ACS Applied Materials & Interfaces
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2024
·
IF 8.3
Shengran Li,Chenyang Zou,Jingyan An,Meiying Lv,Xifei Yu
Liposomes have attracted attention in biomedicine and pharmacy for their benefits including reduced toxicity, extended pharmacokinetics, and biocompatibility. However, their limitations include susceptibility to blood clearance, rapid disintegration, and lack of functionality, restricting their further applications. To address these challenges, inspired by the unique topological features of cyclic polymers and the specific binding property of the choline phosphate (CP) lipid, dipole–dipole interactions between CP molecules are utilized to create a detachable cyclic PEG-embedded CP liposome (d-cycPEG-lipo). In comparison to linear PEG-embedded liposomes (d-linPEG-lipo) and PEGylated liposomes (linPEG-lipo), d-cycPEG-lipo demonstrates enhanced resistance to proteins and macrophages in the bloodstream due to its higher compactness and smoother interface. The packing behavior and lubrication property of cyclic PEG also result in reduced accumulation in organs, leading to an extended pharmacokinetic half-life of 13.6 h. At the tumor site, the PEG embedded in d-cycPEG-lipo detached and facilitated a 3.3-fold higher cell uptake than linPEG-lipo. Notably, d-cycPEG-lipo induces lower inflammation and triggers a stronger immune response than d-linPEG-lipo. In the treatment of breast cancer, d-cycPEG-lipo exhibits a significantly high efficacy of 98.5%. Hence, the reversible combination of cyclic PEG with CP liposomes holds tremendous promise for enhancing drug and antibody delivery in clinical tumor therapy.
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高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2024
·
IF 5.3
Weizhun Jin,Linhua Jiang,Yajun Lv,Keliang Li,Huanqiang Liu,Wenkai Cao,Cheng Chen,Zhiyou Chen,Weihua Li
In this study, the preparation and heat transfer efficiencies of ethylene glycol (EG)/water-based (50:50) hybrid nanofluids were enhanced using graphene oxide (GO)/MXene (1:1) nanoparticles. The stability of the nanofluids was analyzed, and the thermal conductivity and viscosity were tested at 20–60 °C. A correlation equation for the thermal conductivity ratio of the nanofluids was proposed. The heat transfer efficiency of the nanofluids was evaluated using the performance enhancement ratio (PER) and Mouromtseff number (Mo). The prepared EG/water-based GO/MXene nanofluids exhibited good chemical and dispersion stability. The thermal conductivity and viscosity of the nanofluids gradually increased with the GO/MXene dosage. The nanofluid containing 0.3 wt% GO/MXene nanoparticles exhibited the largest thermal conductivity increment of 33.49 % at 60 °C compared with EG/water and maintained the low viscosity. The proposed prediction equation based on the temperature and mass dosage was highly accurate. The PER and Mo demonstrated the suitability of the GO/MXene nanofluids for heat transfer applications.
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APPLIED THERMAL ENGINEERING
·
2024
·
IF 6.1
Hanze Wei,Ziao Zheng,Xiaoling Xu,Chunyuan Zheng,Bin Li,Bingchen Zhao,Ziqing Wei,Xiaoqiang Zhai
Integrating Phase Change Material (PCM) with building envelope is a promising way to reduce building energy consumption. However, leakage and insufficient PCM loading rate for existing encapsulation strategies limit its further application. In this work, a safer and easier way to fabricate Shape-Stable Phase Change Material (SSPCM) is proposed, whose products combine the outstanding leakage-proof property and high PCM loading rate. With the method of in-situ polymerization, not only the Polyethylene Glycol (PEG) is packaged by Polymethyl Methacrylate (PMMA), but the Expanded Graphite (EG) also has a chance to be added as the property regulator. The prepared SSPCMs are proved to be shape-stable over melting temperature with a leakage rate under 1 %. The characterization test reveals that with EG mass fraction increase from 0 to 2.5 %, the thermal conductivity augments from 0.23 to 1.73 W/(m·K) while the phase change latent enthalpy changes from 85.11 kJ/kg to 116.10 kJ/kg. Notably, the EG is more than a thermal conductivity enhancer, it also plays an important role in the modification of comprehensive properties. To optimize the building energy-saving performance of SSPCMs, the factors affecting building cooling electricity consumption like deployment position and thermal properties are evaluated in detail. The simulation results show that the optimum strategy is employing SSPCM with 2.0 wt% EG in the middle of the envelope, the cooling electricity consumption can be reduced by 8.64 % compared with the benchmark. The physical mechanism of energy-saving is also discussed from multiple angles. From a statistical view, sensitivity and uncertainty analysis of the simulation results is completed, to identify the influence of input parameters and validate the reliability of the simulation results. Finally, an economic analysis is carried out, proving the economic feasibility for further application. This research provides valuable insights for SSPCM’s application and design of energy-efficient buildings.
