Journal of Environmental Chemical Engineering
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2020
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IF 4.3
Yong Pan,Tengyang Zhu,Qing Xia,Xi Yu,Yan Wang
Emerging pervaporation technology is very promising to realize clean and renewable bioethanol recovery from biomass fermentation broth. The huge challenge of this technology is the need for a pervaporation membrane with high separation performance. Based on the solution-diffusion mechanism, pervaporation membrane for ethanol recovery should possess hydrophobic selective layer to improve sorption ability toward ethanol molecules, thereby enhancing the separation performance. In this study, a superhydrophobic zeolitic imidazolate framework-8 (ZIF-8) layer with a nano-level bud-like surface morphology was grown on polydimethylsiloxane (PDMS) composite membrane via ZIF-8 particle dip-casting, secondary seeded growth, and hydrophobic modification by n-octadecylphosphonic acid for highly efficient ethanol/water separation. The mole ratio of 2-methylimidazole and zinc nitrate (Hmim/Zn 2+ ) in the process of ZIF-8 secondary growth was systematically studied to construct appropriate micro-nano structure on PDMS composite membrane. The resultant optimal composite membrane exhibited a water contact angle of about 163° and an ethanol contact angle of 0°. In addition, it also displayed an outstanding separation factor of 17.4 corresponding to a total flux of 0.64 kg/m 2 h with 5 wt% ethanol aqueous solution at 30 ℃, and thus the superior pervaporation performance to most other reported PDMS-based mixed matrix membranes. The strategy of constructing superhydrophobic layer on PDMS composite membrane may provide a meaningful guidance for preparing high-performance pervaporation membrane for organic recovery from aqueous solution.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2021
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IF 5.268
Xiaoyan Yang,Huihui Chai,Lingli Guo,Ying Jiang,Liqun Xu,Wei Huang,Yijun Shen,Ling Yu,Yingshuai Liu,Jing Liu
Poly-ether-ether-ketone (PEEK) is a promising material in oral repair and orthopedic implantation field due to its stability and proper elastic modulus. However, the lack of simple but effective strategy to functionalize PEEK and improve its antibacterial function hinders its further biomedical application. In this study, a sulfonated 3D porous PEEK is fabricated via sulfonation treatment, and then decorated with the in situ synthesized zeolitic imidazolate framework-8 (ZIF-8), in which Ag + ions were loaded with high loading capacity. Surface morphology, roughness, chemical composition and hydrophilicity of all the substrates were evaluated in details, suggesting Ag + ions loaded ZIF-8 on sulfonated PEEK (SPZA) was successfully prepared. The antibacterial activity of pristine and functionalized PEEK was evaluated by inhibition zone test, spread plate assay, growth curve, and morphology of bacteria. Experimental results demonstrate that the SPZA has effectively bacteriostatic performance against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ). The excellent antimicrobial activity is attributed to the synergistic effect of Ag + and Zn 2+ ions released continuously from SPZA. This work provides a promising route for surface modification of PEEK and offer a potential candidate for biomedical implants.
