ACS Nano
·
2026
·
IF 16
Minghao Jin,Muge Gu,Keyu Kong,Wenxuan Fan,Sonu Ng,Yuehao Hu,Zhe Wang,Jiemao Su,Wei-En Yuan,Huiwu Li,Zanjing Zhai
Prosthesis-associated osteolysis (PAO), driven by a self-perpetuating inflammatory-osteoclastogenic cycle, remains a critical challenge following arthroplasty. Current single-target therapies inadequately address the spatiotemporal heterogeneity of pathological microenvironments: ROS overload during the early immune activation phase and low pH in the osteoclastic resorption phase. This study develops bovine serum albumin (BSA)-coated copper–manganese carbonate nanocomposites (CuMnCO3@BSA, CMC) that dynamically coordinate immunosuppressive intervention with osteoclast-specific cuproptosis induction through microenvironment-guided functional switching. In vitro studies demonstrate that at neutral pH, Mn2+-mediated SOD/CAT-like nanozyme activity effectively scavenges ROS and reprograms macrophage metabolism to oxidative phosphorylation, thereby suppressing M1 polarization. During late osteoclast differentiation, acid-triggered carbonate decomposition releases Cu2+, selectively eliminating mature osteoclasts via cuproptosis-mediated mitochondrial lipoylated protein aggregation and TCA cycle collapse. In titanium particle-induced osteolysis models, this dual-functional CMC strategy demonstrates superior therapeutic efficacy to bisphosphonates. This study pioneers a microenvironment-adaptive nanotherapeutic approach, innovatively coupling cuproptosis with immune-metabolic regulation, thereby establishing a novel paradigm for osteolytic disease management.
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高影响因子
CERAMICS INTERNATIONAL
·
2022
·Vol. 49
·期 3
·5154-5160
·
IF 5.532
Xiaoyang Wang,Xiaoqing Si,Jianwei Gao,Bo Yang,Mingshen Li,Chun Li,Junlei Qi,Jian Cao
Reactive air brazing (RAB) holds great potential for joining BaZr 0.1 Ce 0.7 Y 0.1 Yb 0.1 O 3-δ (BZCYYb) electrolytes with stainless steel interconnects. But this technique inevitably results in many brittle compounds along the BZCYYb interface and excessive oxidation at the steel interface. Herein, we successfully address the above issues by introducing the Mn–Co spinel coating. The coating prevents the reaction of Cr with the electrolyte and reduces brittle compounds along the BZCYYb interface, thereby elevating the joint strength by 31%. Also, it completely separates CuO and the stainless steel, thus inhibiting the excessive oxidation on the steel surface. Furthermore, the coating remains dense in both oxidizing and reducing atmospheres at 600 for 300 h, significantly enhancing the long-term stability of joints.
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ANALYTICAL CHEMISTRY
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2013
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IF 5.695
He-Fang Wang,Ye-Yu Wu,Xiu-Ping Yan
A room-temperature phosphorescence (RTP) strategy was developed for direct, additive-free discrimination of catechol from resorcinol and hydroquinone based on sodium tripolyphosphate capped Mn-doped ZnS quantum dots (STPP-Mn-ZnS QDs). The RTP response of STPP-Mn-ZnS QDs to the three isomers was pH-dependent, and the greatest difference in the RTP response to the isomers was observed at pH 8.0: catechol enhanced the RTP intensity of the QDs, while resorcinol and hydroquinone had little effect on the RTP intensity of the QDs. The enhanced RTP intensity of 1 μM catechol was not affected by the coexistence of 30 μM resorcinol and 50 μM hydroquinone at pH 8.0. The detection limit of this RTP method was 53 nM catechol, and the precision was 3.2% (relative standard deviation) for five replicate detections of 1 μM catechol. The discrimination mechanism was ascribed to the weak bonded ligand of STPP-Mn-ZnS QDs and the different interaction between the three isomers and STPP-Mn-ZnS QDs. The strong binding of catechol to Zn resulted in the extraction of Zn from the surface of STPP-Mn-ZnS QDs and the generation of holes that were trapped by Mn2+ to form Mn3+. Catechol also promoted the reduction of Mn3+ into Mn2+ excited state, thus ultimately inducing the enhanced RTP response of STPP-Mn-ZnS QDs.