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JOURNAL OF MOLECULAR LIQUIDS
·
2024
·
IF 5.3
Run Li,Xiandong Hao,Bo Wang,Ning Zhao,Zhiyong Xu,Wenbo Zhao
In the present work, a novel non-aqueous 3-aminopropanol/polyethylene glycol 200 (3AP/PEG200) absorbent for efficient carbon dioxide (CO 2 ) capture was designed using environment-benign and non-toxic polyethylene glycol 200 (PEG200) as an alternative to water. The mechanism, physical, thermodynamic, and kinetic properties of absorption process was investigated through a combination of experimental and multi-scale computational simulation approaches including molecular dynamics (MD) simulation and quantum chemical (QC) calculations. It was found that the addition of PEG200 not only enhanced the thermal stability of the absorbent, but also did not significantly increase the viscosity. In addition, kinetic studies revealed that the absorption process conforms to a pseudo-first-order equation, with the activation energy ( E a ) value of 20.40 kJ/mol, significantly lower than that of the benchmark 30 % monoethanolamine (MEA) aqueous solution used in industrial CO 2 capture. Furthermore, the enthalpy change ( ΔH ) and entropy change ( ΔS ) values were found to be more negative than those of other liquid absorption systems, indicating that the 3AP/PEG200 absorbent is favorable for CO 2 absorption even at low partial pressures. Most importantly, the absorption system exhibited good regeneration capability, as demonstrated by five absorption–desorption cycle experiments. In conclusion, the non-aqueous 3AP/PEG200 absorbent exhibits low viscosity, high thermal stability, enhanced absorption capacity, and excellent cyclic performance, positioning it as a promising candidate for CO 2 absorption in industrial applications.
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POLYMER INTERNATIONAL
·
2017
·Vol. 67
·期 3
·313-321
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IF 2.07
Chunyan Luo,Minrui Yang,Wei Xiao,Jingjing Yang,Yan Wang,Weixing Chen,Xia Han
Poly( l -lactic acid) (PLLA) is a good biomedical polymer material with wide applications. The addition of poly(ethylene glycol) (PEG) as a plasticizer and the formation of stereocomplex crystals (SCs) have been proved to be effective methods for improving the crystallization of PLLA, which will promote its heat resistance. In this work, the crystallization behavior of PEG and PLLA/poly( d -lactic acid) (PDLA) in PLLA/PDLA/PEG and PEG- b -PLLA/PEG- b -PDLA blends has been investigated using differential scanning calorimetry, polarized optical microscopy and X-ray diffraction. Both SCs and homocrystals (HCs) were observed in blends with asymmetric mass ratio of PLLA/PDLA, while exclusively SCs were observed in blends with approximately equal mass ratio of PLLA/PDLA. The crystallization of PEG was only observed for the symmetric blends of PLLA 39k /PDLA 35k /PEG 2k , PLLA 39k /PDLA 35k /PEG 5k , PLLA 69k /PDLA 96k /PEG 5k and PEG- b -PLLA 31k /PEG- b -PDLA 27k , where the mass ratio of PLLA/PDLA was approximately 1/1. The results demonstrated that the formation of exclusively SCs would facilitate the crystallization of PEG, while the existence of both HCs and SCs could restrict the crystallization of PEG. The crystallization of PEG is related to the crystallinity of PLLA and PDLA, which will be promoted by the formation of SCs. © 2017 Society of Chemical Industry
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2018
·
IF 3.997
Yongli Shi,Jintao Xue,Shuxin Xu,Yinghua You,Xi Qing Yan,Xiaotong Zhao,Jingjing Cao
In this study, the copolymer of methoxy poly(ethylene glycol) methacrylate- co -poly(methylacrylic acid) [poly(mPEGMA- co -MAA)] was synthesized via radical polymerization. Based on this copolymer, novel chitosan-modified poly(mPEGMA- co -MAA) nanoparticles (CS/NPs) were developed to improve the bio-availability of ibuprofen (IBU). Fourier transform infrared spectroscopy (FTIR) and 1 H nuclear magnetic resonance ( 1 H NMR) spectra were used to confirm the synthesis of the copolymers. The morphology of CS/NPs was investigated with transmission electron microscopy (TEM). Thermogravimetric analysis (TGA) was used to reveal the thermodynamic properties of the CS/NPs. The cytotoxicity of CS/NPs was assessed by the cell viability of 293T cells. FTIR and 1 H NMR spectra confirmed the synthesis of the novel copolymer. TEM photographs showed that the CS/NPs had a core-shell structure. High cell viability indicated that the CS/NPs were nontoxic. The in vitro release profiles suggested that the CS/NPs released IBU in pH 7.4 buffer in a continuous manner. Furthermore, the IBU-CS/NPs showed a long antifebrile effect. Animal experiments showed that the IBU-CS/NPs had obvious antifebrile effects. Therefore, CS/NPs could reduce the dosing frequency of IBU, and improve its bio-availability.
