CARBOHYDRATE POLYMERS
·
2021
·
IF 9.381
Xue-dong Wang,Ya Li,Tao-tao Dai,Xue-mei He,Ming-shun Chen,Cheng-mei Liu,Rui-hong Liang,Jun Chen
Novel pectin/poly(m-phenylenediamine) (P/PmPDA) microspheres with different content of PmPDA were prepared by assembling PmPDA on the surface of pectin microsphere. The successful preparation was confirmed by the results of Fourier Transform Infrared spectra (FTIR), scanning electron microscopy (SEM) and elemental analysis. Compared with pectin microsphere, the Pb 2+ adsorption performance of P/PmPDA microspheres was significantly improved. The results of batch adsorption experiments were in good agreement with the Langmuir isotherm model for Pb 2+ adsorption, indicating the adsorption was monolayer. The maximum adsorption capacity of Pb 2+ was found to be 390.9 mg/g. The kinetic adsorption process was well described by the pseudo-second-order model and chemical adsorption dominated the adsorption process. The potential mechanisms of Pb 2+ adsorption were speculated as ion exchange and chelation, which were supported by X-ray photoelectron spectroscopy (XPS). The P/PmPDA microspheres showed good recyclability after five adsorption/desorption cycles. All these results indicated the potential of P/PmPDA microspheres for removing Pb 2+ .
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING
·
2024
·
IF 4.2
Rui Li,Zewei Wu,Yiyun Yang,Sijia Sun,Ruixin Ma,Hao Ding
A silica-loaded g-C 3 N 4 composite photocatalyst (M-SiO 2 /g-C 3 N 4 ) was prepared by grinding amorphous SiO 2 microspheres (M − SiO 2 ) with melamine and calcining the resulting grinding products. This composite was used for photocatalytic persulfate (PMS) activation to degrade carbamazepine (CBZ). The results showed that the degradation efficiencies of CBZ by M-SiO 2 /g-C 3 N 4 -2.5 (39.16 % of g-C 3 N 4 )-activated PMS were 78.92 % and 100 % after simulated sunlight irradiation for 60 and 120 min, respectively. These values were significantly greater than those of the system with pure g-C 3 N 4 (29.15 % and 42.4 %). In particular, the degradation efficiency of CBZ with M-SiO 2 /g-C 3 N 4 -2.5 decreased by only 9.47 % after 4 cycles of recycling. In the catalytic process, h + , SO 4 •− and O 2 •− were the main reactive species contributing to CBZ degradation. Compared with g-C 3 N 4 , loading g-C 3 N 4 on the surface of M − SiO 2 resulted in a decrease in g-C 3 N 4 lamellar stacking, which increased the number of active surface sites and improved the separation and migration of photogenerated carriers, improving the degradation performance.
研究领域:
环境科学
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Omega
·
2025
·
IF 4.3
Lingchen Meng,Haodong Li,Bofan Liu,Ri Duan,Shenghua Yuan
The challenge of improving the wear resistance of Cu–Bi catalysts continues to persist in the industrial production of 1,4-butynediol (BYD) through the ethynylation of a formaldehyde reaction. Herein, We successfully prepared a hierarchical malachite microsphere catalyst by cooling the crystallization process under atmospheric pressure. The hierarchical malachite microspheres are uniform spheres with a diameter of 18 μm, which are composed of numerous two-dimensional microplatelets paralleling the sphere surface. The cooling rate is a crucial factor that significantly influences the development of the crystal morphologies. A slower cooling rate enhances the crystallinity of the catalyst particles, leading to the formation of larger microplatelets on the catalyst surface. Experimental results demonstrated that the spherical malachite catalyst, synthesized via the cooling crystallization method, exhibits excellent wear resistance and sustained catalytic performance in the ethynylation of formaldehyde for the synthesis of BYD.
