ACS Applied Materials & Interfaces
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2016
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IF 7.145
Wen She,Han Bi,Zhiwei Wen,Qinghe Liu,Xuebing Zhao,Jie Zhang,Renchao Che
A tunable response frequency is highly desirable for practical applications of microwave absorption materials but remains a great challenge. Here, hollow lightweight polydopamine@α-MnO2 microspindles were facilely synthesized with the tunable absorption frequency governed by the aspect ratio. The size of the hard template is a key factor to achieve the unique shape; the polymer layer with uniform thickness plays an important role in obtaining spindles with homogeneous size. With the aspect ratio increasing, the maximum reflection loss, as well as the absorption bandwidth (<−10 dB), increases and then decreases; meanwhile, the microwave absorption band shifts to the low frequency. The optimized aspect ratio of the cavity about the hollow polydopamine@α-MnO2 microspindles is ∼2.8. With 3 mm thickness at 9.7 GHz, the strongest reflection reaches −21.8 dB, and the width of the absorbing band (<−10 dB) is as wide as 3.3 GHz. Via electron holography, it is confirmed that strong charge accumulates around the interface between the polydopamine and α-MnO2 layers, which mainly contributes to the dielectric polarization absorption. This study proposes a reliable strategy to tune the absorption frequency via different aspect ratio polymer@α-MnO2 microspindles.
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高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2017
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IF 6.035
Lin Li,Jun-Wei Wang,Hao Zhong,Lu-Yuan Hao,Hamidreza Abadikhah,Xin Xu,Chu-Sheng Chen,Simeon Agathopoulos
The α-Si 3 N 4 membrane was prepared by tape casting of silicon slurry, followed by calcination at 1300 °C in flowing NH 3 gas. It comprised of α-Si 3 N 4 nanowire of diameter 70 nm which were converted from silicon powder via the vapor–liquid–solid (VLS) growth mechanism. The surface of the obtained membrane was transformed from hydrophilic to superhydrophobic , with a high water contact angle of ~ 160°, by coating with a vesicular SiNCO nano-layer. The experimental results showed that nanowire structure also favored superhydrophobicity. Water desalination performance of the membrane was tested with a sweeping gas membrane distillation (SGMD) device. High water flux of 8.09 l m −2 h −1 was achieved for 20 wt% NaCl aqueous solution in the feed at 90 °C, which was maintained for more than 500 h.
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Journal of Materials Chemistry B
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2016
·Vol. 4
·期 13
·2338-2350
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IF 4.872
Yuanyuan Guo,Boning Niu,Qingle Song,Yongdan Zhao,Yuling Bao,Songwei Tan,Luqin Si,Zhiping Zhang
Developing multifunctional nanoparticles (NPs) to improve therapeutic efficacy is highly desirable in cancer therapy. In an attempt to respond to such a challenge, a novel copolymer, D-α-tocopherol polyethylene glycol succinate-SS-poly(lactide) (TPGS-SS-PLA) with a disulfide linkage between the TPGS and PLA units, was synthesized for paclitaxel (PTX) delivery. PTX-loaded NPs were fabricated using a nanoprecipitation method to form a particle size of ∼130 nm with good in vitro stability, which can be disassociated under intracellular reductive conditions to release PTX rapidly. The detached TPGS can further promote the drug retention and cytotoxicity through its P-glycoprotein inhibiting property. Integrin-specific targeting peptide, cyclic RGD (cRGD), was further conjugated to the surface of the NPs for targeting the drug delivery. The RGD-decorated NPs exhibited enhanced cellular uptake, PTX accumulation and cell cytotoxicity as compared to non-targeted NPs on murine melanoma B16F10 cells, PTX-sensitive human ovarian A2780 cells and PTX-resistant A2780/T cells. In vivo evaluation of the targeted NPs further showed an extended half-life, increased AUC (area under the concentration–time curve), and significant tumor growth inhibition in mouse sarcoma S180- and B16F10-tumor bearing mice, with reduced side effects as compared to Taxol® and non-targeted NPs. These results indicate that the RGD decorated redox-sensitive NPs could deliver chemotherapies specifically inside the cell via receptor-mediated endocytosis with enhanced efficacy, especially in integrin αvβ3/αvβ5-rich tumor cells. Such a targeted nanocarrier against receptor clustering prepared from a non-cytotoxic and biodegradable copolymer might have great potential in cancer treatment.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2016
