计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
为什么选择此级别
提供 ≥99% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
室温。常规运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 25 篇同行评审文献引用。
概述
微溶于水，溶于乙醇 、乙醚 、丙酮、氯仿、苯。薄荷醇氢化生成对烷。A cooling agent that strongly activates TRPM8.
A cooling agent that strongly activates TRPM8.
规格
别名
L-薄荷醇
英文别名
CCRIS 375 | l-Menthol (TN) | (-)-Menthyl alcohol | (1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol | DTXSID1022180 | Levomentholum [INN-Latin] | CHEBI:15409 | Racementol [INN-Spanish] | SR-05000001936 | (1R,2S,5R)-5-methyl-2-propan-2-
规格或纯度
≥99%
英文名称
(1R,2S,5R)-(-)-Menthol
生化机理
(1R,2S,5R)-(-)-薄荷醇是一种降温剂。能强烈激活 TRPM8（冷薄荷受体 1；CMR1）和 ANKTM1（TRPA1）。
储存条件
室温
运输条件
常规运输
纯度
≥99%
名称和识别符
PubChem SID
EC号
218-690-9
分子类型
小分子
IUPAC Name
(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexan-1-ol
INCHI
1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3/t8-,9+,10-/m1/s1
InChi Key
NOOLISFMXDJSKH-KXUCPTDWSA-N
Smiles
CC1CCC(C(C1)O)C(C)C
Isomeric SMILES
C[C@@H]1CC[C@H]([C@@H](C1)O)C(C)C
分子量
156.27
Beilstein号
1902293
Reaxy-Rn
1902288
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1902288&ln=
技术文档
高级数据
系统学分类
分类树（Taxonomy Tree）
| 界（kingdom) | 有机化合物 |
|---|---|
| 超类（Superclass) | 脂质和脂质样分子 |
| 类（Class) | 异戊烯醇脂质 |
| 亚类（Subclass） | 单萜类化合物 |
| 中间层级节点（Intermediate Tree Nodes） | 暂无 |
| 直接上位类(Direct Parent) | 薄荷烷单萜类化合物 |
| 其他上位类（Alternative Parents） | 单环单萜类化合物 环己醇 环状醇及其衍生物 碳氢化合物衍生物 |
| 分子骨架（Molecular Framework) | 脂肪族同单环化合物 |
| 取代基（Substituents） | 羟基苯甲酸酯 - 脂肪族同单环化合物 - 环醇 - 环己醇 - 烃衍生物 - 单环单萜类化合物 - 有机氧化合物 - 有机氧化合物 - 对-薄荷醇单萜烯 - 醛基 |
| 描述（Description） | 该化合物属于有机化合物中的单萜烯类化合物。这类化合物以桉脑烷、间桉脑烷或对桉脑烷骨架为基础结构。对桉脑烷由环己烷环构成，其1位和4位分别连接甲基和(2-甲基)丙基。邻-和间-薄荷烷较为罕见，推测由对-薄荷烷发生烷基迁移形成。 |
| 外部描述符（External Descriptors） | Menthane monoterpenoids |
三维结构
交互式化学结构模型
关联靶点（人）
TRPV3
Tchem
瞬时受体电位阳离子通道亚家族V成员3(Transient receptor potential cation channel subfamily V member 3)
(0 活性数据)
TRPA1
Tclin
瞬时受体电位阳离子通道亚家族A成员1(Transient receptor potential cation channel subfamily A member 1)
(0 活性数据)
TRPM8
Tclin
瞬时受体电位阳离子通道亚家族M成员8(Transient receptor potential cation channel subfamily M member 8)
(1 活性数据)
F2
Tclin
Thrombin
(11687 活性数据)
