Materials Research-Ibero-american Journal of Materials
·
2017
·Vol. 20
·期 3
·592-600
·
IF 0.634
Wen Yong,Pei Li-zhai,Wei Tian
Li doped bismuth oxide nanorods have been prepared using sodium bismuthate and Li acetate. X-ray diffraction (XRD) pattern shows that the nanorods are composed of monoclinic Bi2O4 and cubic LiBi12O18.50 phases. Scanning electron microscopy (SEM) observation shows that the nanorods have the length and diameter of 1-5 µm and 50-350 nm, respectively. The formation of the Li doped bismuth oxide nanorods is closely relative to the hydrothermal conditions. The electrochemical performance for the determination of L-cysteine based on a Li doped bismuth oxide nanorods modified glassy carbon electrode (GCE) has been developed. The CV peak current increases obviously and linearly with increasing the scan rate. Under the optimal conditions, Li doped bismuth oxide nanorods modified GCE exhibits good analytical performance with good reproducibility and stability. The linear range of L-cysteine is 0.0001-2 mM and the detection limit is 0.36 µM and 0.17 µM for cvp1 and cvp2, respectively.
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Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Le Pan,Yanjie Li,Lin Zhu,Buchang Zhang,Yuhua Shen,Anjian Xie
In this study, the poly (ethylene glycol) double acrylates (PEGDA) was first initiated by Spinacia oleracea L. extract (SOLE) to in situ form a polymer hydrogel shell on Hela cells with near infra-red irradiation. The SOLE was also a natural photosensitizer for photodynamic therapy of tumor. The use of SOLE is simple, eco-friendly, low cost, and convenient. More importantly, the PEGDA/SOLE composite hydrogel shell on Hela cells not merely prevents SOLE from diffusing to normal tissue for reducing the side effects, but also keeps high SOLE concentration on tumor cell for improving the antitumor effect. Such a hydrogel system has good biocompatibility and exhibits high therapeutic efficacy. This study extended the application of the SOLE/PEGDA gel in photodynamic therapy.
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RSC Advances
·
2016
·Vol. 6
·期 38
·31934-31946
·
IF 3.289
Wei-Wei Wang,Long Jiang,Wu-Yang Ren,Chun-Mei Zhang,Chang-Zhen Man,Thien-Phap Nguyen,Yi Dan
In this paper a series of di-block copolymers of L-lactide and (meth)acrylate [(M)A, representing methyl methacrylate, tert-butyl acrylate and 2-ethylhexyl acrylate] were synthesized by varying the molecular weight of the polylactide (PLLA) macroinitiator and the structure of the (meth)acrylate monomers. The glass transition temperature, crystallinity and thermal stability of copolymers with different poly(meth)acrylate [P(M)A] blocks were investigated by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). The results indicated that the glass transition temperature of the copolymers could be tuned by changing the chain structure and chain length of the P(M)A blocks. Besides, the crystallization of the copolymers was inhibited by the introduction of P(M)A blocks, and the toughness of the copolymers could be tuned. It is noted that the thermal stability of the copolymers depended on the type of P(M)A blocks and the PLLA/P(M)A blocks ratio. Furthermore, the microphase separation of copolymers in thin films was observed by atomic force microscopy (AFM) and scanning electron microscopy (SEM), and the results showed that the composition of copolymers significantly affected the surface morphology of the block copolymer thin films.