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IF 2.822
Zheng-Jun Huang,Wen-Di Han,Yan-Hong Wu,Xiang-Guang Hu,Ya-Ni Yuan,Wei Chen,Hua-Ping Peng,Ai-Lin Liu,Xin-Hua Lin
A versatile electrochemiluminescent (ECL) immunoassay based on the use of magnetic nanoparticles (MNPs) that act as the carrier for the immobilization of the primary antibody (Ab 1 ) against α-fetoprotein (AFP) has been developed. CdTe quantum dots (QDs) were used to label the same antibody to give a secondary antibody (Ab 2) for use in a sandwich immunoassay. On formation of the MNP-Ab 1 /AFP/QD-Ab 2 sandwich immunocomplex, a strong ECL signal has been obtained at a peak potential of − 1.69 V. The principle of the ECL detection for target AFP was on account of the increment concentration of QD-Ab 2 conjugates after immunoreaction, which resulted in the increase in ECL intensity. The linear response range was between 1.0 and 200 ng mL − 1 , and the detection limit was 0.32 ng mL − 1 for the detection model of AFP. The assay was applied to the determination of AFP in serum by the standard addition method. The immunoassay presented here allows for easy separation and purification of AFP, exhibit strong ECL, highly sensitive, well reproducible and precise. In our preception, it has great potential for detecting other proteinic tumor biomarkers.
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Energies
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2017
·Vol. 10
·期 9
·1296
·
IF 2.262
Yizhi Yan,Haolin Tang,Fan Wu,Rui Wang,Mu Pan
A cocoon-like α-Fe2O3nanocomposite with a novel carbon-coated structure was synthesized via a simple one-step hydrothermal self-assembly method and employed as supercapacitor electrode material. It was observed from electrochemical measurements that the obtained α-Fe2O3@C electrode showed a good specific capacitance (406.9 Fg−1at 0.5 Ag−1) and excellent cycling stability, with 90.7% specific capacitance retained after 2000 cycles at high current density of 10 Ag−1. These impressive results, presented here, demonstrated that α-Fe2O3@C could be a promising alternative material for application in high energy density storage.Keywords:one-step;self-assembly;α-Fe2O3;carbon coating;supercapacitors
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Evidence-based Complementary and Alternative Medicine
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2016
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IF 1.931
Ke Fang,Hui Dong,Shujun Jiang,Fen Li,Dingkun Wang,Desen Yang,Jing Gong,Wenya Huang,Fuer Lu
To determine the effects and the underlying mechanism of diosgenin (DSG) and 5-methoxypsoralen (5-MOP), two main active components in the classical Chinese prescription Hu-Lu-Ba-Wan (HLBW), on insulin resistance, HepG2 cells were incubated in medium containing insulin. Treatments with DSG, 5-MOP, and their combination were performed, respectively. The result showed that the incubation of HepG2 cells with high concentration insulin markedly decreased glucose consumption and glycogen synthesis. However, treatment with DSG, 5-MOP, or their combination significantly reversed the condition and increased the phosphorylated expression of estrogen receptor-α (ERα), sarcoma (Src), Akt/protein kinase B, glycogen synthase kinase-3β (GSK-3β), and the p85 regulatory subunit of phosphatidylinositol 3-kinase p85 (PI3Kp85). At the transcriptional level, expression of the genes mentioned above also increased except for the negative regulation of GSK-3β mRNA. The increased expression of glucose transport-4 (GLUT-4) was meanwhile observed through immunofluorescence. Nevertheless, the synergistic effect of DSG and 5-MOP on improving glycometabolism was not obvious in the present study. These results suggested that DSG and 5-MOP may improve insulin resistance through an ER-mediated PI3K/Akt activation pathway which may be a new strategy for type 2 diabetes mellitus, especially for women in an estrogen-deficient condition.