ESR1
Tclin
Estrogen receptor alpha
(17718 活性数据)
PGR
Tclin
Progesterone receptor
(8562 活性数据)
CHRM2
Tclin
Muscarinic acetylcholine receptor M2
(10671 活性数据)
HTR1A
Tclin
Serotonin 1a (5-HT1a) receptor
(14969 活性数据)
ADRA2A
Tclin
Alpha-2a adrenergic receptor
(9450 活性数据)
AR
Tclin
Androgen Receptor
(11781 活性数据)
CHRM1
Tclin
Muscarinic acetylcholine receptor M1
(12690 活性数据)
MAOA
Tclin
Monoamine oxidase A
(11911 活性数据)
DRD1
Tclin
Dopamine D1 receptor
(9720 活性数据)
ACHE
Tclin
Acetylcholinesterase
(18204 活性数据)
PTGS1
Tclin
Cyclooxygenase-1
(9233 活性数据)
SLC6A2
Tclin
Norepinephrine transporter
(10102 活性数据)
SLC6A4
Tclin
Serotonin transporter
(12625 活性数据)
ADRA1A
Tclin
Alpha-1a adrenergic receptor
(8359 活性数据)
PTGS2
Tclin
Cyclooxygenase-2
(13999 活性数据)
OPRM1
Tclin
Mu opioid receptor
(19785 活性数据)
DRD3
Tclin
Dopamine D3 receptor
(14368 活性数据)
SLC6A3
Tclin
Dopamine transporter
(10535 活性数据)
KCNH2
Tclin
HERG
(29587 活性数据)
CACNA1C
Tclin
Voltage-gated L-type calcium channel alpha-1C subunit
(766 活性数据)
PDE3A
Tclin
Phosphodiesterase 3A
(3309 活性数据)
HTR2B
Tclin
Serotonin 2b (5-HT2b) receptor
(10323 活性数据)
TBXA2R
Tclin
Thromboxane A2 receptor
(5717 活性数据)
PDE4A
Tclin
Phosphodiesterase 4A
(1943 活性数据)
ADORA3
Tchem
Adenosine A3 receptor
(15931 活性数据)
HRH3
Tclin
Histamine H3 receptor
(10389 活性数据)
KDR
Tclin
Vascular endothelial growth factor receptor 2
(20924 活性数据)
UGT1A4
Tbio
UDP-glucuronosyltransferase 1A4
(288 活性数据)
Homo sapiens
(32628 活性数据)
APEX1
Tchem
DNA-(apurinic or apyrimidinic site) lyase
(38016 活性数据)
UGT2A1
UDP-glucuronosyltransferase 2A1
(59 活性数据)
OR5K1
Tdark
Olfactory receptor 5K1
(56 活性数据)
TAS2R7
Tchem
Taste receptor type 2 member 7
(31 活性数据)
关联靶点（其它种属）
Hdac6
Histone deacetylase 6 (222 活性数据)
Mus musculus (284745 活性数据)
rep
Replicase polyprotein 1ab (378 活性数据)
Trpa1
Transient receptor potential cation channel subfamily A member 1 (1003 活性数据)
Trpm8
Transient receptor potential cation channel subfamily M member 8 (889 活性数据)
Monographella nivalis var. nivalis (17 活性数据)
SARS-CoV-2 (38078 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
化学和物理性质
溶解性
Soluble in water (0.46 mg/ml at 25 °C), 100% ethanol, methanol (100 mg/ml), ether, and chloroform.
