modification significantly improves the conductivity, active site density, and structural stability of Cu-MOF, realizing efficient and controllable CO 2 conversion to C1 products. The hydrogen evolution reaction (HER) remains the dominant side reaction, and the Faradaic efficiency toward CH 4 is still moderate, leaving room for further selectivity optimization.This work provides a feasible strategy for designing MOF–carbon composites for electrocatalytic CO₂ reduction to methane.
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ACS Applied Materials & Interfaces
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2026
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IF 7.8
Tong Qi,Xiao Wang,Yijing Han,Chengqi He
The regeneration and functional rehabilitation of peripheral nerve defects remain major clinical challenges. Piezoelectric materials have the potential to restore both nerve morphology and function. Conventional grafts struggle to repair nerves with complex structures. To address this issue, band-aid–inspired tissue-adhesive membranes were designed to accommodate diverse nerve diameters and branching structures. Electrospinning was used to prepare a Janus membrane that served as a suture-free piezoelectric nerve repair membrane. The inner layer comprised oriented adhesive hydrogel fibers fabricated from gelatin methacryloyl and tannic acid, whereas the outer layer comprised piezoelectric silk fibroin fibers that provided barrier function and structural support. In vivo experiments demonstrated that this membrane streamlined surgery, enabled rapid and facile bridging of complex peripheral nerve defects, and significantly facilitated morphological and functional nerve recovery. This finding holds significant promise for advancing personalized, simplified, and more effective clinical management of peripheral nerve defects. Additionally, it is anticipated to treat defects in other tissues and organs, specifically those with irregular morphologies.
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Nano-Micro Letters
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2026
·Vol. 18
·期 1
·430
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IF 38.5
Guo Ping,Wang Kai,An Xuyang,Ren Xuanyu,He Xinxin,Hu Yinhua,Zhou Lijie,Cai Guohua,Wang Lifeng,Liu Tiezhu,Ge Wenyu,Zhang Jia
A novel Yb-doped Bi 2 S 3 H 2 S sensor was fabricated for periodontitis exhalation diagnosis, which enables room temperature detection with high response (3.31/100 ppb) and superior selectivity.
Mechanism analysis combined with density functional theory calculations confirms that Yb doping-induced lattice distortion in Bi 2 S 3 enhances O 2- formation and H 2 S adsorption.
The sensor quantifies H 2 S produced by Porphyromonas gingivalis to confirm the association among pathogens, H 2 S and periodontitis, and is integrated into a portable analyzer for rapid, real‑time diagnosis and severity assessment of periodontitis clinically.
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ACS Applied Materials & Interfaces
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2026
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IF 7.8
Baoyi Liu,Haibo Ning,Zhenghao Gong,Junsheng Chen,Bin Yang,Yuanyuan Feng,Huan Liu,Tianxin Bai,Qingkun Kong
Halide perovskites exhibit exceptional optoelectronic properties, including strong light absorption and efficient generation of photogenerated charge carriers. However, these advantages are extremely limited in electrocatalytic systems, and their full potential remains largely unexplored. In particular, the underlying mechanisms governing light-assisted electrocatalysis in perovskite materials remain poorly understood. Herein, a Pt-modified Cs2PdBr6 all-inorganic halide perovskite (Cs2PdBr6@Pt1.5) is designed, which achieves a low overpotential of 11 mV at 10 mA cm–2 with excellent water stability. Femtosecond transient absorption spectroscopy further demonstrates that the incorporation of Pt increases the population of transient species (<1 ps) and acts as an efficient charge separation channel, thereby promoting charge migration to catalytic active sites and enhancing hydrogen evolution reaction properties. Density functional theory (DFT) calculations reveal that electrons transfer from Cs2PdBr6 to Pt, and Pt-modified Cs2PdBr6 optimizes the adsorption energies of key reaction intermediates, thereby lowering the overpotential for water splitting. These findings highlight the potential of halide perovskites as a stable and efficient platform for light-assisted electrocatalytic water splitting and related energy conversion processes.
