Minocycline hydrochloride is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic . Minocycline hydrochloride is a hypoxia-inducible factor ( HIF )-1α inhibitor. Minocycline hydrochloride shows anti-cancer , anti-inflammatory , and glutamate antagonist effects. Minocycline hydrochloride reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline hydrochloride inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect.

规格

规格或纯度

Moligand™, 10 mM in DMSO

英文名称

Minocycline hydrochloride

储存条件

干燥,-80℃储存

运输条件

特低温运输

名称和识别符

EC号

237-099-7

分子类型

小分子

Isomeric SMILES

CN(C)[C@H]1[C@@H]2C[C@@H]3CC4=C(C=CC(=C4C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C.Cl

分子量

493.94

Reaxy-Rn

4836328

技术文档

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高级数据

化学和物理性质

比旋光度

-170 to -180 deg(C=0.5、0.1mol/L HCl)

闪点(℉)

230°F

闪点(℃)

>110℃

沸点

813℃

熔点

205-210℃

安全和危险性（GHS）

象形图

GHS07

信号词

警告

危险声明

H315: 引起皮肤刺激

H319: 引起严重眼睛刺激

H335: 可能引起呼吸道刺激

H362: 可能对母乳喂养的孩子造成伤害

预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P302+P352: 如皮肤沾染：用水充分清洗。

P321: 特殊处理（请参阅此标签上的...）。

P405: 密闭存放

P501: 将内容物/容器处理到。。。

P264: 处理后要彻底洗手。

P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。

P271: 仅在室外或通风良好的地方使用。

P270: 使用本产品时，请勿进食、饮水或吸烟。

P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。

P403+P233: 存放在通风良好的地方。保持容器密闭。

P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。

P263: 避免在怀孕期间/哺乳期间接触。

P203: 使用前，获取、阅读并遵守所有安全说明。

P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。

P318: 如果暴露或担心，请就医。

P337+P317: 如果眼睛刺激持续：寻求医疗帮助。

P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。

P319: 如果你感到不适，请寻求医疗帮助。

WGK Germany

RTECS

QI7630500

Merck Index

6202

个人防护装备

dust mask type N95 (US),Eyeshields,Gloves

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批号(Lot Number)	证书类型	货号
H2617615	分析证书	M1498682

技术文档和文章

抗生素如何卡住细菌蛋白质合成（附典型产品与选型导航表）

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抗生素

How Antibiotics Halt Bacterial Protein Synthesis (With Representative Products and a Selection Guide)

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Antibiotics

各类抗菌药物特点及科研选用

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抗菌药物抗生素分类作用机制抗菌谱 MIC测定药敏实验耐药机制感染模型