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IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
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2024
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IF 5.6
Hongxin Zhang,Xuegang Li,Xue Zhou,Yanan Zhang,Yong Zhao
As a low-density lipoprotein, tributyrin plays a vital role in food safety and human health. In this work, we first proposed a novel high-performance tributyrin sensor made by supporting zeolitic imidazolate framework-8 (ZIF-8) and lipase onto the optic fiber sensor based on the surface plasmon resonance (SPR) principle. After adsorption of lipase within the ZIF-8 framework, through a rapid aqueous synthesis method, a thin and dense ZIF-8 film can be uniformly formed and stably and tightly bonded to the surface of the optical fiber sensor. ZIF-8 is one of the metal–organic frameworks (MOFs), which not only has the high porosity and specific surface area of MOFs, but also shows good affinity with lipase. The experimental results show that the proposed sensor can achieve the specific detection of tributyrin in the linear range of 0.1–3 mM, the sensitivity is 14.75 nm/mM, with a detection limit of 0.096 mM. The sensor proposed in this article for the first time using ZIF-8/lipase composite material to detect tributyrin has an accuracy of more than 83% in sample detection at the range of 0.1–3 mM. In addition, the stability test of the proposed sensor is as good as 0.47 nm, and the selectivity (in the presence of glycine, acetylcholine, glucose, and urea) of the sensor was analyzed. The sensor proposed in this article has the advantages of a low sample consumption of $100~\mu \text{L}$ , high sensitivity, simple structure, and label-free measurement. This method provides a new route for the rapid and reliable detection of tributyrin, which has potential applications in medical research and clinical diagnosis.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Yinan Qiu,Jia Gao,Wenhui Chu,Shanshan Xia,Chen Huang,Huayue Zhu,Xiaolong Sun,Yongqian Fu
Acute lung injury (ALI) is a critical respiratory syndrome significantly impacting patient health. Tetrastigma hemsleyanum Diels et Gilg (Sanyeqing, SYQ) is a traditional Chinese medicine and its polysaccharides (SYQP) have demonstrated efficacy in counteracting lipopolysaccharide-induced ALI. This study characterized the structure of SYQP and synthesized the SYQP@ZIF-8 composite using biomimetic mineralization, evaluating encapsulation and release efficiency. The biocompatibility of SYQP@ZIF-8 in vitro was assessed by the CCK-8 colorimetric assay and hemolytic activity. Inflammatory cytokine was measured to evaluate the therapeutic effect. The efficacy of SYQP@ZIF-8 in lung injury was assessed using a mice ALI model. Characterization showed SYQP as a homogeneous α-type polysaccharide, comprising galactose, mannose, glucuronide, glucose, galacturonide, and arabinose, with a molecular weight of 516.94 kDa. SYQP@ZIF-8 exhibited high encapsulation rate (> 90 %), rapid pH-responsive release (within 60 min up to ~100 %), low toxicity and favorable hemolytic characteristics. Furthermore, it demonstrated reduced inflammatory cytokine secretion compared to SYQP, along with a superior inhibitory effect. The outcomes of in vivo experiments, including a decrease in the W/D ratio and LDH activity, further confirmed the efficacy of SYQP@ZIF-8 in treating LPS-induced ALI. In conclusion, SYQP@ZIF-8 released SYQP in acidic inflammatory conditions, outperforming SYQP alone in treating ALI.
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DIAMOND AND RELATED MATERIALS
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2024
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IF 4.3
Fenghai Zhou,Wei Li,Junjie Ma,Shaocong Wang,Mingjun Lu,Zheng Liu,Guo-Cheng Han
N-doped porous carbon material (N-PC) was generated through high-temperature cracking, using ZIF-8 as a template, and preparation of Na 3 V 2 (PO 4 ) 2 F 3 /N-PC composites were designed and prepared as cathode materials for sodium-ion batteries, and the electrochemical sodium storage performance was systematically investigated. The physical characterization results showed that the addition of N-PC played a role in increasing the electrical conductivity of Na 3 V 2 (PO 4 ) 2 F 3 material and improving the specific surface area. The electrochemical test results showed that the discharge specific capacity of Na 3 V 2 (PO 4 ) 2 F 3 /N-PC composite was 109.56 mAh/g at 0.1C, and the capacity retention rate was 85.10 % after 100 cycles, and the R SEI of Na 3 V 2 (PO 4 ) 2 F 3 /N-PC composite (81.55 Ω) is better than that of Na 3 V 2 (PO 4 ) 2 F 3 pure-phase material (142.5 Ω), which indicates that the ion transfer impedance of the modified material has been effectively reduced, and the ion de-embedding is more fluent.