研究领域:
分析化学
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纳米材料
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发光传感器
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环境监测
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化学传感
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ACS Catalysis
·
2023
·
IF 12.9
Xiaolong Liu,Yang Zou,Xue Li,Tieyao Xu,Wanglai Cen,Bin Li,Tingyu Zhu
Bimetallic catalysts Pt–M/Ti were prepared by introducing various dopants (M = Mn, Fe, Co, Cu, Ce, Mo) into Pt/Ti with ultralow loadings (0.5 wt % M) and compared in CO oxidation in the presence of H2O and SO2. Among these catalysts, Pt–0.5Mn/Ti contributed the highest oxidation efficiency and strongest sulfur resistance. Further improvement of Mn contents led to the decrease of CO conversion. It was indicated that the introduction of appropriate Mn species enhanced the active oxygen supplying ability of the catalyst, thus improving the reaction activity. The CO oxidation performance of the catalyst was improved through the reaction between *OH from H2O dissociation and CO. The deposition of S on the Pt–0.5Mn/Ti surface did not increase with time extension. Theoretical calculation results revealed that cleavage of S–O–Mn species could be facilitated by Pt, and the SO2 adsorption energy calculations demonstrated that SO2 was more easily adsorbed on Pt/Ti than Pt–0.5Mn/Ti, which was very consistent with its sulfur resistance. In situ DRIFT studies at 260 °C revealed that the introduction of SO2 onto Pt–0.5Mn/Ti showed little change for CO adsorption on different Pt species, while Pt/Ti showed an apparent decrease of Pt0–CO. 18O isotopic experiments in the presence of H218O and SO2 were systematically designed to accurately quantify the CO2 composition including C16O16O, C16O18O, and C18O18O. Accordingly, the reaction mechanism for Pt–0.5Mn/Ti catalyzed CO oxidation consisting of four pathways was proposed.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 13.2
Jia Zhao,Heng Zhang,Mengfan Luo,Hongyu Zhou,Zehua Wang,Jialong Yin,Chuanshu He,Peng Zhou,Jing Zhang,Bo Lai
Ferrate (Fe(VI)) activation by Mn(II) has been proven as a powerful technology due to the high catalytic activity of Mn(II) and the generation of multiple intermediates. However, the reactivity and stability of these intermediates greatly differ, thus necessitating the precise regulation of redox pathways towards the generation of the most desirable intermediates. In this study, we utilized ligand engineering to finely tune the redox pathways between Fe(VI) and Mn(II). Mn(II) complexing with ethylenediaminetetraacetic acid (EDTA) and nitrotriacetic acid (NTA) switched the redox pathways from generating Mn(IV) to more robust intermediates and enhanced the decontamination ability of Fe(VI). Ligand-to-metal charge transfer promoted the electron migration from Mn(II) complexes to Fe(VI), generating Fe(V) and Mn(III) intermediates. Then, complexing regulated the transformation of Mn(III) to generate different reactive species. Specifically, Mn(II)-EDTA activated Fe(VI) through Fe(IV)/Fe(V) and Mn(V), whereas the Fe(VI)-Mn(II)-NTA system relied on Mn(VII). Owing to the weaker chelating effect of NTA, unstable Mn(III)-NTA was successively oxidized via Mn(V) to Mn(VII). In contrast, the stronger stability of EDTA suppressed the excessive oxidation of Mn(V)-EDTA, boosting pollutant interception of reactive species. Accordingly, the Fe(VI)-Mn(II)-EDTA process delivered stronger activation and wider applicability, diminishing contaminant toxicity and resisting background interference. This study provides valuable insights into Fe(VI) activation induced by transition metal complexes and serves as a reference for selecting efficient strategies to avoid excessive consumption of oxidative capacity.