此产品的引用文献

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引用文献

1. Ting Zhu, Jinyang Chen, Shasha Zeng, Jintao Chen, Chunjiao Qi. (2023) Highly Stable Fluorescent-Traffic-Light Sensor for Point-of-Care Detection of Tetracycline. ACS Sensors, [PMID:37862265] [10.1021/acssensors.3c01620]
2. Fei Tong, Pei Wang, Ziqiang Chen, Yifan Liu, Lianguo Wang, Jun Guo, Zhihua Li, Hu Cai, Junchao Wei. (2023) Combined Ferromagnetic Nanoparticles for Effective Periodontal Biofilm Eradication in Rat Model. International Journal of Nanomedicine, [PMID:37192894] [10.2147/IJN.S402410]
3. Keke Huang, Xin Liu, Ziru Lv, Di Zhang, Yuling Zhou, Zhiqing Lin, Juan Guo. (2023) MMP9-Responsive Graphene Oxide Quantum Dot-Based Nano-in-Micro Drug Delivery System for Combinatorial Therapy of Choroidal Neovascularization. Small, [PMID:36871144] [10.1002/smll.202207335]
4. Jinyu An, Xue Jiang, Zhe Wang, Yingqiao Li, Zhiru Zou, Qian Wu, Le Tong, Xifan Mei, He Tian, Chao Wu. (2022) Codelivery of minocycline hydrochloride and dextran sulfate via bionic liposomes for the treatment of spinal cord injury. INTERNATIONAL JOURNAL OF PHARMACEUTICS, [PMID:36244559] [10.1016/j.ijpharm.2022.122285]
5. Ling Yang, Jing Yang, Hua Liu, Jingbin Lan, Ying Xu, Xiaobo Wu, Yushan Mao, Dongming Wu, Kejian Pan, Tao Zhang. (2022) Minocycline binds and inhibits LYN activity to prevent STAT3-meditated metastasis of colorectal cancer. International Journal of Biological Sciences, [PMID:35414768] [10.7150/ijbs.70708]
6. Yule Wang, Huimin Wu, Zhu Han, Hongda Sheng, Yuhan Wu, Yingchao Wang, Xinran Guo, Yan Zhu, Xuecai Li, Yi Wang. (2022) Guhong injection promotes post-stroke functional recovery via attenuating cortical inflammation and apoptosis in subacute stage of ischemic stroke. PHYTOMEDICINE, [PMID:35276592] [10.1016/j.phymed.2022.154034]
7. Lijuan Yang, Lumin Zeng, Yongqing Tao, Dandan Wang, Kailian Zhang, Meng Tian, Zhining Xia, Die Gao. (2021) Galli Gigerii Endothelium Corneum derived fluorescent carbon dots and their application as sensing platform for nitroimidazoles and cell imaging. MICROCHEMICAL JOURNAL, [10.1016/j.microc.2021.107089]
8. Chengzhi Zhou, Yanlong Sun, Fan Zhang, Yuandong Wu. (2021) Degradation of Minocycline by the Adsorption–Catalysis Multifunctional PVDF–PVP–TiO2 Membrane: Degradation Kinetics, Photocatalytic Efficiency, and Toxicity of Products. International Journal of Environmental Research and Public Health, 18 (23): (12339). [PMID:34886061] [10.3390/ijerph182312339]
9. Lijuan Yang, Jing Zeng, Tian Quan, Shaochi Liu, Linlin Deng, Xun Kang, Zhining Xia, Die Gao. (2021) Liquid-liquid extraction and purification of oil red O derived nitrogen-doped highly photoluminescent carbon dots and their application as multi-functional sensing platform for Cu2+ and tetracycline antibiotics. MICROCHEMICAL JOURNAL, [10.1016/j.microc.2021.106391]
10. Xiao-Juan Wang, Gao-Feng Shu, Xiao-Ling Xu, Chen-Han Peng, Chen-Ying Lu, Xing-Yao Cheng, Xiang-Chao Luo, Jie Li, Jing Qi, Xu-Qi Kang, Fei-Yang Jin, Min-Jiang Chen, Xiao-Ying Ying, Jian You, Yong-Zhong Du, Jian-Song Ji. (2019) Combinational protective therapy for spinal cord injury medicated by sialic acid-driven and polyethylene glycol based micelles. BIOMATERIALS, [PMID:31288173] [10.1016/j.biomaterials.2019.119326]