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ADVANCED FUNCTIONAL MATERIALS
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2025
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IF 19
Qingtao Liu,Weihao Liu,Xin Wan,Weiwei Chen,Xiaozhi Liu,Xiaofang Liu,Jiaxiang Shang,Jungang Miao,Dong Su,Xin Sun,Jianglan Shui
Zeolitic imidazolate framework-8 (ZIF-8) is widely used as precursor for carbon-supported single-metal-atom catalysts (M–N–C), but typically yields amorphous carbon with poor stability in proton-exchange-membrane fuel cells (PEMFCs). Traditional methods would lose active site density while increasing the graphitization degree. Here, this study reports that ultra-small nano ZIF-8 can produce graphene-nanostacks-based Fe–N–C that has improvements on both activity and stability. First, anti-sintering nanoporous ZIF-8 (nano-ZIF8) particles are synthesized with unit size of 8 nm (the smallest so far) using a destruction-reconstruction strategy. In situ microscopy reveals that the volatilization of Zn has a decisive effect on the graphitization degree of ZIF-8 and such process is size-dependent. Nano-ZIF8 particles have completed Zn volatilization before graphitization process beginning, leading to graphene nanostacks. These nanostacks preferentially host edge-type FeN 4 sites, which have doubled intrinsic activity and much improved stability compared with conventional Fe−N−C. In PEMFC, the catalyst achieves an activity of 48.5 mA cm − 2 @0.9V iR -free , meeting the US Department of Energy 2025 activity target. In addition, quantitative analysis of active site density is conducted in PEMFC for the first time using nitrite stripping voltammetry. The unique graphitization behavior of nano-ZIF8 paves a new avenue for advancing M–N–C catalysts.
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Food Packaging and Shelf Life
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2025
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IF 10.6
Huixuan Zhang,Xue Yang,Yingying Zhang,E. Zhao,Haimiao Tian,Keshan Wang,Ning Ji,Yuanyuan Liu,Rui Wang
The growing consumer demand for fresh fruit accelerates the advancement of fruit preservation packaging technology. Functional packaging materials, incorporating natural active substances and nanomaterials, offered a foundation for effective preservation. While traditional nanomaterials, predominantly solid in nature, failed to provide adequate channels for material exchange necessary to meet the respiratory requirements of fruits. In this study, porous metal-organic framework zeolitic imidazolate framework-8 (ZIF-8) was synthesized and combined with tannic acid to construct respiratory channels, which were subsequently incorporated into chitosan/gelatin/polyvinyl alcohol composite films. The results demonstrated that ZIF-8@tannin strengthened the cross-linked network structure of the polymer, thereby enhancing the biocompatibility, thermal stability, mechanical strength, and barrier properties of the composite film. Simultaneously, the porous structure provided respiratory pathways that effectively regulated the respiration intensity of preserved blueberries. Notably, the CTZ100 film (100 mg ZIF-8, 20 mg tannin) exhibited optimal overall performance, successfully inhibiting microbial spoilage, weight loss, hardness reduction, and moisture migration during storage. This approach offered valuable insights for developing biodegradable active packaging with antioxidant capabilities and enhanced respiratory support, addressing quality and safety challenges in fruit preservation.
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Molecular Catalysis
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2025
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IF 4.9
Huan-huan Fan,Wei Su,Jing-zhi Wu,Wen-long Liu,Chu-an Lin,Qing-yun Li,You-yan Liu,Ai-xing Tang
This study addresses challenges in the chemoenzymatic epoxidation of α-pinene, such as lipase deactivation, carrier decomposition in acidic environments, and product ring-opening side reactions, by developing a core-shell structured metal-organic framework (MOF)-based immobilized enzyme catalyst, CALB@ZIF-8@Zn-BTC. Candida antarctica lipase B (CALB) was encapsulated into ZIF-8 channels via in situ encapsulation. Trisodium citrate was introduced to accelerate the aggregation and co-precipitation of ZIF-8, while 1,3,5-benzenetricarboxylic acid (H₃BTC) coordinated with surface zinc ions of ZIF-8 to form a core-shell composite with enzyme protection and acid-buffering functionalities. Experimental results demonstrated that sodium citrate significantly enhanced acid scavenging capacity, suppressing acidic side reactions and achieving 96.6 % epoxidation selectivity. The Zn-BTC shell improved ZIF-8 stability in acidic systems, retaining over 60 % activity after 7 cycles. Under optimized conditions (3.35 mol/L ethyl acetate, 0.5 mol/L H₂O₂, 0.1 g sodium citrate), α-pinene conversion reached 83.1 %. Compared to the commercial catalyst Novozym435, CALB@ZIF-8@Zn-BTC exhibited superior catalytic efficiency, selectivity, and reusability. Structural characterization (FESEM, EDS, nitrogen adsorption) confirmed enhanced mass transfer and stability due to the composite’s unique architecture and uniformly distributed sodium citrate. This work provides an innovative solution for green and efficient α-pinene epoxidation and offers theoretical and practical insights for designing MOF-based catalysts in acidic environments.
