ACS Omega
·
2025
·
IF 4.3
Yuxiang Gao,Rong Ma,Lijun Zhu,Zhong Du,Jiabao Xiong,Chi Zhang,Xueliang Zhang,Cailing Ma,Nuernisha Alifu
Near-infrared-II (NIR-II, 900–1700 nm) fluorescence imaging as one of the emerging imaging methods has shown the advantages of excellent spatial resolution and sensitivity. In order to obtain high-quality NIR-II fluorescence images and effective treatment results, it is essential to develop theranostic fluorescent nanoprobes with good tumor targeting and treatment capabilities. Herein, we designed and synthesized novel NIR-II fluorescent theranostic nanoprobes based on the organic dye IR783. IR783 was further encapsulated into liposomes, along with the chemotherapeutic drug doxorubicin (DOX) and the cervical cancer-targeting peptide TMTP1 (NVVRQ), to construct integrated nanoprobes for imaging and treatment. The constructed IR-DT nanoprobes, with its good tumor targeting ability, exhibit excellent imaging performance and significant therapeutic effects. With its powerful imaging capabilities, the IR-DT nanoprobes can achieve high-resolution fluorescence imaging of blood vessels, tumor lesions, and sentinel lymph nodes and could dynamically monitor the dissolution of carotid artery thrombi. The treatment results demonstrate that the nanoprobes possess significant advantages in both tumor-targeting capability and therapeutic efficacy. These findings suggest that it holds great potential to be developed into a theranostic nanoprobe for cervical cancer.
研究领域:
生物医学工程
·
分子影像学
·
癌症治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Daoming Zhu,Meng Lyu,Qinqin Huang,Meng Suo,Ying Liu,Wei Jiang,Yanhong Duo,Kelong Fan
Multifunctional gold (Au)-based nanomaterials with high atomic number (symbol Z) and strong absorbance in the second near-infrared window (NIR-II) property are emerging as promising candidates for tumor thermo-radiotherapy. The main limitations of applying Au-based nanomaterials to biomedical studies include the absence of active tumor-targeting ability, penetrating efficiency, and stability. In this study, we present a novel type of tumor cell-derived stellate plasmonic exosomes (TDSP-Exos) for penetrative targeted tumor NIR-II thermo-radiotherapy and photoacoustic imaging. The TDSP-Exos are abundantly and easily produced by the incubation of tumor cells with gold nanostars, based on which gold nanostars promote the exocytosis of exosomes from tumor cells. Compared with bare gold nanostars, the TDSP-Exos exhibit pronounced accumulation in deep tumor tissues and perform well in both PA imaging and NIR-II thermo-radiotherapy against the tumor. Moreover, the TDSP-Exos improve tumor hypoxia to enhanced radiotherapy by NIR-II photothermal therapy. This work indicates that the tumor cell-derived exosomes have the potential to function as a universal carrier of photothermal agents for targeted tumor NIR-II thermo-radiotherapy.
研究领域:
生物医学工程
·
肿瘤学
·
纳米医学
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Jiajia Wang,Li Li,Ruyi Wei,Renfeng Dong
Here, we report the first PbS quantum dot (QD)-based micromotors with NIR-I light-driven photocatalytic propulsion and NIR-II fluorescence. Under the irradiation of NIR-I light (808 nm), PbS QD-doped cuprous oxide (Cu2O@PbS) micromotors can display efficient propulsion in a variety of biocompatible fuels such as malic acid, glucose, and urea. Among them, the Cu2O@PbS micromotors exhibit the best propulsion performance in a very low concentration of malic acid, with an average speed as high as 11.86 μm/s. The enhanced NIR-I photocatalytic activity of Cu2O@PbS micromotors benefits from the doping of NIR-I PbS QDs that can be excited by NIR-I light and exhibit high electron transport efficiency. The doped PbS QDs can effectively increase the absorption efficiency of the micromotors in the NIR-I region while also inhibiting the recombination of photogenerated electron–hole pairs. Interestingly, due to the presence of NIR PbS QDs, the Cu2O@PbS micromotors demonstrate prominent and stable NIR-II fluorescence (emission wavelength: 1100 nm), which offer promising potential for visualization of their position in vivo. In comparison to other photocatalytic micromotors, the simple fabrication strategy, excellent NIR-II fluorescence, together with the NIR-I light-dependent propulsion behavior of the current Cu2O@PbS micromotors, thus pave the way for further development of advanced smart “robots” for intelligent biomedical applications.
