JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2026
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IF 4.9
Qianqian Liu,Yusong Pan,Peixuan Zou,Ling Peng,Cuilian Wei,Wenjie Luo,Run Huang,Xiuling Lin,Jun Tao
This study overcomes intracellular antioxidant barriers limiting chemodynamic therapy (CDT) by designing an Fe-Cu bimetallic organic framework (MOF) nanocarrier. Synthesized solvothermally, the spindle-shaped MOF (long axis: 3.5 μm; short axis: 2 μm) exhibits a high specific surface area (381.96 m 2 /g) and mesopores (6.69 nm diameter), as verified by SEM/XRD/FT-IR/BET/XPS. The coexisting Fe 3+ /Fe 2+ and Cu 2+ sites enable synergistic catalysis, achieving 68.2 ± 2.1% doxorubicin (DOX) loading with pH-responsive release in tumor-mimetic acidosis (pH 5.4; 78% cumulative release at 72 h, 7.8× higher than neutral pH). In vitro studies confirm dual functions: efficient glutathione depletion (60% absorbance reduction at pH 6.2, 300 μg/mL MOF) and enhanced hydroxyl radical generation via Fenton/Fenton-like reactions (40× TMB absorbance increase). Cell assays demonstrate low cytotoxicity to normal 293T cells within 48 hours (>80% viability at 25 μg/mL) versus potent synergistic efficacy against HeLa cells under simulated tumor microenvironment (100 μM H 2 O 2 ), where chemo-CDT reduces viability to 35% (31.4-37.5% improvement over monotherapies). This work establishes a self-driven platform for tumor-targeted synergistic therapy.
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ACS Applied Materials & Interfaces
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2026
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IF 8.2
Yongting Li,Chenyang Shen,Bowen Chen,Chenjia Liang,Yiming Bi,Congyan Jiang,Qiaolun Liu,Yongzheng Wang,Weiping Ding,Xuefeng Guo
Traditional Fischer–Tropsch synthesis (FTS) on iron-based catalysts is limited by the Anderson–Schulz–Flory (ASF) distribution, with a maximum theoretical selectivity of 58% for the C2–C4 hydrocarbons, accompanied by substantial methane byproduct formation. Suppressing methane formation while enhancing light olefin selectivity is of great significance, however, it remains a major challenge in this field. Herein, we developed a series of Fe/Cux@Al2O3 surrounded catalysts, which in situ formed a unique ε-Fe2C/Cu interfacial structure during the FTS. The optimized Fe/Cu3.8@Al2O3 catalyst achieved 84.7% selectivity toward C2–C4 hydrocarbons, significantly exceeding the ASF distribution limit, with a low CH4 selectivity of 8.9% and an unprecedented light olefin selectivity of 62.3%. Further investigation and theoretical calculations revealed that in the FTS reaction, CO and H2 adsorbed and dissociated on the ε-Fe2C surface, leading to the formation of CHx and CnHm intermediates through hydrogenation and chain-growth processes. Meanwhile, H* dissociated on the Cu surface migrated to the adjacent ε-Fe2C sites via hydrogen spillover. The appropriate supply of H* regulated the hydrogenation and desorption of CHx and CnHm species, simultaneously suppressing CH4 formation and limiting long-chain hydrocarbons (C5+) production. This work provides valuable insights and strategies for designing advanced FTS catalysts for the highly selective production of light olefins from syngas.
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Nano-Micro Letters
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2026
·Vol. 18
·期 1
·131
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IF 36.3
Fang Wei,Ou Zeping,Wang Yifan,Li Zhe,Huang Qian,Zhang Pengchi,Li Xinzhe,Zheng Yujie,Hu Lijun,Li Chen,Ouyang Jianyong,Sun Kuan
A novel Cu + /Cu 2+ redox couple was introduced to enable a thermosensitive crystallization process, significantly enhancing thermopower from 1.47 to 2.93 mV K ‒1 .
A readily fabricated etched carbon cloth electrode offered an enlarged electroactive surface area, demonstrating superior current density through improved kinetics.
The optimized Cu + /Cu 2+ system, achieved through synergistic enhancements in thermodynamic and kinetic performance, delivered an outstanding normalized power density P max ( ΔT ) ‒2 of 3.97 mW m ‒2 K ‒2 .