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Catalysts
·
2025
·Vol. 15
·期 3
·258
·
IF 4
Ling Xie,Zilong Huang,Yapeng Zhan,Jiahao Huang,Chao Wang,Riyang Shu,Junyao Wang,Libin Lei,Jianping Liu,Zhipeng Tian,Ying Chen
Cleavage of C-C bonds is crucial for hydrogen production via aqueous phase reforming of biomass-derived oxygenates. In this study, the hydrogen production performance and C-C bond cleavage capacity of Ni-W/AC catalysts with varying W/Ni ratios are evaluated using ethylene glycol as a model compound. A series of APR experiments conducted suggests that Ni-0.2W/AC catalyst exhibits the highest C1/C2+ratio of 15.87 and achieves a hydrogen yield of 47.76%. The enhanced Ni-W bimetallic interactions, which significantly improve the efficiency of C-C bond cleavage and increase catalyst activity by promoting active site dispersion, are confirmed by detailed characterization techniques. Further analysis of product distribution provides insights into the reaction pathways of ethylene glycol and the reaction mechanism for ethanol during aqueous phase reforming. All the results indicate that this catalytic reforming method effectively facilitates C-C bond cleavage and hydrogen production, contributing to a better understanding of APR mechanisms for biomass-derived oxygenates.
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CARBOHYDRATE POLYMERS
·
2011
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IF 3.463
Quan Li,Bing Xia,Mickey Branham,Wei Ha,Hao Wu,Shu-Lin Peng,Li-Sheng Ding,Bang-Jing Li,Sheng Zhang
The self-assembly of rod–coil carboxymethyl konjac glucomannan-graft-poly(ethylene glycol) (CKGM- g -PEG) and α-cyclodextrin (α-CD) complexes were investigated and used as encapsulating hollow nanospheres for the enzyme glucose oxidase (GOX) in aqueous solution. These hollow nanospheres exhibited “cell-like” semi-permeability allowing enzyme substrates to pass through the surface while restricting the encapsulated enzyme (i.e. GOX) to the interior. Encapsulated GOX exhibited higher thermostability , optimal enzymatic activity over a wider pH range and improved storage stability in comparison to free un-encapsulated GOX. In addition, these CKGM- g -PEG/α-CD hollow nanospheres showed in vitro biocompatibility when exposed to L929 cells when tested using MTT viability assay. These studies suggested that self-assembly of CKGM- g -PEG and α-CD to form stable nanospheres may be an effective method for enzyme encapsulation with numerous biomedical applications.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Chao Zhou,Weina Hao,Jiapei Yao,Tianjun Zhu,Mengdi Sun,Yaojun Lu,Liangliang Wang,Xindie Zhou,Jia Ling Celestine Loh
Chicoric acid (CA) as one of Chinese medicines had anti-inflammatory, less gastrointestinal irritation, less drug-resistance and low cost properties compared with chemical synthesized drug and biologics for rheumatoid arthritis (RA) treatment. To make CA preciously and effectly RA therapy, we firstly developed a supramolecular hydrogel (GHCAP) comprising β -cyclodextrin and graphene oxide (GO) modified hyaluronic acid (CD-HA-GO) as the “host” polymer and adamantane-modified four-arm polyethylene glycol (PEG-AD) as the “guest” polymer, and then the CA was loaded into the supramolecular hydrogel (DGHCAP). The results showed that DGHCAP exhibited injectable, high modulus, high CA loading rate (43.38 %) and slow CA releasing ratio (releasing 80 % in 80 h) compared with those of the supramolecular hydrogel without GO (DHCAP). Moreover, the DGHCAP demonstrated excellent compatibility and effect anti-inflammatory (down regulated proinflammatory cytokines such as IL-1β, IL-6, TNF-α and iNOs) in both in vitro and in vivo assays. The supramolecular hydrogels loaded Chinese medicine could provide another method to treat RA in clinical.