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JOURNAL OF HAZARDOUS MATERIALS
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2026
·
IF 10.6
Zhe Xu,Weilan Zhen,Chengfeng Liu,Jiantong Zhou,Taicheng An
The speciation compatibility of Cu-ligand complexes and catalytic oxidation systems fundamentally governs their decomplexation efficiency, exhibiting pronounced ligand concentration dependence. While contemporary methodologies predominantly focus on stoichiometric Cu(II)-ligand complexes, their efficacy in treating wastewater with ligand excess remains technologically contentious. This study demonstrates the Mn(II)/peroxymonosulfate (PMS) process as a robust solution for the elimination of Cu(II)-ligand complexes even in excessive ligand environments. Using Cu(II)-EDTA as the representative complex, 90% decomplexation was achieved within 1 and 5 min at [EDTA] 0 :[Cu] ratios of 1:1 and 2:1, respectively, surpassing reported decomplexation approaches such as UV/H 2 O 2 , UV/peroxydisulfate (PDS), and Co 2+ /PMS. Mechanistic investigations through oxidation species characterization and product analysis revealed a successive decarboxylation of EDTA by non-radical pathway, i.e., high valence metals and singlet oxygen, enhancing process selectivity while minimizing oxidant consumption ([PMS] 0 :[EDTA] 0 = 30:1). The system exhibits dual mechanistic regimes: (i) instantaneous decomplexation under ligand-deficient conditions via PMS activation by in-situ formed CuO through alkaline precipitation, and (ii) cascade decomplexation for ligand-rich systems involving Mn-Cu synergistic destruction of excessive EDTA prior to CuO-catalyzed degradation of residual ligand. Such synergism is believed to stem from the electron transfer from Cu(II) to Mn(V/VI), forming reactive Cu(III) for decomplexation through intramolecular electron transfer. The Mn(II)/PMS system also exhibited the applicability in treating various Cu(II)-ligand complexes and real wastewater. This work establishes a practical strategy for reliable treatment of industrial wastewater containing non-stoichiometric Cu-ligand complexes.
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Biomaterials Advances
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2026
·
IF 6.7
Jia Chen,Minghui He,Junxiao Li,Yunqi Shen,Xinkun Shen,Min Lai
Excessive oxidative stress and associated inflammation significantly impair bone regeneration around implants. To address this, we developed a novel therapeutic strategy based on metal-polyphenol nanoparticles self-assembled from tannic acid (TA) and manganese ions (Mn 2+ ). These Mn-TA nanoparticles (Mn-TA NPs) were subsequently incorporated into a gelatin methacryloyl (GelMA) hydrogel, which was then applied as a coating onto TiO 2 nanotube (TNT) surfaces by spin coating. The resulting modified titanium was designated as TNT-GelMA@NPs. Surface and interfacial characterization using scanning electron microscopy (SEM), atomic force microscopy (AFM), contact angle measurement, spectroscopic ellipsometry and nanoindentation confirmed the successful fabrication of a uniform, adherent hydrogel coating on the TNT surfaces. The coating reduced surface roughness while maintaining hydrophilicity, and achieved sustained Mn 2+ release, as verified via inductively coupled plasma atomic emission spectroscopy (ICP-AES). TNT-GelMA@NPs exhibited potent ROS scavenging capacity, protected mitochondrial membrane potential, and upregulated antioxidant genes. Moreover, it promoted macrophage polarization from pro-inflammatory M1 to anti-inflammatory M2 phenotype, thereby creating a favorable osteoimmune microenvironment. Additionally, it promoted osteogenic differentiation by increasing ALP activity, mineralization, and the expression of osteogenic genes. In a rat femoral defect model, TNT-GelMA@NPs implants reduced oxidative damage and inflammation, while enhancing bone formation, as evidenced by histological staining and micro-CT analysis. This study demonstrates that the Mn-TA NP-reinforced hydrogel coating acts as a multifunctional biointerface with excellent potential for advanced implant surface engineering.