研究领域:
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Qingjun Xu,Yang Zhao,Pingping Yuan,Xuan Ma,Sheng Wang,Lin Li,Ping Cheng,Shaoqi Qu
The escalating prevalence of multidrug-resistant (MDR) bacterial infections has emerged as a critical global health crisis, undermining the efficacy of conventional antibiotic therapies. This pressing challenge necessitates the development of innovative strategies to combat MDR pathogens. Advances in multifunctional drug delivery systems offer promising solutions to reduce or eradicate MDR bacteria. Inspired by the fact that the growth of bacteria requires essential nutrients, core–shell porous poly(lactic-co-glycolic acid) (PLGA) microspheres coated with pH-responsive polydopamine (PDA) were fabricated to improve delivery, resulting in enhanced efficacy through nutrient restriction and combination therapy. The PDA chelates iron ions in the environment, preventing bacteria from absorbing iron and thus suppressing their growth and proliferation. Subsequently, the released antibiotics from the porous PLGA core, rifampicin and polymyxin B, accelerate bacterial eradication by disrupting their inner and outer membrane structures. Such a multifunctional microsphere platform clears 99% Salmonella Typhimurium in 4 h and shows increased efficiency in a lethal intestinal infection model in mice. These findings provide a drug delivery system that integrates bacterial nutrient restriction and antibiotic killing, highlighting the potential of targeting bacterial iron regulation as a strategy for developing new antimicrobial delivery systems to address MDR bacterial infections.
研究领域:
生物医学工程
·
微生物学
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYST
·
2024
·
IF 3.6
Qingqing Liu,Aihua Qu,Chuanlai Xu,Xinxin Xu,Liqiang Liu,Hua Kuang
In this research, we used a novel hapten to generate a sensitive monoclonal antibody (mAb) 2C3 that targeted etomidate (ET) and metomidate (MT). We used this mAb to establish a lateral-flow immunoassay (LFIA) that incorporated fluorescent microsphere sensors, enabling both the qualitative and quantitative detection of ET and MT within 10 min. Analysis indicated that the visual colorimetric values for ET and MT in water samples were 0.3 µg/kg, respectively, with quantitative detection ranges of 0.08 to 1.31 µg/kg and 0.08 to 2.21 µg/kg, respectively. The visual colorimetric values for ET and MT in urine samples were 0.3 to 1 µg/kg, with quantitative detection ranges of 0.12 to 3.13 µg/kg and 0.09 to 2.98, respectively. The visual colorimetric values for ET and MT in serum samples were 3 µg/kg, with quantitative detection ranges of 0.15 to 21.2 µg/kg and 0.08 to 13.8 µg/kg, respectively. Recovery tests and detection were conducted in water, urine and serum samples, validating the reliability of this method in real clinical samples. Collectively, our novel LFIA provides a promising option for rapid on-site detection of ET and MT.
研究领域:
医学检测
·
免疫学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Electronic Materials
·
2024
·
IF 4.3
Chen Wang,Jianye Guang,Ruizhi Fan,Ming Lin,Jianuo Nie,Fang Wang,Wei Peng,Mengdi Lu
Flexible strain sensors have gained prominence in applications such as wearable devices, smart healthcare, and human motion monitoring due to their excellent adaptability and sensitivity. However, challenges such as high production costs and complex fabrication processes hinder their widespread commercial adoption. This study presented a fatigue-resistant polystyrene (PS) microsphere nanoarray optical strain sensor based on a polydimethylsiloxane flexible substrate, fabricated using a simple hemispherical indentation-assisted method. The sensor exhibited exceptional stability, enduring over 950 cycles, and demonstrated remarkable durability and sensitivity (−0.371 nm/%) at stretching speeds of 62.5 μm/s. Finite element analysis, supported by the experimental data, clarified the mechanical behavior of PS nanoarrays under varying strain angles and analyzed the influence of these angles on the sensing spectrum. Besides, fatigue points caused by repeated use could be naturally recovered, with the restored sensor maintaining excellent stability. The results suggested that this proposed flexible nanostructure offered a high-performance, cost-effective, and straightforward manufacturing option for strain optical sensors.
