计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥99% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
避光,充氩,干燥,-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 1 篇同行评审文献引用。
概述
MMI-0100 is a cell-permeant peptide inhibitor of mitogen activated protein kinase activated protein kinase II ( MK2 ). MMI-0100 reduces intimal hyperplasia ex vivo and in vivo. MMI-0100 suppresses IL-6 expression without effect on IL-8 expression. MMI-0100 suppresses fibrotic processes such as vein graft disease.
In Vitro
Naphthofluorescein (compound 19) (0-10 μM; 24 hours) suppresses the HIF-1 reporter activity in a concentration-dependent manner.. MMI-0100 (0.25 and 0.5 mM; 24 hours) slightly increases cell proliferation in both cell types compared to control cells treated with 20 ng/ml TNF-α alone. MMI-0100 (1 mM) treatment also increases both EC (11%) and SMC (7%) proliferation as compared to control, this response is not as robust as that induced by treatment with 0.5 mM MMI-0100. MMI-0100 does not induce EC apoptosis at any dose. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: human endothelial cell (EC) and smooth muscle cell (SMC) Concentration: 0.25, 0.5, and 1 mM Incubation Time: 24 hours Result: Slightly increased cell proliferation in both cell types compared to control cells.
In Vivo
MMI-0100 (100 μM; 28 days) inhibits intimal hyperplasia in a mouse vein graft model . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 12-week-old C57Bl/6 wild type mice (intimal hyperplasia) Dosage: 100 μM Administration: vein graft, 28 days Result: Diminished wall thickness at all postoperative time points in vein grafts treated with MMI-0100, with a ratio of 2.6-fold thicker at 4 weeks, compared to 4.7-fold thicker at 4 weeks in control grafts.
Form:Solid
规格
规格或纯度
≥99%
英文名称
MMI-0100
生化机理
MMI-0100 是丝裂原活化蛋白激酶活化蛋白激酶 II（MK2）的细胞渗透肽抑制剂。MMI-0100 可减少体内外内膜增生。MMI-0100 可抑制 IL-6 的表达，但不影响 IL-8 的表达。MMI-010
储存条件
避光,充氩,干燥,-80℃储存
运输条件
特低温运输
纯度
≥99%
名称和识别符
分子类型
蛋白质
Isomeric SMILES
C[C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CC=C(C=C1)O)N
PubChem CID
分子量
2283.64
技术文档
高级数据
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
化学和物理性质
溶解性
H2O : 100 mg/mL (43.79 mM; Need ultrasonic)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
此产品的引用文献
溶液计算器
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