计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥99% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
避光,-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
MM-401 (TFA) is a MLL1 H3K4 methyltransferase inhibitor. MM-401 inhibits MLL1 activity ( IC 50 = 0.32 µM) by blocking MLL1-WDR5 interaction. MM-401 can induce cell cycle arrest, apoptosis and differentiation. MM-401 can be used for the research of MLL leukemia
In Vitro
MM-401 maintains high binding affinity to WDR5 with a K i value of < 1 nM and disrupts WDR5-MLL1 interaction with an IC 50 value of 0.9 nM. MM-401 is able to specifically inhibit MLL1 activity (IC 50 value of 0.32µM) by blocking MLL1-WDR5 interaction and thus the complex assembly. MM-401 (20 μM; 48 h) specifically inhibits MLL1-dependent H3K4 methylation in cells. MM-401 induces similar changes in MLL-AF9 transcriptome as the MLL1 deletion. MM-401 (10, 20, 40 μM; 48 h) specifically inhibits growth of MLL leukemia cells by inducing cell cycle arrest, apoptosis. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: Murine MLL-AF9 and Hoxa9/Meis1 cells Concentration: 10, 20, 40 μM Incubation Time: 48 h Result: Specifically induced apoptosis of MLL-AF9 cells. Cell Cycle AnalysisCell Line: Murine MLL-AF9 and Hoxa9/Meis1 cells Concentration: 10, 20, 40 μM Incubation Time: 48 h Result: Induced prominent G1/S arrest in MLL-AF9 cells in a concentration dependent manner. RT-PCRCell Line: MLL-AF9 cells Concentration: 20 μM Incubation Time: 48 h Result: Significantly decreased H3K4me, expression of 5 Hox A genes, especially Hoxa9 and Hoxa10.
Form:Solid
IC50& Target:Ki: < 1 nM (WDR5),IC50: 0.9 nM (WDR5-MLL1 interaction), 0.32 µM (MLL1)
规格
别名
MM-401 三氟乙酸
规格或纯度
≥99%
英文名称
MM-401 TFA
生化机理
MM-401 (TFA) 是一种 MLL1 H3K4 甲基转移酶抑制剂。 MM-401 通过阻断 MLL1-WDR5 的相互作用来抑制 MLL1 的活性（IC 50 = 0.32 µM）。MM-401 可诱导细胞周期停滞、凋亡和分化。MM-401 可用于研究 MLL le
储存条件
避光,-80℃储存
运输条件
特低温运输
作用类型
抑制剂
纯度
≥99%
名称和识别符
分子类型
小分子
分子量
700.75
技术文档
高级数据
化学和物理性质
溶解性
DMSO : 100 mg/mL (142.70 mM; ultrasonic and warming and heat to 60°C)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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溶液计算器
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