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高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
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2017
·Vol. 134
·期 19
·
IF 1.86
Lingfeng Xu,Caihong Lei,Ruijie Xu,Xiaoqing Zhang,Feng Zhang
A new kind of flame retardant (ZS) with layered α-zirconium phosphate disks (α-ZrP) as the core and inorganic flame retardant (gel-silica, GS) to shield solid acid sites on the surface of α-ZrP as the shell, was synthesized via a facile method. The incorporation effects of ZS with silicone resin on the thermal properties and flame retardance of PC composites were investigated. The presence of ZS could improve the thermal stability of PC matrix. With the addition of ZS contents increased to 3 wt %, the limiting oxygen index (LOI) of the composite was 32.3% and the vertical burning (UL-94) test reached a V-0 rating. However, with more contents of ZS, the LOI value decreased, and without the GS layer, the LOI value was decreased significantly as well. The synergism between the α-ZrP core and gel-silica shell, also with the silicone resin were found. Based on these results, the flame-retardant mechanism was proposed. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 44829.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2024
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IF 3.8
Hongbin Ju,Lizhi Zhang,Heqin Guo,Litao Jia,Bo Hou,Debao Li,Tao Geng
The catalytic epoxidation of α-olefin with long carbon chains has always been a challenge. Traditional homogeneous or heterogeneous catalysts showed poor performance toward the reaction. In this paper, layered organic–inorganic catalysts were prepared by the reaction of phosphotungstic acid and a Gemini quaternary ammonium salt, which could convert long α-olefin to epoxide with a selectivity of 85% in the absence of organic solvents. Combined with characterization results, it was confirmed that the catalyst was layered structure materials, which was supported by a quaternary ammonium salt chain, and the active molecules were distributed between the layered structures. The possible mechanism was also discussed preliminarily.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Jin-Jin Liu,Yu-Ke Hou,Xin Wang,Wei-Wei He,Xiao-Jun Huang,Jun-Yi Yin,Shao-Ping Nie
Polysaccharides are the important bioactive macromolecules in Agrocybe cylindracea , but their changes are as yet elusive during developmental process. This study investigated the dynamic changes of polysaccharides from A. cylindracea fruiting body water extract at four developmental stages and its structure characteristics. Results revealed that the polysaccharides from A. cylindracea water extract significantly increased at the pileus expansion stage and the increased fraction could be α-glucan. The further purification and identification indicated that this α-glucan was a glycogen. It had typical morphology of β particles with a molecular weight of 1375 kDa. Its backbone comprised α-D-(1 → 4)-Glc p and α-D-(1 → 4,6)-Glc p residues at a ratio of 5:1, terminated by α-D-Glc p residue. Rheological behavior suggested that it was a Newtonian fluid at the concentration of 1 %. In addition, despite both the glycogen and natural starch were composed of d -glucose, they exhibited the entirely distinct Maltese cross characteristic and unique crystalline structure. This study is the first to demonstrate the presence of abundant glycogen in the pileus expansion stage of A. cylindracea , which provides new insights on the change patterns of fungal polysaccharides.
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高影响因子
POLYMER COMPOSITES
·
2024
·Vol. 45
·期 10
·9209-9223
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IF 4.8
Sensen Han,Shuangshan Li,Dongyan Liu,Yu Dong,Ziqi Gao,Yanxi Zhang,Qingshi Meng
The development of polyurethane composites with significant flame retardancy and corrosion resistance for widening its practical application is a great importance. In this study, supramolecular wrapped α-ZrP (MCP@ZrP) was prepared via self-assembly of melamine, cobalt ions (Co 2+ ) and phytic acid (PA) on the surfaces of α-zirconium phosphate (α-ZrP). It was found that both compatibility and dispersion of α-ZrP sheets in thermoplastic polyurethane (TPU) matrices were improved with the incorporation of organic supramolecular components in TPU/MCP@ZrP nanocomposites. Moreover, their fire-retardant characteristic was significantly enhanced, along with effective suppression of smoke and toxic gas emission. By adding 5 wt% MCP@ZrP, peak heat release rate, total heat release, total smoke production, and total CO production of such nanocomposites were reduced by 35.66%, 18.01%, 15.52%, and 41.42%, respectively. The generation of a continuous and dense char layer benefited from well-dispersed MCP@ZrP nanohybrids, which resulted in tortuous effect to impede heat diffusion and prevent the evaporation of volatile gasses. By means of the barrier effect of ZrP, TPU/MCP@ZrP composite films also showed improved anticorrosion performance. Effective interfacial adhesion, achieved by combining MCP supermolecules and α-ZrP sheets, offers a viable approach to improve protective properties of TPU nanocomposites. Highlights Supramolecular-wrapped α-ZrP was prepared via self-assembly strategy. MCP@ZrP showed good dispersion and interface adhesion within TPU matrices. MCP@ZrP enhanced the flame retardancy and mechanical performance of TPU. MCP@ZrP preventing smoke and toxic gas evaporation.