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RSC Advances
·
2016
·Vol. 6
·期 106
·104193-104200
·
IF 3.289
Lili Lv,Lijuan Wang,Yanan Zou,Rui Chen,Jiaojiao Yu
A chiral nonaqueous capillary electrophoresis (NACE) method using L-sorbose–boric acid complexes as the chiral ion-pair selectors was developed for enantioseparation of nineteen chiral analytes including eight β-blockers, seven β-agonists, two phenothiazines antihistamines, and two fluoroquinolone antibiotics. The effects of L-sorbose and boric acid concentrations, triethylamine concentration, applied voltage, and capillary temperature on the enantioseparation were systematically investigated. Under the optimized conditions, thirteen pairs of enantiomers were baseline resolved and five pairs of enantiomers were partially enantioseparated. Salbutamol showed a sign of separation with a shoulder peak. A reversal of propranolol enantiomer migration orders took place in the case when different concentrations of triethylamine were added into the NACE running buffers. The mass spectrometry (MS) results confirmed that triethylamine could promote the formation of negatively charged L-sorbose–boric acid complex chiral counter ions with different complex ratios. The enantioseparation results were compared with the previous work. Calibration curves showed excellent linearity with square of correlation coefficients (r2) greater than 0.9994 over concentration ranges of 5.0–500.0 μg mL−1 for each enantiomer of clenbuterol and esmolol, and 12.5–500.0 μg mL−1 for that of metoprolol. The limits of detection (LODs) and limits of quantitation (LOQs) for each enantiomer were 0.4–1.25 μg mL−1 and 1.5–4.0 μg mL−1, respectively. The relative standard deviations (RSDs) of intra-day and inter-day precisions of migration times were ≤1.64% (n = 6), and ≤6.54% (n = 15), respectively. The peak areas were ≤4.03% (n = 6), and ≤3.92% (n = 15), respectively. This method can likely be applied to the determination of each enantiomer in pharmaceutical formulations.
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Journal of Food Measurement and Characterization
·
2016
·Vol. 11
·期 2
·548-555
·
IF 0.521
Xiaohong Zhang,Zhidong Zhao,Xiongwei Lou,Jian Li,Guohua Hui
A maltose, L-rhamnose sensor based on porous Cu foam and electrochemical techniques was investigated in this paper. Cu foam material was prepared and characterized by scanning electron microscopy (SEM). The electro-oxidation reaction process of sweeteners occurred on Cu foam electrode was evaluated by cyclic voltammetry (CV) scanning. At an applied potential of 0.5 V, the linear range for maltose is 0.18–3.47 mM with sensitivity of 1.0492 mA cm −2 mM −1 . The limit of detection (LOD) was 15.86 μM (S/N = 3). The linear range for maltose is 0.18–3.47 mM with sensitivity of 0.6881 mA cm −2 mM −1 . The LOD was 24.18 μM (S/N = 3). Compared with Cu sheet electrode, Cu foam electrode showed higher current response towards maltose and L-rhamnose, leading to enhanced electrocatalytic activity, higher sensitivity, and lower LOD. Sweetener qualitative discrimination was carried out by stochastic resonance (SR) signal-to-noise ratio (SNR) spectrum eigen peak located noise intensities.
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JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
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2017
·
IF 3.255
Tong Wang,Jiao Jiao,Qing-Yan Gai,Peng Wang,Na Guo,Li-Li Niu,Yu-Jie Fu
Nowadays, green extraction of bioactive compounds from medicinal plants has gained increasing attention. As green solvent, deep eutectic solvent (DES) have been highly rated to replace toxic organic solvents in extraction process. In present study, to simultaneous extraction five main bioactive compounds from fig leaves, DES was tailor-made. The tailor-made DES composed of a 3:3:3 molar ratio of glycerol, xylitol and D-(−)-Fructose showed enhanced extraction yields for five target compounds simultaneously compared with traditional methanol and non-tailor DESs. Then, the tailor-made DES based extraction methods have compared and microwave-assisted extraction was selected and optimized due to its high extraction yields with lower time consumption. The influencing parameters including extraction temperature, liquid-solid ratio, and