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MICROCHIMICA ACTA
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2026
·Vol. 193
·期 7
·496
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IF 5.4
Yao Haixu,Wang Yan,Shi Jincheng,Gao Xinzhuo,Yang Xueqiong,Liu Mengyuan,Li Yuxin,Jin Yingyu,Zhou Qin,Cui Feiyun
Real-time, synchronous profiling of key inflammatory cytokines such as IFN-γ, IL-6 and TNF-α is critical for understanding and managing dysregulated immune responses, including cytokine storms associated with severe infections. However, conventional immunoassays are not readily compatible with the requirements of rapid, multiplexed analysis in point-of-care settings. Herein, we report a multiplexed electrochemical biosensing platform based on biomimetic interfacial encoding using Fe 3 O 4 @Au nanoplatforms (BIENs). The core sensing element consists of extracellular vesicle-mimetic nanocomposites functionalized with cell membranes overexpressing specific cytokine receptors, enabling native-like molecular recognition. This encoded biomimetic interface affords high-affinity and selective detection of IFN-γ, IL-6 and TNF-α with wide linear ranges (0.1 ~ 1000 pg/mL) and low detection limits (0.043 ~ 0.159 pg/mL). The sensor exhibits excellent selectivity, operational stability, and reproducibility, and maintains high accuracy in serum samples with minimal matrix interference. Beyond analytical performance, this work establishes a receptor-mimetic interfacial encoding strategy for multiplexed biosensing, offering a versatile and scalable paradigm for the development of next-generation intelligent biointerfaces and dynamic immune monitoring systems. Graphical
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
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IF 9.6
Haijun Wu,Shenggui Ma,Dianhang Wei,Yaolin Wang,Quanwei Lv,Ziheng Jin,Xinrui Wang,Xin Tu,Xia Jiang
A strategy for plasma-coupled O v -rich catalytic hydrogen production is proposed. • The catalyst shows high activity and universality for hydrogen production. • Synergistic cascade from plasma dissociation to catalytic surface reforming. • The key mechanism of “hydrogen promotion and anti-coking” were revealed. Hydrogen production from plastics contributes to the circular economy by enabling both waste valorisation and green energy generation. Integrated pyrolysis-plasma catalytic technology offers notable advantages in improving hydrogen production, but it still faces challenges such as catalyst coking and limited understanding of the reaction mechanisms. This study proposes a water vapor plasma-coupled oxygen vacancy-rich (O v -rich) catalytic strategy to systematically investigate the improved hydrogen production from plastics over an anti-coking catalyst. The results show that the O v -rich catalyst exhibits outstanding hydrogen production activity, strong synergistic effect, and universality in the non-thermal plasma catalytic (NTP-C) reforming reaction of mixed model compounds in plastic pyrolysis oil. Crucially, its practical effectiveness was successfully validated in the NTP-C reforming of polyethylene (PE)/polypropylene (PP) pyrolysis oils. Moreover, the O v -rich catalysts significantly inhibited coking and maintained good stability for 1800 min in a multi-component mixed system. The mechanisms of hydrogen production and coking inhibition were revealed via Density Functional Theory (DFT) calculations, in situ plasma-coupled Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS), and Optical Emission Spectroscopy (OES). A synergistic reaction pathway, coupling plasma gas-phase dissociation with catalytic surface reforming, was identified as a key mechanism for enhancing hydrogen yield in plasma-catalytic systems. The study offers valuable insights for advancing plasma-assisted hydrogen production technologies. Download: Download high-res image (150KB) Download: Download full-size image
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INDUSTRIAL CROPS AND PRODUCTS
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2026
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IF 6.4
Lijuan Hou,Cheng Zhang,Ying Li,Wanchao Hou,Honggang Tang,Xing Zhang,Zhenyu Wang,Xianjun Dai
LBL-assembled MPN-LYS-PEC nanoparticles enable microbiota-targeted quercetin delivery. • The nanoparticles show high quercetin encapsulation and structural stability. • The nanoparticles alleviate HFD-induced intestinal injury in D. melanogaster . • Germ-free assays confirm a gut microbiota-dependent protective mechanism. Quercetin is a bioactive flavonoid; however, its poor stability and low bioavailability limit its protective effect against intestinal injury. To address this limitation, quercetin-Fe 2 + metal-phenolic network (MPN) nanocores are constructed using a solvent exchange method, followed by layer-by-layer electrostatic assembly with positively charged lysozyme (LYS) and negatively charged pectin (PEC) to form ternary MPN-LYS-PEC nanoparticles. Comprehensive physicochemical characterization confirms effective charge regulation and