研究领域:
纳米技术
·
生物医学工程
·
材料科学
✓ 已验证
DOI
高影响因子
Advanced Science
·
2025
·
IF 14.1
Yueyang He,Jinyan Lin,Jingwen Bai,Xiao Shen,Kangliang Lou,Yuanyuan Zhu,Zishan Qiao,Weiling Chen,Yang Li,Xiaolong Liu,Guojun Zhang
Breast-conserving surgery (BCS) has become the standard care for early-stage breast cancer. The accurate assessment of tumor margins is urgently required for BCS because positive resection margins often lead to local recurrence. To address this clinical dilemma, a Hf(IV)-coordinated NIR-II fluorescence “turn-on” nanoprobe based on the clinically approved NIR-II fluorescent dye indocyanine green (ICG) for intraoperative tumor visualization is developed. Notably, the fluorescence of ICG can be efficiently quenched by Hf(IV) and subsequently recovered in vivo, showing a remarkable fluorescence “quenching-recovery-amplification” capacity. This nanoprobe can effectively accumulate in tumor sites, accurately identifying submillimeter-sized primary and residual tumors with high sensitivity. In addition, subcutaneous, muscle-infiltrating, and orthotopic breast cancer models are built to repeatedly prove that this ultrasensitive nanoprobe is feasible for precise imaging-guided surgery in breast cancer. Overall, this study constructs an activatable fluorescent nanoprobe for real-time intraoperative tumor margin visualization, holding promise for complete surgical resection and reduction of local recurrence.
研究领域:
肿瘤学
·
生物医学工程
·
分子影像学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Taihe Han,Shuai Mu,Qin Huang,Jiaxing Sun,Xin Lv,Yanxia Zhang,Xiaoyan Liu,Wei Guo,Haixia Zhang
The development of high fluorescence quantum yield molecular fluorophores for second-order near-infrared (NIR-II) imaging is highly desirable but remains challenging due to the lack of reliable design guidelines. We report a method to construct “J-aggregates” by combining the inhibition of twisted intramolecular charge transfer (TICT) and electron-withdrawing strategies. Introducing electron-withdrawing substituents at the middle position of the classic boron dipyrromethene (BODIPY) backbone promotes J-type slip stacking, enhancing NIR-II fluorescence through increased electrostatic repulsion and intermolecular hydrogen bonding. The 3,5-aryl position is modified with sulfone and quaternary piperazine groups. The negative inductive effect (–I effect) from strong electron-withdrawing action increases the ionization potential (IP) of the amino group, inhibiting the TICT process and improving the quantum yield to 9.03 % and 16.9 %, respectively. Notably, the fluorescence quantum yield of NBDP-SO 2 increased to 18.2 % after self-assembly with F127, successfully applied in bioimaging. This study provides a new method for constructing high fluorescence quantum yield NIR-II emission by manipulating molecular stacking and establishing the relationship between molecular structure, intermolecular interactions, and fluorescence properties.
研究领域:
生物医学工程
·
分子影像学
✓ 已验证
DOI
高影响因子
Inorganic Chemistry Frontiers
·
2024
·Vol. 11
·期 15
·4711-4720
·
IF 6.1
Zhexuan Gao,Yi Zhang,Yinyan Li,Shilong Zhao,Peng Zhang,Xiaolong Dong,Degang Deng,Shiqing Xu
The second near-infrared window (NIR-II, 1000–1700 nm) emitting phosphor is a key component for the phosphor-converted light-emitting diode (pc-LED), which has garnered significant attention. However, it remains a major challenge to discover efficient NIR-II broadband phosphors that can be excited by blue LEDs. Herein, Cr3+ and Ni2+ ions were co-doped into the Li2ZnSn3O8 (LZSO) host. LZSO:Cr3+,Ni2+ phosphor achieves a broadband NIR-II emission peak at 1465 nm with a large full width at half maximum (FWHM) of 300 nm and internal quantum efficiency (IQE) of 43.31% under excitation at 426 nm because of the efficient energy transfer (ET) from Cr3+ to Ni2+. In addition, a dual-emissive doped phosphor across the NIR-I (700–1000 nm) and NIR-II regions with a higher sensitivity at physiological temperatures was obtained. The relative sensitivity value (Sr) reaches 1.44% K−1 at 293 K, indicating that the LZSO:Cr3+,Ni2+ phosphor is a potential candidate for NIR optical thermometers in biotechnological applications. The manufactured NIR-II pc LED provides a radiative flux of 8.26 mW with a photoelectric conversion efficiency of 2.71% at a drive current of 100 mA and has promising potential in night vision, medical imaging, and spectral analysis applications.