密度
0.89
折光率
1.46
比旋光度
-50 ° (C=10, EtOH)
闪点(℉)
213.8 °F
闪点(℃)
93℃
沸点
212°C
熔点
41-43°C
分子量
156.260 g/mol
XLogP3
3.000
氢键供体数Hydrogen Bond Donor Count
1
氢键受体数Hydrogen Bond Acceptor Count
1
可旋转键计数Rotatable Bond Count
1
精确质量Exact Mass
156.151 Da
单同位素质量Monoisotopic Mass
156.151 Da
拓扑极表面积Topological Polar Surface Area
20.200 Ų
重原子数Heavy Atom Count
11
形式电荷Formal Charge
0
复杂度Complexity
120.000
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
3
未定义的原子立体中心计数Undefined Atom Stereocenter Count
0
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
1
安全和危险性（GHS）
信号词
危险
危险声明
H315: 引起皮肤刺激
H318: 造成严重的眼睛损伤
H335: 可能引起呼吸道刺激
预防措施声明
P264: 处理后要彻底洗手。
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P321: 特殊处理（请参阅此标签上的...）。
P302+P352: 如皮肤沾染：用水充分清洗。
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。
P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。
P337+P317: 如果眼睛刺激持续：寻求医疗帮助。
P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。
WGK Germany
2
RTECS
OT0700000
Merck Index
5837
个人防护装备
dust mask type N95 (US),Eyeshields,Gloves
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技术文档和文章
What a Disagreement in Specific Rotation Results Reveals About Method Control: Why Specific Rotation Values for Chiral Samples Cannot Be Discussed Apart from Measurement Conditions
目录： 技术文章
此产品的引用文献
引用文献
| 1. Ang Li, Song Xue, Yu Xu, Sihui Ding, Di Wen, Qi Zhang. (2022) A feasibility study on the use of hydrophobic eutectic solvents as pseudo-stationary phases in capillary electrophoresis for chiral separations. ANALYTICA CHIMICA ACTA, [PMID:36628761] [10.1016/j.aca.2022.340693] |
| 2. Liyu Liu, Zaiyong Zhang, Yinxiang Cheng, Yihua Jiang, Liye Lu, Jian-Rong Wang, Xuefeng Mei. (2022) Stabilizing L-Menthol by Cocrystallization: Supramolecular Cavities Succeeded in Retaining the Volatile Flavor. CRYSTAL GROWTH & DESIGN, [10.1021/acs.cgd.2c00919] |
| 3. Li Yang, Shuang Wang, Zhongshui Xie, Rongrong Xing, Runqin Wang, Xuan Chen, Shuang Hu. (2022) Deep eutectic solvent - loaded Fe3O4@MIL-101(Cr) with core–shell structure for the magnetic solid phase extraction of non-steroidal anti-inflammatory drugs in environmental water samples. MICROCHEMICAL JOURNAL, [10.1016/j.microc.2022.108150] |
| 4. Xinjiao Cui, Donghao Ye, Jiankun Wei, Xiaodi Du, Pengzhao Wang, Junsheng Li. (2022) Controlled Thermal Release of L-Menthol with Cellulose-Acetate-Fiber-Shelled Metal-Organic Framework. MOLECULES, 27 (18): (6013). [PMID:36144758] [10.3390/molecules27186013] |
| 5. Li Liu, Wenna Wu, Xiaoli Chen, Jingcheng Hao, Xingcen Liu, Shuli Dong, Shoutao Cao, Binbin Yao, Hongxiao Yu. (2022) Responsive emulsion gels of glycyrrhizic acid and alanine for cigarette capsules. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, [10.1016/j.colsurfa.2022.129878] |
| 6. Taotao Fan, Zongcheng Yan, Chanyuan Yang, Shunguo Qiu, Xiong Peng, Jianwei Zhang, Lihua Hu, Li Chen. (2021) Preparation of menthol-based hydrophobic deep eutectic solvents for the extraction of triphenylmethane dyes: quantitative properties and extraction mechanism. ANALYST, 146 (6): (1996-2008). [PMID:33507168] [10.1039/D0AN01864C] |
