MIR96-IN-1 targets the Drosha site in the miR-96 (miRNA-96, microRNA-96) hairpin precursor, inhibiting its biogenesis, derepressing downstream targets, and triggering apoptosis in breast cancer cells. MIR96-IN-1 binds to RNAs with K d s of 1.3, 9.4, 3.4, 1.3 and 7.4 μM for RNA1, RNA2, RNA3, RNA4 and RNA5, respectively.
In Vitro
MIR96-IN-1 (Compound 1) selectively inhibits production of mature miR-96 and triggers apoptosis in breast cancer cells at micromolar concentrations. MIR96-IN-1 (Compound 3) binds a UU loop in miR-96 and inhibits its biogenesis. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
规格
规格或纯度
≥98%
英文名称
MIR96-IN-1
生化机理
MIR96-IN-1 靶向 miR-96(miRNA-96,microRNA-96)发夹前体中的 Drosha 位点,抑制其生物生成,抑制下游靶点,并引发乳腺癌细胞凋亡。MIR96-IN-1 与 RNA 的结合 K d s 分别为 1.3、9.4 和 3.4、