Nature Nanotechnology
·
2023
·
IF 38.3
Luo Zhenyu,Lu Yichao,Shi Yingying,Jiang Mengshi,Shan Xinyu,Li Xiang,Zhang Junlei,Qin Bing,Liu Xu,Guo Xuemeng,Huang Jiaxin,Liu Yu,Wang Sijie,Li Qingpo,Luo Lihua,You Jian
Pharmaceuticals have been developed for the treatment of a wide range of bone diseases and disorders, but suffer from problematic delivery to the bone marrow. Neutrophils are naturally trafficked to the bone marrow and can cross the bone marrow–blood barrier. Here we report the use of neutrophils for the targeted delivery of free drugs and drug nanoparticles to the bone marrow. We demonstrate how drug-loaded poly(lactic-co-glycolic acid) nanoparticles are taken up by neutrophils and are then transported across the bone marrow–blood barrier to boost drug concentrations in the bone marrow. We demonstrate application of this principle to two models. In a bone metastasis cancer model, neutrophil delivery is shown to deliver cabazitaxel and significantly inhibit tumour growth. In an induced osteoporosis model, neutrophil delivery of teriparatide is shown to significantly increase bone mineral density and alleviate osteoporosis indicators.
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JOURNAL OF ELECTRONIC MATERIALS
·
2023
·Vol. 52
·期 7
·4564-4574
·
IF 2.1
Lu Jingmin,Qian Haoran,Ge Lei,Zhang Zhongcheng,Hao Hequn,Xu Zezhong,Yu Tingting,Li Minghua,Tian Changan,Xie Jinsong
In this paper, Ag/TiO 2 composites with different Ag doping ratios (0.5%, 1%, 2% and 3%) were prepared by a one-pot solvothermal method without post calcination. Glycine promoted the formation of rod-like TiO 2 growing along the (101) plane and introduced Ag nanoparticles (NPS) onto the surface of TiO 2 . A series of characterization tests, including x-ray diffraction (XRD), scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HR-TEM), x-ray photoelectron spectroscopy (XPS), UV–Vis diffuse reflectance spectroscopy (DRS), photoluminescence (PL) spectroscopy, nitrogen adsorption and desorption measurement, and electrochemical measurements were employed. The measurements confirmed that the formed Ag/TiO 2 nanorod composite with 1% Ag loading ratio (Ag/TiO 2 -1), consisting of length up to 22 nm and Ag nanoparticles (NPS) with a diameter of about 5.5 nm, had an appropriate energy band gap of 2.95 eV and a large specific surface area of 158.3 m 2 /g, which shows that the Ag/TiO 2 -1 has abundant photocatalytic active sites to increase its visible-light absorption ability. The Ag/TiO 2 -1 sample has the highest photocatalytic efficiency, with up to 95% and 98% degradation for tetracycline (TC) and Rhodamine B (RhB), respectively, in 25 min under simulated solar light. After the sixth cycle experiment, Ag/TiO 2 -1 still maintained 94% and 95% degradation of TC and RhB, respectively. The trapping active species experiment confirmed that the hole (h + ) and superoxide radical \(\left( { \cdot {\text{O}}_{2}^{ - } } \right)\) are the main active species. This work has practical significance for the simultaneous study of the photocatalysis of Ag/TiO 2 composites for dyes (RhB) and antibiotics (TC).
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JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
·
2021
·Vol. 147
·期 15
·8145-8155
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IF 4.626
Tao Lili,Xu Yue,Liu Lubin,Li Bin,Xu Miaojun
A novel mono-component P/N/B-containing intumescent flame retardant poly(methylphosphonic-boric acid piperazine neopentylgcol ester) named MBPNE was synthesized. The chemical structure of MBPNE was analyzed by FTIR, 13 C and 31 P solid-state NMR tests. The results of thermal gravimetric analysis indicated that MBPNE possessed excellent charring capability, and its residual char was 27.5 mass% at 800 °C. Besides, MBPNE occurred melting and expansion process during charring evolution process. MBPNE was used to prepare flame retardant polyolefin elastomer (POE) composites. The 1.6 mm POE/MBPNE specimens achieved UL-94 V-0 rating and their LOI value was 25.5% when 22 mass% MBPNE was incorporated. The sheet was extinguished quickly after departing the flame, and no dripping appeared. Furthermore, the incorporation of MBPNE effectively enhanced the residual char mass after cone calorimeter tests, and the heat release was suppressed. The compact, expanded, partially graphitized and coherent char layer was generated on POE composites surface during burning process and exerted isolation effect in condensed phase. Meanwhile, the degradation products of MBPNE quenched active free radicals in gaseous phase, which effectually interrupted the combustion chain reaction of POE composites. Consequently, the POE composites were endowed excellent flame retardant performance.