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DESALINATION
·
2026
·
IF 9.9
Sehria Zia,Muhammad Kashif,Haojie Ge,Yafei Guo,Tianlong Deng
Mn-Co/Al-LDH enables efficient lithium capturing from Salt Lake Brines. • Fiber adsorbent exhibits excellent Li + selectivity, mechanical stability and durability. • PVDF@Mn-Co/Al-LDH design as fiber functionalization via wet spinning. • Dynamic uptake capacity of Li + 14.94 ± 1.23 mg·g −1 from Da-Qaidam Salt Lake. Lithium‑aluminum layered double hydroxides (LiAl-LDH) have been successfully used on a commercial scale to extract lithium from salt lake brine, their uncertain extraction procedure and inadequate Li + adsorption ability prevent further development of their uses. High selectivity of Li + has been achieved by the LDHs adsorption from high Mg/Li ratio salt lake brine, but zinc and titanium-based LDH adsorbents are unstable in acidic environments and pose environmental hazards. In this study, a novel trimetallic-based PVDF@Mn-Co/Al-LDH fibrous composite material with tunable properties is compared to bimetallic-LDHs. Density Functional Theory (DFT) is used to optimize the composite design and adsorption sites calculations. To approach the industrial application of Mn-Co/Al-LDH powder, it was further fabricated into porous nature fiber by wet spinning technology with cost effective PVDF form as strong binder with hydrophilicity exhibited Li + maximum adsorption capacity by 50% Mn-Co/Al-LDH fiber composition of 16.73 ± 1.02 mg.g −1 from Li + brine and the dynamic adsorption capacity is 14.94 ± 1.23 mg·g −1 with a 93% elution rate and 4–5% dissolution rate of Mn/Co ions. This synthetic fibrous composite adsorbent highlights a promising approach for evaluating LDH's potential in lithium extraction from rich‑lithium high Mg/Li ratio brine resources, due to its superior selectivity, adsorption/desorption performance and cyclic stability. Download: Download high-res image (139KB) Download: Download full-size image
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TETRAHEDRON
·
2026
·
IF 2.1
Zhi Luo,Jialei Gao,Enqi Bai,Weiwei Liu
A bis(NHC)Mn-catalyzed N-alkylation method for phosphinic amide synthesis has been developed in this work. By utilizing the borrowing hydrogen/hydrogen autotransfer (BH/HA) process, 24 examples with good to excellent yields have been obtained. This method has been demonstrated to be versatile and efficient, enabling new syntheses of bioactive molecules and functional materials, as well as the conversion of simple alcohols into complex organics.