研究领域:
材料科学
·
生物医学工程
·
光学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF LUMINESCENCE
·
2024
·
IF 3.3
Xiaoyu Wu,Yang Yu,Kejie Li,Mingqin Huang,Zuoling Fu
The near-infrared-II (NIR-II) fluorescence thermometer based on rare earth-doped double perovskite is rarely. Herein, Er 3+ -Ho 3+ and Yb 3+ co-doped lead-free double perovskite La 2 MgTiO 6 (LMTO) phosphors were synthesized by a conventional high temperature solid phase method. The phase purity and morphology of the samples were analyzed using XRD and FE-SEM. The NIR-II luminescence properties of LMTO: Er 3+ -Ho 3+ -Yb 3+ phosphors were systematically investigated under laser irradiation at 980 nm. A NIR-II fluorescence thermometer was also designed based on non-thermal coupled energy levels originated from the 4 I 13/2 energy level of Er 3+ and the 5 I 6 energy level of Ho 3+ . The maximum value of relative sensitivity (S r ) was 0.54 % at 513 K. Compared to visible thermometers (LMTO: Er 3+ -Yb 3+ and LMTO: Ho 3+ -Yb 3+ ), the NIR-II thermometers offer better temperature measurement capability and penetration depth. All the experimental results show that the NIR-II thermometer with a wider range and higher sensitivity has been realized, which puts forward a new idea for the design and optimization of NIR-II thermometers.
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Yichi Chen,Wenxin Xu,Huimin Tian,Junbin Gao,Yicheng Ye,Hanfeng Qin,Hong Wang,Yanzhen Song,Chuxiao Shao,Fei Peng,Yingfeng Tu
Light-propelled nanomotors, which can convert external light into mechanical motion, have shown considerable potential in the construction of a new generation of drug delivery systems. However, the therapeutic efficacy of light-driven nanomotors is always unsatisfactory due to the limited penetration depth of near-infrared-I (NIR-I) light and the inherent biocompatibility of the motor itself. Herein, an asymmetric nanomotor (Pd@ZIF-8/R848@M JNMs) with efficient motion capability is successfully constructed for enhanced photoimmunotherapy toward hepatocellular carcinoma. Under near-infrared-II (NIR-II) irradiation, Pd@ZIF-8/R848@M JNMs convert light energy into heat energy, exhibiting self-thermophoretic locomotion to penetrate deeper into tumor tissues to achieve photothermal therapy. At the same time, functionalized with an immune-activated agent Resiquimod (R848), our nanomotors could convert a “cold tumor” into a “hot tumor”, transforming the immunosuppressive microenvironment into an immune-activated state, thus achieving immunotherapy. Dual photoimmunotherapy of the as-developed NIR-II light-driven Pd@ZIF-8/R848@M JNMs demonstrates considerable tumor inhibition effects, offering a promising therapeutic approach in the field of anticancer therapy.
研究领域:
纳米技术
·
癌症治疗
·
生物医学工程
·
光化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Science
·
2025
·
IF 14.1
Mengfei Li,Xue Zheng,Xinyang Yu,Shaolong Qi,Shoujun Zhu,Guocan Yu,Songling Zhang
mRNA vaccines have been widely implemented and revolutionized the landscape of oncology and epidemiology. Potent vaccination demands precise control over injection depth to ensure optimal lymphatic drainage, driving the development of non-invasive imaging techniques to visualize the distribution and efficacy of mRNA vaccines. Herein, near-infrared-II (NIR-II) lipid nanoparticles (NIR-II-LNPs) are fabricated for mRNA delivery by integrating a cationic fluorophore amphiphile (IR780-C16) into traditional LNPs, enabling longitudinal, quantitative, and non-invasive trafficking of mRNA vaccines. The in vivo behaviors of mRNA vaccines are characterized with different vaccination protocols in mice and rabbits by NIR-II fluorescence imaging. Results proved that following a 25 µL injection of mRNA vaccines into the mouse thigh at a depth of 4 mm or a 500 µL injection volume into a rabbit at a depth of 7 mm via the intramuscular route, the vaccines rapidly and abundantly accumulated in the inguinal lymph nodes. Flow cytometry and tissue immunofluorescence analyses further validated that optimized vaccination parameters effectively activated antitumor immunity and greatly boosted the therapeutic efficacy in B16-OVA and HPV-associated mouse tumor models. NIR-II-LNPs offer a unique modality for non-invasively monitoring the fate of vaccines, reinforcing its role in preclinical and clinical mRNA therapeutics.