| 7. Xiao-Hong Fan, Li-Tao Wang, Yuan-Hang Chang, Juan-Yan An, Ya-Wei Zhu, Qing Yang, Dong Meng, Yu-jie Fu. (2020) Application of green and recyclable menthol-based hydrophobic deep eutectic solvents aqueous for the extraction of main taxanes from Taxus chinensis needles. JOURNAL OF MOLECULAR LIQUIDS, [10.1016/j.molliq.2020.114970] |
| 8. Long Ye, Yichao Lv, Yuanjiang Zhao, Zhuxian Zhou, Youqing Shen, Liming Jiang. (2020) Encapsulation of fragrances in micron-size silk fibroin carriers via coaxial electrohydrodynamic techniques. MATERIALS CHEMISTRY AND PHYSICS, [10.1016/j.matchemphys.2020.124167] |
| 9. Ziman Hu, Songnan Li, Shaokang Wang, Bin Zhang, Qiang Huang. (2020) Encapsulation of menthol into cyclodextrin metal-organic frameworks: Preparation, structure characterization and evaluation of complexing capacity. FOOD CHEMISTRY, [PMID:32822901] [10.1016/j.foodchem.2020.127839] |
| 10. Xiao-Hong Fan, Yuan-Hang Chang, Li-Tao Wang, Ya-Wei Zhu, Ming-Zhu Dong, Mu-Jie Lv, Juan-Yan An, Qing Yang, Jiao Jiao, Dong Meng, Yu-Jie Fu. (2020) A simple and efficient sample preparation for taxanes in Taxus chinensis needles with natural menthol-based aqueous deep eutectic solvent. JOURNAL OF SEPARATION SCIENCE, 43 (7): (1339-1347). [PMID:32017401] [10.1002/jssc.201900754] |
| 11. Changcheng Wu. (2015) Synthesis and Characterization of a Series of Cholesterol-Based Liquid Crystalline Dimers with a Chiral (-)- Menthyl Terminal Group. MOLECULAR CRYSTALS AND LIQUID CRYSTALS, [10.1080/15421406.2014.953759] |
| 12. Qi Tan, Yiwen Liu, Ruifeng An, Heping Wu, Zhiqiang Tian, Bingliang Gao. (2024) DBN-based molecular solvents for highly efficient and reversible CO2 capture. Journal of Environmental Chemical Engineering, [10.1016/j.jece.2024.114470] |
| 13. Jiawei Zhou, Yumin Sang, Zhuang Wang, Jiacheng Feng, Linjiang Zhu, Xiaolong Chen. (2024) Enhancing the Enantioselectivity and Catalytic Efficiency of Esterase from Bacillus subtilis for Kinetic Resolution of l-Menthol through Semirational Design. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:38235660] [10.1021/acs.jafc.3c08321] |
| 14. Bo Yang, Xu Zhang, Liguo Zhang, Jinjin Wu, Wei Wang, Qiaomei Huang, Zhenyuan Wang, Jichuan Zhang, Tongjie Xu, Chengyu Wu, Jiaheng Zhang. (2024) Ionic Liquid-Based Grapeseed Oil Emulsion for Enhanced Anti-Wrinkle Treatment. Pharmaceuticals, 17 (10): (1273). [PMID:39458914] [10.3390/ph17101273] |
| 15. Jiamin Luo, Heng Lu, Bao-Ying Wen, Qiaowen Zheng, Junying Zhang, Yishan Li, Wenping Hong, Shanshan Zhao, Libo Shun, Feiming Li, Zhixiong Cai, Jin-Ming Lin, Qiang Chen, Maosheng Zhang, Jian-Feng Li. (2024) Natural Deep Eutectic Solvents as Absorbing Solution and Preparation Solvent of Perovskite Nanocrystals Simultaneously for CH3I Gas Visual Sensing. ANALYTICAL CHEMISTRY, [PMID:39307967] [10.1021/acs.analchem.4c04776] |
| 16. Jue Chen, Hexiang Zhong, Shan Zhu. (2024) Study on Cu(II) extraction process optimization and mechanism from acidic leaching solution using the deep eutectic solvent P507/Menthol. JOURNAL OF MOLECULAR LIQUIDS, [10.1016/j.molliq.2024.123968] |