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BIOMACROMOLECULES
·
2017
·
IF 5.246
Yunxia Ni,Jing Sun,Yuhan Wei,Xiaohui Fu,Chenhui Zhu,Zhibo Li
Amphiphilic block copolymers containing polypeptides can self-assemble into a variety of nonspherical structures arising from strong interactions between peptide units. Here, we report the synthesis of a pH-responsive poly(ethyl glycol)-block-poly(l-glutamic acid)-block-poly(N-octylglycine) (PEG-b-PGA-b-PNOG) triblock copolymers by sequential ring-opening polymerization using amine-terminated poly(ethyl glycol) as the macroinitiator followed by selective deprotection of the benzyl protecting group. The obtained triblock copolymer can be directly dispersed in aqueous solution with hydrophilic PEG, pH-responsive PGA block, and hydrophobic PNOG. We present a systematic study of the influence of pH, molar fraction, and molecular weight on the self-assemblies. It was found that the PEG-b-PGA-b-PNOG triblock tends to form two-dimensional nanodisks and nanosheet-like assemblies. The nanodisk-to-nanosheet transition is highly dependent on the pH and molar fraction despite the different molecular weights. We demonstrate that the dominant driving force of the nanodisks and nanosheets is the hydrophobicity of the PNOG blocks. The obtained bioinspired 2D nanostructures are potential candidates for applications in nanoscience and biomedicine.
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高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2017
·Vol. 40
·期 6
·1369-1376
·
IF 2.557
Weixuan Yao,Zhefeng Fan,Suling Zhang
A sensitive microextraction method based on a new poly(methacrylic acid-ethylene glycol dimethacrylate- N -vinylcarbazole) monolithic capillary column, coupled with gas chromatography and electron capture detection, was established for the determination of three benzodiazepines (estazolam, alprazolam, and triazolam) in urine and beer samples. Owing to the abundant π electrons and polar surface of N -vinylcarbazole, N -vinylcarbazole-incorporated monolith showed a higher extraction performance than neat poly(methacrylic acid-ethylene glycol dimethacrylate) because of the enhanced π–π stacking interactions derived from the π-electron-rich benzene groups from N -vinylcarbazole. The monolith exhibited a homogeneous and continuous structure, good permeability, and a long lifetime. Factors affecting the extraction such as solution pH, salt concentration, sample volume, desorption solvent, and desorption volume were investigated. Under the optimized conditions, limits of detection of 0.011–0.026 ng/mL were obtained. The one-column and column-to-column precision values were ≤7.2 and ≤9.8%, respectively. The real samples were first diluted with deionized water and then treated by the monolith microextraction before gas chromatography analysis. The recoveries were 81.4–93.3 and 83.3–94.7% for the spiked samples, with relative standard deviations of 4.1–8.1 and 3.8–8.5%, respectively. This method provides an accurate, simple, and sensitive detection platform for drug analysis.
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MOLECULAR PHARMACEUTICS
·
2024
·
IF 4.5
Haonan Tang,Xiao Zhou,Lijuan Liu,Ziyu Wang,Chen Wang,Ningbin Luo,Guanqiao Jin
Erastin can induce ferroptosis in tumor cells as an effective small molecule inhibitor. However, its application is hampered by a lack of water solubility. This study investigated the effects of superparamagnetic iron oxide (SPIO)–erastin–polyethylene glycol (PEG) nanoparticles prepared by loading SPIO–PEG nanoparticles with erastin on ferroptosis. SPIO–erastin–PEG nanoparticles exhibited square and spherical shapes with good dispersibility. The zeta potential and hydrodynamic size of SPIO–erastin–PEG were measured as (−37.68 ± 2.706) mV and (45.75 ± 18.88) nm, respectively. On T2-weighted imaging, the nanosystem showed significant contrast enhancement compared to no-enhancement magnetic resonance imaging (MRI). SPIO–erastin–PEG induced ferroptosis by increasing reactive oxygen species and iron content and promoting the accumulation of lipid peroxides and the degradation of glutathione peroxidase 4. Pharmacokinetic experiments revealed a half-life of 1.25 ± 0.05 h for the SPIO–erastin–PEG solution in circulation. Moreover, significant antitumorigenic effects of SPIO–erastin–PEG have been demonstrated in 5–8F cells and mouse-bearing tumors. These results indicated that the synthesized SPIO–erastin–PEG nanoplatform could induce ferroptosis effects in vitro and in vivo while exhibiting favorable physical characteristics. This approach may provide a new strategy for theranostic nanoplatform for nasopharyngeal cancer.
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