extraction time were optimized using response surface methodology (RSM). Under optimal conditions the extraction yield of caffeoylmalic acid, psoralic acid-glucoside, rutin, psoralen and bergapten was 6.482 mg/g, 16.34 mg/g, 5.207 mg/g, 15.22 mg/g and 2.475 mg/g, respectively. Macroporous resin D101 has been used to recovery target compounds with recovery yields of 79.2%, 83.4%, 85.5%, 81.2% and 75.3% for caffeoylmalic acid, psoralic acid-glucoside, rutin, psoralen and bergapten, respectively. The present study suggests that DESs are truly designer and efficient solvents and the method we developed was efficient and sustainable for extraction main compounds from Fig leaves.mg/g
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Inorganic Chemistry Frontiers
·
2017
·Vol. 4
·期 11
·1862-1869
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IF 4.036
Mu Gao,Xiaofeng Lu,Maoqiang Chi,Sihui Chen,Ce Wang
Mixed transition-metal oxides (MTMOs) have attracted much research interest because of their promising applications in artificial enzymes. In this work, uniform hollow MnCo2O4 nanofibers have been fabricated via an electrospinning technique followed by a calcination process, which can be used as efficient oxidase mimics. In detail, the as-prepared hollow MnCo2O4 nanofibers display excellent oxidase-like activity toward the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) superior to their corresponding single-metal oxides without the addition of H2O2. Based on the high catalytic activity of hollow MnCo2O4 nanofibers and their inhibition effect by specific substances, the system of hollow MnCo2O4 nanofibers–TMB has potential to be applied in assays to detect sulfite and L-cysteine using a colorimetric approach with high sensitivity and selectivity. This work implies a broad application prospect of MTMOs in biosensors, environmental protection, food safety and medical science.
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JOURNAL OF MOLECULAR STRUCTURE
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2017
·
IF 1.753
Xuefang Shang,Jie Li,Kerong Guo,Tongyu Ti,Tianyun Wang,Jinlian Zhang
Inspired from biological counter parts, chemical modification of Schiff base derivatives with function groups may provide a highly efficient method to detect amino acids . Therefore, a fluorescent probe involving Schiff base and hydroxyl group has been designed and prepared, which showed high response and specificity for Arginine (Arg) among normal eighteen standard kinds of amino acids (Alanine, Valine , Leucine , Isoleucine , Methionine , Asparticacid, Glutamicacid, Arginine, Glycine, Serine , Threonine , Asparagine , Phenylalanine , Histidine , Tryptophan , Proline , Lysine, Glutamine, Tyrosine and Cysteine). Furthermore, theoretical investigation further illustrated the possible binding mode in the host-guest interaction and the roles of molecular frontier orbitals in molecular interplay. In addition, the synthesized fluorescent probe exhibited high binding ability for Arg and low cytotoxicity to MCF-7 cells over a concentration range of 0–200 μg mL −1 which can be also used as a biosensor for the Arg detection in vivo.
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ELECTROPHORESIS
·
2013
·Vol. 34
·期 6
·846-853
·
IF 3.261
Haizhi Zhang,Li Qi,Ying Shen,Juan Qiao,Lanqun Mao
Amino acid ionic liquids (AAILs) with l -lysine ( l -Lys) as anion were synthesized and applied as new chiral ligands in Zn(II) complexes for chiral ligand-exchange CE. After effective optimization, baseline enantioseparation of seven pairs of dansylated amino acids was achieved with a buffer of 100.0 mM boric acid, 5.0 mM ammonium acetate, 3.0 mM ZnSO 4 , and 6.0 mM [C 6 mim][ l -Lys] at pH 8.2. To validate the unique behavior of AAILs, a comparative study between the performance of Zn(II)- l -Lys and Zn(II)-[C 6 mim][ l -Lys] systems was conducted. In Zn(II)-[C 6 mim][ l -Lys] system, it has been found that the improved chiral resolution could be obtained and the migration times of the three test samples were markedly prolonged. Then the separation mechanism was further discussed. The role of [C 6 mim][ l -Lys] indicated clearly that the synthesized AAILs could be used as chiral ligands and would have potential utilization in separation science in future.