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FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
Guangyu Yan,Yaru Wang,Lei Yu,Jun Bo,Hua Fang,Weizhu Chen,Yiping Zhang,Hui Chen,Zhuan Hong
Glycosaminoglycans are a class of naturally occurring macromolecular heteropolysaccharides with α-glucosidase inhibitory effects, which play an essential role in regulating postprandial hyperglycemia. However, the significant molecular weight hinders their inhibitory activity. In this study, oyster glycosaminoglycans were used for purification and depolymerization studies to obtain oyster glycosaminoglycan oligosaccharides (OGAG-Oli) and to study their inhibitory activity against α-glucosidase in vitro and hypoglycemic effect on hyperglycemic zebrafish in vivo . The results showed that the OGAG-Oli with optimal α-glucosidase inhibition obtained by the β-elimination mechanism of chondroitinase ABC had a molecular weight of about 2400 Da with five disaccharide repeating units, and their inhibitory effect on α-glucosidase was significantly enhanced with an IC 50 value of 0.12 mg/mL, which was related to the strong binding capacity with α-glucosidase as evidenced by molecular docking. FT-IR and NMR results showed that the conformation of OGAG-Oli was predominantly in the α-configuration, which indicated that its inhibitory effect on α-glucosidase mainly depended on the α-glucosidic bond therein. The enzymatic depolymerization process of glycosaminoglycans was optimized, and the process conditions were determined as phosphate buffer solution pH 8.0, reaction time 3 h, reaction temperature 30 °C, chondroitin enzyme ABC activity 0.5 mU. The hypoglycemic ability of OGAG-Oli was evaluated in diabetic zebrafish, and the results showed that OGAG-Oli at a high-dose (0.12 mg/g, bw/d) could extremely significantly reduce fasting blood glucose in zebrafish, with an effect close to that of acarbose ( p > 0.05), and exceptionally significantly ( p < 0.01) reduced the elevation of TC, TG, and LDL-C caused by prolonged hyperglycemia, and extremely significantly ( p < 0.01) increased the HDL-C level. This study showed that the structurally modified oyster glycosaminoglycans had intense α-glucosidase inhibitory activity, and exhibited biological activity of reducing glucose uptake and consequently improving body weight and lipid metabolism in diabetic zebrafish. As a bioactive ingredient of natural origin, this study provides a theoretical basis for the development and utilization of glycosaminoglycans with hypoglycemic effects in foods and drugs.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Wei Zheng,Lingyan Xu,Yingming Wang,Chongqi Liu,Lu Liang,Zhentao Qin,Lixiang Lian,Yanyan Lei,Qinzeng Hu,Wanqi Jie
Organic semiconductor single crystals with tissue-equivalent properties present promising advantages for detecting ionizing radiation, particularly X-rays. However, few organic semiconductor materials can exhibit excellent radiation detection performance. In this study, we focus on 9,10-bis(phenylethynyl)anthracene (BPEA) single crystals with two different crystalline phases (α-BPEA and β-BPEA). A slow solution evaporation method is employed to grow centimeter-sized α-BPEA and β-BPEA crystals with high quality. The sandwich-type α-BPEA detector demonstrates exceptional ionizing radiation detection capabilities, with resistivity of 2.72 × 10 12 Ω cm and hole mobility of 2.93 cm 2 V −1 s −1 . The α-BPEA detector also achieves rapid detection of 5.49 MeV α-particles with detection time of 7 ms. The energy resolution and hole mobility-lifetime product are calculated to be 29.93 % and 2.51 × 10 −5 cm 2 V −1 , respectively, marking the best α-particle energy spectrum performance among current organic semiconductor detectors. The α-BPEA detector exhibits X-ray detection sensitivity as high as 451.37 μC Gy air −1 cm −2 and detection of limit as low as 26.28 nGy air s −1 . The α-BPEA detector also demonstrates good operational stability and outstanding imaging capabilities, achieving a spatial resolution of 1.6 lp mm −1 . The BPEA single crystals suggest significant potential for direct ionizing radiation detection and broader optoelectronic applications.
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危险品化学品经营许可证（带存储）