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POLYMER BULLETIN
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2026
·Vol. 83
·期 11
·593
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IF 4.2
Tang Zhong-Xiang,Wu Bin,Shi Ying-Jia,Jin Meng,Yu Tian,Ren Hui,Ma Ning,Zhan Xue-Qing,Tsai Fang-Chang
Efficient wound management remains a critical challenge in clinical medicine and public health. Hydrogel-based wound dressings have garnered significant attention due to exceptional moisture retention and inherent cooling analgesia effects. This study develops an electrically triggered PVA/Cu-BTC@Aloe composite hydrogel for advanced wound healing. By incorporating Cu-BTC@Aloe nanocomposites (synthesized via Aloe adsorption onto Cu-BTC followed by freeze-thaw crosslinking with polyvinyl alcohol), the material achieves enhanced mechanical properties (tensile strength: 438.9 ± 42.7 kPa, + 47% vs. pure PVA) and dual functional capabilities. Under 3 V electrical stimulation, the cumulative release of Aloe at 3 h increased from 47% to 62%. Meanwhile, the hydrogel achieved antibacterial efficiencies of 97.8 ± 2.2% against Staphylococcus aureus and 99.9 ± 0.1% against Escherichia coli, while maintaining favorable cytocompatibility and promoting directional cell migration toward the anode of fibroblasts. The integration of electroresponsive materials, natural bioactive constituents, and electrical stimulation provides a promising multifunctional platform for electrically assisted wound management.
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AICHE JOURNAL
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2026
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IF 4.4
Yajie Yu,Haiyi Chen,Kaiji Xu,Jinxin He,Bin Chen,Kok Bing Tan,Dongren Cai,Guowu Zhan
Conventional supported Cu catalysts for the reverse water-gas shift (RWGS) reaction suffer from activity-selectivity trade-offs and stability issues. Herein, we report a carrier-free Cu catalyst (bio-Cu) synthesized via a pollen-templated strategy. The template creates a hierarchical porous framework and enables in situ carbon doping (~4 wt%), ensuring homogeneous Cu dispersion and inhibiting agglomeration. In the RWGS reaction, the bio-Cu catalyst exhibits outstanding performance, achieving >99.1% CO selectivity with 25.3% CO 2 conversion at 340°C and 3 MPa, approximately 3.2 times higher than a conventional Cu benchmark. Under ambient pressure at 450°C, it maintains 30.5% conversion with 99.99% CO selectivity and shows exceptional stability over 100 h. Mechanistic studies reveal that carbon doping generates electron-deficient Cu δ+ species and promotes a synergistic carbon cycle that operates alongside the conventional redox pathway, collectively enhancing the catalytic efficiency. This work provides new insights into the rational design of high-performance, carrier-free CO 2 hydrogenation catalysts.
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JOURNAL OF BIOMATERIALS APPLICATIONS
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2026
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IF 2.4
Xuejiao Ma,Yunhan Huang,Xinyu Wang,Jingrui Chang,Xiangru Xu,Aolin Chen,Bo Lu
Precisely targeting the site of bacterial infection while reducing harm to healthy tissues has turned into the primary aim of bacterial infection treatment. Based on this background, an acidity-triggered aggregation nanomaterial Cu2+/ZIF-8@PDA-GCS (CZPG) based on bimetallic doped metal-organic frameworks was designed. The zinc-based metal-organic framework doped with Cu2+, namely Cu2+/ZIF-8 (CZ), was first synthesized, followed by modification with polydopamine (PDA) and glycol chitosan (GCS) to endow the CZ with photothermal properties and pH-sensitive charge characteristics, respectively. Under normal physiological conditions, the potential value of CZPG is approximately neutral, and it shows poor affinity to normal tissue cells, but the surface potential of CZPG flips to positive potential at the site of acidic bacterial infection. This allows CZPG to aggregate and adhere on the surface of negatively charged bacteria to ensure the spatial accuracy of CDT/PTT and thus enhance the antibacterial effect.
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ACS Sustainable Chemistry & Engineering
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2026
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IF 7.6
Jiahui Zhou,Ziyi Zhang,Chenghao Jin,ShanShan Tong,Yunteng Qu
Electrochemical CO2 reduction reaction (CO2RR) to diverse high-value chemicals represents a promising carbon mitigation strategy, yet precisely controlling product selectivity remains a considerable challenge. Herein, we report a size-dependent Cu/CN catalyst for modulating the selectivity of CO2RR. Specifically, small Cu NPs on CN (∼5 nm, S–Cu/CN) achieved a 76.2% C2+ product selectivity at 0.6 A cm–2, while the large one (∼50 nm, L-Cu/CN) reached a 67.5% CH4 selectivity at 0.6 A cm–2. Physical characterizations revealed that S–Cu/CN displays partial Cu+ sites, whereas L-Cu/CN higher Cu+ content. Mechanism analysis revealed a balanced Cu0/Cu+ ratio in S–Cu/CN promotes C–C coupling at Cu+ sites to form C2+ products. Conversely, higher Cu+ content in L-Cu/CN decreased the *CO coverage and improved H2O dissociation, steering continuous hydrogenation toward CH4 generation. This work offers a novel strategy to design high-efficiency CO2RR electrocatalysts toward desired products.