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JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL
·
2012
·
IF 2.947
Hui-xue Ren,Han-jie Ying,Ping-kai Ouyang,Ping Xu,Jing Liu
Efficient and pollution-free catalysts play an essential role in the ultimate biodegradation of products in the synthesis of biodegradable and recyclable poly( l -lactic acid) (PLLA). Therefore, macroporous resin was utilized as the solid acid for the first time, on which lactate that could be absorbed in vivo was composited to catalyze the synthesis of PLLA. It was discovered that macroporous resin Amberlyst-15 showed good catalytic activity in oligomerization and polymerization, and lactate showed different catalytic efficiencies due to the differences in ionic radius and ionic charge. Compared to the traditional catalysts of SnCl 2 ·2H 2 O/TSA, the composite catalyst can improve the quality, yield and optical purity of its product, which can also be recycled without any residual in products. PLLA with molar mass of about 110,000 g mol −1 was synthesized at the yield of 93%. The product exhibits pure color (white), and its optical purity and crystallinity are 98% and 55%, respectively. A possible catalytic mechanism was proposed. The resulting PLLA products were characterized by GPC, 1 H NMR, DSC, and polarimeter.
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ANALYTICA CHIMICA ACTA
·
2012
·
IF 4.555
Yu Chen,Lei Chen,Ruilin Bi,Lan Xu,Yan Liu
A novel chiral molecularly imprinted polymer (MIP) sensor for l -Phenylalanine has been developed, which is constructed by electrochemically driven cross-linking a pendant polymer precursor, poly[2-( N -carbazolyl)ethyl methacrylate-co-meth-acrylic acid]s (PCEMMAs). In this MIP sensing material, the recognition sites, the insulating polymethylacrylic acid (PMAA), were covalently bonded to the conducting polycarbazole which could be used as signal transfer interface between recognition layer and electrode. The mole ratio of copolymerizing monomers, 2-( N -carbazolyl) ethyl methacrylate:methylacrylic acid (CE:MAA), and the scanning cycles of electropolymerization were adjusted during the preparation of MIP sensing material. The optimized conditions, CE:MAA = 3:2 and 20 scanning cycles, were obtained. And then the properties of MIP films were characterized by atomic force microscope (AFM), X-ray photoelectron spectroscopy (XPS) and water contact angle. Open circuit potential–time technique was used to estimate the enantioselectivity of the MIP sensor. The results indicate that the promising sensor preferentially responses l -Phenylalanine ( l -Phe) over d -Phenylalanine ( d -Phe) with a selectivity coefficient K D L = 5.75 × 10 − 4 and the limit of detection (LOD) is 1.37 μM, which reveals its good enantioselectivity and sensitivity.
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FOOD SCIENCE AND BIOTECHNOLOGY
·
2015
·Vol. 24
·期 3
·1131-1138
·
IF 0.653
Wang Huaqian,Li Dongli,Du Zhiyun,Huang Mou-Tuan,Cui Xiaoxing,Lu Yujing,Li Chenyue,Woo Swee Lian,Conney Allan H.,Zheng Xi,Zhang Kun
Stems and leaves of Acanthopanax trifoliatus (L) Merr (AT) are commonly used as an edible vegetable in China. The scientific basis of antioxidant and antiinflammatory activities of AT was investigated. The polyphenol contents and free radical scavenging activities of AT ethanol extracts (EAT) were determined. Chlorogenic acid, isochlorogenic acid A, isochlorogenic acid C, and rutin were identified as major components in EAT. LPS-induced NO production in RAW264.7 cells was decreased significantly ( p <0.05) after EAT treatment, compared with controls. In vivo studies indicated that EAT had more activity than chlorogenic acid per mg of dry weight for inhibition of TPA-induced ear edema. TPA-induced increases in cytokine production (TNF-α, IL-6, MMP-9, and TIMP-1) were significantly ( p <0.05) reduced by EAT treatment, compared with controls. EAT exerts anti-inflammatory activities probably due, at least in part, to chlorogenic acid.
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