Origin: Native. Isolated from human peripheral blood polymorphonuclear leukocytes. Apparent Molecular Weight: approx. 150 kDa (contains 2 subunits each of a heavy chain with 64 kDa and a light chain with 13 kDa) Function Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
Store at 4°C short term. Store at -80°C long term. Upon delivery aliquot. Avoid freeze/thaw cycle.
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Native Human Myeloperoxidase Protein (M572740) - SDS-PAGE 3 μg/lane of Native Human Myeloperoxidase Protein was resolved with SDS-PAGE under reducing (R) condition and visualized by Coomassie® Blue staining, showing the band at 57.9 & 12.9 kDa under reducing condition.