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SENSORS AND ACTUATORS A-PHYSICAL
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2026
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IF 5.1
Yufang Cui,Wanyin Ge,Maohao Yang,Xin Dong,Bochuan Zhang
Breakthrough: Ag/Cu bimetallic sensitization and UV activation enables efficient room-temp NO 2 detection. • High response (2180 to 200 ppm NO 2 ) with fast 7/10 s response/recovery at RT under UV. • High selectivity and moisture resistance, integrated into smart masks for breath-level detection. Metal oxide semiconductor (MOS) NO 2 gas sensors are hindered from achieving high-performance, low-power practical applications due to their slow response/recovery times and excessively high operating temperatures. To overcome these obstacles, we propose a synergistic strategy combining silver/copper (Ag/Cu) bimetallic nanoparticle surface modification with ultraviolet (UV) light activation. Using NH 2 -MIL-68 as a sacrificial template, In 2 O 3 rod-like materials were prepared via a hydrothermal method, and Ag/Cu bimetallic nanoparticles were further decorated on their surface to construct a high-performance NO 2 sensor (Ag/Cu-In 2 O 3 ) capable of operating at room temperature. Under UV light excitation, the Ag/Cu-In 2 O 3 -1 sensor exhibited a high response of 2180 toward 200 ppm NO 2 , with response and recovery times as short as 7 s and 10 s, respectively. Moreover, the sensor showed excellent selectivity for NO 2 against various interfering gases and good humidity tolerance. The enhanced performance is attributed to the synergistic sensitization of Ag/Cu bimetallic nanoparticles and the photogenerated holes induced by UV illumination during response and recovery. This study highlights the potential of Ag/Cu-In 2 O 3 for room-temperature NO 2 sensing and demonstrates the effectiveness of UV excitation in boosting MOS gas sensor performance. Download: Download high-res image (135KB) Download: Download full-size image
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CHEMICAL ENGINEERING SCIENCE
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2026
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IF 5.1
Lin Li,Kaiyun Yang,Zhan Ding,Chang Liu
Spodumene is often associated with quartz in ore deposits. Due to their similar physicochemical properties, achieving selective flotation separation using sodium oleate (NaOL) alone is challenging. This study proposes an innovative reagent scheme for selectively separating spodumene from quartz via flotation. The approach employs a Cu(II)/peroxymonosulfate (PMS) advanced oxidation process to activate the spodumene surface, which subsequently promotes the adsorption of NaOL as the collector. Single-mineral flotation tests demonstrated that under the conditions of pH 8, NaOL concentration of 8 × 10 −4 mol/L, Cu(II):PMS molar ratio of 3:1, and total Cu(II)/PMS concentration of 3 × 10 −4 mol/L, the recovery of spodumene reached 93.48%, while that of quartz was only 0.91%. Artificial mixed mineral flotation tests yielded a spodumene concentrate with a Li 2 O grade of 6.52% and a recovery of 83.46%. The activation mechanism was investigated using zeta potential, contact angle, Fourier transform infrared spectroscopy (FTIR), electron paramagnetic resonance (EPR), scanning electron microscopy with energy dispersive spectroscopy (SEM), and X-ray photoelectron spectroscopy (XPS) analyses. The results indicate that OH generated by the Cu(II)/PMS system is associated with cleaning of the spodumene surface and modification of its chemical environment, which in turn correlates with enhanced NaOL adsorption and increased surface hydrophobicity. These observations are consistent with the improved flotation separation of spodumene from quartz under the tested conditions. This study presents a promising activation strategy for the efficient flotation of spodumene.