研究领域:
材料科学
·
传感器技术
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Small
·
2024
·
IF 13
Ya-Jun Fu,Rao-Kaijuan Wang,Cheng-Ye Ma,Li-Ya Wang,Si-Yu Long,Kai Li,Xing Zhao,Wei Yang
The delayed healing of infected wounds can be attributed to the increased production of reactive oxygen species (ROS) and consequent damages to vascellum and tissue, resulting in a hypoxic wound environment that further exacerbates inflammation. Current clinical treatments including hyperbaric oxygen therapy and antibiotic treatment fail to provide sustained oxygenation and drug-free resistance to infection. To propose a dynamic oxygen regulation strategy, this study develops a composite hydrogel with ROS-scavenging system and oxygen-releasing microspheres in the wound dressing. The hydrogel itself reduces cellular damage by removing ROS derived from immune cells. Simultaneously, the sustained release of oxygen from microspheres improves cell survival and migration in hypoxic environments, promoting angiogenesis and collagen regeneration. The combination of ROS scavenging and oxygenation enables the wound dressing to achieve drug-free anti-infection through activating immune modulation, inhibiting the secretion of pro-inflammatory cytokines interleukin-6, and promoting tissue regeneration in both acute and infected wounds of rat skins. Thus, the composite hydrogel dressing proposed in this work shows great potential for dynamic redox regulation of infected wounds and accelerates wound healing without drugs.
研究领域:
生物材料学
·
创伤修复
·
医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Polymers
·
2024
·Vol. 16
·期 5
·647
·
IF 4.7
Lin Qi,Teng Hang,Weijie Jiang,Sinong Li,Hui Zhang,Xiang Liang,Le Lei,Qiangqiang Bi,Hang Jiang,Yunxing Li
Microalgae are highly regarded as ideal materials for the creation of liquid biofuels and have substantial potential for growth and utilization. However, traditional storage and culture methods for microalgae are plagued by challenges such as uncontrolled growth, bacterial contamination, and self-shading among algae. These issues severely impede the photosynthetic process and the efficient extraction of biomass energy. This study tackles these problems by utilizing magnetic hydrophobic protein particles to stabilize water-in-oil Pickering emulsions. This allows for the micro-compartment storage and magnetic transfer of algae. Additionally, the successful encapsulation of Chlorella cells in high-internal-phase water-in-oil Pickering emulsions effectively mitigates the settling problem of Chlorella cells in the liquid phase, thereby enabling the potential use of Pickering emulsions for the confined cultivation of microalgae.
研究领域:
生物技术
·
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER
·
2024
·
IF 4.1
Fang Wang,Naipin Chen,Jiaqi Liu,Xinbao Zhu
The ability of an active protective organic coating to restore its protection functionality in the event of a coating defect is crucial for ensuring durable performance under harsh corrosive conditions. In the present work, a novel thermogenesis effect polyurethane complex microsphere with a particle size of approximately 430 nm was developed using CNCs and LNPs as Pickering emulsifiers. The obtained microspheres (4 wt%) were incorporated into epoxy-amine networks, resulting in improved toughness and bending strength. Additionally, tensile measurement results demonstrated that the composite resin exhibited a self-healing efficiency of 81.25 % at room temperature within 30 min. Meanwhile, for the NIR-triggered self-healing process, the damaged samples could be locally repaired quickly. Experiments also showed that the microspheres exhibited excellent anti-ultraviolet aging performance and satisfying storage stability for more than 20 days at room temperature. Importantly, the as-prepared epoxy complex resin served as an in-situ self-healing metal coating, confirming its long-lasting corrosion resistance. This work provides an efficient strategy for high-performance self-healing materials, particularly epoxy anti-corrosion coatings.
研究领域:
材料科学
·
化学工程
·
腐蚀与防护
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Minerals Metallurgy and Materials
·
2025
·Vol. 32
·期 3
·718-727
·
IF 7.2
Wen Haoliang,Zhang Weidong
The increase in the utilization of infrared heat detection technology in military applications necessitates research on composites with improved thermal transmission performance and microwave absorption capabilities. This study satisfactorily fabricated a series of MoS 2 /BN- xyz composites (which were characterized by the weight ratio of MoS 2 to BN, denoted by xy : z ) through chemical vapor deposition, which resulted in their improved thermal stability and thermal transmission performance. The results show that the remaining mass of MoS 2 /BN-101 was as high as 69.25wt% at 800°C under air atmosphere, and a temperature difference of 31.7°C was maintained between the surface temperature and the heating source at a heating temperature of 200°C. Furthermore, MoS 2 /BN-301 exhibited an impressive minimum reflection loss value of −32.21 dB at 4.0 mm and a wide effective attenuation bandwidth ranging from 9.32 to 18.00 GHz (8.68 GHz). Therefore, these simplified synthesized MoS 2 /BN- xyz composites demonstrate great potential as highly efficient contenders for the enhancement of microwave absorption performance and thermal conductance.