11. Yi Quan, Tan Fang-hui, Tan Jia-an, Chen Xiu-hui, Xiao Qing, Liu Ying-hua, Zhang Gui-ping, Luo Jian-dong. (2019) Minocycline protects against myocardial ischemia/reperfusion injury in rats by upregulating MCPIP1 to inhibit NF-κB activation. ACTA PHARMACOLOGICA SINICA, 40 (8): (1019-1028). [PMID:30792486] [10.1038/s41401-019-0214-z]
12. Yule Wang, Yiran Li, Yue Zhou, Yue Gao, Lu Zhao. (2024) Guanxinning Tablet Alleviates Post-Ischemic Stroke Injury Via Regulating Complement and Coagulation Cascades Pathway and Inflammatory Network Mobilization. Drug Design Development and Therapy, [PMID:39308695] [10.2147/DDDT.S479881]
13. Binwang Yang, Zhixiong Ye, Feiyu Lu, Jianna Yu, Jiaxu Liu, Xiuqing Zheng, Cheng Wang, Lian Duan, Zhijian Yang, Guoxing Jing, Wen Liu, Wenshan Li, Wenjie Liu. (2024) High Resolving Power Electrospray Ionization Ion Mobility Spectrometer Based on Fourier Deconvolution Multiplexing. ANALYTICAL CHEMISTRY, [PMID:39413295] [10.1021/acs.analchem.4c04549]
14. Yuwei Zheng, Jiaying Chi, Jiayu Ou, Ling Jiang, Liqing Wang, Rui Luo, Yilang Yan, Zejun Xu, Tingting Peng, Jianfeng Cai, Chuanbin Wu, Peng Teng, Guilan Quan, Chao Lu. (2024) Imidazole-Rich, Four-Armed Host-Defense Peptidomimetics as Promising Narrow-Spectrum Antibacterial Agents and Adjuvants against Pseudomonas Aeruginosa Infections. Advanced Healthcare Materials, [PMID:39039988] [10.1002/adhm.202400664]
15. Hongchao Dai, Lei Yuan, Luyao Fan, Jia Yang, Xinan Jiao. (2024) Occurrence and risk-related features of Bacillus cereus in fluid milk. INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY, [10.1111/1471-0307.13054]
16. Yuehong Li, Qingzheng Zhang, Zongtai Liu, Weiguo Xu, Changfeng Fu. (2025) Intravenously injected poly(amino acid) nanoformulation relieves spinal cord injury through synergistical modulation of microenvironments. Materials Today Bio, [PMID:40893356] [10.1016/j.mtbio.2025.102227]
17. Ting Zhu, Yu Yang, Yuhui Shang, Yali Liu, Jinyang Chen. (2025) All-in-one prepared highly stable fluorescent copper nanocluster composite for point-of-care sensing of tetracycline. ANALYTICA CHIMICA ACTA, [PMID:41093536] [10.1016/j.aca.2025.344688]
18. Pei Wang, Lianguo Wang, Yilan Zhan, Yifan Liu, Ziqiang Chen, Jia Xu, Jun Guo, Jun Luo, Junchao Wei, Fei Tong, Zhihua Li. (2023) Versatile hybrid nanoplatforms for treating periodontitis with chemical/photothermal therapy and reactive oxygen species scavenging. CHEMICAL ENGINEERING JOURNAL, [10.1016/j.cej.2023.142293]
19. Xingchen Xu, Pei Wang, Fei Tong, Yifan Liu, Xinyang Hu, Jian Yang, Jun Guo. (2025) Polydopamine-Coated Magnetic Nanoplatform for Magnetically Guided Penetration and Enhanced Antibacterial Efficacy in Root Canal Biofilm Elimination. Polymers, 17 (10): (1305). [PMID:40430601] [10.3390/polym17101305]
20. Xie Min, Cheng Yu, Yang Lizhen, Lin Zijin, Shen Hao, Zhou Xinhua, Liu Zheng, Xing Jieyu, Zhou Sigui, Chen Haiyun. (2025) Tetramethylpyrazine-caffeic Acid Hybrid CT-011 Exerts Dopaminergic Neuroprotection Through Inhibiting Microglia-mediated Neuroinflammation. MOLECULAR NEUROBIOLOGY, 63 (1): (44). [PMID:41239042] [10.1007/s12035-025-05310-9]
21. Yu Cheng, Yao Wen, Zhaohan Wang, Lizhen Yang, Junming Liao, Jieyu Xing, Zheng Liu, Xiaoyan Sheng, Lingli Zhou, Sigui Zhou, Jian Zou, Haiyun Chen. (2026) Anti-Parkinson's disease polysaccharide PFP50-1 attenuated neuroinflammation via inhibition of TLR4/NF-κB and PI3K/Akt pathways and suppression of NLRP3 inflammasome activation. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:41616997] [10.1016/j.ijbiomac.2026.150579]