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Journal of Bionic Engineering
·
2021
·Vol. 18
·期 6
·1378-1390
·
IF 2.682
Li Pengfei,Ruan Liming,Wang Ruofan,Liu Tianqi,Song Gao,Gao Xiaofei,Jiang Guohua,Liu Xiaoyan
Nanofibers (NFs) have been widely used in tissue engineering such as wound healing. In this work, the antibacterial ZnO quantum dots (ZnO QDs) have been incorporated into the biocompatible poly (ε-caprolactone)/collagen (PCL/Col) fibrous scaffolds for wound healing. The as-fabricated PCL-Col/ZnO fibrous scaffolds exhibited good swelling, antibacterial activity, and biodegradation behaviors, which were beneficial for the applications as a wound dressing. Moreover, the PCL-Col/ZnO fibrous scaffolds showed excellent cytocompatibility for promoting cell proliferation. The resultant PCL-Col/ZnO fibrous scaffolds containing vascular endothelial growth factor (VEGF) also exhibited promoted wound-healing effect through promoting expression of transforming growth factor-β (TGF-β) and the vascular factor (CD31) in tissues in the early stages of wound healing. This new electrospun fibrous scaffolds with wound-healing promotion and antibacterial property should be convenient for treating wound healing.
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MICROCHIMICA ACTA
·
2021
·Vol. 188
·期 12
·1-9
·
IF 5.833
Tang Zhuoyun,Wei Zeliang,Huang Ke,Wei Yinhao,Li Dongdong,Yan Shixin,Huang Jin,Geng Jia,Tao Chuanmin,Chen Piaopiao,Ying Binwu
Human immunodeficiency virus (HIV) infection inflicts significant economic and social burdens on many countries worldwide. Given the substantial morbidity and mortality from HIV infection, there is an urgent need for accurate and early detection of the virus. In this study, immunofluorescence and visual techniques are described that detect the HIV-1 p24 antigen, which relied on selective recognition of Ag + /Ag nanoparticles (Ag NPs) and Cu 2+ /Cu + using cadmium telluride quantum dots (CdTe QDs). After the sandwich immunoreactions were accomplished, the alkaline phosphatase (ALP) hydrolyzed L-ascorbic acid 2-phosphate (AAP) to form ascorbic acid (AA) that further reduces Ag + and Cu 2+ to Ag NPs and Cu + , respectively. This method was highly sensitive and selective and could detect as low as 1 pg/mL of p24 antigen by naked eyes and had a good linearity in the concentration range 1–100 pg/mL. When using Ag + and Cu 2+ as media, the limit of detection (LOD) of the new method was 0.3 pg/mL and 0.2 pg/mL, respectively. Compared with clinical electrochemiluminescence immunoassay (ECLIA) results and clinical data, this method demonstrated good consistency for the quantification of HIV-1 p24 antigen in 34 clinical serum samples. In addition, this method could accurately distinguish HIV from other viruses and infections such as hepatitis B virus , systemic lupus erythematosus , hepatitis C virus , Epstein-Barr virus , cytomegalovirus , lipemia , and hemolysis . Therefore, our dual-mode analysis method may provide additional solutions to identify clinical HIV infection. Graphical abstract An immunofluorescence and visualization dual-mode strategy for the detection of p24 antigen was constructed based on immune recognition reaction and a phenomenon that cadmium telluride quantum dots (CdTe QDs) can selectively recognize Ag + /Ag nanoparticles (Ag NPs) and Cu 2+ /Cu + .