研究领域:
材料科学
·
物理化学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Taiyu Liu,Jingjing Li,Wenqing Li,Yue Du,Wenyan Zhang,Fanyu Qian,Ziyue Wang,Xiaoning Wang,Lisha Liu,Lifang Yin
Mucin-integrated ternary microspheres achieve robust gastro-protection and targeted intestinal co-delivery of E. coli Nissle 1917 and mucin glycoproteins. • Prophylactic gut modulation concurrently restores microbiome equilibrium, fortifies epithelial barrier integrity, and attenuates systemic hyperinflammation. • Preventive intervention significantly reduces bacterial translocation, mitigates end-organ damage, and improves survival in experimental sepsis. Sepsis remains a leading cause of mortality worldwide, in part because current treatment is typically initiated after systemic inflammation and organ injury are already established. This temporal limitation highlights the need for prophylactic strategies before sepsis fully develops. Growing evidence indicates that gut microbiota dysbiosis and intestinal barrier disruption are active drivers of sepsis pathogenesis, yet practical approaches to modulate the gut microenvironment prophylactically remain limited. Here, we reported a paradigm shift from conventional probiotic delivery to a microenvironment-centered strategy that enhances bacterial integration and mucosal defense. We developed a mucin-integrated probiotic microsphere system for the oral co-delivery of Escherichia coli Nissle 1917 (EcN) and mucin glycoproteins. This formulation combines a gastro-resistant alginate shell with a biocompatible HAMA/mucin hydrogel core, which not only protects bacteria during gastrointestinal transit but also mimics the natural mucosal niche to facilitate EcN retention and barrier reinforcement. In vivo , prophylactic administration of these microspheres enhanced intestinal barrier integrity, restored gut microbiota balance, and suppressed systemic inflammation, ultimately reducing bacterial translocation and attenuating organ injury. Our findings demonstrate that regulating the gut microbiota–barrier–immune axis represents a practical approach to sepsis prophylaxis.
✓ 已验证
产品关联
DOI
高影响因子
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
·
2026
·
IF 2.6
Yuan Zhu,Yongqi Lv,Jiaqi Xu,Yingshu Feng,Caleb Kesse Firempong,Runfeng Wang,Haibing He,Guoqing Zhang,Hongfei Liu
Objective This study presents a novel injectable microsphere-gel system for sustained intra-articular delivery of triamcinolone acetonide (TA) to treat osteoarthritis.Significance This system aims to overcome the shortcomings of conventional TA suspensions, such as short joint residence time and significant systemic exposure, thereby improving therapeutic efficacy and safety for osteoarthritis treatment.Methods TA-loaded polycaprolactone (PCL) microspheres (TA@PCL) were prepared using microfluidic technology under optimized conditions. The TA@PCL microspheres were incorporated into the cross-linked hyaluronic acid (CLHA) gel matrix to form an injectable composite (TA@PCL@CLHA), which was evaluated by in vitro studies (rheological property, stability, and drug release) and in vivo studies (plasma pharmacokinetics and drug retention in knee joints).Results TA@PCL microspheres with uniform size (D50 value of 61.4 ± 1.9 µm, span value of 0.075) and high encapsulation efficiency (87.2 ± 4.1%) were successfully prepared. The TA@PCL@CLHA composite exhibited excellent injectability (extrusion force of 12.1 ± 0.4 N) and physical stability over 90 days. In vitro, the CLHA gel effectively mitigated the initial burst release and provided a more sustained TA release profile over one month. In vivo evaluation in rabbits demonstrated that TA@PCL@CLHA significantly reduced the peak plasma concentration (Cmax reduced by approximately 65%) and decreased systemic exposure (AUC0-∞ reduced by about 49%), while maintaining detectable drug levels in the synovial fluid for at least 30 days.Conclusion The TA@PCL@CLHA microsphere-gel composite provides an effective local drug delivery system with minimized systemic exposure, offering a promising strategy for OA treatment.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）