structural stability throughout the assembly process, together with a high quercetin encapsulation efficiency (92.57 ± 0.67%) and loading efficiency (25.98 ± 2.59%). The multilayered architecture further protects quercetin during gastrointestinal digestion, enabling microbiota-targeted delivery. In a high-fat diet (HFD)-induced female and male Drosophila melanogaster ( D. melanogaster ), the nanoparticles effectively reduced intestinal leakage, cell death, and oxidative stress, and improved metabolic dysregulation. They also beneficially reshaped gut microbiota by enriching Commensalibacter and reducing Novosphingobium . Importantly, experiments in germ‑free D. melanogaster further demonstrate that the gut‑protective effects induced by MPN‑LYS‑PEC nanoparticles are associated with the gut microbiota. Collectively, these findings establish the self-assembled MPN-LYS-PEC nanoparticle as an effective strategy for gut microbiota-targeted quercetin delivery, thereby alleviating HFD-induced intestinal injury and restoring metabolic homeostasis. Download: Download high-res image (184KB) Download: Download full-size image
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Huo Ming-Wei,Liu Jing-Yi,Zhang Ye-Chao,Feng Xin,Gu Le-Yan,Ping Cai-Yi,Qu Yan-Kai,Pan Honghao,Guo Beizhen,Jin Bihe,Tang Yongan,Cao Qing-Ri
Androgenetic alopecia (AGA) is a widespread condition characterized by progressive follicular miniaturization and hair loss, yet current topical therapies are often limited by insufficient follicular retention and undesired systemic exposure. Herein, we report cationic nanoemulsions specifically designed to promote follicle-associated delivery of two clinically approved anti-AGA drugs with reduced systemic exposure, thereby achieving potent therapeutic efficacy against AGA. The two anti-AGA drugs, minoxidil (MXD) and finasteride (FNA), are incorporated into a cationic polymer-coated nanoemulsion with a favorable nanoscale droplet (72.64 nm), high encapsulation efficiency (90.46% for MXD and 92.44% for FNA), and positively charged surface (zeta potential 51.2 mV). This cationic interface promoted local cutaneous retention and preferential follicle-associated localization, while substantially reducing systemic absorption. In testosterone-induced AGA mouse models, the dual-drug-loaded nanoemulsion outperformed commercial MXD tincture and single-drug formulations in promoting hair regeneration by inhibiting 5α-reductase-mediated dihydrotestosterone production and TGF-β1 signaling, while activating β-catenin and VEGF pathways to reprogram the follicular microenvironment. Importantly, repeated topical application showed good skin compatibility and no obvious systemic toxicity under the tested conditions. These findings highlight a cationic surface-functionalized nanoemulsion strategy that enhances follicle-associated retention while limiting systemic exposure, offering a clinically translatable approach for AGA therapy. Graphical Cationic nanoemulsions achieve follicle-associated delivery with reduced systemic exposure, enabling safer therapy for androgenetic alopecia
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Antioxidants
·
2026
·Vol. 15
·期 8
·1008
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IF 8.2
Zhengyan Tan,Pei Xu,Dan Wang,Zongna Han,Huaying Chen,Qianqian Zhu,Yang Yang,Wei Pan,Piao Wang,Rongxiang Chen
This study established an activity-oriented analysis method based on offline two-dimensional liquid chromatography–electrochemical detection (2D-LC-ECD) combined with ultra-high-performance liquid chromatography–Orbitrap-MS/MS (UHPLC-Orbitrap-MS/MS), which was used to comprehensively characterize the antioxidant components ofPolygonum multiflorumThunb. leaves (PML) and screen for differential compounds in samples from different origins. Antioxidant components were screened using 2D-LC-ECD combined with in vitro radical scavenging experiments; structure identification was conducted via UHPLC-Orbitrap-MS/MS, and chemometric analysis alongside quantitative determination of 19 major components was carried out across 31 batches of samples. A total of 43 potential antioxidant compounds were identified from PML, including 11 phenolic acids, 29 flavonoids, 2 stilbene glycosides, and 1 amino acid; phenolic acids and their derivatives, along with flavonoids, were identified as major contributors to antioxidant activity. Hierarchical clustering analysis and principal component analysis both grouped samples into four categories by origin; the orthogonal partial least squares discriminant analysis model (R2X = 0.933, R2Y = 0.941, Q2= 0.846) screened 10 key markers (VIP > 1). The quantitative results showed that polygonacetophenoside had the highest content in PML. In summary, the 2D-LC-ECD coupled with LC-Orbitrap-MS/MS strategy confirmed that phenolic acids and flavonoids are the core material basis for PML’s antioxidant capacity, providing scientific evidence for the industrial development of PML as a natural antioxidant.
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危险品化学品经营许可证（带存储）