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Yuhao Yuan,Linya Zeng,Lun Yuan,Qingsu Cheng,Yibo Chen,Panyu Li,Liming Ge,Yandong Mu,Changdao Mu,Zhilang Xu,Defu Li
The repair of irregular periodontal bone defects remains a formidable clinical challenge due to the complex oral microenvironment, which demands that therapeutic materials integrate early antibacterial and anti-inflammatory effects with sustained osteogenic support. Herein, we present an injectable multifunctional double-cross-linked hydrogel (GGCM) based on gelatin and chondroitin sulfate (CS), incorporating Mg/Mn-based nanozymes (MPM NZs) for photothermal therapy of periodontitis. MPM NZs were first synthesized via chemical deposition of nano-MnO2 onto mesoporous MgO nanoparticles and subsequently incorporated into a dual-cross-linked network formed by glycidyl methacrylate-modified gelatin and oxidized chondroitin sulfate (OCS) through sequential Schiff base and photopolymerization reactions. The resulting GGCM hydrogel exhibited a favorable microporous architecture, robust physicochemical properties, and excellent injectability to fill irregular periodontal pockets. Notably, MPM NZs endowed the hydrogel with potent photothermal antibacterial activity (>95%), superoxide dismutase (SOD)- and catalase (CAT)-mimetic activities for reactive oxygen species (ROS) scavenging, and the sustained release of bioactive Mg2+ and Mn2+ ions for immunomodulation and osteogenesis. Importantly, GGCM enables a time-sequential regenerative therapeutic cascade comprising rapid periodontal pathogen elimination upon NIR irradiation, subsequent anti-inflammatory immunomodulation via M2 macrophage polarization, and continuous osteogenic promotion and alveolar bone resorption reduction. Collectively, this multifunction-integrated MPM NZ-enhanced double-cross-linked hydrogel exhibits promising potential for periodontal bone regeneration, positioning it as a highly attractive photothermal therapeutic strategy for periodontitis and even other complex infectious bone defects.
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CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Lixia Jia,Qi Zhou,Yuanwei Li,Weizhong Wu
In this study, Mn-C composites using different MnO 2 contents and solid carbon material were prepared to explore the synchronous removal performance of nutrients and SMX. Higher nitrate removal performance (97–98 %) with quickest nitrate removal rate (4.97 mg N L -1 h −1 ) was obtained in Mn_20 systems. The increased Mn content and Mn-P compound were observed via surface characteristics, indicating the involvement of MnOx in pollutants removal , particularly for higher phosphorus removal (84–89 %) via Mn-P precipitation and BioMnOx adsorption. Nevertheless, compared to systems based on Mn_0 composites (74 %), systems with Mn-C composites presented lower SMX reduction efficiency (34–51 %), which might be attributed to the large Mn(II) accumulation, impairing certain microbes and lower the MnOx function. Higher abundance of genera affiliated to Bacteroidetes_vadinHA17 and Rhodocyclaceae was observed in the Mn-C composites, as well as the gathering of Geobacter and Desulfovibrio as keystone taxa, responsible for the removal of nitrate and SMX and microbial interactions. Besides, the increase of sulfonamide ARGs was closely related to the predominant microbes in the Mn-C composites, which acted as the hosts of ARGs. This study broadens the knowledge of Mn-C composites in synergetic removal of nutrients and organics, and supports the potential application of manganese oxide in wastewater treatment.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 23
·64233-64245
·
IF 5.8
Jin Qi,Dong Yingbo,Pan Hanlin,Lin Hai
It is challenging to separate the materials for treating arsenic contamination of soil and water from systems. The natural magnetite covered with Fe–Mn bimetallic (oxyhydr)oxide (Fe–Mn MSM) was effectively created in this study, and its potential use in removing As from water and soil was investigated. Batch adsorption studies showed that the As(V) adsorption on Fe–Mn MSM could achieve equilibrium after 120 min when the initial As(V) concentration was 39.85 mg/L. The calculated maximum adsorption of Fe–Mn MSM for As(V) was 17.94 mg/g at 20 °C. The mechanism of As(V) adsorption was confirmed to be a combination of ligand exchange and electrostatic attraction by the outcomes of FTIR analysis, SEM, and batch adsorption tests. Fe–Mn MSM can also be a successful amendment for cleaning up As-polluted soil. The 5% Fe–Mn MSM treatment group had the lowest exchangeable fraction of As (EX-As) concentration, 0.039 mg/kg (8.3% of initial EX-As), after 40 days. Magnetic separation could be used to quickly and completely recover the used Fe–Mn MSM from the soil. EX-As was present in higher concentrations on Fe–Mn MSM than that of the original soil. As a result, this work offers a strategy that may be put into practice to cheaply remove As from soil and water while also encouraging the reuse of natural magnetite. Graphical abstract
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危险品化学品经营许可证（带存储）