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Nanoscale Research Letters
·
2021
·Vol. 16
·期 1
·1-11
·
IF 4.703
Zhao Shubi,Luo Yiqun,Chang Zong,Liu Chenchen,Li Tong,Gan Lu,Huang Yong,Sun Qinchao
The second near infrared window is considered to be the optimal optical window for medical imaging and therapy as its capability of deep tissue penetration. The preparation of the gold nanorods with long wavelength absorption and low cytotoxicity is still a challenge. A series gold nanorods with large aspect ratio have been synthesized. Strong plasma absorption in the second near infrared window from 1000 to 1300 nm could be observed. The biocompatibility of the synthesized gold nanorods is dramatically improved via coating by bovine serum albumin (BSA), while the optical properties of which remains. The breast cancer tumor-bearing mouse could be well treated by the prepared gold nanorods with the NIR-II light intensity as low as 0.75 W/cm2. In summary, these results demonstrate the feasibility of using low illumination dose to treat tumor in the NIR-II region via the large aspect ratio gould nanoparticles.
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JOURNAL OF MATERIALS RESEARCH
·
2021
·Vol. 36
·期 24
·5002-5012
·
IF 3.089
Zhou Haijun,Jiresse Nguetsa Kuate Loic,Zhang Weirun,Chen Zhengyang,Zhang Yamei,Zhang Jiaoxia
The photodegradation technology can improve the status quo of environmental problems seriously which hindered the development and progress of human society. In this work, the two-dimensional transition metal carbide Ti 3 C 2 was prepared by HF etching of Ti 3 AlC 2 , and subsequently TiO 2 crystals were produced by hydrothermal method to prepare TiO 2 /Ti 3 C 2 composite. The Ag nanoparticles were then doped by photoreduction to form a ternary Ag/TiO 2 /Ti 3 C 2 composite. The effect of photocatalytic degradation of the methyl orange solution by Ag/TiO 2 /Ti 3 C 2 was investigated. The degradation only with Ag/TiO 2 /Ti 3 C 2 is worser than TiO 2 /Ti 3 C 2 , so H 2 O 2 was added to improve the catalytic ability and explore the photocatalytic mechanism. In 420 min, the degradation efficiency of methyl orange (MO) solution reached 71.09% due to the active-free radicals preventing the recombination of electron hole pairs to improve the catalytic performance of photocatalytic materials. Graphical abstract
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JOURNAL OF NANOBIOTECHNOLOGY
·
2021
·Vol. 19
·期 1
·1-19
·
IF 10.435
Deng Xingyu,Chen Xiabin,Geng Fang,Tang Xin,Li Zhenzhen,Zhang Jie,Wang Yikai,Wang Fangqian,Zheng Na,Wang Peng,Yu Xiaohua,Hou Shurong,Zhang Wei
Background The poor regenerative capability and structural complexity make the reconstruction of meniscus particularly challenging in clinic. 3D printing of polymer scaffolds holds the promise of precisely constructing complex tissue architecture, however the resultant scaffolds usually lack of sufficient bioactivity to effectively generate new tissue.Results Herein, 3D printing-based strategy via the cryo-printing technology was employed to fabricate customized polyurethane (PU) porous scaffolds that mimic native meniscus. In order to enhance scaffold bioactivity for human mesenchymal stem cells (hMSCs) culture, scaffold surface modification through the physical absorption of collagen I and fibronectin (FN) were investigated by cell live/dead staining and cell viability assays. The results indicated that coating with fibronectin outperformed coating with collagen I in promoting multiple-aspect stem cell functions, and fibronectin favors long-term culture required for chondrogenesis on scaffolds. In situ chondrogenic differentiation of hMSCs resulted in a time-dependent upregulation of SOX9 and extracellular matrix (ECM) assessed by qRT-PCR analysis, and enhanced deposition of collagen II and aggrecan confirmed by immunostaining and western blot analysis. Gene expression data also revealed 3D porous scaffolds coupled with surface functionalization greatly facilitated chondrogenesis of hMSCs. In addition, the subcutaneous implantation of 3D porous PU scaffolds on SD rats did not induce local inflammation and integrated well with surrounding tissues, suggesting good in vivo biocompatibility.Conclusion sOverall, this study presents an approach to fabricate biocompatible meniscus constructs that not only recapitulate the architecture and mechanical property of native meniscus, but also have desired bioactivity for hMSCs culture and cartilage regeneration. The generated 3D meniscus-mimicking scaffolds incorporated with hMSCs offer great promise in tissue engineering strategies for meniscus regeneration.Graphical Abstract
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Food Analytical Methods
·
2021
·Vol. 15
·期 4
·993-1000
·
IF 3.366