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Inorganics
·
2026
·Vol. 14
·期 7
·183
·
IF 3.4
Xianguang Bai,Huiping Wang,Zebao Lu,Bin Li
A novel carbohydrazide-based ligand (L) and its binuclear Cu(II) complex were successfully synthesized and characterized. Structural analysis confirmed that the Cu(II) complex adopted a monoclinic crystal system with a distorted coordination configuration, in which the multidentate Schiff base ligand chelated and bridged two Cu(II) centers. The in vitro anti-tumor results revealed that the Cu(II) complex exhibited prominent cytotoxicity against five human cancer cell lines with much lower IC50values than the free ligand, copper chloride and cisplatin. Mechanistic studies demonstrated that the Cu(II) complex significantly increased intracellular ROS and MDA levels, decreased the GSH/GSSG ratio, and reduced ATP content, thereby disrupting cellular redox balance and bioenergetic metabolism. In addition, flow cytometry analysis verified that the complex effectively triggered tumor cell apoptosis. In contrast, free CuCl2showed almost no anticancer activity, indicating that the synergistic effect between the Schiff base ligand and copper ions contributed to the excellent anti-tumor performance. This work suggests that the prepared binuclear Cu(II) complex can serve as a promising candidate for developing metal-based anticancer agents.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
·
IF 9.6
Ji Liu,Long-peng Fang,Yuan-gu Xia,Meng-fan Liu,Jia-he Wang,He-ming Liu,Bin Hu,Kai Li,Zhen-xi Zhang,Qiang Lu
Trace Ag (Ag/Cu = 0.001) significantly enhanced Cu-Zn catalyzed CO 2 hydrogenation. • STY MeOH of Cu-Zn-Ag 0.001 was 467.8 g·kg −1 ·h −1 , 1.82 times higher than Cu-Zn. • Ag promotes oxygen vacancy formation around active sites at the Cu-ZnO interface. • Methanol synthesis follows the formate pathway with Ag lowering energy barriers. The methanol synthesis from catalytic CO 2 conversion has emerged as an attractive strategy for carbon valorization and sustainable energy generation. However, the catalytic efficiency of conventional Cu-Zn-based catalysts remains far from satisfactory. Herein, a Cu-Zn-Ag catalyst, synthesized via a facile co-precipitation method, exhibited a significantly improved methanol production activity compared with Cu-Zn catalysts. Notably, a trace amount of Ag doping (the Ag/Cu molar ratio was 0.001) could significantly elevate the methanol generation, with its space-time yield increasing from 258 ± 17 to 468 ± 23 g MeOH ·kg cat −1 ·h −1 , an increase of 1.82 times, while further increasing Ag doping would lead to reduced activity. Structural characterizations confirmed the Ag presence, being doped in the Cu lattice, and Ag doping was significantly beneficial to oxygen vacancy formation, which was deemed the active sites for methanol formation. The detailed reaction pathway (formate pathway) for methanol synthesis was also investigated based on density functional theory (DFT) calculations, where Ag doping lowered the energy barriers. This work elucidates the mechanism of Ag doping in Cu-Zn catalysts and provides key insights into the reaction mechanism of CO 2 hydrogenation to methanol, highlighting its potential for sustainable methanol synthesis. Download: Download high-res image (177KB) Download: Download full-size image
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MATERIALS CHARACTERIZATION
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2026
·
IF 6.2
Huadong Ye,Haohao Zou,Xinru Gong,Weiwei Zhu,Ying Han,Pan Dong,Xu Ran
A 3 vol% Ti 3 C 2 Tx@Ag addition achieves a strength–ductility synergy in Cu composites. • The Ag decoration improved MXene dispersion and interfacial bonding with Cu. • The Ti 3 C 2 Tx@Ag/Cu composites exhibited enhanced mechanical and tribological properties. Aerospace, rail transportation, and electronics require Cu-based materials with high thermal conductivity together with adequate mechanical and tribological performance. However, the relatively low strength, hardness, and wear resistance of Cu limit its use under demanding service conditions. Herein, Ti 3 C 2 T x MXene nanosheets were decorated with Ag nanoparticles, and Ti 3 C 2 T x @Ag/Cu composites were fabricated by ball milling followed by fast hot-press sintering. Ag nanoparticles were uniformly distributed on the Ti 3 C 2 T x surfaces, and the addition of Ti 3 C 2 T x @Ag progressively refined the Cu matrix grains from 5.31 μm in pure Cu to 1.24 μm at 10 vol% reinforcement. The 3 vol% Ti 3 C 2 T x @Ag/Cu composite exhibited the best strength–ductility balance, with an ultimate tensile strength of 288.5 MPa and an elongation of 41.8%, compared with 255.3 MPa and 37.6% for pure Cu, respectively. The hardness increased continuously from 48 to 116 HBW, whereas thermal conductivity showed a non-monotonic dependence on reinforcement content. Ti 3 C 2 T x @Ag produced only a modest change in the average friction coefficient but markedly improved wear resistance; the wear rate decreased from 21.24 × 10 −5 mm 3 ·(N·m) −1 for pure Cu to 6.29 × 10 −5 mm 3 ·(N·m) −1 at 10 vol%, corresponding to a 70.4% reduction. Worn-surface, wear-debris, and cross-sectional observations indicate that the improved wear resistance is mainly associated with suppressed cracking and large-scale material spalling, while friction-induced mechanical mixing and oxidation may provide an additional contribution. These results demonstrate that Ag-decorated Ti 3 C 2 T x is an effective reinforcement for jointly regulating the mechanical, thermal, and tribological behavior of Cu composites.
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