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Frontiers in Bioengineering and Biotechnology
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2025
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IF 4.8
Bo Zhou,Chen Zhang,Sheng Dai,Jin Zhao,Huaiyu Li,Yanbin Peng,Yunfeng Chu,Zhong Chen,Haotian Qin,Hui Zeng
Background: Chronic diabetic wounds remain a major clinical challenge due to persistent ischemia, oxidative stress, and impaired angiogenesis. Injectable hydrogels capable of adapting to irregular wound beds and delivering bioactive cues offer promising therapeutic potential for enhancing tissue regeneration.Methods: We developed a multifunctional injectable hydrogel by incorporating cinnamaldehyde-loaded ZIF-8 nanoparticles (CA@ZIF-8) into a gallic acid–grafted gelatin (GGA) matrix, followed by transglutaminase-mediated crosslinking. The physicochemical characteristics, drug release behavior, and mechanical performance of the CA@ZIF-8/GGA hydrogel were systematically evaluated. In vitro assays using human umbilical vein endothelial cells (HUVECs) were conducted to assess cytocompatibility and angiogenic activity. A full-thickness skin wound model in streptozotocin-induced diabetic rats was employed to evaluate in vivo wound healing efficacy and biocompatibility.Results: The CA@ZIF-8/GGA hydrogel exhibited favorable injectability, enhanced mechanical strength, and sustained release of both cinnamaldehyde and Zn2+. In vitro, the hydrogel significantly promoted HUVEC proliferation, migration, and tube formation, accompanied by upregulated expression of CD31 and VEGF. In vivo, CA(0.6)@ZIF-8/GGA-treated wounds demonstrated accelerated closure, enhanced granulation tissue formation, increased neovascularization, and re-epithelialization compared with control groups. No histological abnormalities were observed in major organs, indicating good systemic biocompatibility.Conclusion: This study presents an injectable CA@ZIF-8/GGA composite hydrogel that effectively promotes angiogenesis and diabetic wound regeneration. The synergistic integration of MOF-based controlled release and polyphenol-enhanced bioactivity highlights its potential as a clinically translatable platform for chronic wound management.