Yu Lili,Jiang Chenrui,Xi Liping,Zhang Xiaoni,Tong Jinzhe,Chen Zhuo,Chen Rong,He Hua
In this paper, a simple and effective strategy was designed for colorimetric sensing of benzoyl peroxide (BPO) based on the morphological transition of silver nanoprisms (AgNPRs). The decomposition of O–O bond of BPO generated strong oxidant benzoyl oxide free radical, which could be first oxidized the silver atoms at the corner areas and the {110} facet of AgNPRs. With the increase of the BPO concentration, AgNPRs were oxidized to produce nanodisks and a blue shift of the in-plane dipole plasmon resonance peak could be observed. In addition, a distinct color change of AgNPRs solution from blue to purple, fuchsia, and finally colorless appeared with 10 min, which could be easily observed by naked eyes. Under the optimal conditions, a linear relationship between the blue shift of the in-plane dipole plasmon resonance peak and BPO concentration ranged from 2 to 80 μM with the detection limit of 0.47 μM. The practical applicability of this assay was verified by successfully determining BPO in flour samples with a good recovery, which demonstrated its great potentials in food safety field. Furthermore, a simple, inexpensive, and portable test kit for the visual detection of BPO in flour samples was also designed by utilizing agarose hydrogel as a visual detection platform. Thus, the proposed sensor provided a promising prospective candidate for the rapid detection and surveillance of BPO.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2021
·Vol. 331
·期 1
·365-373
·
IF 1.371
Li Chunhui,He Hui,He Mingjian,Gao Yang,Zhang Meng,Jiao Caishan
A detailed extraction equilibrium study is experimentally performed to understand the extraction mechanisms of Ce(IV) by 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (C 4 mimNTf 2 ) in 1,2-dichloroethane. Further, the influence of adding TBP on the distribution ratio is investigated and demonstrated. The ceric aqueous chemistry in the nitric acid solution and slope analysis are combined to reveal the extraction mechanism. The monovalent anionic complex HCe(NO 3 ) 6 − is the dominant species, which extracted by C 4 mimNTf 2 . Importantly, this study demonstrates the antagonistic effect between TBP and C 4 mimNTf 2 on the extraction process.
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JOM
·
2021
·Vol. 73
·期 12
·4376-4386
·
IF 2.474
Zou Qi,Le Qichi,Chen Xingrui,Ban Chunyan,Jia Yonghui,Guo Ruizhen,Wang An
This work investigated the corrosion resistance of AZ80 (Mg-8Al-0.5Zn alloy) with different Nd contents in alkaline solution by the mass loss test, electrochemical test, scanning electron microscope, energy spectrum analysis, and x-ray diffraction. To remove the influence of the Mg 17 Al 12 phase, alloys were heat treated at 410°C for 10 h. Results revealed that Al 2 Nd and AlMnNd phases mainly exist in the alloy. The corrosion rate of the alloy increased when the Nd content was < 0.4 wt.% because the Al 2 Nd phase formed galvanic corrosion with the Mg matrix. With the increase of Nd content, AlMnNd phase appeared in the alloys, which decomposed during the corrosion process and formed a good protective film to reduce the corrosion rate.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2021
·Vol. 29
·期 14
·20711-20720
·
IF 4.223
Jiang Ying,Du Linna,Cheng Qilu,Jin Zhuo,Hui Cai,Zhao Yuhua,Jiang Hui,Xu Ligen
Nanoparticles and organic pollutants are two major contaminants found in aquatic environments. Algae are regarded as the model organism for the risk assessment of pollutants in water. In our previous study, we investigated the toxic effects of nonylphenol (NP), a typical organic water pollutant, on algae; however, it remains unclear how algae respond to the coexistence of NP and nanoparticles. In this study, a concentration gradient of nanoscale zero-valent iron (nZVI; 10, 50, 100, and 200 mg/L) was added to NP-exposed Dictyosphaerium sp. to investigate both the toxic effects of this combination and the potential for NP removal. nZVI had a dose-dependent effect on NP-exposed algae, with high nZVI concentrations significantly decreasing algal biomass and pigment content, as well as severely damaging algal cellular ultrastructure. In addition, genes involved in antioxidant response, photosynthesis, and ribosome synthesis were significantly altered when NP-exposed algae were incubated with nZVI. In contrast to high nZVI concentrations, adding a small concentration of nZVI led to reduced toxicity in NP-exposed algae, while significantly enhancing the NP removal rate. This study improves our understanding of algal responses to various pollutants and suggests that nZVI may assist in the remediation of NP in aquatic ecosystems.
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