研究领域:
肿瘤学
·
免疫学
·
生物医学工程
·
分子成像
·
疫苗学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
·
2021
·
IF 7.446
Yang Li,Jianfeng Gao,Shuping Wang,Mingxia Du,Xiaowen Hou,Tian Tian,Xue Qiao,Zhiquan Tian,Peter J. Stang,Shijun Li,Xuechuan Hong,Yuling Xiao
Complete excision of the last remaining 1–2% of tumor tissue without collateral damage remains particularly challenging. Herein, we report thiophenthiadiazole (TTD)-derived fluorophores L6-PEGnk (n = 1, 2, 5) as new-generation NIR-II (1000–1700 nm) probes with exceptional nonfouling performance and significantly high fluorescence quantum yields in water. L6-PEG2k can self-assemble into vesicular micelles and exhibited minimal immunogenicity, low binding affinities, ultralong blood circulation (t1/2 = 59.5 h), and a supercontrast ratio in vivo. Most importantly, L6-PEG2k achieved excellent in vivo CT-26 and U87MG tumor targeting and accumulation (>20 d) through intraperitoneal or intravenous injection. A subcutaneous U87MG tumor and orthotopic brain glioma were successfully resected under NIR-II FIGS in our animal model via intraperitoneal injection in an extended time window (48–144 h). This study highlights the potential of using L6-PEG2K as self-assembling molecular probes with long-circulation persistence for routine preoperative tumor assessment and precise intraoperative image-guided resection.
研究领域:
生物医学工程
·
分子影像学
·
癌症研究
✓ 已验证
DOI
高影响因子
ACS Applied Optical Materials
·
2024
·
IF 0
Yonghang Li,Yang Lu,Haonan Ju,Wei Wang,Dong Tu,Hongyu Lu,Jiayu Wang,Hua Zou
Near-infared phosphor-converted light-emitting diodes (NIR pc-LEDs) are next-generation NIR light sources due to their long life, low cost, and compactness. Unfortunately, there is a lack of efficient NIR-II phosphors with high efficiency and large full width at half-maximum (fwhm) that can be excited by violet LED. Here, a series of Cr3+/Ni2+-codoped LiAlSiO4 with unprecedented emission peaking at 1150 nm (∼1000–1400 nm, fwmh ∼191 nm) were synthesized via a solid-state reaction. More importantly, the phosphors exhibit high efficiency and excellent thermal stability under violet emission excitation. Moreover, the NIR pc-LED devices as a NIR-II light source have been fabricated through a combination violet LED and optimized LiAlSiO4:Cr3+/Ni2+ phosphors, which are well applied to high-penetration imaging and nondestructive fruit damage inspection. These results indicate that the LiAlSiO4:Cr3+/Ni2+ phosphors have great potential applications as NIR light sources.
研究领域:
材料科学
·
光学工程
·
电子器件
✓ 已验证
DOI
JOURNAL OF CONTROLLED RELEASE
·
2022
·
IF 11.467
Yang Li,Jianfeng Gao,Shuping Wang,Shijun Li,Xiaowen Hou,Yanna Pan,Jialu Gao,Xue Qiao,Zhiquan Tian,Deliang Chen,Hai Deng,Zixin Deng,Xuechuan Hong,Yuling Xiao
Nanocarriers hold great promise for the controlled release of therapeutic payloads to target organs/tissues and extended duration of anticancer agents in the bloodstream. However, limited data on their in vivo pharmacokinetics and delivery process hamper clinical applications. Here we report a series of micellar nanocarriers self-assembled from new-generation thiophenthiadiazole (TTD)-based NIR-II fluorophores HLAnP ( n = 1–4) for simultaneous bioimaging and drug delivery. The NIR-II HLA4P nanocarrier displays exceptional non-fouling performance, minimal immunogenicity, ultralong blood half-life, and high tumor accumulation even with different administration routes. When used as a drug carrier, HLA4P with encapsulated doxorubicin (DOX) realized accurate tumor targeting and continuous real-time in vivo NIR-II tracking of drug delivery and therapy, showing a sustained release rate, improved therapeutic effect, and diminished cardiotoxicity as compared to free DOX. This study provides a new perspective on the design of dual-functional NIR-II fluorophores for diagnostic and therapeutic applications.
研究领域:
生物医学工程
·
药学
·
分子影像学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）