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CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Zixuan Wang,Wei Ran,Juan Shen,Yuanyuan Cao,Zhongzhong Wang,Simeng Zhang,Rongzhang Hao
The detection of volatile organic compounds (VOCs) markers in exhaled breath based on surface-enhanced Raman scattering (SERS) technology is expected to become a non-invasive diagnosis method for lung cancer patients. However, the inherently low Raman scattering efficiency of trace VOCs in exhaled breath, coupled with the inadequate stability and uniformity of conventional Raman substrates, has hampered the practical application of SERS technologies for lung cancer biomarker detection. Additionally, the development of nanomaterials that simultaneously exhibit superior electromagnetic enhancement capabilities and efficient molecular enrichment functions remains a significant challenge. Herein, we have reported a size-effect-driven strategy for constructing Au nanocube (Au NC) @ zeolite imidazolate framework-8 (ZIF-8) core-shell nanoparticles. Tunability of Au NC@ZIF-8 shell thickness from 3 nm to 40 nm was achieved through cetyltrimethylammonium bromide (CTAB) concentration gradient control (0.5–2 mL) and ice bath kinetics control. This method requires no harsh conditions, featuring simple operation, mild reaction, and short synthesis time, successfully fabricating thin ZIF-8 shell layers with controllable structural properties. This unique architecture integrates the strong localized surface plasmon resonance (LSPR) effect of Au NCs with the porous adsorption capability of ZIF-8, realizing ultrasensitive detection of benzaldehyde (BA) with a limit of detection (LOD) of 2.5 ppb. As a straightforward approach for synthesizing homogeneous and controllable core-shell SERS-active nanoparticles, this method not only offers valuable insights for the preparation of analogous core-shell materials but also provides a robust material foundation and technical support for the non-invasive screening of lung cancer.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2025
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IF 9.7
Haiqiang Ma,Bo Yin,Tong Ye,Ishioma Laurene Egun,Yafei Li,Xianglan Zhang,Haiyong He
Hard carbon rich in closed pores is considered a highly promising anode candidate for advanced sodium-ion batteries (SIBs). Nevertheless, the precise regulation of closed pore structures is significantly impeded by the structural complexity of hard carbon. In this study, a hard carbon with tunable closed-pore architecture was constructed by using ZIF-8-derived porous carbon with uniform pore size (~0.8 nm) and adjustable pore structure as the substrate. Carbonization temperature control and a chemical vapor deposition (CVD)-based pore-sealing strategy were combined to tailor the pore structure and optimize sodium storage performance. The results revealed that the size and number of closed pores are determined by the open-pore characteristics of the carbon substrate; specifically, substrates with larger micropores and higher specific surface areas promote the development of a greater number of closed pores of larger diameters. Benefiting from the optimized closed-pore architecture, the sample ZCHC-1200 exhibits outstanding electrochemical performance, delivering a high reversible capacity of 436.5 mAh g −1 , with a plateau capacity of 265 mAh g −1 . At a high current density of 2C, it provides 236.8 mAh g −1 and retains 86.5 % of its capacity after 100 cycles. In situ Raman and ex situ X-ray photoelectron spectroscopy (XPS) analyses revealed that the predominant contributor to the elevated plateau capacity is Na + filling within closed pores. This study offers a novel strategy for designing closed pores through open-pore modulation, shedding light on the development of next-generation hard carbon anodes for SIBs.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2022
·Vol. 415
·期 5
·855-865
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IF 4.478
Lai Haohong,Niu Yuanyuan,Ming Pingtao,Wang Jinhao,Wang Shumei,Xu Yan,Zhai Haiyun
In this paper, a novel electrochemical sensor was constructed for the detection of purine bases. Ultrafine carbide nanocrystals confined within porous nitrogen-doped carbon dodecahedrons (PNCD) were synthesized by adding molybdate to ZIF-8 followed by annealing. With MoC-based PNCDs (MC-PNCDs) as the carrier, gold nanoparticles (AuNPs) were deposited on the electrode surface via potentiostatic deposition as the promoter of electron transfer, forming a AuNPs/MC-PNCDs/activated glassy carbon electrode (AGCE) sensor. MC-PNCDs had a large specific surface area, which combined with the excellent electrocatalytic activity of AuNPs, synergistically improved the electrocatalytic activity. The morphology and structure of the electrode surface modifier were characterized by scanning electron microscopy, transmission electron microscopy, energy-dispersive X-ray photoelectron spectroscopy, infrared spectroscopy, X-ray diffraction, nitrogen adsorption–desorption analysis, and electrochemical characterization. Under the optimal conditions, the linear detection range of guanine (G) and adenine (A) was 0.5–160.0 μM, and the detection limits (S/N=3) were 72.1 and 69.6 nM, respectively. AuNPs/MC-PNCDs/AGCE was successfully constructed, and was used to simultaneously detect G and A with high sensitivity and selectivity. Moreover, the sensor was successfully used to detect G and A in herring sperm DNA samples. Graphical abstract
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危险品化学品经营许可证（带存储）