| 17. Zinuo An, Liangbin Hu, Yuyin Fan, Zhenbin Liu, Hongbo Li, Dan Xu, Lu Tian, Jiayi Zhang, Haizhen Mo. (2025) Thermally-triggered L-menthol release system based on starch sodium octenyl succinate/Nisin-stabilized high internal phase Pickering Emulsion: Development, characterization and meatball coating application. Current Research in Food Science, [PMID:40937070] [10.1016/j.crfs.2025.101187] |
| 18. Zongtao Li, Shaodui Ye, Leshou Zhang, Zhenjuan Duan, Shengchun Yang, Yong Liu, Xiaodong Wen. (2025) Highly sensitive and selective sensing of lead (II) ions in Paris polyphylla using fluorescence-enhanced sulfur quantum dots in deep eutectic solvent micelles. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, [PMID:40896916] [10.1016/j.saa.2025.126868] |
| 19. Yi Chen, Xuan Wang, Hongyang Ma, Shyam Venkateswaran, Benjamin S. Hsiao. (2025) Chiral electrospun nanofibrous membranes for selective adsorption of chiral compounds. POLYMER, [10.1016/j.polymer.2025.128893] |
| 20. Fuhui Luo, Zhongqiao Zhao, Yong He, Fenfen Zeng, Xia Yang, Fengxiang Zhang, Wei Shi. (2025) A novel pH-switchable deep eutectic solvents system regulated by alkaline/acidic electrolytic water: Efficient extraction of polyphenolic compounds and solvent recycling. CHEMICAL ENGINEERING JOURNAL, [10.1016/j.cej.2025.169349] |
| 21. Danni Lin, Sisi Hu, Leyuan Zhou, Xiaojuan Ma, Lihui Chen, Dong Wang, Liulian Huang. (2025) Enhancing separation and anti-fouling performance of cellulose acetate ultrafiltration membranes by introducing natural deep eutectic solvent. Journal of Water Process Engineering, [10.1016/j.jwpe.2025.109042] |
| 22. Xuejian Zhang, Xiaoke Shi, Hong Xu, Yao Wang, Dikai Zhu, Jianan Liu, Tingting Zhang, Hongqian Shentu, Wei Ding, Jun Lu, Feiyan Tao. (2026) Targeted alleviation of local inflammation by a hydroxypropyl-cyclodextrin-encapsulated prodrug of methyl salicylate and menthol though Nrf2/NF-κB pathway. INTERNATIONAL IMMUNOPHARMACOLOGY, [PMID:41512796] [10.1016/j.intimp.2026.116171] |
| 23. Xiaotong Lyu, Qi Jiang, Kemin Linghu, Yifei Zhou, Mengqian Yu, Chunhui Wei, Liangcai Lin, Qi Zhou, Zhengshu Zhou, Cuiying Zhang. (2026) Digital transformation of Jiangxiangxing Baijiu production: integrating flavor compound analysis, machine learning recognition, and genetic algorithm blending of multi-rounds. FOOD RESEARCH INTERNATIONAL, [PMID:41794499] [10.1016/j.foodres.2026.118635] |
| 24. Zang Yu, Hou Rui, Wei Bohua, Liu Yuting, Wang Jianjun, Liu Jiao, Xu Liang, Zhang Wei. (2026) Cascade-controlled porous composite membranes: pore-supporting synergy enabling high-flux enantioseparation of amino acids and pharmaceuticals. Science China-Materials, [10.1007/s40843-025-3936-8] |
| 25. Lyu Xiaotong, Wang Keen, Zhou Meiyi, Dong Yuchen, Deed Rebecca C., Lin Liangcai, Wang Guoming, Li Yanke, Ren Changcheng, Zhu Yan, Wei Chunhui, Zhang Cuiying. (2026) Identification of Key Aging-Related Aroma Compounds in Sesame-Flavor Baijiu via Chemometrics and Molecular Docking: Insights into Flavor Formation Mechanisms. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 74 (34): (27218-27234). [PMID:42690767] [10.1021/acs.jafc.6c08828] |
溶液计算器
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